Categories
Biohacking Chronic Disease

Day 1948 and Rotational Work

I’ve been struggling with migraines since I was diagnosed with an autoimmune condition maybe six or so years ago.

I seem to be particularly struggling with them the last two months, as I work through an experiment with hormonal balancing and tapering off biologic autoimmune inhibitors.

And so I am rotating various different activities every day in the hopes of avoiding triggering a migraine, while still getting in adequate movement and exercise, as well as treatments within the biomechanical profile that I have put together with my doctors and helpful AIs.

If I stuff too many experiments into a given day, I’ll almost surely end up with a migraine. Even if I only do one sometimes I get unlucky. Red light and infrared are, of course, a classic way to trigger a migraine, so I try to do those carefully and when my heart rate is stable and low.

Of course, sometimes you need to get your heart rate up, and there’s nothing you can do but get your exercise and hope it won’t trigger a migraine. Afterwards exertion when I have a need to get down my heart rate, I’ll try to mix that with my hyperbaric oxygen chamber therapy.

I’m in the middle of my second round of HBOT treatments and enjoying seeing things like my VO2 max improve. I’ll be tempted to do something like go for a longer walk to test my lungs and trigger some neck compensation, and then I’ll be right back where I started with a migraine.

I’m always rotating something in and around keeping my brain from feeling the pressure of my body’s adjustments. There is no stable equilibrium just the constant pressure to find a new balance.

Categories
Biohacking Chronic Disease Medical

Day 1945 and Always Adjusting

I am adjusting, yet again, to a new set of daily protocols in my never-ending attempt to improve my health. I am experimenting with peptides but don’t tell anyone. I’ve also got a hormone experiment in its second round.

I am trying to get healthier, but that suggests it is even an achievable goal. It would be wonderful to get back to endless working hours or even just eight hours on my feet.

Every time I make a tweak to my routines and I see a change in my biometrics, it’s becomes eventually cause for concern. There’s no stable equilibrium to be found, and I know that’s part of life, but I’d like a stable equilibrium that’s a little bit better than one day at a time or ideally a couple weeks at a time.

Take my experiment with Bimzelx. Even when I achieve an outcome like getting my CRP rates into the normal bounds, it came at a cost that is simply too high to maintain. I had four separate incisions and surgeries last year from soft tissue infections.

What good is a drug that tamps down my immune system so much that I need to always go under the knife? It was like Goodhart’s Law came to haunt me personally.

I am going off the biologic (I am 12 weeks from my last injection) and already seeing change in the wrong direction. Not enormously bad but my immune system will pop if it’s not locked down.

Yet there’s very little I can do except keep going and hope that the balance will be more manageable, as I don’t know that I could have another year like 2025 again.

I set out trying to reboot my immune system last year, and it certainly seems like it worked. But can I keep the numbers in a place that are low enough to let me live, and ideally live with fewer medications?

I am constantly working against some new tweak or some new problem, and even little gentle experiments like a Pilates reformer workout or 10 minutes on the trampoline can turn into a full-day migraine if I am not immediately able to tamp it down. Thoracic pain will pop up crushing my breathing if I take a nice slow hike in the pastures beyond our house

Categories
Aesthetics Biohacking

Day 1929 and Lacking The Executive Function for Dysphoria

I am no spring chicken. That’s why we bought some spring chickens this weekend. I kid I kid. I do however have a forever 35 face. I come from a line of women who age well sure but I have very consistent habits.

I’m lucky to have an ageless look. My husband would say I have a forever 28 face as I somehow look better having crossed into my forties than I did when we met at 28. Meanwhile my husband has gone from boyish wonder with full head of hair to distinguished grey beard with a bald pate.

Now sure husbands are supposed to say nice things like “no honey you haven’t aged a day!” Except I really do seem to have benefited greatly from genetics and routine.

He may be right, not out of any urge to flatter me, but simply because some women do look better with a little age on them. I looked young with a rounded features right until I looked ageless somewhere in my late thirties.

