I feel like I got quite a scare and yet you’d think I’d be used to it, as this is all downstream of the interleukin-17 inhibitor that I changed onto at the beginning of the year for my autoimmune condition.
Every single quarter, and in some cases every other month this year, I have had some bizarre skin infection resulting from otherwise pretty benign situations. An infected gland in my eye (twice!) an abscess that turned into a deep tissue infection, and a tiny incision that allowed in a subcutaneous infection all rocked my world.
As much as I am thrilled to see all of my inflammatory numbers rolling in to baseline normal, I just don’t know if I can sustain having a health crisis this frequently for a medication that is supposedly working. It’s working at an extremely high cost to my sanity and body.
And you might say, “Well, the numbers don’t lie.” And I’d agree. But there are many other factors I have to consider, not the least of which is that healthcare access in America is so bad that I have managed two of the four crisis points with medical tourism abroad.
I am going to give my IL-17 inhibitor a full year as dosing on and off biologics is no easy matter and the compounding effects are quite real. But I do very much wonder if in order to go forward I must turn back.
My inner child finds the idea asking if “you want to see something gross” to be funny. Of course, I want to see.
Gore and violence don’t get this reaction from me. I dislike it in movies and in the real world. But to see gross and the weird in the real world. I get it. Maybe lots of humans thinks seeing gross things are cool.
I think it is a bit sweet. It is as a very human reaction go “ewww cool” when faced with non lethal wounds. Maybe it’s truer with boys than girls, but if a kid said “do you want to see something gross?!” in Colorado when I was a tween the answer was a rousing yaah! Gross things are cool.
Maybe it’s a type of survival mechanisms where if we can learn more about what is lethal, and lethal injuries look like, it then improves our Darwinian fitness. We judge risk more accurately.
Flesh wounds need proper care and do turn out absolutely fine. And boy have we improved on the science of wound care since I was a kid. We have evolved past the bandaid.
But even in a hard situation like a fire burn or the dermis getting sliced open, I still had a bit of that bravery of a little girl. That is cool! The bravado of a human who believes we can fix it
If you enjoy a story of plucky Rocky Mountain woman learning to do emergency care for herself and her community I’m glad we shared this time together.
Hopefully you never need these emergency skills. We take learn the risks and practice for them so we may never experience them.
So if you don’t feel this way, I’m giving you your ticket out of here. Stop reading now. But if you want to see something gross stay on.
This is my wound on Wednesday morning after I had the procedure. It’s much bigger a slice than I’d expected but first time practitioners (I asked for the experiment) and while the treatment is safe across most vectors, I was a nervous immune compromised patient who prepared for the worse.
So this a real 10/10 “let’s see how it goes from here” experiment especially if the returns it delivers are real. I hope for the energy, pain tolerance and healing benefits the average patient sees
So I am using a 90 minute full 2 atmosphere protocol already as I go went this treatment. I had also begun testing the GLOW stack from a peptide spot where I trust the owner. I’m helping him test. And this is the recommended stack for recovery.
.01 of the GLOW stack which is a regenerative peptide therapy with three peptides—BPC‑157, TB‑500, and GHK‑Cu—it was made to promote healing, tissue regeneration, and collagen production,
So I am absolutely throwing the gold care package at this. I am taking collagen and biotin, we’ve got the local food and the lack of seed oils, we’ve got the best current standard for peptides on injury and surgical recovery.
And somehow I am still scared. I never heal well or easily. I bruise easily and badly. I was so slow this summer to heal from an abscess surgery. I took a risk and I worried.
But I woke up this morning and my open wound has closed and the bruising has retreated in just five days to this. I’ll be in the scar mitigation territory in no time, and soon it won’t even be visible to the naked eye.
Day 5 of recovery from testosterone pellets
Progressively, the wound has moved from acute bruising and erythema toward decreased inflammation and resorption of bruising, with steady wound closure. Monitoring should continue, but the pattern suggests healthy tissue repair
So I hope you enjoyed seeing something gross. As it is keeping less and less gross by the minute.
