Tag: Safety

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Politics

Day 1291 and Gabby, Steve, and Donald

I started getting coded as right wing sometime in the last four years. I found this confusing. I have significant public opposition to Republican policies and Donald Trump in particular.

I’ve been small “l” libertarian for most of my adult life. I’ve vote for quite a few Democrats as I opposed neoconservatism. I registered Republican as the Democrats went from embracing business and technological growth to opposing it. I didn’t see free enterprise as a threat but as the engine of our progress.

I vote for Biden as I sincerely thought it was the best choice after a tumultuous four years under the ostensibly Republican Trump where I saw nothing but a bigger government and frayed norms around containing that government’s authority.

I don’t like a large state apparatus in principle and feel America is the nation that most sincerely pursues the liberty of its citizens. The state has been granted the sole monopoly on violence. That monopoly must exist for civilization but necessarily must be constrained by the rights of the citizens who consented to be governed.

I’m proud of the American experiment as a citizen, a Christian (in particular a Protestant) and a capitalist. That may sound conservative to some but in practice tended to get me left coded as I support less government involvement in nearly everything.

Drugs, sex work, reproductive freedom, medical freedom (which ranges from vaccines to sex & gender choice), speech (which includes compute), religion freedom and commerce are liberties best decided upon by responsible adults of good conscience.

We have codified this in our constitution and democracy is the working progress of finding a way to agree to be governed together. Whether it leans left or right is hardly the point. Each generation reacts with the choices it inherited from the one before it.

The political fight is to remain a citizenship that consents to be governed. America isn’t a monolith. We respect the liberties of our fellow citizens who have agreed to respect each others rights. If we disagree we arbitrate that through the government we’ve consented to be governed by. That is only possible insofar as we respect each others fundamental rights.

Violence is not meted out by individuals. The state alone has that monopoly and it ends at our personal rights. No citizen should ever claim the mantle of irreversible violence. Violence against those who we choose to govern us considered the most unacceptable to all citizenry. Political violence is never acceptable.

When we discuss a crisis of democracy and invoke mortal or existential threats we override the bonds that make us Americans. My respect for my fellow citizens must be in equal measure their respect for me. We are responsible for ourselves so that we may be responsible amongst and to other.

When I think of the violence that we’ve seen in the political process of deciding who represents us in our state I am furious. It is unacceptable that any of our representatives have been subject to violence. Since 2011 we’ve had three attempts at deadly political violence against Gabby Giffords, Steve Scalise and Donald Trump. This is terrorism and untenable.

The shock I feel today after witnessing an attempt on Donald Trump’s life last night substantial. I probably should have felt it more intensely for our Congressional representatives. I have taken so much for granted as an American.

The liberty I’ve felt to articulate my own views is unprecedented. We as a nation have tremendous capacity for disagreements. The political is a negotiation and we all accept compromises. All three of those politicians have positions I find to be unacceptable infringements on my liberty. Which is why I speak my case and vote for my positions.

I’ve felt perhaps wrongly that living my own freedom was politics enough And that means I have to speak when I see unacceptable things. We cannot continue to escalate the stakes.

I want America to remain a United States. I recognize I hold positions others disagree with. I may disagree with you. I don’t know how I’ll be coded from here and I don’t care. I am committed to being an American. I remain committed to the protection of my fellow citizens full liberties.

That Americans would die for them has been made more than metaphor too many times. Let us do all we can to prevent that so we can continue to live together in freedom. Let the blood of patriots remain imagery so we can continue to live united.

Categories
Biohacking Medical

Day 1290 and Covid Experiment

I caught a case of Covid at the very end of May that took me down hard. I’d been struggling with “long” symptoms

So I tried an experiment. A pretty crazy one at that suggested by my osteopath and supervised by a doctor.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th

Day 1283 Nicotinic acetylcholine receptors (nAChRs)

The principle was pretty simple but not proven yet in clinical trials.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits

Please do go read the original post with lots of caveats as nicotine is an addictive substance and this is not something to try without consulting your doctor.

