Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology.
I am doing alright with it. I was wary of keeping the patch on all night long (I am very sensitive to stimulants such that I won’t drink caffeine past 10am) so I removed it at about 5pm. That may have been a mistake.
Yesterday my Whoop recorded physiological stress. I wasn’t coughing, I had more capacity for exertion, and I felt generally less exhausted.
But I didn’t come down easily for sleep. I ended up taking a number of anti-inflammatory medications as well as an Ambien. My heart rate was stable but I felt “up” which I don’t care for at night.
And I did not wake up to good news. My HRV absolutely tanked. There are lots of confounding variables here in that I got good restorative sleep (medicine induced surely) but some strain has clearly been too much. 40% down isn’t a rousing endorsement.
I am also noticing a lot of chatter around addiction and whether or not it’s responsible to discuss these things. The fear that the average person is in fact prone so addiction and will have adverse affects. Which I’m sure is true. I don’t think normal people should take unnecessary risks and it’s good to have the minimum viable dose be none at all.
It’s wise to remember that I am not at all living in average circumstances nor do I have average medical conditions so I am not necessarily who you should be looking to for health advice. You should do the basics like eat more protein, lift heavy things, sleep an adequate amount, be in the sun and move around, and manage your baseline health metrics first.
I can’t think about most of this at the moment as I am officially on my Maximum Health Protocols which is a mix of expensive piss and biohacking basics with a hint of woo and a triple helping of pharmaceuticals.
I still feel like shit but my hope is that dedication will save me from long post viral complications. I’ve worked too hard on my health to let some stupid inflammatory Covid event get me off track.
Covid isn’t any more worrying than most triggers to my overclocked autoimmune system but the additional pain of the inflammation isn’t doing me any favors. Does anyone else remember cytokine storms? To quote South Park, I member
I dislike the brain fog and exhaustion as it feels like writing about illness has become boring. I’d rather be going on tangents and rants but I’m stuck linking to posts recommending vitamins and sleep. Probably a sign that I love my work that my irritation is this strong.
I have been enjoying the mild weather of May. I’ve not had any extremes which is a sort of pleasant surprise. Climate and weather intersect poorly too often these days.
I was explaining to a mutual how we’d settled on Montana to buy land and much of the calculation was about the pleasures of a cold, dry and mountainous climate. It’s sunny without much in the way of humidity which makes for enjoyable winters even when it gets cold.
I am not much of a fan of humidity. It hurts my joints and reminds me of my ankylosis. I’m much more prone to trouble with inflammation when it’s damp.
Whenever I encounter a coastal climate I struggle a bit. Others may love a riviera but I’ve never found one I liked. I’ve been to a reasonably diverse array from San Francisco to coastal Mediterranean and I can do without.
The weather is however about to change. Soon it will be the season of air conditioning. I’ll be going through Texas for a conference at the end of May. I’m not looking forward to the heat.
I get really bad migraines. I do what o can to manage them but they are a frequent and challenging enough issue for me that I’ve got 45 separate entries on the topic.
I’d prefer not to discuss it at all as it’s not a very pleasant experience but it can be so overwhelming that it’s all I can think about on a given day. I probably should have seen it coming when I starters making jokes about Cardassians light torture yesterday.
I’ve taken about as much medication as I can (more than two Imitrex otherwise known as Sumatriptan it is a dynamite medicine but you don’t want to risk over doing it as overuse can make the migraines worse. It’s the 109th most prescribed drug in American with over five million prescriptions in 2021 so there is a lot of good data. Plus there is some fun asides.
Overdose of sumatriptan can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to green, due to the integration of sulfur into the hemoglobinmolecule
I do not care for podcasts but I listen to a Bloomberg podcast called Odd Lots for entertainment. I’m an avid participant in the niche in-group you might have once called Financial Twitter. The hosts of the podcast Joe and Tracy are part of this community as well.
Usually I listen to it for the fun expert guests who come to do commentary on their corner of the markets. Today’s episode was titled how the American workforce got hooked on adderall. Which I personally think is a very provocative title.
