I can’t say I have fully recovered from pushing myself to my operational limits to do work (which looks a lot like socializing in my line of work) while still recovering from an infection after dental work.
It’s always recovering from an infection these days. I’ve been on some kind of antibiotic or anti-fungal every day since October.
2025 for me was getting an infection and then recovering from an infection on repeat. Ever since I decided to swap my biological injection 15 months ago from Coesyntx to Bimzelx and I think I’ve hit my limit.
It’s just too damn depressing that it’s a constant threat that I’ll have either a soft tissue infection or an abscess or a swollen gland that turns into a staphylococcus colony.
It’s as if I’ve got no skin biome left which is almost certainly true. I think I’d rather have CRP and sed rates and risk other infections than be rotating antibiotic varietals like some kind of junky afraid to develop a dependency.
Except instead of pain pills or lady downers it’s amoxicillin versus doxycycline versus Cipro with the occasional dalliance with a macrolide. I’ve also come to appreciate the benefits of Fluconzole. It’s not great. If you want a quick AI generated overview scan along
- Beta-lactams: This broad group includes penicillins (e.g., amoxicillin), cephalosporins (e.g., cephalexin), and carbapenems (e.g., meropenem). They work by inhibiting cell wall synthesis.
- Macrolides: (e.g., azithromycin, erythromycin) These inhibit protein synthesis and are often used for respiratory infections.
- Tetracyclines: (e.g., doxycycline) Used for a wide range of infections, they inhibit protein synthesis.
- Fluoroquinolones: (e.g., ciprofloxacin, levofloxacin) Broad-spectrum antibiotics that inhibit DNA synthesis.
My problem is that going back to my old biologic will take three to four months to full dose and it’s not a risk free process. And my full biometric panel is better on Bimzelx so is it really so bad that my resting heart rate is in the upper nineties every other week?
I think it may be time for me to make a pilgrims to the remaining clinics and pretend that I have any remaining institutional trust. Maybe I can vibe code something usual along the way.
I intend to support others on this journey as I’ve been chronically this journey a long time and the times are changing as we bring more artificial intelligence to the inference issues around our biometrics.