It’s a topic on which I have written extensively, as I am one of the women who was hurt by the American approach of high hormone intensity to extract eggs efficiently. To make a long story short, it kicked off an autoimmune process in me that we’ve never fully gotten under control.
I think a lot about what the fertility industry did unknowingly to me and how it forever changed the course of my life. I went from thinking I had an insurance policy to being too ill to work within the space of a year. There is no recovery for me as of yet, even though I spend quite a bit of time and effort on my health.
If you were a millennial or Zoomer thinking about these procedures, I’d like you to consider reading her research and my personal experiences and educating yourself so you can make the most informed decision in your family planning.
Becoming a mother may have been an easy or unexpected decision for other generations of women, but we live in a very different time with very different technologies and different social constructs.
The more you know about your options, the more likely it is that you will find the right path for yourself without doing harm to your body in the process.
I seem to have accidentally fallen into polyphasic sleep. Those experimental not for human consumption, long amino acid chains that everyone is doing n of 1 research with?
Well, my n of 1 experiment seems to be yielding the occasionally odd sleep pattern. I’ll be up early after having a night of sleep that feels more nap than fully weighed sleep hours.
Think out by 9pm and awake before dawn. I feel fine, so I pack in the full day till around 3pm when lunch digestion & the general slumps have me saying “maybe a short nap.”
I’ll find myself popping back up at 6pm with an eye on dinner. Another accidental siesta has stolen the afternoon hours back from the long evening hours to which I’d applied them.
I won’t have any trouble going to sleep on time early. This pattern seems to be applied to days where I have a lot of physical strain.
If I get in a workout, a long shower, extra walking time, and other physically demanding tasks in alongside my mental work I end up needing the nap and still fall asleep on time.
If I stuff too many experiments into a given day, I’ll almost surely end up with a migraine. Even if I only do one sometimes I get unlucky. Red light and infrared are, of course, a classic way to trigger a migraine, so I try to do those carefully and when my heart rate is stable and low.
Of course, sometimes you need to get your heart rate up, and there’s nothing you can do but get your exercise and hope it won’t trigger a migraine. Afterwards exertion when I have a need to get down my heart rate, I’ll try to mix that with my hyperbaric oxygen chamber therapy.
I’m in the middle of my second round of HBOT treatments and enjoying seeing things like my VO2 max improve. I’ll be tempted to do something like go for a longer walk to test my lungs and trigger some neck compensation, and then I’ll be right back where I started with a migraine.
I’m always rotating something in and around keeping my brain from feeling the pressure of my body’s adjustments. There is no stable equilibrium just the constant pressure to find a new balance.
I have been feeling rather sad. I am stymied on a few matters (family matters, visas for said family) and absolutely wretched over the state of artificial intelligence. The successes are in shadow and so I need to cheer up.
In an effort to do, I have a little group chat going for women interested in having friendly conversations about pretty skills. That’s right being pretty is a skill set. From nutrition and exercise to scalp care and makeup, looking good is a series of skills that can be taught.
If one feels like personal agency is a stretch, nothing is quite so fine a balm as learning a new skill. And might I suggest your personal appearance as an easy uplifting place to start?
Pulling together a beautiful look is not just some genetic privilege meted out by fate. Our presentation is something we sculpt with attitude, posture, movement, care and thousands of tricks and tips that add up to a lifetime of skills. Pretty is a skill set.
If you didn’t learn those from your mother or aunts or an elder sister. Or if you learned everything and want to pass it down. It’s safe to share and learn the skill sets you’ve picked up that make you feel pretty. It’s in your hands.
So if you want a space to learn more about those skills there are a bunch of women who want to be friends with you.
I am trying to get healthier, but that suggests it is even an achievable goal. It would be wonderful to get back to endless working hours or even just eight hours on my feet.
Every time I make a tweak to my routines and I see a change in my biometrics, it’s becomes eventually cause for concern. There’s no stable equilibrium to be found, and I know that’s part of life, but I’d like a stable equilibrium that’s a little bit better than one day at a time or ideally a couple weeks at a time.
