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Biohacking Medical

Day 1723 and Hormonal Rollercoaster Rides

We spent a long time at the doctor’s yesterday as Alex and I gutted it out with our excellent physician (with AI assists) through a myriad of different tests. We were attempting to figure out why he keeps getting respiratory infections and why I’m such a tasty treat to skin bacteria.

In truth, my basic inflammatory biometrics have improved so much on the new IL-17a inhibitor Bimzelx that it’s probably worth the hassle of occasionally having to slice open a random effected gland or abscess once a quarter. It’s just a shocking amount of work to do whack mole with pathology reports.

What I don’t seem to be able to improve is my low testosterone and the flavors of migraine headache that come with the roller coaster of my luteal phase. Which is presumably a clue and we are following it.

Astonishingly my lady hormones are in tip top shape. Though the “you should have no trouble getting pregnant if we can get off the medicines that stabilize you” remarks remains a heads trip. Yes I asked.

It is not a head trip that makes one’s husband enthusiastic about the prospect. Which is fair, as we have no family support, no backup plans for me regressing physically, and the family that does support us can’t get to America. So one can see why a CEO husband with sick investor wife who would have to give up work, plus potentially messed up baby, isn’t super appealing. Anyways! TFR is a fun topic.

I started with basic supplements in the precursor category like DHEA and STRO about a year ago when my testosterone came in at a 2 nanograms per deciliter (ng/dL) when it should be somewhere between 9 to 55 nanograms per deciliter (ng/dL). For context, adult men typically have levels in the 240–950 ng/dL.

The one sticky widget is that my testosterone remains stubbornly low. You wouldn’t think such a raging “see you next Tuesday” such as myself would be overburdened with the feminine hormones and lacking in ball buster hormones but I am.

I managed to eke it up to 5 with supplements and nutrition but it really didn’t match my otherwise excellent hormonal profile. Having ruined my chances at a healthy immune system when we tried the first half of IVF, I’ve spent some time working on and with my natural cycles.

Good information for all humans

I loathe being in my luteal phase but when I’m in my follicular phase I get 90% of my work done. We had presumed it was the rapid decline in estrogen and progesterone but maybe my floor rate testosterone was more of the issue.

For the past 8 weeks I’ve been using a testosterone cream that clicks up your dose and you rub it between your thighs. I know it’s gross. So I was curious to see where I might land. And praise the Lord I am now at 15 ng/dL. From 2 to 5 to 15 is some excellent progress but still below where we’d like me to hit. So we are going to run another test and try out the tiny pellets they slice into your skin. Since I’m already used to scalpels and antibiotics I figure why not?

Categories
Biohacking

Day 652 and Startled Awake

There are few things more disorienting than waking up without realizing where, or even when, you’ve fallen asleep.

The first few moments of regaining consciousness are the stuff of genuine terror. As your senses do their best to bring their data to your brain, there are a few agonizingly slow beats where you genuinely have no idea what the fuck is going on.

I imagine this phenomenon is where our vocabulary of phrases like “startled awake” get their origin. Perhaps you weren’t awoken by anything surprising, or particularly startling, but the small gap in processing between sense and mind is such a chasm in that singular moment that it all feels startling.

I had lay down to wait for a Midol to kick in to ease my first day of menstruation cramps at around 1:30pm. I remember asking my husband if he could find a heating blanket. I don’t remember much past that except a few hazy details of wrapping my entire lower torso with a heating blanket.

I had not turned off any lights. Nor had I thought to put on a sleeping mask. I thought I was simply waiting for the sweet relief of caffeine, Tylenol and diuretics. I had even told my girlfriend Ellie who had been expecting me to come up upstairs to hang out that I just needed a quick lie down. Turns out the lie part was true. It was not quick however. Which is some fun wordplay.

When I regained consciousness I had no sense of how much time had passed. As I fumbled about for my cell phone I swear I felt my neurons firing off rapidly in an attempt to gain data points for my poor addled mind to do some damned interpreting.

I was wrapped in something hot with a cord. Did that mean I wasn’t in my own bed? I didn’t generally sleep with anything electronic. I briefly panicked as I felt trapped in what was previously providing my body with comfort. I’d forgotten about the electric heating blanket, leaving the cord with no other function but to panic my hind brain with a fear of being strangled.

As all my lights were on, the various lamps were washing out any indication of the hour. I could hear noises above me so perhaps someone was awake. Did that mean it was the afternoon? What was with all the stomping above. It felt like it must be day.

I simply wasn’t getting enough orientation information from my initial position and I couldn’t seem to find my phone. I doubt more than a second or two has passed as I went through my startled awake process.

As I attempted to make sense of all these inputs I finally realized that I had passed out on top of my phone and I’d let it slip under my pillow. It was a bit past 3pm. I texted Ellie to let her know I’d accidentally passed out. The brief pumping of adrenaline and cortisol was easing back. I was at home in bed quite safe and a bit overly warm. But I certainly felt a new appreciation for the limits and frailty of my human mind.