Alex and I at 29 where you absolutely can spot my pre-retinol skin
Alex and I two weeks ago before touring the West Wing during our trip to D.C

I don’t look all that different when I compare and contrast between photos from then and now. I gained and lost as much weight as a Kardashian (more than once damn you prednisone and bless you semaglutide) but my face has somehow retained its plump without a maximalist approach without gaining wrinkles. I’ve lost the fine lines.

Yet the approaches are getting more and more maximalist by the year. The difference between a 2016 routine and 2026 routine is enough to warrant a fresh round of social panic and scolding complete with a Big Story from New York Magazine’s The Cut.

Now I myself have left comments on extreme routines for twenty somethings to convince them that it’s too early for Botox as you do want to keep tools in the box for when you need them.

I didn’t start Botox till forty and I’m grateful as I need much less now. I didn’t pull anything out either even when cut looks were all the rage. I’m glad for my rounded features now.

But I have added in more to my beauty routine as I age because I enjoy it. I found it humorous when a 31 year old pursing a doctorate in clinical psychology said out loud what I’ve darkly joked about with girlfriends for years. It’s really hard to be completely controlled.

For a year in my early 20s, I was also spending literally all of my money on a psycho 100-step skin-care process. Looking back, I didn’t have the executive functioning to be successfully anorexic, which is what I also wanted. But I did have the discipline to enjoy this complicated multistep ritual of the skin care. I found it satisfying.” New York Magazine

Now we can all joke and say she shouldn’t be in practice but I never felt I could pull off an eating disorder either even though I often wished I could. That eating disorders are dangerous enough to kill you isn’t the point. It’s being able to control your body enough that you can kill yourself that we desire.

I hated that no matter how much effort I put into diet and exercise I could never achieve the standards of waif like beauty put out in the heyday of Anna Wintour’s heroin chic era. Millennial beauty expectations were a bitch and I could never quite work up the control to hate myself. Sure I got really fit with a heck of a squat but I always had to watch every single macronutrient and instead of skinny I got lean.

And while I appreciate a good Molière joke about The Imaginary Invalid, weight was never the issue that got me in trouble. It was hormones that got me.

So I knew poor health with a healthy weight and I knew poor health with a lot of weight gained trying to fix the poor health.

I will never allow myself to get over the BMI band again to avoid the medical discrimination I faced when I gained weight while on prednisone.

Alas no my autoimmune condition was not mitigated even an iota by weight loss. I had it before I was fat. I got fat treating it. I still have it now that I’m at a healthy weight.

But the desire to maximize your looks and your health always intertwine with women. Increasingly it does for men too. Body dysmorphia respect neither sex nor gender. I doubt it will ever again.

Beauty is a skill set. And some of that skill set is now pharmaceutical in nature. And if we are honest, it’s been that way for a few decades. It’s just that everyone know about it now. The network age comes for us all.

Categories
Preparedness Startups

Day 1917 and Bragging

My brain feels pretty scrambled at the moment. I wish I could say it was over easy but I’m clearly closer to fried than coddled at the moment. Yesterday had some big news. Valar is prepared for a long slog and that means on paper I’ve got a unicorn and a fund returner.

There’s nothing quite so satisfying as becoming big enough that instead of listing the founder and the team, they mention the celebrity investors.

It’s good that people know we have dry powder for an important mission, just as energy insecurity becomes a real concern, along with all of the cascading effects of side products and elements that are part of the hydrocarbon processing chain. Don’t worry. They’ve got a plan for nitrogen if it comes to it.

And obviously I want to brag, as do all of the other people who took a risk on this exceptional team, especially those who wrote multiple checks (we followed on three times) when it was unclear how far we could go and how fast it could be given regulatory hurdles and funding constraints. Those are now gone.

I do feel like I paid a number of social consequences for being a loud mouth and also generally being anti-consensus during the first few years. And I am glad to have paid that price. Real reward comes from real risk.

I felt we had not adequately addressed American energy independence, clean energy, renewable energy, or any of the many effects of our rampant demand for energy.

I do believe that carbon heats the planet and we have to address it in a way that meets our demands and gives us abundant supplies. I thought well how we could possibly serve it in a way that is sustainable and clean without nuclear?