Take my experiment with Bimzelx. Even when I achieve an outcome like getting my CRP rates into the normal bounds, it came at a cost that is simply too high to maintain. I had four separate incisions and surgeries last year from soft tissue infections.
What good is a drug that tamps down my immune system so much that I need to always go under the knife? It was like Goodhart’s Law came to haunt me personally.
I am going off the biologic (I am 12 weeks from my last injection) and already seeing change in the wrong direction. Not enormously bad but my immune system will pop if it’s not locked down.
Yet there’s very little I can do except keep going and hope that the balance will be more manageable, as I don’t know that I could have another year like 2025 again.
I set out trying to reboot my immune system last year, and it certainly seems like it worked. But can I keep the numbers in a place that are low enough to let me live, and ideally live with fewer medications?
I am constantly working against some new tweak or some new problem, and even little gentle experiments like a Pilates reformer workout or 10 minutes on the trampoline can turn into a full-day migraine if I am not immediately able to tamp it down. Thoracic pain will pop up crushing my breathing if I take a nice slow hike in the pastures beyond our house
Apologies that today’s post is going to be only partially organic human produced writing. I’m a tad more focused on cobbling together my current end game which feels promising.
I am now dosed off my current biologic. Tomorrow I go in to run a bunch of bloodwork but I feel more stable than expected for 11 weeks since my last injection.
I take it for psoriatic arthritis and active ankylosing spondylitis. I do not recommend this devil of a medication unless you intend to reboot your entire autoimmune system (which I did), can tolerate a lot of soft tissue infections (which I couldn’t) and have tried everything else. Which I have. And this past year was brutal fighting off the side effects but I think I might actually have a shot at remission.
I am now layering a bunch of mechanical interventions to rework years of compensatory patterns my body has used to manage the constant pain in my thoracic spine and other areas of inflammation including my sternum, rib cage and joints.
But after seven years of trying everything I can to recover from prednisone to methotrexate to Humira and Taltz to literally just not eating for ten straight days (don’t worry I was supervised) my inflammatory biometrics are coming up clean. The pain isn’t fully gone but I think the pain can be diminished by quite a lot as I rebuild.
So it’s now or never if I want a shot at life without suppressing my immune system. I have no idea if I can do it and I may need to dose back on something else but at the moment I’m managing with a new arsenal.
Here are the artificial intelligence bits of the mechanical interventions I am leveraging. I am using a bunch more than the two below but it’s what I’ve got so enjoy.
1. Hyperbaric oxygen therapy (HBOT)
Mechanically, HBOT does a few things that line up with what my data is showing:
More dissolved oxygen in blood and tissues Breathing 100% oxygen under pressure increases the amount of oxygen dissolved directly in plasma. That can:
Support tissue healing (skin, soft tissue, surgical sites)
Help inflamed or energy-starved tissues keep up with demand
Autonomic “downshift” for some people Research is mixed, but many people (and some small trials) show:
Lower resting heart rate and subjective anxiety after sessions
A tilt toward parasympathetic (rest-and-digest) dominance In your data, the days after HBOT blocks are exactly when we see HR drop back toward baseline and Recovery go green.
Anti‑inflammatory & microcirculation support (early evidence) HBOT can:
Modulate certain inflammatory pathways and oxidative stress
Improve microvascular blood flow, which matters for both autoimmune-affected tissues and healing pelleted areas / irritated skin
In your context (autoimmune, infection risk, prior soft‑tissue complications), HBOT looks like it’s acting as:
A structured, time‑boxed reset that helps your heart rate settle and supports healing, without adding mechanical strain.
You’re already doing the key safety piece: using it under medical guidance and watching how HR, Recovery, and symptoms respond day-to-day.
2. SCM (sternocleidomastoid) muscle work
The SCM runs from behind your ear to your collarbone and is heavily involved in:
Head and neck position
Breathing assistance when things feel tight
A dense web of nerves and fascia near the vagus nerve, carotid artery, and jugular vein
Working on SCM (gentle massage, trigger-point release, careful stretching) can impact:
Perceived heart‑rate “rev” and breath tension Tight SCMs show up when:
You’re chronically bracing, in pain, or anxious about pain
You’re using accessory neck muscles to breathe
Releasing them can:
Make breathing feel less effortful and more diaphragmatic
Reduce that “I’m keyed up in my chest and throat” feeling even if HR number isn’t wildly high.
