Categories
Chronic Disease Culture Politics Preparedness

Day 1901 and Burying Ehrlich

For as much time as I spend kvetching about my own petty problems (and I know that it is a not insubstantial amount of time), I am what my husband calls a macro optimist.

This is somewhat in contrast to him, who is on a day-to-day basis, a micro optimist but doesn’t quite see the long-term horizon as positively as I do.

Different temperaments are a good thing when it comes to balancing outlooks and outcomes. This is arguably why we are a good team and have managed to stay married for a decade.

I look out for the macro level future and optimize for it being successful and he optimizes the day-to-day, making sure that the micro level is successful.

I titled this post “Burying Ehrlich” because Paul Ehrlich passed away at the age of 93 last Friday. You might know him as the co-author of the 1968 best seller Population Bomb.

An entomologist by training, his book jumped to much bigger claims saying Earth faced imminent mass starvation urging governments to reduce population. That has not so far proven to be true. Even now the New York Times obituary said his claims were premature. We just love an impending disaster.

It’s a cruel historical irony that a man who wrote his thesis on butterflies would end up having such an enormous butterfly effect on the number of human beings being born. His neo-Malthusian insights were a huge hit.

And unfortunately we will experience the consequences of his public intellectual adventurism. We will have fewer humans and the famine he predicted never materialized. And now if we have more troubles facing us, we have far fewer humans able to take up the task of finding the solutions we will need.

Maybe if he had been a little bit more of a macro-level optimist, he would have been able to see what I see everyday. Despite daily travails due to my chronic disease, I see the micro-optimism of humans like my husband every single day. While I can’t always be positive every day, I remain positive that together we can find a way to improve on yesterday.

Humans are incredible at finding a way around life’s intractable problems. We produce little innovations, little inventions, little tweaks and little solutions. And they add up.

We are social animals whose evolutionary pressures seem to have yielded a culture of engineering. These little fixes we constantly produce when added up together have made for major improvements.

We even occasionally see extraordinary catalysts that allow us to go much faster with our improvements. We’ve had a number of revolutions, industrial and otherwise. Indeed the last 50 years or so have shown the Malthusian fears of food production to be histrionic in comparison to the progress we’ve made.

We have fed the planet but we will never get back the babies who were not born either because of China’s one-child policy or simple cultural attitude acceptance that one or two children should be enough. In my generation it may end up being more common to not have children at all.

Now it may seem rich that someone who goes in for quite a bit of preparedness should speak against a man who saw the value of taking action in the face of what he saw as long odds.

But next time someone tells you that the end is near and all is lost, remember that Paul didn’t end up being correct in any of his assumptions.

Not because at the time it was so crazy to think we weren’t producing enough food, but because he couldn’t conceive of a world in which we were able to solve our problem.

So I pray as his family buries him that we as a species can remember to bury some of our own alarmism. Our job is to keep on going in the face of long odds, just as every one of our ancestors has done before us.

Categories
Biohacking Chronic Disease

Day 1899 and Off To Sleep

I regret to say that after yesterday’s various excitements through my continued ill health; did not leave me with anything for today.

I crawled out of bed for a coffee far too late. Was greeted by marginally better biometrics such I think my Whoop took pity on me by giving me a green.

The trouble with context and personalization? It was only barely better than the reds of the worst that continued into a week of yellows where my resting heart rate and heart rate variability went in the wrong direction.

I largely spent today sleeping because I could t get enough last night. I hope you don’t mind if I go back to my nap as waking up was a challenge.

Categories
Chronic Disease Medical Politics

Day 1895 and If Not Us Then Who?

Despite persistent efforts to mitigate the downsides of my various medications, as well as maintaining dedicated wholistic lifestyle routines for my chronic diseases, I am not making adequate progress. I’d go so far as to say today it feels like I am sliding backwards.

But that is partially a function of luteal phase acute migraines and not the full picture on the ground. Yes, it’s true multiple metrics have gotten significantly worse over the 15-month span of my IL-17 inhibitor experiment with Bimselx and I am preparing to make the decision on what to do next. Many biometric markers are much better but the trade-offs are severe. It just feels like I can’t overcome them right now because I feel awful.