And I’m as surprised as anyone that the Republicans are the ones championing this but we’re in a place where it’s very clear that we have industrial needs and a geopolitical context that require us to go much faster and invest much more deeply in the solutions that we’ve put off for so many years.

I didn’t get into technology to do some set of financial arbitrages or eke out an extra few dollars so I could have status in the world. I know it’s naive but I’m not very transactional and I do it because I think it’s the right thing to do.

We need to slowly push the markets towards funding the things that are necessary and not just the things that give extra capital to people fighting for status and power. I hope that I can look back on the work I’ve done and feel proud that I tried.

Thanks to this blog God knows I’ve got the receipts for it. We’re barely out of the first quarter. Not even confident we’re at halftime. There’s so much work to be done but I feel like I’m playing the right game.

Categories
Aesthetics Politics Startups Travel

Day 1909 and All The Twinks Standing In The Line For The Bathroom

I am not an early riser, especially not when I’m out late for happy hours and dinners and the like. So I wasn’t planning on being at the 8am opening for the conference I’m attending in D.C amongst all the side programming.

I had a ten thirty talk I was particular excited to listen to as it was most salient to my work in artificial intelligence policy. Well, that was a dumb decision on my part. Not to arrive earlier.

I’ll take full responsibility for being a moron on that front, but I stood amongst a gaggle of gorgeous well dressed, well groomed and bright eyed young men hungry to build the world of the future. What a crowd of young people.

Being a chatty Cathy I asked about vintage Barbour jackets, bulldog ties, pocket squares, the merits of gel versus more advanced soft hold hair products, the declining quality of Moscot eyewear and other important topics to ambitious young men who are looksmaxxing to win the great game.

I didn’t have much else to do as the line was not moving. No one was getting in. Until people left no one was getting off the line. And that included others who had already been in and had their passes. The hottest ticket in town was perhaps a bit over capacity.

Someone rolled out a portable Starlink and we all piled in to tweet, chat, roll calls and (in my case) send tweets, Signal messages, and Slack channel responses. I got told my tweet about the two hour wait wasn’t ideal so I deleted it as I appreciate any attention to me running my mouth as I assume no one ever listens to me. I barely do.

But maybe I’m wrong? Last night checking into Butterworth’s, the woman manning check-in in lit up when I gave my name “I love your Twitter!” So maybe people do notice what I say. I still find that an a funny notion.

That said, it did take the full two hours to get into the giant event hall which made all the rush and planning a laugh. More people left the line and went back to work than stayed at 10am but everyone determined to participate seemed to make the best of it.

I asked if this was normal for a DC event and no one seemed to be from DC. So I didn’t get any good answers. This was an unexpected wrinkle that the venue was full was full up as an enormous crowd circled the block twice.

Since we remainders had decided to make the best of it we got to know each rather. Every man was quite a gentleman as we chatted oblivious to status till we were let in and others let us all know the pecking order. One of the young men I spent my wait, who is I learned later was literally the heir to one of the most important fortunes on the planet. Another was launching containerized autonomous weapons.

But that time of work and waiting was rather like being on an elevator stuck together, we might as well get to know each other. We are all equal before a tough door.

Thankfully we did get into the room before Jamie Dimon spoke. And he was the big boss of the handsome executive crowd.

I titled this “all the twinks standing in line for the bathroom” as yes a lot of handsome queer men were in attendance. But twink is an all purpose gender fluid aesthetic and not reflective of anyone’s sexual preferences.

And the line for the men’s y was a lot longer than the women’s. Ten to one ratios make me think this would be quite the dating scene for the ambitious woman.

But yes there are a lot of very well groomed young men in Washington D.C and everyone wants to build solutions for America. And being beautiful doesn’t hurt. To my single lady have you consider meeting a man in DC? Good odds and I doubt even a fraction of the twinks are gay.

Categories
Politics Travel

Day 1904 and Ms Fredrickson Goes to Washington

I will be in our nation’s capital next week for a gathering called the Hill and Valley Forum. It’s been ongoing for a few years but I am not someone with a lot of exposure to Washington and wasn’t sure I should pitch myself when the forum describes itself as such.