I was unable to do the full 7mg but cut the patches down to 3.5 to 5mg over the five days. The side effects included headaches for the first day or so and a persistent queasiness.

Within a day I was lifted out of my exhaustion (which you’d expect from something modestly stimulative even though it was a low slow release dose). By the end of the second day my persistent coughing lifted entirely. I’d been struggling with congestion and coughing after even modest exertion like a walk outside.

I was functional on the fourth and fifth day like I hadn’t been since I got Covid. You can see me go into the red on my first day (my HRV dropped significantly but my RHR was only up by a few BPM). I slowly felt better and saw better recoveries even while taking on a little bit more exertion. I pushed a little too hard and found myself back in the red on my last day.

My Whoop recovery and strain chart for the five days of experiment beginning on the 6th and ending on the 11th of July

I was really relieved to stop the patch by the end. The last day of treatment I had overextended myself so I was in the red and feeling it even as the nicotine pushed my system up. I wanted to rip it off and did eventually cave at the end of the day instead of doing it all night.

My symptoms seem to be at bay. I feel decent enough so days after wrapping even as I began menstruation this morning. I hate to report that it also improved my usually debilitating PMS which typically includes intense migraines.

I would do it again if I got Covid. I cannot imagine ever using a nicotine patch consistently. I didn’t not enjoy the extra push of energy except insofar as it got me out of the exhaustion of the illness. I feel like it would be too much if I were otherwise feeling healthy. I have no cravings or side effects after.

Honestly I’m still wrapping my head around how well this worked. A part of me is confused, indignant and angry that a substance I was taught to fear has therapeutic benefit. Updating your mental models around long held beliefs is an uncomfortable process. But it’s a heck of a lot better than long covid symptoms.

Categories
Biohacking

Day 1284 and The Average Person

I am in the middle of a “don’t try this at home” biohacking experiment in which I am using a low dose nicotine patch to treat my week seven Covid malingering. A quick overview of the method of action.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology.

nAChRs

I am doing alright with it. I was wary of keeping the patch on all night long (I am very sensitive to stimulants such that I won’t drink caffeine past 10am) so I removed it at about 5pm. That may have been a mistake.

Yesterday my Whoop recorded physiological stress. I wasn’t coughing, I had more capacity for exertion, and I felt generally less exhausted.

But I didn’t come down easily for sleep. I ended up taking a number of anti-inflammatory medications as well as an Ambien. My heart rate was stable but I felt “up” which I don’t care for at night.

And I did not wake up to good news. My HRV absolutely tanked. There are lots of confounding variables here in that I got good restorative sleep (medicine induced surely) but some strain has clearly been too much. 40% down isn’t a rousing endorsement.

I am also noticing a lot of chatter around addiction and whether or not it’s responsible to discuss these things. The fear that the average person is in fact prone so addiction and will have adverse affects. Which I’m sure is true. I don’t think normal people should take unnecessary risks and it’s good to have the minimum viable dose be none at all.

It’s wise to remember that I am not at all living in average circumstances nor do I have average medical conditions so I am not necessarily who you should be looking to for health advice. You should do the basics like eat more protein, lift heavy things, sleep an adequate amount, be in the sun and move around, and manage your baseline health metrics first.

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine …

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

Categories
Politics Preparedness

Day 1276 and Not Just A River in Egypt

I’m pretty comfortable with being embarrassed. I get stuff wrong and I have to come to terms with it even as my ego complains bitterly. The ego protects itself with denial but that doesn’t mean its conclusions are correct.

Being impartial about your reality is hard. Denial is such a normal part of catastrophic events the CDC even has handy public health explainers. I hope post pandemic everyone can enjoy the irony of that.

Taking an impartial view when approaching a problem is hard. If it’s an especially destructive situation (as most forms of crisis tend to be) wanting to put off action is a common coping mechanism. We do it as individuals and we do it within the meta-organisms that form the cultural and political systems we live within.

