Category: Medical

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Biohacking Medical

Day 1290 and Covid Experiment

I caught a case of Covid at the very end of May that took me down hard. I’d been struggling with “long” symptoms

So I tried an experiment. A pretty crazy one at that suggested by my osteopath and supervised by a doctor.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th

Day 1283 Nicotinic acetylcholine receptors (nAChRs)

The principle was pretty simple but not proven yet in clinical trials.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits

Please do go read the original post with lots of caveats as nicotine is an addictive substance and this is not something to try without consulting your doctor.

I was unable to do the full 7mg but cut the patches down to 3.5 to 5mg over the five days. The side effects included headaches for the first day or so and a persistent queasiness.

Within a day I was lifted out of my exhaustion (which you’d expect from something modestly stimulative even though it was a low slow release dose). By the end of the second day my persistent coughing lifted entirely. I’d been struggling with congestion and coughing after even modest exertion like a walk outside.

I was functional on the fourth and fifth day like I hadn’t been since I got Covid. You can see me go into the red on my first day (my HRV dropped significantly but my RHR was only up by a few BPM). I slowly felt better and saw better recoveries even while taking on a little bit more exertion. I pushed a little too hard and found myself back in the red on my last day.

My Whoop recovery and strain chart for the five days of experiment beginning on the 6th and ending on the 11th of July

I was really relieved to stop the patch by the end. The last day of treatment I had overextended myself so I was in the red and feeling it even as the nicotine pushed my system up. I wanted to rip it off and did eventually cave at the end of the day instead of doing it all night.

My symptoms seem to be at bay. I feel decent enough so days after wrapping even as I began menstruation this morning. I hate to report that it also improved my usually debilitating PMS which typically includes intense migraines.

I would do it again if I got Covid. I cannot imagine ever using a nicotine patch consistently. I didn’t not enjoy the extra push of energy except insofar as it got me out of the exhaustion of the illness. I feel like it would be too much if I were otherwise feeling healthy. I have no cravings or side effects after.

Honestly I’m still wrapping my head around how well this worked. A part of me is confused, indignant and angry that a substance I was taught to fear has therapeutic benefit. Updating your mental models around long held beliefs is an uncomfortable process. But it’s a heck of a lot better than long covid symptoms.

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Biohacking Medical

Day 1269 and Reconditioning

I feel as if I lost a lot of ground to a gnarly case of Covid over the past couple of weeks. I had two weeks of clear infection symptoms and then a week of simply being exhausted and unable to get out of bed.

The benefit of keeping trace of one’s biometrics that I at least have some visibility into the misery. Of course, the downside is that I have visibility into how much misery. An extremely both sides of the bus meme situation.

I have a lot of reconditioning in front of me. Or at least my health data suggests that. It’s very discouraging to have health apps say you’ve had a 90% decrease in activity.

This week I slowly began the work of going back to life. I attended a policy gathering. I’ve been working on deals. I suppose I was doing that while I had symptoms too. It’s been hard as I want this to be better but I lost a lot of ground and relatively quickly.

I’m now doing all the little things one does help get your body back on track. Simply changed and reminders are most effective if you have injuries or are chronically ill.

I have little routines where I get up and do body weight squats on the hour. I’ll make sure to walk 500 steps each time I get up. I’ll touch my toes and stretch.

All these things feel very hard at the moment and I get blaring warning signals from the trackers suggesting physiological strain when I do. The slog of not giving up is a permanent part of the human condition and I refuse to let entropy win. But I am discouraged by how much work it is to do the basics. You can’t ever escape that life is just chop wood and carry water

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Biohacking Medical

Day 1264 and Party’s Over

I am going on my third week of having Covid symptoms. I don’t know if it’s time to call it “Long Covid” but my autoimmune response to it feels like it’s being dragged out.

My family doctor (an absolute gem of a general practitioner with a concierge clinic if you are ever in need in Montana) helpfully reminded me of the basics of immune response.

The infection is cleared but my immune cells did not get this memo. I’m still coughing, I’ve got clear phlegm, and I am struggling with a high respiratory rate. I am exhausted.

Yesterday I went for a short 15-20 minute stroll to get sunshine and I found myself with a very heightened respiratory rate overnight.

Apparently even small stressors like pollen count or exertion are hard when your immune response is overactive. I’ve been living with an autoimmune condition for years so while rationally I know this, it helps to be reminded.

If one is inclined to a forced metaphor, the party is over and the guests have left but the host hasn’t figured out it’s time to turn off the stereo, lock up and pick up the trash.

Calming immune responses is a tricky business. Sometimes you succeed by waiting it out as your system slowly resets to a healthy baseline. Sometimes you use more interventionist approaches with either local or systemic steroids. I try to avoid this but sometimes the only approach is the brutal one.

It’s my hope that the party being over means I can simply manage the mop up but I hope my immune cells decide to chill and get back to baseline soon.

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Internet Culture Medical

Day 1260 and Boredom

I’ve never understood boredom. I am very much the kind of nerd who enjoys learning. I’m mostly topic agnostic so life has been a pretty joyful experience of deep dives & rapt attention.

I struggle to be empathetic towards boredom as everything interests me. I don’t know if curiosity is innate or learned but I’m glad I have it in abundance.

The closest I get to understanding boredom is the exhaustion and brain fog that comes with illness. I’ve had an awful bout of Covid that I’ve intermittently worked through over the past two weeks.

My mind just has less capacity to hold onto focus. I’m in pain and the misery of the experience makes it harder to do more than the basics. I normally thrive on focus but now I’m stuck in ongoing being able to do tasks that require less cognitive overhead.