We host public discussions, panels, and published dialogues that highlight leading voices at the intersection of technology, security, and geopolitics.

Perhaps it’s silly not to think of myself as a leading voice in technology but I don’t know much about security (or its cousin defense) and my commentary on geopolitics is for fun on Twitter.

However, having seen others fail where I have succeeded, in passing successful bipartisan artificial intelligence policy I thought this year I should throw my cap in the thing. It’s not a nice feather having successfully brought the right to compute campaign from citizenry to policy to law in Montana.

It is now succeeding at the national level as states like New Hampshire have passed it in their house and well respected bipartisan policy organizations like ALEC have recommended it as policy.

My husband made a pilgrimage to our capital as the gentleman from Montana to testify before Congress last spring. I was very proud of him. I suspect he is easily as proud of my work on compute policy.

So if you’d like to meet some real Americans (8 wasn’t aware we had fake ones) and are in Washington D.C. drop us a line. I’m hoping to do a little meetup maybe on Monday but not all of my in groups will each other so maybe I’ll do more than one.

But wherever happens I’m excited to share time with other patriotic Americans who do the hard work of making sure we are governed well.

Categories
Startups

Day 1873 and Flying A Micro-Reactor on a C-17

I spent most of yesterday on an airplane. I flew nearly 12 hours along the polar routes to go from Heathrow to America’s west coast. I flew British Airways and was disinclined to spend the many pounds for internet access.

Alas this meant I missed the rollout of the joyful flight of one of my favorite investments. Valar Atomics began its journey from California to Utah just as I too was flying. Me and the reactor I angel invested in were both up in the air like bluebirds and sunshine.

HILL AIR FORCE BASE, Utah, Feb 15 – The U.S. Departments of Energy and Defense on Sunday for the first time transported a small nuclear reactor on a cargo plane from California to Utah to demonstrate the potential to quickly deploy nuclear power for military and civilian use.

The agencies partnered with California-based Valar Atomics to fly one of the company’s Ward microreactors on a C-17 aircraft — without nuclear fuel — to Hill Air Force Base in Utah. Via Reuters

I tear up just thinking of the incredible accomplishments of millions of people coordinating together across centuries that these technologies represent.

It’s easy to think of ourselves as being small in the vastness of time and space. I almost cannot believe I was handed such gifts in this life, but I can claim a small but early part in Valar’s story.

U.S. Energy Secretary Chris Wright and U.S. Under Secretary of Defense for Acquisition and Sustainment Michael Duffey on board a C-17 cargo plane that transported Valar Atomics’ Ward nuclear microreactor from March Air Force Base in California to Hill Air Force Base in Utah, at the Hill Air Force Base in Utah, U.S., February 15, 2026. On the right, with the American flag and the Valar logo on his jacket is our CEO Isaiah Taylor

Just a little over three years ago I sent Isaiah a message on Twitter. We had a lot in common and I felt a kinship with this young entrepreneur. It was before he had even begun the incorporation work on Valar. He was working on something else, but I trusted his quiet intelligence and admired his humble inquisitiveness. We kept in touch as he mapped out his path.

His lack of ego instantly marked him as special, as it meant he could hear even the hardest criticisms. His fortitude was clear. He could incorporate what was necessary into his mission, a skill usually developed much later in life.

It’s rare to build trust so early on, and yet we both did. I told him I’d back anything he did so long as he was the CEO. Little did I know just how lucky I would end up as his very first backer.

You might think you will have doubts in high risk early stage investing. But I’d be lying if I said I didn’t believe in him from day one. I knew he was on a mission bigger than any of us. I knew it and he knew it. For God and country as they say.

That faith was required, as it was tested in rapid succession again and again over the next three years. Chewing glass is part of every startup. Even when you go as rapidly as Valar has gone, there are harsh conditions, brushes with death, and moments of utter joy in between.

