Categories
Biohacking Chronic Disease Emotional Work

Day 1708 and Calendaring Pareto Optimal Care on a Worsening Trajectory of Biometrics

I like to manage my days with buffers around my routines and obligations. I find tight schedules to be tiring and unhelpful as I manage my energy, pain, and workload. A packed calendar raises my cortisol.

I believe I am easily stressed by shouldering too much, but I also fear I am on a downward health trajectory which will require more time, energy and effort. I am beginning to contemplate reworking my style of effort management as conditions on the ground change. Can I schedule my way out of a spiral down? What is my Pareto optimal plan here?

My 2025 has been significantly worse than my 2024 and an almost entirely different realm of issues than I faced prior to that. As I compare, 2022 and 2023 were entirely different worlds than my 2025. I thought I was pretty sick then but improving my inflammatory markers has nuked my HRV & stamina.

I’m back to the bleak bottom quartile biometrics I had when I was first diagnosed with my complex chronic inflammatory diseases case.

I fear I never recovered from my two Covid cases including the one which eventually turned into a brutal pneumonia.

The stress of a permanently lowered baseline of biometrics makes me feel despair even as I have new tools at my disposal to mitigate them.

Will my whole life be dedicated to the care and feeding of my broken body? Is that something I can live for instead of simply living with?

I just don’t know how much effort will be put into managing this new baseline and what the effort to reward ratio looks.

Is there a Pareto principle I can apply to permanent disability which I can, and maybe even should, emotionally accept? Or do I soldier on hoping that my middle aged body may repair itself if I do absolutely everything right? And what am I doing all of that for?

It just seems as if no matter the time management, advanced medical care, constant research and daily effort I only get worse. I’ve been under a scalpel three times this year.

Each time I think I have found a new drug or treatment modality I am quickly slapped with second order side effects. And then those side effects have new side effects as I treat them.

It’s the pimp my ride recursion of biohacking, but instead of liking a thing and adding it to my car, I’m adding more and more mitigation measures to manage the results of the biohacking.

Pimp my biohacking

Now I have a new load of emotional stress and grief weighing on me as father died this weekend. I don’t even know what that process will look like, especially given the challenging modern family situation I have.

Any positive aspects of my year (passing the right to compute bill into law, progress in my startup portfolio) seems pale in contrast to emergency surgery, slow burdensome recovery and the arrival of mortality. I’m only at the halfway point of life (and a little bit past that for the year) and I feel done in completely.

Categories
Finance Startups

Day 255 and Bias Towards Fuckround

There is a tendency to believe that startups have a bias against older people. While ageism is alive and well, I’d argue what appears to be a bias against older teams is actually a bias against teams with experience. No one wants to invest in a team who don’t fuck around. We want teams that will find out.

One of the reasons I work with early stage startups is because their trajectory is not yet set. Every conversation has a hint of “fuck around and find out” because your vision is far away. You need to experiment, test, throw spaghetti against the wall. Pick your metaphor. The bias towards action and the bias for momentum exist in investor minds because the alternative is death.

This has the second order effect of selecting against teams with experience. It isn’t ageism. It is a bias against a certain kind of professional that knows too much. It’s not that anyone thinks experience is bad. It’s harder to fund teams with no exposure to the industry they are working in. It means that some types of experience will function as negative signaling. We think you know too much to solve the big problems. We are afraid you aren’t flexible enough to do the work of throwing out all existing assumptions.

While being an expert in a field means you have a better sense of how you will get from point A to B, it also means you have a less flexible mindset. You have seen what hasn’t worked. You have opinions about can or cannot be done. Even worse, you have an idea of how things must be done. Simply put a certain kind of battle tested, “expert in their field” persona isn’t trusted to fuck around enough.

If you are one of these founders, you have to fight against this signaling issue. Show investors your commitment to fucking around and finding out. Telegraph that all your experience and knowledge from your past work could very well be bullshit. Show us you will be committed to testing even more rigorously every hypothesis of how your roadmap will unfold. Then your experience becomes an asset.

We will trust that you have more opportunities to fuck around and find out than a less experienced founder because you plan to test what you think you know. Which is a lot! Show that no truism of your space will be held sacred. While a neophyte team will need to discover all the truths of a space to even begin to test. you will be ahead of them running test after test. Jujitsu that shit. Use the energy of your experience to show that you will bring the maximum amount of flexibility to finding new outcomes. The unbiased but experienced mind has the best chance at achieving momentum.

Categories
Finance Internet Culture Startups

Day 151 and The New Capital Networks

A lack of network has generally meant capital constraints if you were an entrepreneur. Being hooked up with capital allocators was crucial to being a good operator. Access tended to compound over time like interest. Which is why we make “funny because it’s true” jokes about how successful founders usually had a head start in a few areas. I’m not saying that is going away, but decentralized finance is fucking with some of the consensus knowledge around how capital gets raised and deployed.

And what convinced me we are moving towards an inflection point, over the next decade, where capital allocators and operators decouple, wasn’t my tony Silicon Valley network. No, I’ve had access to the minds of those players for years. What clicked my mind into a position to take action? I spent an hour and a half getting a tutorial from one of my anon reply crypto friends on yield farming and liquidity mining. I don’t want to blow up their spot but Alpha Ketchum dropped a lot of knowledge on me today. And it shifted my energy from belief into understanding. From there action will be seen in my investments.

I’m still chewing through a lot of the details but I’m going to make a bet that scaling DeFi is going to require significant institutional capital and the support of experienced operators to realize its full potential. Thats why I’m invested in folks like Cambrian and Martin Green and would love to get my dollars into Arca and David Nage. That’s why, of my four thesis areas I’m pursuing in my own fund Chaotic Capital, two are explicitly dedicated to both organizational and systemic flexibility and how it plays out across new business opportunities.

We’ve seen capital decoupling from traditional centralized authority systems and trust based networks. The perpetual fundraising machine of tokens, coins and market making techniques like yield farming, are funding everything from esoteric art projects and to the next generation of insurance. Thing about that, the innovative companies that drive growth won’t have their capital needs met just on Wall Street or Sand Hill Road. If you don’t believe me look at what has already been built

Exchanges → SushiSwap, Uniswap, Bancor

Insurance → NexusMutual, Cover

Derivatives → Perp Protocol, Opyn,

Credit Markets → Aave, Compound, Maker

Middleware → Chainlink, Grt

Asset Management → Enzyme, Yearn Finance

Aggregators → 1inch and Matcha