My suspicion is that some of our current political problems are a result of denialism. Seeing things as they are is impossible for some people. Avoidance, rationalization and minimization is practically a skill set.

I’d hope in a crisis I would attempt to solve a problem with whatever meager tools and skills I had at my disposal. I’ve done my best to take action on a few slow moving problems. And yet impartiality only arises when I can accept reality. And I wouldn’t blame anyone who finding the reality completely unacceptable.

Categories
Internet Culture Preparedness

Day 1261 and the Jackpot

Dedicated roamers of the internet are people who like to notice things. Cyperpunk aesthetics made it romantic to experience global abstractions even as the reality of the power of oligarch, state and corporation blended into murky dystopian reality.

I said recently on this photo that we’ve got to stop hyperstitioning William Gibson. We keep finding ourselves further into the future. Just look at these anonymous accounts (so you can enjoy being a participant in the propaganda) joking about a drone operator in Ukraine.

We have netrunners. They’re autistic Ukrainian drone operators and their ice baths are niccy rushes

It’s hard to remember that real people exist on the other side of the abstractions. And yet here we are about to be those real people facing history. And it does seem like the time for taking action is now.

Venkatash Rao wrote an essay “many shoes are dropping” that gave me the kind of frisson of living in future, but as Gibson famously says, a bit unevenly. Across all narrative and technical arcs and and inside geopolitical realities we are starting to see the change.

In this I can’t help but see Gibson’s Jackpot. The elements that Rao calls out are multiple significant elections (not the least of which is the final installment of Biden vs Trump), the capital and nation state power consensus he calls “after Westphalia” and the intertwined fates of artificial intelligence and crypto.

A lot can change in a world where every form of power is being tested. I’ve written about this Jackpot energy before.

The fictional “jackpot” described in the novels is an “androgenic, systemic, multiplex” cluster of environmental, medical and economic crises that begins to emerge in the present day and eventually reduces world population by 80 percent over the second half of the 21st century

The Jackpot Trilogy.

I myself think it a privilege to even be a bit player in this moment in time. That I can allocate resources in any way feels high leverage in a way I didn’t anticipate experiencing.

We are the adults in the room. It may not be mich but we have agency. I feel good about putting my focus on crypto, AI and nuclear energy. Like Rao I can tie together past thoughts across a wide corpus by writing here every day and make decisions based on what has emerged.

Categories
Internet Culture Startups

Day 1245 and AI: Tool Versus Master

A bad workman blames his tools

Idiom

As we rapidly accelerate the power of our computing tools, machine learning has blossomed into the most heated topic in government policy, business strategy, and popular culture, as artificial intelligence begins to affect everyday life.

The focus on harms, and in particular singularity doomerism, has (ironically) pulled focus from the implications of the seminal “attention is all you need” paper.

Astonishing as it may seem at times, intelligence does not top out at “median human”, but can, and possibly will, go much further.

What a triumph this represents. We will all have access to tools that will enable our entire species to build. More intelligence applied to more problems means more solutions to very real human problems.

I am in Austin Texas for Consensus 2024. I’ll be participating a town hall to discuss how crypto’s mindset of open-source, decentralized computation might help us grapple with who builds, maintains, & owns AI tools.

Policymakers and Silicon Valley executives are both calling for regulation of artificial intelligence as fears grow over its potential harms. But others warn of entrenching a dominant, opaque, centralized Big Tech model and instead advocate for open-source code, decentralized computation and distributed data sourcing. Whom should policymakers listen to? What, if anything, can governments do to help this vital technology evolve in a pro-human way?

Thankfully, we aren’t starting from scratch in building a regulatory framework for artificial intelligence. Code has been treated as speech in Bernstein v. United States Department of State. It would seem like a reasonable precedent to consider algorithms speech as well.

And let us be clear, math and computing power are as essential as speech. In today’s world, they ARE speech. Humans may speak in natural language, but the way we extend ourselves, build things, and grow as a species is through our tools. Computation is a tool. To presume that these tools do harm is to make us bad workmen.