Many moons ago, when I was first attempting to get a diagnosis for why I was always in pain and exhausted, I got a battery of allergy tests. I did the “gold standard of allergy testing” called patch testing which is a form of pin prick testing designed to pick up responses that may be delayed.
It was an awful experience. I barely made it through the 5 day trial between the 100 allergen pin pricks and final measurements.
I remember begging the doctor for a way to measure early. I asked if I could take some Benadryl to take the edge off. Alas the only way it would be accurate and covered by my insurance is if I gutted it out.
You are not allowed to shower, sweat, be exposed to UV rays (no going outside) or take immune suppressants that might subdue your body’s response.
I was struggling to breathe, my entire body itched and ached, and I had a migraine so bad I couldn’t see for the stars & dizziness. It’s possible I wasn’t stable enough to have adequately consented to the test but I did get my final results.
Out of 100 common allergens tested it was confirmed I was extremely allergic to 10 of them with another moderate sensitivity set of twenty or so that I should merely try to avoid as opposed to my firm “no go” list.
The dermatologist gave me a sheet with 75 different chemical names and formats that I might encounter in the wild from these core allergens:
I instructed to search ingredient lists for these names any time I purchased a household product, personal care item, cosmetic or other item which might include these ingredients which ranged from nail care to vaccines.
It was honestly quite overwhelming. And some of the above ingredients are in basically everything. I dare you to avoid Limonene for a month.
So my husband and one of our best friends did what any practical minded engineer would do and they made me simple Google sheet where all 75 varietals could be checked if I plugged in the ingredients from any item.
I used it for years. I’d plug in the INCI from every brand I encountered into the sheet no matter what. I gave away a lot of products to friends.
Today it occurred to Alex that we should probably vibe code the thing into a proper web application using Replit so other people could check ingredient lists for their own allergies.
You can set your own allergens or click a few buttons for common allergens and “clean ingredient standards” and run a check for an all clear.
It isn’t super fancy but it doesn’t need to be. It just needed to keep your data safe, be easy to log into so you can securely check and access your personal list and generally functional enough to change and set allergens. We’ve put it on our own little domain just to see how much this will cost to run (and we’ve set up alerts so it doesn’t go bonkers) but we figured this should be accessible and simple.
And while there are other options on the market, most are bloated, overly paranoid and designed for scaring California moms rather than quickly helping people with clear preferences for avoidance and actual tested allergies. So hopefully our pain can help you breathe easier.
Some options for chemicals and irritants you can select on our app. My own settings of allergies and sensitivities
We may have some room for improvement technique with it so I am encouraged if the is as bad as it gets. I am not seeing any benefits from it yet and ugly bruising and a bit of an opening on an incision isn’t so bad.
A lot will depend on how well I recover and how much the hormone actually helps when I’m not healing. I’m also in the luteal horrors phase where my hormones are most ridiculous so I’m curious to see the curve.
The best part of this remains that I have a world class treatment for skin wounds on hand. Hyperbaric chamber oxygen therapy’s best research has been in wound management from burns to slow healing diabetics. So if I have to nurse a wound doing it with oxygen at pressure is actually pretty baller.
And to make it even more on theme, I spent most of my time in there writing out a column on skincare and the Great Male Renunciation of Appearances as part of my beauty shopping column and excuse to write about the secret history of appearance and its power.
Every time life gets intense I wonder to myself why am I speeding into the turn? And then I look back at the last almost half decade (which is easier than I’d expected as I’ve written every day) and I feel the achingly slow pace at which we tackle the challenges of our lives.
We’ve had really big wins and really glass chewing teeth grinding bloody inch by inch progress that barely feels like a win at all.
Some pain has given me relief and some has been so heartbreaking it crushes me that it’s beyond my control. Bodies and borders are often beyond the control of mortals.
My husband and I are both sick. It’s the kind of “not quite respiratory, not quite sinus, not quite right” viral infection that always seems to take twice as long to clear as you expect.
Aging and stress is part of it but so is the damage we both have from covid-19 infections that turned into pneumonia. We’ve never been the same.
The good/bad news is that everyone we know seems to have the same basic set of physical degradations that we do. Varying levels of impact are met with varying levels of healthcare and wellness routines. From peptides to hyperbaric oxygen chamber therapy, no one is taking this shit sitting down.
