Categories
Culture Politics

Day 1296 and Mandate of Heaven

If you’ve been educated in the Western Cannon you are probably familiar with hubris. One does not defy the will of the gods.

The evolution of hubris from ancient Greece to modernity has extended our understanding of the prideful ego’s journey to arrogance. To be arrogant suggests a break with reality.

The term arrogance comes from the Latin adrogare, meaning “to feel that one has a right to demand certain attitudes and behaviors from other people”. To arrogate means “to claim or seize without justification… To make undue claims to having”

Who can claim the Mandate of Heaven? To even dare to do in many faiths suggests hubris. The breaching of limits and violations of the natural order suggest that Man should not suggest he knows the will of God.

And yet we push against the natural order all the time. Sometimes it is even demanded by the mythology of our moment. To make bold claims is to be sure you have a right to make them.

Watching the American mood witness invoking the will of any god is heady stuff. It is from the land of myths and those programs run on old operating systems. It’s not very hard to crash systemically when running on old programs. But I’d guess that is obvious to more than a few of us.

Categories
Culture Politics

Day 1295 and The Politics of Envy

Wanting what isn’t yours is very human. Monkey see, monkey do. Coveting always struck me as one of the most reasonable taboos.

Envy is an ugly emotion which deprives you of the joys you already have in your life. And yet so much of politics seems dedicated to stoking the suffering of unmet longing. The politics of envy may win votes but it can never produce a real policy.

I’ve been thinking perhaps too much about the consent of the governed. The state is granted a monopoly on violence through our consent. I fear a politics of envy because it eventually produces policies that will rely on not just on coercion but violence.

I don’t know where we are headed in America but I fear where envy leads us. It’s not simply about material things. One can envy power, prestige, cultural capital, beauty, intellect and countless other blessings.

Some of those things can be earned surely but many are providence. Those blessings cannot be taken as easily but they surely can be envied. I don’t wish us to follow those dark roads in search of riches which cannot be granted.

Categories
Culture

Day 1292 and Well Heeled

Kayfabe is the art of being a real fake in professional wrestling. You are cast in a role and it is maintained for the audience. Many fans would agree that the most role is the heel.

A heel isn’t exactly a villain but they are antagonists and rule breakers.

 “The role of a heel is to get ‘heat,’ which means spurring the crowd to obstreperous hatred, and generally involves cheating and any other manner of socially unacceptable behavior.”

The Art of the Heel – Baffler.

When we can no longer agree on a hero, it is the heel who moves opinions. A personal mythos is more easily punctured than Kayfabe in the internet age of total recall. You step out of your assigned role and the hero’s journey is revealed to be a fraud. But a heel is always breaking rules.

We are in a well heeled age. Everywhere you turn is an antagonist. Cheering and jeering, we the audience long to see our heat applied. The heel relishes it and we relish their antagonism.

Would you rather be loved or feared? Machiavellians can debate but the audience loves a heel because they fear a world where no rules can ever be broken. His freedom represents their own.

Categories
Aesthetics Culture

Day 1288 and Real Fake Girlbosses

All I wanted the first time I raised venture capital was to be able to make my business case. Once I’d done that I was sifted into into the wider cultural moment of girlbossism with everyone else in my cohort.

It quickly became the way to raise money because heaven forbid gender not be important. I was no Diane Green so I better get comfortable mugging for the cameras. I’d not so secretly hoped I’d be able to offload some of that lifestyle element to someone else. Someone more suitable.

At first I figured fine whatever it takes to get the money who cares embarrassing shit like becoming avatars for the zeitgeist doesn’t matter.

But now I think maybe it did. Every time a piece of social media goes viral with women messing around at the office I think what did we do? I’d envisioned that the difference between me in 2014 and the new younger, better, more ambitious versions of me 2024 to be, well, actually better?

Maybe they are. Media isn’t reality. But I had visions of women quietly running companies and venture funds competently and without concern for their gender. Surely in ten years more would have changed?

Instead we’ve got we’ve got the simulacra version of women like me filtered through Cosmopolitan features and glossy magazine spreads into TikTok dances for a company that makes pimple and acne treatments.