Nevertheless it’s important to remain grounded in the here and now. I think part of my trouble may be I am adjusting both to a new time zone and my normal altitude. Maybe I’m overly concerned by data points that will get smoothed out over time but it feels very spik.

Alas there is little room in life for downtime or bad days. Portfolio companies are fundraising, politics is getting uglier by the second, and one key blocker in my life has remained unsolved now for years.

I’ve never experienced a blocker quite so persistent as the American State Department’s handling of visa and immigration work. And yes that includes being disabled and chronically ill. That’s how bad state capacity is right now. My years-long attempt to get visas for family members to come help has not seen an iota of success.

But we keep going. There is much to be done, both practically and at higher levels of abstraction, and I am being whipsawed by hormone migraines over the last 48 hours. It is not an ideal time for weakness in one’s body.

Yesterday the best I could do in terms of writing was some rambling about my irritation with new retail sales cadences at Sephora feeling down market. Not that I necessarily need this space to be filled with decent content but I know that I am not running at even 10% capacity.

We all have to contribute our talents to this moment in time and there are projects that I wish to commit more time and energy to, even though it feels like it may be the death of me. But if not me then who? It’s a question we should all be asking ourselves and I hope more of us rise to the challenge.

Categories
Aesthetics Travel

Day 1892 and California Soul

As you may have guessed I wasn’t in Montana the last few weeks. I was in San Diego for a short stint. Some might call it working remotely. I’d also say I was testing a few health theories which remain inconclusive.

It’s always hard to determine health experiment when a random bit of personal maintenance details like needing dental work messes your data up. Biohacking works best in routine and I only keep them up seasonally.

I did get to spend quiet time on bluffs and beaches with my thoughts and a few friends. I’ve been listening to cocktail lounge classics intermixed with California Soul. Do you know the way to San Jose?

Connie Francis knows the way to San Jose

Going to California in the winter and it not being San Francisco is a bit of a new thing even though my husband went to college at UCSD. Any hints of early results in biotechnology used to come through their labs. And even some of their neurologists contributed important math to gradient descent

It’s a shame to have lost so much of the frontier to the petty encroachment of fiefdoms and institutional capture. California has a lovely soul. And imagining my parents finding a cheap way into housing in San Jose seems almost comical but maybe you could put $100 down and get a car. But now the place with a lot of space to get some peace of mind is the rocky mountainside. Maybe one day they will fix prop 13.

Coastal grandmother

Categories
Biohacking Medical

Day 1890 and It Bears Repeating Or Does It?

I can’t say I have fully recovered from pushing myself to my operational limits to do work (which looks a lot like socializing in my line of work) while still recovering from an infection after dental work.

It’s always recovering from an infection these days. I’ve been on some kind of antibiotic or anti-fungal every day since October.

2025 for me was getting an infection and then recovering from an infection on repeat. Ever since I decided to swap my biological injection 15 months ago from Coesyntx to Bimzelx and I think I’ve hit my limit.

It’s just too damn depressing that it’s a constant threat that I’ll have either a soft tissue infection or an abscess or a swollen gland that turns into a staphylococcus colony.

It’s as if I’ve got no skin biome left which is almost certainly true. I think I’d rather have CRP and sed rates and risk other infections than be rotating antibiotic varietals like some kind of junky afraid to develop a dependency.

Except instead of pain pills or lady downers it’s amoxicillin versus doxycycline versus Cipro with the occasional dalliance with a macrolide. I’ve also come to appreciate the benefits of Fluconzole. It’s not great. If you want a quick AI generated overview scan along

  • Beta-lactams: This broad group includes penicillins (e.g., amoxicillin), cephalosporins (e.g., cephalexin), and carbapenems (e.g., meropenem). They work by inhibiting cell wall synthesis.
  • Macrolides: (e.g., azithromycin, erythromycin) These inhibit protein synthesis and are often used for respiratory infections.
  • Tetracyclines: (e.g., doxycycline) Used for a wide range of infections, they inhibit protein synthesis.
  • Fluoroquinolones: (e.g., ciprofloxacin, levofloxacin) Broad-spectrum antibiotics that inhibit DNA synthesis.

