Tag: Biohacking

Categories
Aesthetics Culture

Day 1925 and The Road to Nora Ephron

Yesterday both my husband and I were quite sick. We had very different symptoms but my worst one was a fever which added additional pain to the usual autoimmune nonsense. Naturally I subjected myself to more pain by spending the day on the internet. There is a lot going on and my brain was foggy in the wilds of the open internet.

Thankfully my fixation on consumer packaged goods’ price risk coincide with the arrival of a fresh round of skincare as well as a number of grim stories on the K shaped economy. Southeast Asian is rationing fuel while in Harper’s Bazaar wanted me to know that K-Beauty was coming for my neck. .

I don’t write headlines but I thought it was a bit on the nose to suggest fashion magazines are vampires. I clicked though.

It turns out there is a lot you can do for your neck but be warned the skin is thinner so promote collagen growth and be aware fewer sebaceous glands means it is dryer and more prone to irritation when exposed to actives like retinol. Useful information reinforcing my recent experiment with using Medicube’s PDRN Pink Niacinamide Milky Toner on my neck.

The beloved director of romantic comedies Nora Ephron m released a book in 2006 about the trials of womanhood. One essay was dedicated to how her neck was giving away her age. At the time I don’t even know one could be anxious about one’s neck but I filed it away as a to do in the endless list of feminine expectations.

“Short of surgery, there’s not a damn thing you can do about a neck. The neck is a dead giveaway. Our faces are lies and our necks are the truth. You have to cut open a redwood tree to see how old it is, but you wouldn’t have to if it had a neck.” – Nora Ephron’s “I Feel Bad About My Neck: And Other Thoughts on Being A Woman

I Feel Bad About My Neck illustrates book cover

Now maybe back in 2006 there wasn’t as much you could do about your neck when you’d smoked, tanned, and I will presume maybe occasionally enjoyed m drinking or other substances. But her Boomer fears encoding their neurosis into my generation was not in vein. I did none of those things.

Now that my fever has broken, I’ve been able to enjoy simple pleasures like the arrival of a box of skincare for myself (and also Alex because obviously I help him out) and ponder that I can feel anxiety about risk in the petroleum derivative markets like consumer packaged goods and also I can worry if my neck isn’t aging well.

I imagine I won’t get to enjoy that luxury forever. We have it very good in America with access to the best French pharmacies and South Korea plastic surgery clinics have have produced. I slathered on a milk toner and then topped it with hyaluronic acid water cream and a few drops of a Matrixyl peptide to boost collagen and elastin production.

The Internet as we know it is under new pressures from artificial intelligence as automation washes across digital spaces once populated by humans. The pressures in the market for technology private debt as it reconciles old Internet companies with cash flow against changing terrain.

It’s not just creative destruction in software businesses. Storied luxury families like the owners of Puig and Estee Lauder are discussing a merger. Price inputs are a killer when share prices are under pressure. Thats more of a geopolitical risk worsened by consumer struggles. The top 20% of the market does 80% of the spending is the new horror metrics.

So much for the lipstick indicator eh? Maybe I’ll look back and be glad I stocked up on serums, creams, drops, peptides and other petrochemical packed Swiss and Seoul laboratory style miracles. There is always shea butter and beeswax.

Categories
Biohacking Emotional Work

Day 1920 and Walking The Dream Roads to Costco

Yesterday I was really struggling with pain. It was all I could do to scribble up an appreciation for my 18th anniversary using WordPress for my writing.

I am doing everything I can to biohack my way around a chronic autoimmune condition that interferes with my quality of life. My love for my life and work is strong.

Sometimes it is strong enough that I willingly try all kinds of therapies from oxygen to hormones. Now I am working through a hormonal treatment recovery (my 2nd attempt) as I believe it is working.

Of course, life happens constantly, which means juggling deep dark horrific pains while the business of war and the business of my own portfolio goes on.

I’ve not had good sleep this week between the excitement of huge wins and the terror of facing down another global crisis brought on my conflict.

You’d think I’d be used to it. Russian invaded Ukraine the week before I left to live in Frankfurt. I was living in Tallinn when 10/7 happened. I was also there when Estonian cables to Finland were cut. One of my best performing companies has had to work around three kinetic wars.

No wonder sleep can be elusive. Yesterday all dream roads carried me to horrors. I woke myself multiple times. You can literally see in my sleep tracking the spiking heart rate and my forced waking.

The positive side to this fitful pained sleep was being up early enough this morning to prepare for a Costco preparedness run and still arrived before their executive member hour was finished.

We rotated our basics like rice and beans. Tinned fish, chicken and other canned and stable shelf proteins are just part of preparing for a nightmare that we hope never comes. Preparedness is a civic obligation. Help yourself to take the strain off the system so we all make it.