Not only did we write a first check in the angel round, but in tight spots before the seed closed we wired follow on within minutes when a concern about a cash flow question arose. We put together special purpose vehicles. Nothing could jeopardize this mission. I’d invest more if I could.

We weren’t always the ideal investors as we struggled to showcase to bigger and better firms our conviction. Not too long ago it was all about being asset light and software as a service. Thankfully the execution always outshone the skeptics and we were ahead of the times. And while the skepticism was fierce, Isaiah never wavered. Neither did I.

Today is day 1873 in my daily writing log. I first wrote about Isaiah on Day 1145 which means somewhere around day 780 or so is likely when we first met. I wrote on day 1510 almost a year ago about their seed round and the first successful thermal testing. On day 1721 they broke ground in Utah.

And you can better believe that I am looking forward to July 4th this year. We promised the president we’d be turning on the reactor, so there is much to be done between now and then.

Even the Department of Defense (War?) is writing swan songs about Valar from the Pentagon Twitter account

At March Air Reserve Base, California, yesterday, a next-generation nuclear reactor was loaded aboard a C-17 Globemaster III aircraft for transport to Hill Air Force Base, Utah. The reactor will eventually head to the Utah San Rafael Energy Lab for testing and evaluation.

The Ward 250 is a 5 megawatt nuclear reactor that fits into the back of a C-17 aircraft could theoretically power about 5,000 homes.

For military use, such a reactor could provide energy security on a military base ensuring the mission there need not depend on the civilian power grid, and in military operations overseas, such reactors would mean U.S. forces could operate without concern that an enemy might cut fuel supplies.

A reactor such as the Ward 250 also means greater energy security for the entire United States. It is firmly in line with President Donald J. Trump’s executive orders to reshape and modernize America’s nuclear energy landscape.

The president signed four executive orders designed to advance America’s nuclear energy posture, May 23, 2025. Those include “

Reinvigorating the Nuclear Industrial Base,

” “

Reforming Nuclear Reactor Testing at the Department of Energy

,” “

Ordering the Reform of the Nuclear Regulatory Commission

,” and “

Deploying Advanced Nuclear Reactor Technologies for National Security

.”

Michael P. Duffey, the undersecretary of war for acquisition and sustainment, said the partnership between the War and Energy Departments is critical to advancing the president’s nuclear energy initiatives.

“It’s clear to me that advancing President Trump’s priority on nuclear energy depends on close coordination between the Department of Energy and the Department of War,” Duffey said. “This partnership ensures advanced nuclear technologies are developed, evaluated and deployed in ways that strengthen energy resilience and national security.”

The future of warfare is energy-intensive, he said, and includes AI data centers, directed-energy weapons, and space and cyber infrastructure. The civilian power grid was not built for that, and so the War Department will need to build its own energy infrastructure.

“Powering next generation warfare will require us to move faster than our adversaries, to build a system that doesn’t just equip our warfighters to fight, but equips them to win at extraordinary speed,” Duffey said. “Today is a monumental step toward building that system. By supporting the industrial base and its capacity to innovate, we accelerate the delivery of resilient power to where it’s needed.”

Secretary of Energy Chris Wright said that with small reactors like those transferred from March Air Reserve Base to Hill Air Force Base, the United States is aiming for a nuclear energy renaissance.

“The American nuclear renaissance is to get that ball moving again, fast, carefully, but with private capital, American innovation and determination,” Wright said. “President Trump signed multiple executive orders that have unleashed tremendous reform of all the things that stopped the American nuclear industry from moving.”

Part of that effort, he said, will mean that by July 4, three small reactors will be critical — or running smoothly.

“That’s speed, that’s innovation, that’s the start of a nuclear renaissance,” Wright said. By

C. Todd Lopez

, Pentagon News

Categories
Travel

Day 1870 and Cutting Down On Packing Time

I am a very thorough, well honed and time tested, and Karen hardened packing methodology.

I have a little bit of childhood anxiety around packing for having moved around a lot that has alas never left me. Many people having anxiety about flying so at least it is a bit relatable but I don’t know if packing anxiety is as common.