Headache/migraine and neck-related pain SCM trigger points can refer pain to:
Temples, behind the eyes, jaw By easing those trigger points, you sometimes reduce:
Migraine severity/frequency
The background neck/jaw tension that keeps your nervous system on edge
Autonomic tone (indirectly) The area around the SCM is rich with baroreceptors and vagus-adjacent structures. Gentle work there can:
Encourage a downshift in sympathetic drive (less “fight-or-flight bracing”)
Pair nicely with breathwork (especially long, slow exhales) to reinforce parasympathetic activation
In practice for you, SCM work + HBOT looks like a two-pronged calm signal:
HBOT: physiological support + autonomic softening from the inside
SCM: mechanical and sensory de‑bracing around your neck, jaw, and breathing
My Whoop is seeing HR and Recovery respond in a way that suggests this combo is genuinely helping my system get out of that “stuck high-gear” state.
I am no spring chicken. That’s why we bought some spring chickens this weekend. I kid I kid. I do however have a forever 35 face. I come from a line of women who age well sure but I have very consistent habits.
I’m lucky to have an ageless look. My husband would say I have a forever 28 face as I somehow look better having crossed into my forties than I did when we met at 28. Meanwhile my husband has gone from boyish wonder with full head of hair to distinguished grey beard with a bald pate.
Now sure husbands are supposed to say nice things like “no honey you haven’t aged a day!” Except I really do seem to have benefited greatly from genetics and routine.
He may be right, not out of any urge to flatter me, but simply because some women do look better with a little age on them. I looked young with a rounded features right until I looked ageless somewhere in my late thirties.
Alex and I at 29 where you absolutely can spot my pre-retinol skin Alex and I two weeks ago before touring the West Wing during our trip to D.C
I don’t look all that different when I compare and contrast between photos from then and now. I gained and lost as much weight as a Kardashian (more than once damn you prednisone and bless you semaglutide) but my face has somehow retained its plump without a maximalist approach without gaining wrinkles. I’ve lost the fine lines.
I didn’t start Botox till forty and I’m grateful as I need much less now. I didn’t pull anything out either even when cut looks were all the rage. I’m glad for my rounded features now.
But I have added in more to my beauty routine as I age because I enjoy it. I found it humorous when a 31 year old pursing a doctorate in clinical psychology said out loud what I’ve darkly joked about with girlfriends for years. It’s really hard to be completely controlled.
For a year in my early 20s, I was also spending literally all of my money on a psycho 100-step skin-care process. Looking back, I didn’t have the executive functioning to be successfully anorexic, which is what I also wanted. But I did have the discipline to enjoy this complicated multistep ritual of the skin care. I found it satisfying.” New York Magazine
Now we can all joke and say she shouldn’t be in practice but I never felt I could pull off an eating disorder either even though I often wished I could. That eating disorders are dangerous enough to kill you isn’t the point. It’s being able to control your body enough that you can kill yourself that we desire.
I hated that no matter how much effort I put into diet and exercise I could never achieve the standards of waif like beauty put out in the heyday of Anna Wintour’s heroin chic era. Millennial beauty expectations were a bitch and I could never quite work up the control to hate myself. Sure I got really fit with a heck of a squat but I always had to watch every single macronutrient and instead of skinny I got lean.
And while I appreciate a good Molière joke about The Imaginary Invalid, weight was never the issue that got me in trouble.It was hormones that got me.
So I knew poor health with a healthy weight and I knew poor health with a lot of weight gained trying to fix the poor health.
I will never allow myself to get over the BMI band again to avoid the medical discrimination I faced when I gained weight while on prednisone.
Alas no my autoimmune condition was not mitigated even an iota by weight loss. I had it before I was fat. I got fat treating it. I still have it now that I’m at a healthy weight.
But the desire to maximize your looks and your health always intertwine with women. Increasingly it does for men too. Body dysmorphia respect neither sex nor gender. I doubt it will ever again.