It’s possible we are facing an industrial process cascade thanks to the war in Iran and I like us have supplies just in case. We can’t know what comes next but it’s good practice to check expiration dates and make sure you have everything from first aid kit supplies to soap. You’d be surprised at just how much processing fuel fuels the rest of the world’s production.

After all this, I was happy to get stumble into bed and take a long nap. I didn’t even wash the sunscreen off my face. I was running a deficit and wanted to have REM sleep where I wasn’t trapped in horror. Thankfully I got almost two hours of restorative sleep this afternoon and I am ready to go back to bed as soon as I can.

Categories
Biohacking Chronicle

Day 1919 and Happy WordPress Anniversary

I feel terribly today. I do not know why other than some vague gesturing at my current biohacking experiment with hormones (testosterone & estradiol pellets inserted into my left buttcheek) required prophylactic antibiotics.

Antibiotics never makes you feel great, but here is a nice thing to get me off the hook of having to write something cogent.

I have been using WordPress so long my account would have the vote if it were human. While yes I have been writing for nearly two thousand days in row on this blog, it is not my first WordPress blog.

I wrote in college and that turned into a fashion blog which turned into an advertising and blog network. I took a break from blogging after I felt I had enough visibility but came back to it five years ago and here I am.

Now I’m going to nurse this migraine as my daily writing commitment with myself is “as long as I get down a few sentences or a couple paragraphs it is good enough.”’ And you too can be good enough to write every day for many years too if you just decide to start.

Categories
Biohacking Medical

Day 1915 and Physiological Stressers

Last October I did an experiment to balance out my core hormones by inserting pellets of testosterone and estradiol into my left buttcheck.

We’re started me with 10mg of estradiol (range 6-25mg with 8-10mg being most common), and 75mg of testosterone (range 50-150mg with the most common being 75-100mg. Day 1748

If you are interested in learning why women are optimizing their hormones, Cate Hall wrote an amazing piece on how it affected her life. A week or two after I did my own experiment the New York Times did a long lifestyle piece on the treatment’s growing popularity.

I had been working to raise my testosterone level to a baseline minimum with diet and supplements like DHEA with mixed success which is how we ended up trialing this new pellet method. And it worked very well very fast you can see from several rounds of bloodwork.

We did not do the full 75mg but landed around 62mg in the pellet which raised my testosterone right off the bat. It then quickly dropped off from very high to comfortably high. This go around we will do a lower testosterone dose to start and a lower estradiol one as well and test within the month to see if we can moderate them better over time.

Alas I did have some complications on my first attempt as my insertion sight got infected rather badly and took over a month to resolve.

If thr last fifteen months on my immunotherapy Bimzelx has had a theme it would be soft tissue infections. I am however as far out from a shot as I can be and am planning to stop it entirely as a girl can’t spend her whole life on antibiotics.

Though I am on quite a dose at the moment as we won’t make the same mistake twice. We stitched me up and prophylactically began a dose of a very intense antibiotic with the hope that I won’t lose a whole month of the four that these pellets dissolve through fighting cellulitis.

My goal is a balanced blend of estradiol, testosterone and progesterone so I have energy and focus and maybe fewer migraines during my luteal phase. You may wonder why I share all of this personal information and I wonder why more women don’t share it. We are in a brave new world of challenges in our healthcare and environment and the more we can share with each other the better our chances at finding solutions for all of us.

Categories
Biohacking Chronic Disease

Day 1914 and Restoration Hardware

Montana spring doesn’t come at the Equinox but today we had both sun and warm temperatures. I am grateful for the weather as I needed a day of restoration as I felt quite rundown from my sprint through Washington D.C last week.

After a morning walk to take in the sunlight, I went through my collection of “restoration hardware” in an effort to build my resilience. I am restarting another round of hyperbaric chamber oxygen therapy as it has been four months since my original 40 session course.

I ran my infrared mask not only on my face but my neck, scalp and another personal area “down under” as a have been struggling with soft tissue infections with my autoimmune therapy Bimzelx.

I have decided to stop the Bimzelx entirely and see where my bloodwork goes as my inflammation biometrics look good and it’s been a source of so much trouble. I gave it an 18 month run and while the results have been positive in my bloodwork the cure may be worse than the disease.

Now I’m laying on my heater PEMF mat from Higher Dose as the red light of the bedroom lulls my circadian rhythm down into the evening hours. I have no idea if it does much but the heat is soothing.

Categories
Biohacking

Day 1912 and Informing Ourselves

Some 20 years ago, before I knew I’d have medical troubles of any length, my college job was working for a medical ethicist who was a physician with a grant to study informed consent.