Now of course incumbent powers may try to keep the disruptive and democratizing power of these tools out of the hands of the populace “for their own safety”, but imagine if the first amendment had been frozen in time at the printing press and didn’t protect the internet? We cannot accept permanently lowered standards of fundamental rights.

The 90s era fight for strong encryption enabled a flourishing of digital businesses from finance to e-commerce. We must insist that the freedom to innovate remains the default for U.S. digital policy.

Ultimately, I agree with R Street’s Adam Thierer. He says “fear based narratives that prompt calls for preemptive regulation of computational processes and treat AI innovations ‘as guilty until proven innocent’ are no way to make good policy.”

America does not have a Federal Computer Commission for computing or the internet but instead relies on the wide variety of laws, regulations, and agencies that existed long before digital technologies came along.

R Street Comments on NTIA

If we are to regulate sensibly, let us treat artificial intelligence as we would any other tool and let us do so within the existing framework of our constitutional rights and their interpretations within past precedents.

Categories
Chronicle

Day 1218 and Start Stop

When you have to “make the most of something” you’ve already done some calculus of personal expectations. I know I will have try to pack as much into a trip to balance out the various costs of travel. It’s not always financial as time, emotions, and focus all have value in your life.

If you have too much variability across these costs or can be hard to justify against your personal expectations. I’ve been known to run as fast as I can once I’m in motion because I believe acceleration is more expensive than stasis. That’s not always true obviously as staying in the same place can be very expensive.

So when I stop-start through life I hope I’m not making the ride more uncomfortable simply because I can’t manage the fuel calculations. Being fueled to make the best of a situation means being prepared.

In other news, I didn’t eat lunch before I ran some errands and I regret it because everything always takes longer than you expect.

Categories
Emotional Work

Day 1217 and Triggered

I deliberately put myself into an exercise today where I gave another person permission to trigger me. I mean trigger in the emotional sense.

caused to feel an intense and usually negative emotional reaction : affected by an emotional trigger

Merriam Webster

I very much recommend the experience. If we workout our bodies and our minds surely we should consider the value in working our emotions over.

Openly welcoming emotional punches may seem about as sane as welcoming an actual punch but like in all things practice makes perfect. It’s good to prepare with the relevant skills for all kinds of things.

I am not a boxer or martial artist myself but I appreciate fight metaphors and their applications in the power dynamics of life. Much of living feels like a conflict to even the most level headed of us. Which I’m not sure is a title I can claim honestly but I do try to follow the maxim in “Hitchhiker’s Guide to the Galaxy.”

Don’t panic”

Douglas Adams

Even if we opted into some level of being available in the rituals of being alive we can find ourselves surprised to be considered fair game in the agendas and power struggles of others.

We are all civilians in our own mind. Sometimes we’ve stepped conflict without even knowing and you’d best keep your wits about you. Consequences for actions have a tendency to come back around for even the most cautious.

So if you’ve got the opportunity to be put into “fight or flight” you might find the opportunity worth the while. After all, everyone’s got a plan till they are punched in the face. So stay safe everyone!

Categories
Emotional Work

Day 1215 and Impartiality

I am taking the Connections course run by Joe Hudson’s Art of Accomplishment. I was introduced to the approach through Johnny Miller’s Nervous System Mastery course. I was lucky enough that be able to participate in one of Joe’s live coaching sessions I was so inspired by the work I saw I committed to a longer course of study.

The Connections curriculum takes you through an approach whose acronym can be shortened to VIEW.

Vulnerability

Impartiality

Empathy

Wonder

Art of Accomplishment

Today’s sessions was on impartiality. Impartiality is owning what you want without imposing it on yourself or others. It’s harder than it sounds discovering an agenda for yourself and others.

With their exercises and a partner you find your own assumptions and defensive thinking in short order

I don’t want to get reveal more than is available online but I encourage you to go check it out if it sounds interesting for your own emotional work. The podcast on Impartiality is available for anyone to listen online.