I was already chronically ill before the world changed forever. It’s now common to have a flavor of autoimmune inflammatory chaos. I feel both less alone but much more frustrated at the crisis in American healthcare.
My medical billing codes as ankylosing spondylitis (arthritis in my spine) and psoriatic arthritis (psoriasis but it’s inside your body and it hurts!) but the tldr is constant pain, occasionally losing the capacity to walk, and the persistent exhaustion of chronic inflammation.
As we both cancel travel plans (for a charity event we’ve supported for years) and struggle to manage food and medication, I am reminded of the grief we are all carrying around.
As the world goes on with the “before times” as l memory for older generations, and the idea of any kind of positive “before” is unimaginable to the young, the grief comes and goes. The elders we stopped civilization to keep alive are dead or dying and our youth are distraught.
I remember being so angry and afraid for him when he left for cruise as lockdowns went into effect. I begged him to cancel the trip. I was afraid he would get sick or die.
He didn’t share those fears. He got stuck on the boat for an extra week or two, as no port would let them dock. He had the time of his life. I was locked in an apartment in Manhattan.
I don’t think he ever got Covid. For which I am grateful. I know far too many who did. I know many angry Zoomers grieving lost high school and college years.
Housing went up by 50% as we printed to survive the crisis. Strange times for us all and now we face the Great Ravine where the choices we made catch up to us.
My investment thesis of an increasingly chaotic world was novel when I first began and now it’s the same pitch every Tom, Dick and Harry espouses. What was once unclear is now the consensus. I am I am alive to see it and find no satisfaction in being right. The grief is all around us. Grief is for the living.
We spent a long time at the doctor’s yesterday as Alex and I gutted it out with our excellent physician (with AI assists) through a myriad of different tests. We were attempting to figure out why he keeps getting respiratory infections and why I’m such a tasty treat to skin bacteria.
What I don’t seem to be able to improve is my low testosterone and the flavors of migraine headache that come with the roller coaster of my luteal phase. Which is presumably a clue and we are following it.
Astonishingly my lady hormones are in tip top shape. Though the “you should have no trouble getting pregnant if we can get off the medicines that stabilize you” remarks remains a heads trip. Yes I asked.
It is not a head trip that makes one’s husband enthusiastic about the prospect. Which is fair, as we have no family support, no backup plans for me regressing physically, and the family that does support us can’t get to America. So one can see why a CEO husband with sick investor wife who would have to give up work, plus potentially messed up baby, isn’t super appealing. Anyways! TFR is a fun topic.
I started with basic supplements in the precursor category like DHEA and STRO about a year ago when my testosterone came in at a 2 nanograms per deciliter (ng/dL) when it should be somewhere between 9 to 55 nanograms per deciliter (ng/dL). For context, adult men typically have levels in the 240–950 ng/dL.
The one sticky widget is that my testosterone remains stubbornly low. You wouldn’t think such a raging “see you next Tuesday” such as myself would be overburdened with the feminine hormones and lacking in ball buster hormones but I am.
For the past 8 weeks I’ve been using a testosterone cream that clicks up your dose and you rub it between your thighs. I know it’s gross. So I was curious to see where I might land. And praise the Lord I am now at 15 ng/dL. From 2 to 5 to 15 is some excellent progress but still below where we’d like me to hit. So we are going to run another test and try out the tiny pellets they slice into your skin. Since I’m already used to scalpels and antibiotics I figure why not?
I slept rather poorly last night. I get anxious before medical appointments. Interfacing with America’s medical system can range from merely uncomfortable to actively hostile so I suppose some heightened vigilance isn’t irrational.
I really yearn for an uptick in qualitative metrics I associate with higher quality of life like energy for my favorite physical activities (weightlifting and hiking). The fatigue and stress from the pain, and downstream side effects are constant reminders of poor health.
So I am looking for improvements in basic markers like my CRP and Sed Rate as those inflammatory markers should coincide with the qualitative improvements.