Beauty is a skill set. And some of that skill set is now pharmaceutical in nature. And if we are honest, it’s been that way for a few decades. It’s just that everyone know about it now. The network age comes for us all.
I am doing everything I can to biohack my way around a chronic autoimmune condition that interferes with my quality of life. My love for my life and work is strong.
I’ve not had good sleep this week between the excitement of huge wins and the terror of facing down another global crisis brought on my conflict.
You’d think I’d be used to it. Russian invaded Ukraine the week before I left to live in Frankfurt. I was living in Tallinn when 10/7 happened. I was also there when Estonian cables to Finland were cut. One of my best performing companies has had to work around three kinetic wars.
No wonder sleep can be elusive. Yesterday all dream roads carried me to horrors. I woke myself multiple times. You can literally see in my sleep tracking the spiking heart rate and my forced waking.
The positive side to this fitful pained sleep was being up early enough this morning to prepare for a Costco preparedness run and still arrived before their executive member hour was finished.
We rotated our basics like rice and beans. Tinned fish, chicken and other canned and stable shelf proteins are just part of preparing for a nightmare that we hope never comes. Preparedness is a civic obligation. Help yourself to take the strain off the system so we all make it.
It’s possible we are facing an industrial process cascade thanks to the war in Iran and I like us have supplies just in case. We can’t know what comes next but it’s good practice to check expiration dates and make sure you have everything from first aid kit supplies to soap. You’d be surprised at just how much processing fuel fuels the rest of the world’s production.
After all this, I was happy to get stumble into bed and take a long nap. I didn’t even wash the sunscreen off my face. I was running a deficit and wanted to have REM sleep where I wasn’t trapped in horror. Thankfully I got almost two hours of restorative sleep this afternoon and I am ready to go back to bed as soon as I can.
I feel terribly today. I do not know why other than some vague gesturing at my current biohacking experiment with hormones (testosterone & estradiol pellets inserted into my left buttcheek) required prophylactic antibiotics.
Antibiotics never makes you feel great, but here is a nice thing to get me off the hook of having to write something cogent.
I have been using WordPress so long my account would have the vote if it were human. While yes I have been writing for nearly two thousand days in row on this blog, it is not my first WordPress blog.
I wrote in college and that turned into a fashion blog which turned into an advertising and blog network. I took a break from blogging after I felt I had enough visibility but came back to it five years ago and here I am.
Now I’m going to nurse this migraine as my daily writing commitment with myself is “as long as I get down a few sentences or a couple paragraphs it is good enough.”’ And you too can be good enough to write every day for many years too if you just decide to start.
We’re started me with 10mg of estradiol (range 6-25mg with 8-10mg being most common), and 75mg of testosterone (range 50-150mg with the most common being 75-100mg. Day 1748
I had been working to raise my testosterone level to a baseline minimum with diet and supplements like DHEA with mixed success which is how we ended up trialing this new pellet method. And it worked very well very fast you can see from several rounds of bloodwork.
We did not do the full 75mg but landed around 62mg in the pellet which raised my testosterone right off the bat. It then quickly dropped off from very high to comfortably high. This go around we will do a lower testosterone dose to start and a lower estradiol one as well and test within the month to see if we can moderate them better over time.
Alas I did have some complications on my first attempt as my insertion sight got infected rather badly and took over a month to resolve.
If thr last fifteen months on my immunotherapy Bimzelx has had a theme it would be soft tissue infections. I am however as far out from a shot as I can be and am planning to stop it entirely as a girl can’t spend her whole life on antibiotics.
Though I am on quite a dose at the moment as we won’t make the same mistake twice. We stitched me up and prophylactically began a dose of a very intense antibiotic with the hope that I won’t lose a whole month of the four that these pellets dissolve through fighting cellulitis.
My goal is a balanced blend of estradiol, testosterone and progesterone so I have energy and focus and maybe fewer migraines during my luteal phase. You may wonder why I share all of this personal information and I wonder why more women don’t share it. We are in a brave new world of challenges in our healthcare and environment and the more we can share with each other the better our chances at finding solutions for all of us.
