I enjoyed a long weekend mostly offline and with a group of interesting people. I enjoyed the extra elbow room of mountain remove as much as I enjoyed the atmosphere of a purpose driven community retreat amongst exceptional individuals.
I am however quite tired from the exertion of it. The danger of using a long weekend for anything that requires exertion from me feels ever present. I have so little room for error, and even with keeping my participation more limited than almost anyone else, it was still more than I could handle.
I even left a little early so I could have a full day at home without work to recover. I can feel my immune system overreacting and hope that this will be better by tomorrow. Anytime I feel flare symptoms I naturally get nervous. And frankly I’ve got a busy week ahead of me so I can’t afford needing more recovery time.
The busy season kicks off in earnest tomorrow and I feel sad that in reaching for a more demanding schedule to experience an important gathering that I’ve hurt myself in the process. Not going hurts in quite a different way. There is no winning with chronic illness just trade offs.
I’ve been on a very steady health trajectory for the last six weeks or so after I kicked my lingering Covid symptoms from an infection I picked up at the beginning of the summer. Alas today I found myself with a significant pain flare.
I can barely focus on simple tasks like writing the pain is so forceful. Usually I have some warning with pain as it’s a symptom of an autoimmune inflammatory condition. If I over stress myself I’ll have consequences a few days later just like a regular person.
But today I went from working out to flat on my back in bed taking the highest doses of medication I’ve got. And I still at a 7 or 8 pain wise. I don’t quite know what to do about it expect as I’m not comfortable taking more medication.
I’m hoping it’s an anomaly and I’ll feel better tomorrow. I wish I could provide a better accounting of the sudden misery. But honestly the pain is so bad this is the best I can manage. Please no one worry as I don’t have the capacity to respond right now. I just can’t think clearly enough to write about anything but the pain so I’m stuck with chronicling it. And I’ve got a habit to maintain here where I write every day.
It’s always baffling to me when something that is supposed that is supposed to make you feel good makes me awful. And yet it’s a very consistent experience for me.
Every time I get bodywork done (massages, acupuncture, osteopathic spinal work, physical therapy) I feel like absolute shit for 24-48 hours afterwards.
I have an autoimmune condition called ankylosing spondylitis which is a fancy form of arthritis. It’s well controlled with medication and a healthy lifestyle but I am always looking for ways to increase my functionality as well as my capacity to tolerate stress.
This naturally leads me to want incorporate positive stress techniques like cold showers, saunas, and the thousands of other hacks to improve your capacity to tolerate stress.
I’ve tried supplements magnesium supplements to adaptogenic mushrooms and most major modalities of body work to even the whackiest of woo.
Yesterday I had an amazing osteopath work on my spine and yet today I feel about 10x worse than I did before I went in. The dip is just a misery of exhaustion, pain which leads to some anxiety from being tired and in uncomfortable.
I trust I’ll feel better after this dip and some progress as I recover from the good stress but at the moment I’m just miserable.
My assumption is that many things in life that make you feel better in the long term are uncomfortable. Delayed onset muscle soreness is a common issue for new weight lifters and pushes many out of their routines before they even get started.
It’s such an art finding the correct amount of stress to put your body under and I wish I had a more perfect intuition about how to do it. Until I do I’ll probably have to work through many types of dips.
Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.
But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.
At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.
She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.
In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.
Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.
I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.
I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.
Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.
The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].
Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].
Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.
This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.
It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.
Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].
The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].
Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/ TL;DR is that reducing the affinity may increase neutralizing immune response.
I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.
All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.
I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.
With all that said, let’s see if it helps me out. I’ll post because it is in my nature.
Montana has blessedly been free of excess heat and fire season doesn’t seem to have arrived. But it was a wet spring and I fear we have a long summer ahead of me. I live in one of the best possible places to spend a summer and I still find it challenging m.
I was looking back at pictures from this time last year and I was not in the best health. I’ve never been a summer person and I have to accept some aspect of its misery is likely to forever plague me.
Other people have season affect disorder in the winter. I guess my people are a winter people. I can’t wait for snow to return.
I’m sure my mood is affected by the lingering Covid (does it count as long when you feel shitty 7 weeks later?) as well as the general unease in American politics. I’ll do what I can to shake it. But I’ll never understand anyone’s affection the season.
I may give myself an out today to get very little written as despite me being a bit further into my “I’ve got Covid” saga I am in no way feeling better.