An auspicious pair of numbers for today’s date and I started something new which has been in the works since January began today. Our long awaited hyperbaric chamber has arrived and been fully set up in our yellow barn.
A lazy boy lounger and oxygen under two atmospheres of pressure.
It feels good to begin a positive focused wellness activity after what was otherwise a chaotic week of travel, geopolitics and violence.
As expected, it is not fun living through my own investment thesis. So you better believe I test my theories on myself. I want to survive the Jackpot.
Before Trump’s inauguration, we decided to purchase a hyperbaric chamber after one of our mutuals told us about his HBOT trial at a conference in the fall. It went very well for him and the research is promising for inflammatory conditions.
Over the winter break I happened to be in a city where I could test HBOT cheaply and was very impressed with the results in only ten sessions during a flare in my autoimmune condition. Crimping from Bryan Johnson
Hyperbaric Oxygen Therapy (HBOT) involves breathing pure or nearly pure oxygen (95-100%) in a pressurized chamber at anything above atmospheric pressure (2 ATA is equivalent to being 33 feet under seawater).
The increased pressure enhances the lungs’ ability to absorb oxygen, boosting oxygen levels throughout the body. The therapy aims to promote rejuvenation by increasing oxygen concentration in tissues, supporting healing, cellular repair, and vascularization.
This sent me down a rabbit hole as I did a bunch of deep dives, got some text books and came to a simple conclusion after a lot of medical papers that it’s pretty simple.
It’s almost philosophically the way of life in the mountain west. Oxygen and pressure work on the biomechanics of a functional body. Alas getting my basic market model to Montana ended up being a cluster fork of issues. We placed the order in January.
For months we waited for what we’d been told would be a 6-8 week process. Alas all hell broke loose. We had tariffs uncertainty with the importer and the OEM.
I have now, in September, after a long journey but a simple set up process, begun my first intensive protocol for autoimmune diseases on our own hyperbaric chamber.
Love your body enough to put it under pressure and take a deep breath.
I will complete a minimum of 40 sessions (5 sessions weekly) at 2 atmospheric pressures, in a hard chamber from OxyRevo with each session 90 minutes while breathing 100% oxygen for 20 minutes separated by a 5 minute break.
If you are interested and see strip mall options note that these are not consumer grade machines. The protocol requires a hard chamber to achieve that pressures. It’s quite a bit higher than soft chambers on the market.
There are risks associated with HBOT from correct pressurization issues to impacts like tinnitus. The more prepared you are to adapt to changing pressure with breathing techniques and equalization (looking to divers for these protocols) the happier your central nervous system will be.
We often talk about solving “pain points” when doing product development and market fit work for startups. We have popular metaphors in this vein. Start a company that sells painkillers not vitamins is so ubiquitous a piece of advice I can’t even locate its original source.
I’ve been thinking a lot about how much I personally apply this motto to the pain I’ve experienced in my own life. I’ve had personal pain points (travel and miniatures cosmetics sounded small but the market proved itself out) and now I am working on a medical spa concept as a side project in our barn in Montana.
The two growth areas in America, and soon I imagine the world, is artificial intelligence and healthcare for aging populations. I’ve been particularly interested in complex chronic diseases and the holistic approach required to treat them as I myself suffer from one.
If I experience a problem my instinct is to solve it for everyone. So I figure if the data coming from Jackson Hole is to be believed I should find a way to integrate what I know well (technology and complex disease management) and use that experience help our elders age with less pain. Literally painkillers perhaps in some cases.
I found this listicle in some dreck of an SEO bot optimized website so apologies to any original bloggers but it’s a decent list of how to think through why we like this metaphor. Skip if you just want my human written personal content. I’m just experimenting with including extra content from AI for my own recording keeping.
The Reality Test: Do users actively seek solutions, or do you need to educate them?
• The Money Test: Does budget appear instantly, or do they “need to think about it”?
• The Urgency Test: Do they want it this month, or is it “maybe next quarter”?
• The Solution Test: Are they actively looking for alternatives?
• The Decision Test: Do deals close in 1-2 calls?
• The Value Test: Can they quantify the cost of the problem?
• The Team Test: Does the whole team being sold on it want it?