Now, years later, as I have worked my way through institutional resistance to how I may come to be disabled and generally dismissed as a patient, I come to find that much of the skepticism my mother had as a crunchy hippie is now functionally being proved a quarter century on. These uncomfortable trends drives skepticism in even the most informed minds. And most patients can only ever be expert on their symptoms.

This comes at the end of a crisis of communication about the value of public health and personal responsibility in a community. Many people did not feel that they were given adequate consent and no longer trust anything said by doctors. Would most medical professionals agree they had informed consent? I think most argue they were. I agree.

Now of course we’re all desperately trying to prevent harms here and patients more than ever feel that, as they don’t trust what’s coming to them because we’ve not effectively decoupled population-level information from the individual human behind a given case. Is that informed consent? Yeah as best we can do it.

Now how does research play into all this? I also happen to have the misfortune of having working on the early years of on one of the worst medical misinformation spreaders in all of healthcare. I say this lovingly: it is Gwyneth Paltrow.

Now if you root around Twitter, you will find commentary about how the supplements hawked on Goop and the supplements hawked on various right-wing sites are functionally identical. But she got a lot right because she is a rich well connected white woman with money. So again who is informed and to what degree?

Unfortunately some of the things that are sold as treatments or supplements they sell are real and have proven out. We’re working our way through the science on our gut biome, infection and its links to preventable autoimmune diseases, and any number of other previously heretical paths.

But we’ve really not transformed the way we process our information on what we know and what is actually considered best practices. The gap is very wide. Like a chasm. I am way outside the norms because I fucked myself up believing I wouldn’t be a statistic as it mostly worked for most women.

So I live with issues. But do I think that people have a right to experiment with what we think might be snake oil? Absolutely. Everyone calculates their own risk. Heck Sarno is just one giant placebo doctor on letting go.

We know that some of the avenues of exploration will prove to be placebo effect if they work. And we still somewhat trust things that are actually going to cause harm aren’t really making it into the popular press and mass consumption unless there’s some evidence. I sort of believe that to be true.

More people should feel that they have the right, if they have informed themselves over a period of time as patients, to work around the system if they make no progress despite best efforts and years of work.

There’s just a lot to balance on being informed about your conditions and your capacity to manage your own health that is up to you. I think that generally speaking the paternalistic attitude has not produced superior outcomes.

And the quality of care I get as someone who can pay for health care anywhere in the world, it is galling to me that the gap between what we know and how far we can go in practice is so wide.

So let the guy advertise the doggy cancer vaccine because at least it’s teaching people that we have solutions to more than they know. They can judge risk reward and be a little bit strange. Humans are humans.

You get to decide it based on your own understanding of your own life and you get what you get. I was disabled by my own misjudgment of informed consent on treatments recommended by a COO of a major company who paid to have as a perk to her workforce. Egg freezing was an approved elective procedure that everyone was on board with ten years ago.

I was informed. I consented. I got it wrong. Now let me see if I can fix it in my own manner of choosing. And I won’t trust mere authority next time. Neither celebrity nor pharmaceutical company is to be trusted.

Categories
Chronic Disease Culture Politics Preparedness

Day 1901 and Burying Ehrlich

For as much time as I spend kvetching about my own petty problems (and I know that it is a not insubstantial amount of time), I am what my husband calls a macro optimist.

This is somewhat in contrast to him, who is on a day-to-day basis, a micro optimist but doesn’t quite see the long-term horizon as positively as I do.

Different temperaments are a good thing when it comes to balancing outlooks and outcomes. This is arguably why we are a good team and have managed to stay married for a decade.

I look out for the macro level future and optimize for it being successful and he optimizes the day-to-day, making sure that the micro level is successful.

I titled this post “Burying Ehrlich” because Paul Ehrlich passed away at the age of 93 last Friday. You might know him as the co-author of the 1968 best seller Population Bomb.

An entomologist by training, his book jumped to much bigger claims saying Earth faced imminent mass starvation urging governments to reduce population. That has not so far proven to be true. Even now the New York Times obituary said his claims were premature. We just love an impending disaster.

It’s a cruel historical irony that a man who wrote his thesis on butterflies would end up having such an enormous butterfly effect on the number of human beings being born. His neo-Malthusian insights were a huge hit.

And unfortunately we will experience the consequences of his public intellectual adventurism. We will have fewer humans and the famine he predicted never materialized. And now if we have more troubles facing us, we have far fewer humans able to take up the task of finding the solutions we will need.

Maybe if he had been a little bit more of a macro-level optimist, he would have been able to see what I see everyday. Despite daily travails due to my chronic disease, I see the micro-optimism of humans like my husband every single day. While I can’t always be positive every day, I remain positive that together we can find a way to improve on yesterday.

Humans are incredible at finding a way around life’s intractable problems. We produce little innovations, little inventions, little tweaks and little solutions. And they add up.