Over the last few years, users of the popular ADHD drug Adderall have been frustrated by regular shortages in getting their prescriptions filled. Various regulatory and supply chain factors have contributed to the inability of producers to keep up with demand. But this raises the question: why is there so much demand in the first place? How did a significant chunk of the labor force — from tech workers to Wall Streeters — begin using the drug as an aid for their work and everyday lives? On this episode of the podcast, we speak with Danielle Carr, an assistant professor at the Institute for Society and Genetics at UCLA, who studies the history of politics of neuroscience and psychology. We discuss the history of this medicine and related medicines, what it does for the people who take it, and how market forces opened the drug up to almost anyone.
My impression of Danielle Carr was of a nuanced thinker with a lot of historical insight who happened to have haplessly taken on some academic moralizing about whether the wrong class of person might be abusing stimulants. I’m perhaps the wrong class of person to be commenting as I don’t use any stimulants stronger than a cup of coffee in the morning.
I was struck how the narrative eventually came to demonizing market demands in contrast to the I’m sure completely neutral national health systems. The theory being we might keep better track of the vulnerable in such a system struck me as classist. Adderall may be an American healthcare market issue only because those poor London bankers have another go to black market stimulant. We just don’t mind because they make money.
Moral panics around pharmacological intervention seem to be a flavor of the decade sort of thing. Prohibitions catch on when the wrong kind of person gets themselves into trouble of abusing something that was otherwise contained to social sanctioned consumption.
Perhaps in less inclined to judge on these things because I don’t witness the abuse but I also think paternalism is the excuse schoolmarms and aristocrats love in equal measure.
I’d describe her experience as literal shape rotation with what is a “memory palace” visualization of the world.
I can’t imagine not having inner monologue. I have a bicameral mind and can picture imagery and movement in my head and discuss it with myself.
Her description of her thought process is akin to having filing system and seeing her thoughts in that system rendered in a flexible database. It’s like she’s a computer.
Other reactions to this video have churned through my mind. Is self awareness maladaptive? Would a future intelligence find this bicameral mind inefficient and go back to unicameral. What other forms exist? Can we toggle it up and down? Is it a gradient in humans of types of cognition and the inner voice is just a processing error?
Can’t find it in the thread atm but thanks to the person who made this. “The end point of this thinking is self awareness is maladaptive”
Oh my god, I get it now. The bicameral mind is still in the process of breaking down. Inner monologues are holdovers, doomed to be outcompeted by more efficient mind
Is this “breakdown” a the shift away from perceiving the voice as external to the self? Is it the erasure of the voice wholesale? What will artificial intelligences make of these differences in human minds? Is this special? A tiger isn’t bicameral.
I think this is relevant to our moment in artificial intelligence development. A Finnish mathematician wrote one of the best science fiction novels I read in the last decade on quantum minds and memory palaces. There is a side plots with embodied intelligences on Mar.
The Quantum Thief is a science fiction novel by Finnish writer Hannu Rajaniemi and the first novel in a trilogy featuring the character of Jean le Flambeur; the sequels are The Fractal Prince and The Causal Ange
Wikipedia
I’ve got a hazy theory about Nordic decentralized engineering culture and mental organization. It’s not a coincidence that fifteen years ago a Silicon Valley Finnish computer scientist wrote some of the best science fiction about a theory of mind that was interior and perfectly organized right?
I may need to go read Julian Jaynes.
An un-cameral mind, as proposed by Julian Jaynes in his theory of bicameral mentality, refers to a state where cognitive functions are divided between two parts without consciousness or meta-reflection. In this non-conscious mental state, individuals lack the ability to reason, articulate mental contents, or have executive ego functions like deliberate mind-wandering. The breakdown of this division led to the emergence of consciousness in humans, characterized by the capacity for introspection and autobiographical memory[1][3].
Jaynes suggests that ancient people in the bicameral state experienced auditory hallucinations as commands from gods, guiding their actions without conscious evaluation. This theory has influenced discussions on consciousness, language, and culture, although it has faced criticisms and debates. Despite differing opinions, Jaynes’s work remains a thought-provoking exploration of the origins of consciousness and continues to inspire research in psychology and consciousness studies[3][5].