And it’s all grist for the mill. People want to blame feminism and gender studies. Pffft. Cute. It’s not gender studies or critical theory that got us here. For all the Baudrillard, Foucault and Judith Butler we all absorbed, the thing is just a representation of a reality that never existed.

Jean Baudrillard’s Simulacra and Simulation explores the concepts of simulacra, simulation, and hyperreality. Simulacra are copies or representations that become detached from their original reality, leading to a state where distinctions between reality and representation blur. Baudrillard identifies four stages of simulacra: the faithful copy, the perversion of reality, the absence of profound reality, and pure simulacrum, where the representation becomes reality itself

Perplexity’s Synopsis

If you want a crack in the timeline go decide what the Summer of 68 produced as a culture. Maybe they were just reactionaries. Maybe I’m just a reaction to them. These girls are a reaction to me.

If you want to be a cynic there is no shortage of commentary on how media showed us culture that didn’t serve us. Those Summer of 68 men turned into Yuppie midlife crisis dads who weren’t there for their children and wives. Feminism giving depressed stifled women a chance to not regret their choices. But the choices already exist.

Your cultural war mileage may vary. Now we have cowardly millenial man children and forever princess boss bitches and endless rounds of upset every time we see women in an office doing something silly.

You can rage at critical theory all you like but this just one elaborate morality play being accountable. And no one wants that. Real fake Girlbossism selling blemish cream.

Everyone deserves better than this. I deserved better than this. The horror of contortions required to simply pursue work means you must do what media and finance require of you to succeed. Go watch Margin Call and see if you think you’d fare better in making those choices.

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

Categories
Emotional Work Media

Day 1279 and Not The Whole Story

I have recently been prioritizing correcting mistaken impressions of the world. As the rationalist set say, I like to update my heuristics.

It’s just not all that uncommon to believe wrong things and for the wrong reasons. We find out with alarming about retracted studies, updates to long held beliefs about culture or politics, or simply something galling about reality. And so sometimes we have to adjust our priors. We never have the whole story.

I recently found myself comparing myself to another person only to get quickly reminded of a set of circumstances that made our situations basically incomparable. I simply didn’t have the whole picture.

My mother loved a hippie bumper sticker about the folly of sincere youthful knowledge.

Quick ask your teenage for advice while they still know everything

The best part of middle age is discovering just how little you know. It can feel paralyzing at times. I’m sure you can imagine how “I don’t know the whole story” can be interpreted in many ways. I hope to be on the sunny side of learning.

Two men sit on a bus. On the dark side facing a dark mountain we see scared sad man with a “I don’t know the whole story” thought bubble. On the bright side of the bus with a wide vista a man thinks “I don’t know the whole story!”
Categories
Community Politics

Day 1277 and Don’t Lose Your Head

Everyone has their entertainment and mine is makes me a little bit of a stereotype. I hate podcasts but do most of my chores while listening to Bloomberg’s Odd Lots podcast.

I was catching up today with an interview with equities analyst Tom Lee. My attention got caught and stuck on his description of Bitcoin.

“Yes, Bitcoin is unlike other asset classes because there is a cooperative value. You know, the people who contribute to the network benefit from it. And that’s different than any other asset class.”

From Odd Lots: Why Tom Lee Thinks We Could See S&P 15,000 by 2030, Jun 24, 2024

Now I don’t think this is unique to Bitcoin. Cooperative value can be found in everything from nationalist politics to luxury handbag resale pricing. But I do this it’s important to have cooperative values be baked into a network for it accrue value.

We’ve traditionally mitigated concerns about market cooperation through clear property rights and legal protections. We’d backed up those claims with things as abstract as a monarch. We’ve evolved to it to the slightly more concrete full faith of the United States and Byzantine bodies of securities law. Fiduciary duty and all that.

But as we become less inclined to trust that the buck does in fact stop “anywhere” we are looking for ways to mitigate that risk. How to operate in a world without trust? You develop trustless protocols. Humans have plenty of intuitions about trust and many these intuitions struggle without a clear person with authority to act.

So I ask if we are heading into a “headless” age?

As distrust in institutional power struggles we are seeking out new ways to continue the business of life and civilization even if a high trust society is in question.