We are social animals whose evolutionary pressures seem to have yielded a culture of engineering. These little fixes we constantly produce when added up together have made for major improvements.

We even occasionally see extraordinary catalysts that allow us to go much faster with our improvements. We’ve had a number of revolutions, industrial and otherwise. Indeed the last 50 years or so have shown the Malthusian fears of food production to be histrionic in comparison to the progress we’ve made.

We have fed the planet but we will never get back the babies who were not born either because of China’s one-child policy or simple cultural attitude acceptance that one or two children should be enough. In my generation it may end up being more common to not have children at all.

Now it may seem rich that someone who goes in for quite a bit of preparedness should speak against a man who saw the value of taking action in the face of what he saw as long odds.

But next time someone tells you that the end is near and all is lost, remember that Paul didn’t end up being correct in any of his assumptions.

Not because at the time it was so crazy to think we weren’t producing enough food, but because he couldn’t conceive of a world in which we were able to solve our problem.

So I pray as his family buries him that we as a species can remember to bury some of our own alarmism. Our job is to keep on going in the face of long odds, just as every one of our ancestors has done before us.

Categories
Biohacking Chronic Disease

Day 1899 and Off To Sleep

I regret to say that after yesterday’s various excitements through my continued ill health; did not leave me with anything for today.

I crawled out of bed for a coffee far too late. Was greeted by marginally better biometrics such I think my Whoop took pity on me by giving me a green.

The trouble with context and personalization? It was only barely better than the reds of the worst that continued into a week of yellows where my resting heart rate and heart rate variability went in the wrong direction.

I largely spent today sleeping because I could t get enough last night. I hope you don’t mind if I go back to my nap as waking up was a challenge.

Categories
Chronic Disease Medical Politics

Day 1895 and If Not Us Then Who?

Despite persistent efforts to mitigate the downsides of my various medications, as well as maintaining dedicated wholistic lifestyle routines for my chronic diseases, I am not making adequate progress. I’d go so far as to say today it feels like I am sliding backwards.

But that is partially a function of luteal phase acute migraines and not the full picture on the ground. Yes, it’s true multiple metrics have gotten significantly worse over the 15-month span of my IL-17 inhibitor experiment with Bimselx and I am preparing to make the decision on what to do next. Many biometric markers are much better but the trade-offs are severe. It just feels like I can’t overcome them right now because I feel awful.

Nevertheless it’s important to remain grounded in the here and now. I think part of my trouble may be I am adjusting both to a new time zone and my normal altitude. Maybe I’m overly concerned by data points that will get smoothed out over time but it feels very spik.

Alas there is little room in life for downtime or bad days. Portfolio companies are fundraising, politics is getting uglier by the second, and one key blocker in my life has remained unsolved now for years.

I’ve never experienced a blocker quite so persistent as the American State Department’s handling of visa and immigration work. And yes that includes being disabled and chronically ill. That’s how bad state capacity is right now. My years-long attempt to get visas for family members to come help has not seen an iota of success.

But we keep going. There is much to be done, both practically and at higher levels of abstraction, and I am being whipsawed by hormone migraines over the last 48 hours. It is not an ideal time for weakness in one’s body.

Yesterday the best I could do in terms of writing was some rambling about my irritation with new retail sales cadences at Sephora feeling down market. Not that I necessarily need this space to be filled with decent content but I know that I am not running at even 10% capacity.

We all have to contribute our talents to this moment in time and there are projects that I wish to commit more time and energy to, even though it feels like it may be the death of me. But if not me then who? It’s a question we should all be asking ourselves and I hope more of us rise to the challenge.

Categories
Aesthetics Travel

Day 1892 and California Soul

As you may have guessed I wasn’t in Montana the last few weeks. I was in San Diego for a short stint. Some might call it working remotely. I’d also say I was testing a few health theories which remain inconclusive.

It’s always hard to determine health experiment when a random bit of personal maintenance details like needing dental work messes your data up. Biohacking works best in routine and I only keep them up seasonally.

I did get to spend quiet time on bluffs and beaches with my thoughts and a few friends. I’ve been listening to cocktail lounge classics intermixed with California Soul. Do you know the way to San Jose?

Connie Francis knows the way to San Jose

Going to California in the winter and it not being San Francisco is a bit of a new thing even though my husband went to college at UCSD. Any hints of early results in biotechnology used to come through their labs. And even some of their neurologists contributed important math to gradient descent

It’s a shame to have lost so much of the frontier to the petty encroachment of fiefdoms and institutional capture. California has a lovely soul. And imagining my parents finding a cheap way into housing in San Jose seems almost comical but maybe you could put $100 down and get a car. But now the place with a lot of space to get some peace of mind is the rocky mountainside. Maybe one day they will fix prop 13.

Coastal grandmother