My problem is that going back to my old biologic will take three to four months to full dose and it’s not a risk free process. And my full biometric panel is better on Bimzelx so is it really so bad that my resting heart rate is in the upper nineties every other week?

I think it may be time for me to make a pilgrims to the remaining clinics and pretend that I have any remaining institutional trust. Maybe I can vibe code something usual along the way.

I intend to support others on this journey as I’ve been chronically this journey a long time and the times are changing as we bring more artificial intelligence to the inference issues around our biometrics.

Categories
Chronic Disease Startups

Day 1889 and Recovering from Normalcy

I had such a lovely day touching grass (and sand) yesterday. I slowly worked through a 36-48 hours of of talking, walking, strategizing and occasionally reapplying sunscreen (I still got burned a little on my shoulders) with a friend who is preparing for big life and company changes.

These are the activities of normal life that I cherish, but my body seems hardly able to manage the strain this week. Now perhaps these activities are stressful on the mind and soul, but should they really be so physiologically taxing for me?

My Whoop is showing high strain

Now yes I am recovering from some dental work and on antibiotics but shouldn’t I be able to have a calm day that most would consider restorative? The serene peace of sitting on sandy shores should surely outweigh any areas from consequential questions of power, compute, realism and human purpose right?

I have barely been able to get out of bed today and the ten minutes of squats and planks I did to test my capacity spiked my heart rate into the stratosphere.

Which is odd as I woke up with my RHR in the 60s which is much better than usual. I only get into the 60s or 70s consistently when I am on heavy antibiotics.

The two weeks I was on Cipro recovering from surgery this summer my RHR was in the mid sixties so clearly I’ve got something going on with low grade infections.

I struggled mightily to organize my thoughts enough to write even this post. I feel I might even have it in me to go for a walk. Which is encouraging as I missed the sunset. The sunsets are obviously an event when you have a beach or far off horizon to enjoy with then.

Categories
Biohacking Internet Culture Politics

Day 1886 and Whoop There It Is

Quite a weekend for Americans and the wider Persian Gulf. Let us hope it is resolved swiftly and with the least loss of life possible.

It happened quickly. On Friday night policy types were arguing about artificial intelligence with our department of war about use cases and contacts. And then on Saturday we bombed Iran and they bombed pretty much every neighbor they have. No wonder they had a midnight deadline eh?

I’ll stick to human interest here but Chief of Staff Susie Wiles appeared to be wearing a Whoop tracker in a secure room which was confirmed by the company’s CEO by tweet.

The original concern being that some fitness trackers break NSA protocols as they have audio recording and other data recording which wouldn’t be appropriate in a dark room type the situation room.

Interestingly Whoop is approved by the NSA for use in these situations. Per the CEO the Whoop does not include a microphone, GPS, or cellular capability of any kind and has long been on the NSA approved PED list.

I myself wear both an Apple Watch and a Whoop everywhere but I rarely need to be out of the prying ears of recoding devices but it’s good to know.

Whoop’s CEO joked that given the success of the mission Susie Wiles must have had a green recovery score (quality sleep, low resting heart rate and high HRV) though I imagine she must be feeling the stress now that it’s over.

I wonder if her score worse than mine. I needed steroids and antibiotics to manage the flare post dental work and my body is under more strain than you’d imagine.

It’s somehow nice to know that the most powerful people on the planet use the same tools as I do to track their biometrics. From billionaire founders like Bryan Johnson to the Chief of Staff of the President to little old me. We all wear the same track. If you want a referral code here you go.

Categories
Travel

Day 1874 and Delayed Jet Lag

When you travel as much as I do, you get pretty good at managing the logistics of it. It’s a common theme on the blog as I relish being competent at travel but I also have complicated emotional baggage about its necessity.