I do not want to have a long case of Covid or the much dreaded/debated Long Covid and I am trying to remain optimistic about the situation.
I do not feel optimistic about it as absolutely every aspect of my normal health troubles are 10x worse and I’ve got all your other fun symptoms like coughing.
I’m scared as it’s not getting better which brings up the anxiety that I’ll be back to where I was in 2019-2020 when stabilizing my health was more than a full time job.
I don’t mind having a part time job managing my health. Or as I prefer to think of it a side hustle as a biohacker. Except instead of making money I spend money.
I can’t think about most of this at the moment as I am officially on my Maximum Health Protocols which is a mix of expensive piss and biohacking basics with a hint of woo and a triple helping of pharmaceuticals.
I still feel like shit but my hope is that dedication will save me from long post viral complications. I’ve worked too hard on my health to let some stupid inflammatory Covid event get me off track.
Covid isn’t any more worrying than most triggers to my overclocked autoimmune system but the additional pain of the inflammation isn’t doing me any favors. Does anyone else remember cytokine storms? To quote South Park, I member
I dislike the brain fog and exhaustion as it feels like writing about illness has become boring. I’d rather be going on tangents and rants but I’m stuck linking to posts recommending vitamins and sleep. Probably a sign that I love my work that my irritation is this strong.
I get really bad migraines. I do what o can to manage them but they are a frequent and challenging enough issue for me that I’ve got 45 separate entries on the topic.
I’d prefer not to discuss it at all as it’s not a very pleasant experience but it can be so overwhelming that it’s all I can think about on a given day. I probably should have seen it coming when I starters making jokes about Cardassians light torture yesterday.
I’ve taken about as much medication as I can (more than two Imitrex otherwise known as Sumatriptan it is a dynamite medicine but you don’t want to risk over doing it as overuse can make the migraines worse. It’s the 109th most prescribed drug in American with over five million prescriptions in 2021 so there is a lot of good data. Plus there is some fun asides.
Overdose of sumatriptan can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to green, due to the integration of sulfur into the hemoglobinmolecule
I am not feeling well today and used all the capacity I had to simply push at the edges of my universe and scream a bit into the abyss.
Screaming into the abyss is my pet name for being on the internet. Mostly Twitter. I know it sounds stupid.
Sometimes there are actual people on there still which is a small comfort. Just telegraphing into the universe that you are a “live one” is half the battle of bringing the future into the present.
I know it sounds like a stupid way to bring in resources and deals and alliances but it works. Make of that what you will. I’ll get on a phone call now and again if you are really compelling and intelligent. I spent some time on the phone with one of my favorite people and it was more energy than I would have anticipated.
Sometimes that’s just how it goes. There is only so much you can do when your time horizons for results are measured in a ten year cycle anyway.
It’s occasionally embarrassing to admit there are days I don’t have the energy to manage what what I eat, how much I exercise, whether I bath or do farm chores or otherwise manage the work of physical reality.
A few days of the month I do the absolute minimum to manage stasis and I honestly even that was a stretch. But like the classic Monty Python sketch of another era “I’m not dead yet!”
At the risk of being “TMI” (this is a gesture of self knowledge to readers not an actual concern of mine that I will ever include too much information), I did something stupid to my personal biome today.
I took an expired a probiotic. I fucked up my bacterial mix. In my defense, I didn’t know it was possible to have an expired Lactobacillus mix. Expired doesn’t seem to mean dead. It just is not doing what I’d hoped and I feel worse not better.
I honestly sort of believed that most probiotics on the self were bullshit. It’s hard to decide what’s medical woo anymore. But I acquired it from a German pharmacy last year and I guess GlaxoSmithKline supplies better shit in Frankfurt than it does in Bozeman.
I immediately nuked the new, supposedly friendly, bacteria from orbit with a one-two punch of doxycycline. I always carry some with me when I travel. Don’t tell my health insurance I’m so cavalier with my over-the -counter bacteria.
I’m joking, but only just. I’m sure artificial intelligence will be put out to nefarious purposes like denying health care coverage to random idiots who blog about their bodies any day now. I just doubt any lawyer will care what nonsense I got up to with yogurt when so many other forms of Medicare fraud are more accessible.
So in the spirit of my blogging forefathers and mothers, I’ve included you in the circle of trust as to the inner workings of my co-infections, symbionts, and other biological processes. Let’s hope, unlike in the case of Ripley, that nuking from orbit works. No need to be carrying aliens in my dark places.