We’ve got networks like Bitcoin that work without a head. We have new corporate structures like decentralized autonomous organization (DAOs) that can operate strictly based on cooperative rules, and indeed now entire memetic cultures (like e/-cc) which hold power while being headless.

Lest you think this is some frontier tech idea that doesn’t apply to you we’ve headless content moderation systems & headless retail platforms. Huge swathes of financial tech is living above the API.

You could even argue that we’ve got headless political parties as the Democrats and Republicans both struggle with defacto heads nobody particular trusts. I don’t know if we can live in a headless democracy. Deciding who is a citizen is a very different matter than deciding who is a shareholder.

Categories
Politics Preparedness

Day 1276 and Not Just A River in Egypt

I’m pretty comfortable with being embarrassed. I get stuff wrong and I have to come to terms with it even as my ego complains bitterly. The ego protects itself with denial but that doesn’t mean its conclusions are correct.

Being impartial about your reality is hard. Denial is such a normal part of catastrophic events the CDC even has handy public health explainers. I hope post pandemic everyone can enjoy the irony of that.

Taking an impartial view when approaching a problem is hard. If it’s an especially destructive situation (as most forms of crisis tend to be) wanting to put off action is a common coping mechanism. We do it as individuals and we do it within the meta-organisms that form the cultural and political systems we live within.

My suspicion is that some of our current political problems are a result of denialism. Seeing things as they are is impossible for some people. Avoidance, rationalization and minimization is practically a skill set.

I’d hope in a crisis I would attempt to solve a problem with whatever meager tools and skills I had at my disposal. I’ve done my best to take action on a few slow moving problems. And yet impartiality only arises when I can accept reality. And I wouldn’t blame anyone who finding the reality completely unacceptable.

Categories
Internet Culture Politics

Day 1272 and GWOT

As an elder millennial fascinated by the mass media I have a lot of mixed feelings on the American government and how it waged the “war on terror.”

It is heavy on my mind with the current news of Julien Assange’s agreement with the American government.

I think a lot about media, and in particular the technology that powers media. An informed population can still act in its own best interests but what we get told affects what we perceive as our best interests. And as we become more informed naturally some skepticism of the intentions of power arise.

Media affects how nation states wage wars. As we’ve evolved from print to television to radio to the internet how we sell the costs of war changed. But there are always populations who pay enough attention to be skeptical.

The open internet was born of that skepticism of government even so much of the technology emerged thanks to America’s heavy investment in defense industries.

Scientists used to have a wide range of politics and it’s not a surprise that defending American interests is a popular idea amongst people who work for the government. But maybe you see things and fight for more accountability along the way.

The GWOT unevenly affected millennials. If you were middle class your kid probably didn’t join up unless being in the service was how you got to being middle class. There was no draft.

Being in Colorado I had exposure to folks who worked for defense contractors as a lot of the private sector had settled around the cluster of talent from Boulder’s science labs down to the Air Force Academy in Fort Collins.

But there has been skepticism in all the branches of government as it became harder to control the narratives. And Americans don’t particularly like the idea of having propaganda even though I’d argue we produce and consumer enormous quantities of it as a nation.

I wish I could be more cogent about any of this. I am regularly shocked by how little people seem to remember how we prosecuted these long wars. We quickly forget.

Don’t be too sure human nature had changed. Don’t be too keen to give the government power because you are afraid. We’ve already seen what they do with it.

Categories
Emotional Work

Day 1270 and Chin Up

I’d like to maintain some degree of optimism about, well, everything. And yet I am struggling to maintain attitude control.

I like a little joke about navigating in space because I’m the sort of dork who enjoys science fiction books with lengthy digressions about spin and 3 axis stabilization.

But equally I do think it’s important to keep your chin up. Or nose up. It depends on whether you are piloting your emotions or a some other type of craft. It’s going to be forced metaphor post.

There is no need to crash yourself by getting disoriented navigating a situation in which you have some coordinates. It’s possible to calculate what’s going on and get yourself going in right the direction.

I am trying to do so by articulation, which yes is meant to be read as navigation joke, but is really just another goofy way of saying that writing helps me straight myself out.

So I am doing my best to keep my chin up emotionally and keep navigating what’s in front of me. It’s certainly better than a crash.