Still I would relish a competitive packing game. I think a game show akin to Supermarket Sweeps but with managing a multi-leg transcontinental commercial flight would be great television.

Alas the fun and games stop where your body begins. And your body is never quite as capable as you might wish. Being evolved for living by circadian rhythms means jet lag is just a gnarly feeling no matter the tactics you use to combat it.

Yesterday was taken up by a work victory lap which kept my cortisol pumping and my energy up. Today however I can feel the jet lag hitting like a brick. I’ve been trying all day to work up the energy for basic tasks and losing. Tomorrow is another day.

Good thing private taxis for burritos exist as I might have simply chosen to fast for lack of energy to make or even acquire food. Though fasting wouldn’t have been a bad way to spend this clustering of holidays. It’s Shrove Tuesday, Lunar New Year and Ramadan. Much of humanity will be in joy and prayer today so that out to help lift anyone’s spirits.

Categories
Travel

Day 1870 and Cutting Down On Packing Time

I am a very thorough, well honed and time tested, and Karen hardened packing methodology.

I have a little bit of childhood anxiety around packing for having moved around a lot that has alas never left me. Many people having anxiety about flying so at least it is a bit relatable but I don’t know if packing anxiety is as common.

For me it’s not about being in the air but rather leaving behind an established base for parts unknown. Will I be able to find medicine for issue that arise or soap that won’t trigger eczema? What if I need to appear at an event requiring a dress & makeup? What if I need to walk for two miles with all those things?

Every time I pack I go through the same routine and I use the same bags with the same labeling system to manage all the permutations I might encounter. And it is a science.

I have a small pajama bag I carry in my backpack in case of an unexpected overnight or long delay. I carry small clear vanity case to clean & groom myself with full allergy protocols that passes even the crankiest Heathrow checkpoint. I am prepared.

I carry on my person a a small pill bag with every detail labeled that can handled medical incidents big and small along with my first responder certificate. If you have an issue on an airplane you want to be seated next to me.

From there in my carry on suitcase I label the packing cubes with every item I bring, from underwear to wrap dress and ballet flats. Everything that is packed in my larger Tumi that gets checked is also labeled and I place an itinerary on top as I find my bags opened more frequently than seems reasonable.

There are no questions from the TSA or the most belligerent customs agent that won’t be immediately cleared up with minor inspection. Now with artificial intelligence I can translate my labels on the fly into any language.

Despite this clarity and organization, I admit I’ve had a few amusing incidents. Once through Heathrow I unsettled a British Airways agent with my fiber and protein powder baggies. Because clearly middle aged woman would smuggle in a quart sized baggie of cocaine in her purse.

I really wish with all the travel I do and my very strict system that this would all somehow take a little bit less time than it does. I generally allow myself two days to pack as I like to check and double check as it’s an iron law that things will be forgotten. And Montana is remote enough that if I forget a fancy serum or a favored sweater I won’t get a replacement easily. We only just got a Sephora this year.

I am however headed for a large American city that has absolutely everything I could possibly want in short order. So as I leave behind a European home base where I do keep things on hand (I didn’t always but extended family has been kind to me) I feel much less pressure this time. And still somehow I will allow myself to let it take more time than I’d prefer.

Categories
Chronic Disease

Day 1863 and Head Above Water

Yesterday I wrote that I had no gas in the tank. Today is not much better. I am barely keeping my head above the proverbial water line. I finished a major purchase which I thought would give me respite for a few days.

Alas changes in destination, an emergency dental appointment for a family member, and the promise of rest was more like a promise of fretful semi-consciousness.

After days of rushing around seem to have swept me off my feet and into bed I still am not quite rested.

I thought I was mended yesterday but it seems as if I’m on the second day of exaggerated sleeping patterns with long arcs of sleep in the wrong places and times. Add in a bit of overheating on top of it and something feels off.

It’s not unusual for me to absorb major changes and shifts throughout their unfolding via some migraine induced osmotic pressure. I feel the animal spirits and global vibes push in past my physical limits and I shut down. I hope I’ll reboot soon.