This has led to a kind of boom and bust set of cognition for me as I save up my focus for the deals that just can’t wait and then I am like a zombie on my fun unable to do much as finish a pdf about “situational awareness.” Maybe this is what they meant by boredom all along?

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Chronic Disease Medical

Day 1253 and Dragging

I may give myself an out today to get very little written as despite me being a bit further into my “I’ve got Covid” saga I am in no way feeling better.

I do not want to have a long case of Covid or the much dreaded/debated Long Covid and I am trying to remain optimistic about the situation.

I do not feel optimistic about it as absolutely every aspect of my normal health troubles are 10x worse and I’ve got all your other fun symptoms like coughing.

I’m scared as it’s not getting better which brings up the anxiety that I’ll be back to where I was in 2019-2020 when stabilizing my health was more than a full time job.

I don’t mind having a part time job managing my health. Or as I prefer to think of it a side hustle as a biohacker. Except instead of making money I spend money.

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Chronic Disease Medical

Day 1252 and Maximum Health Protocols

I must have wanted some early 2022 vibes as my current “Covid infection after a traveling to a crypto conference” feels aesthetically familiar. It still feels like we are in the same long now of Empire’s End but this time with more geopolitical risk.

I can’t think about most of this at the moment as I am officially on my Maximum Health Protocols which is a mix of expensive piss and biohacking basics with a hint of woo and a triple helping of pharmaceuticals.

I still feel like shit but my hope is that dedication will save me from long post viral complications. I’ve worked too hard on my health to let some stupid inflammatory Covid event get me off track.

Covid isn’t any more worrying than most triggers to my overclocked autoimmune system but the additional pain of the inflammation isn’t doing me any favors. Does anyone else remember cytokine storms? To quote South Park, I member

I dislike the brain fog and exhaustion as it feels like writing about illness has become boring. I’d rather be going on tangents and rants but I’m stuck linking to posts recommending vitamins and sleep. Probably a sign that I love my work that my irritation is this strong.

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Biohacking Medical

Day 1251 and Summer Covid

I don’t know why this didn’t occur anyone earlier but this morning as I went about my news review the New York Times surfaced a piece on handling a rise in summer covid cases. My brain went huh so I took a Covid and as it turns out this viral thing is in fact just fucking Covid.

Whomp whomp.

A blast from the past. A positive Covid test!

If anyone wants to make some jokes about how I was just at a crypto convention I could use some throwback pandemic humor. I am certainly enjoying the irony.

As new variants of the coronavirus continue to gain traction, doctors and researchers are bracing for a potential rise in cases this summer. KP.2, one of these variants, now accounts for 28.5 percent of cases, and data from the Centers for Disease Control and Prevention shows a small increase in Covid-related emergency room visits and positive tests

Summer 2024 Covid

I am naturally not thrilled. I know no one takes covid seriously anymore so protocols are lax but I’ve got an overactive immune system. I don’t want to give myself any chance at post-viral nonsense nor do I want to put anyone around me at any additional risk.

For what it’s worth I hate being sick in public so only my husband Alex has been in particular close proximity to me as my symptoms got worse. I pulled back from the conference as soon as my symptoms really hit.

I will not be leaving bed until I’m sure I’ve got this absolutely licked. I am throwing all the usual suspects in the biohackers arsenal at this thing. If you’ve got suggestions for fending off post-viral nonsense send them my way.

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Medical Travel

Day 1250 and Viral Load

I very much picked up something awful and I suspect viral in Texas and am going to be coping with its fallout for a few days.

I’ve lost track exactly of its onset as my brain is scrambled by cold medication, decongestants and the process of being sick. You go very hard trying to show up for panels and dinners and then you find you can’t get out of bed at all.

I do find it modestly funny to crack jokes about being high on DayQuil and experiencing coughing fits so strong incontinence is a concern. But I guess it depends on your sense of humor. Yes that’s a diaper joke. Either way I’m useless to myself and others except as a source of amusement.

I haven’t had the sort of viral or bacterial load type infection that one would qualify as a cold or flu for sometime.

My immune system is so overclocked that your common cold barely stands a chance. I have endless autoimmune problems but actually having the flu is a bit unusual. I hope it passes soon. Till then I’ll be in bed hopefully not wetting it.

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Medical Travel

Day 1248 and DayQuil High

I got a bit of a viral thing going on as my time in Austin for the Consensus conference wraps up. I feel as if missed a lot of time with people I’d wanted to catch up with simply because I was sick. I made it to all the programming and a few gatherings.

I am not the only one who is being stricken by various forms of infection. It seems like a lot of folks even at the conference were struggling. So perhaps it’s just a case of conference crud but it’s still annoying as nothing is so awful as a DayQuil high.

If I missed hanging with you I am very sorry. I am available on other channels. And I hope my panels were ok! For now I’ll rest and appreciate that the DayQuil high is keeping the misery at bay

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Biohacking Medical

Day 1229 and Hormones

I was pleased to wake up to a near perfect recovery score on my Whoop today. Because I manage a few chronic health issues I am a bit of a stereotypical biohacker type.

I happen to be rounding the corner into my best two weeks of the month and am seeing my biometrics improve.

While it’s fun to joke about moody women, I sometimes wonder if we’ve done ourselves a disservice by insisting that our hormonal rhythms be kept outside of polite conversation.

It’s not any fairer to men to keep discussions hormonal health quiet. Culture war nonsense aside, one of our major health systems surely deserves more public discussion and advancement.

As if the bounds of social propriety simply cannot accommodate anyone discussing say the follicular phase for women or what men can do to increase testosterone. Our fucked fertility deserves better than polite Victorian euphemisms.

If you aren’t sure about the state of your hormones and feel as if you could be in better health consider this permission to learn more about yourself. Your body deserves your self knowledge.