Sources [1] Bicameral mentality – Wikipedia https://en.wikipedia.org/wiki/Bicameral_mentality [2] The Origin of Consciousness in the Breakdown of the Bicameral Mind http://www.compilerpress.ca/Competitiveness/Anno/Anno%20Jaynes%20Bicameral%20Mind1.htm [3] The Origin of Consciousness in the Breakdown of the Bicameral Mind https://en.wikipedia.org/wiki/The_Origin_of_Consciousness_in_the_Breakdown_of_the_Bicameral_Mind [4] Retrospective: Julian Jaynes and The Origin of Consciousness in … – jstor https://www.jstor.org/stable/10.5406/amerjpsyc.125.2.0237 [5] The Origin of Consciousness in the Breakdown of the Bicameral Mind https://www.amazon.com/Origin-Consciousness-Breakdown-Bicameral-Mind/dp/0618057072
I saw someone else say meditation is literally teaching people how to run a monocameral emulator. I’ve done these types of exercises as a child. It sounds a bit Bene Geserit but mental exercises around focus was part of the German theosophical tradition that gave us Rudolf Steiner.
I wish I’d be a bit more organized on this but I’ve been fully back on work so this will have to do for today.
At the risk of being “TMI” (this is a gesture of self knowledge to readers not an actual concern of mine that I will ever include too much information), I did something stupid to my personal biome today.
I took an expired a probiotic. I fucked up my bacterial mix. In my defense, I didn’t know it was possible to have an expired Lactobacillus mix. Expired doesn’t seem to mean dead. It just is not doing what I’d hoped and I feel worse not better.
I honestly sort of believed that most probiotics on the self were bullshit. It’s hard to decide what’s medical woo anymore. But I acquired it from a German pharmacy last year and I guess GlaxoSmithKline supplies better shit in Frankfurt than it does in Bozeman.
I immediately nuked the new, supposedly friendly, bacteria from orbit with a one-two punch of doxycycline. I always carry some with me when I travel. Don’t tell my health insurance I’m so cavalier with my over-the -counter bacteria.
I’m joking, but only just. I’m sure artificial intelligence will be put out to nefarious purposes like denying health care coverage to random idiots who blog about their bodies any day now. I just doubt any lawyer will care what nonsense I got up to with yogurt when so many other forms of Medicare fraud are more accessible.
So in the spirit of my blogging forefathers and mothers, I’ve included you in the circle of trust as to the inner workings of my co-infections, symbionts, and other biological processes. Let’s hope, unlike in the case of Ripley, that nuking from orbit works. No need to be carrying aliens in my dark places.
I’d love to know if this happens to anyone else. I find I’m easily influenced by the data that my fitness trackers share with me. Sometimes it will even affect my mood negatively. A green recovery can make me feel more optimistic.
I’m a user of both a Whoop and an Apple Watch. I’ve got a whole biohacking routine like every other Silicon Valley bro.
This morning, after a fitful seven and a half hours of sleep, my Whoop showed my recovery was in the red. My HRV was 26 which is low even my my standards.
I felt worse yesterday than I do today so it’s my hope that my Whoop is merely showing me the bad day I had after the fact. Pain can affect my recovery significantly as it’s a lot of stress. I’ll manage my way through it slowly and with lots of rest. And I’ll try not to let it get to my head. A quiet day in bed reading the internet is is a good day in my book.
I am however finding it to be really tiring to do all of the cooking and cleaning in a tight space. I feel like I just don’t have the energy to keep up with it. I am more tired by it than I has hoped I’d be.
I actually feel pretty good except that it’s just a lot more strain than I’d like to manage the basics of life. I benefit a lot from access to help as I similarly don’t have that much spare energy in a day.
Thankfully it’s possible to find civilization with a little effort. No matter how remote it is possible to find someone who would like to exchange their labor cooking a meal for your capital. Trade is the connective tissue of our species.
I hope the rest of America is enjoying the polar vortex that is bearing down on them. Our weather improved somewhat from from there last two days of -40 into the comparatively balmy -5.
I do feel a little bit stir crazy being inside for this long or maybe I’m just feeling a little crazy from pain. I’m feeling some intense pain in my spine and joints during this freeze. It’s unclear if the pain weather related but I’ve got no reason to be experiencing any kind of flare so my mind has tied them together.
I’m hoping that as the weather recedes for us on the western half of the country I’ll be ready to leap into action. I’m a bit antsy. I’ve been considering a number of moves as I have commitments to work on a number of portfolio and founder related initiatives as well as the most crucial #FreedomToCompute campaign.
I’d write more but I am not at the top of my game so I’ll dip back into reading and hope tomorrow is a good day.