For me it’s not about being in the air but rather leaving behind an established base for parts unknown. Will I be able to find medicine for issue that arise or soap that won’t trigger eczema? What if I need to appear at an event requiring a dress & makeup? What if I need to walk for two miles with all those things?

Every time I pack I go through the same routine and I use the same bags with the same labeling system to manage all the permutations I might encounter. And it is a science.

I have a small pajama bag I carry in my backpack in case of an unexpected overnight or long delay. I carry small clear vanity case to clean & groom myself with full allergy protocols that passes even the crankiest Heathrow checkpoint. I am prepared.

I carry on my person a a small pill bag with every detail labeled that can handled medical incidents big and small along with my first responder certificate. If you have an issue on an airplane you want to be seated next to me.

From there in my carry on suitcase I label the packing cubes with every item I bring, from underwear to wrap dress and ballet flats. Everything that is packed in my larger Tumi that gets checked is also labeled and I place an itinerary on top as I find my bags opened more frequently than seems reasonable.

There are no questions from the TSA or the most belligerent customs agent that won’t be immediately cleared up with minor inspection. Now with artificial intelligence I can translate my labels on the fly into any language.

Despite this clarity and organization, I admit I’ve had a few amusing incidents. Once through Heathrow I unsettled a British Airways agent with my fiber and protein powder baggies. Because clearly middle aged woman would smuggle in a quart sized baggie of cocaine in her purse.

I really wish with all the travel I do and my very strict system that this would all somehow take a little bit less time than it does. I generally allow myself two days to pack as I like to check and double check as it’s an iron law that things will be forgotten. And Montana is remote enough that if I forget a fancy serum or a favored sweater I won’t get a replacement easily. We only just got a Sephora this year.

I am however headed for a large American city that has absolutely everything I could possibly want in short order. So as I leave behind a European home base where I do keep things on hand (I didn’t always but extended family has been kind to me) I feel much less pressure this time. And still somehow I will allow myself to let it take more time than I’d prefer.

Categories
Internet Culture Preparedness

Day 1868 and Educating An An Entire Species or Start With Your Family

A viral essay was posted a few days ago by a Matt Schumer meant to help introduce the current state of artificial intelligence tools to people who do not work in technology.

It’s a very compelling piece of writing (or maybe it’s just reading), which I believe is well received by normal people especially older family members or technical skeptics. They are often the hardest to reach because of age and experience gaps and a smooth essay goes down well.

The author is the founder of HyperWrite. His company offers a suite of AI writing and research tools. So yes, his excellent writing and wide reach (over 40 million views so far) were achieved thanks his fluent use of AI for both writing and promotion.

The end result of using tools is an excellent essay distributed far and wide. Or if you prefer, the end product was a tool shaped object which gave people a sense of understanding. That’s valuable.

Don’t let his usage of AI in producing this writing and publishing stop you from taking his points seriously. In fact, it should encourage you to read it and consider if you want to share it.

You too will soon be competing in a world where regular people like Matt are capable of super human feats. Perhaps you’d like the same leverage for yourself and your family.

All of us can learn to work with the amplifying effects of networks and artificial intelligence algorithms with practice and usage. Allowing us global reach and potentially maximizing the potential of our insights and points of view. That should make us feel better about where we are headed and not worse.

I feel it is useful to share the essay with your skeptical family and friends who are either scared, confused, angry or indifferent about the rapid changes because it is the current reality we all live in.

I know it’s hard as a middle aged professional to learn new tricks. I’m in the middle of it too. But we have to educate all of us and it’s going to take some time. I’d rather we get started on it. And on that note my lunch break from Montana’s digital innovation committee is only an hour so I’ll get back to it.

Categories
Politics

Day 1867 and Rage Against What Exactly

I feel a struggle to continue this writing experiment. I feel a struggle to continue on at all in a public fashion online as the world is refolded and restructured around us.

I am just so tired and I fear an early death as the life and treasure of my generation is squandered on the perpetuation of systems that no longer work. I was texting with my mother about her husband’s third knee surgery (ain’t Medicare great) as enormous protest raged outside my window. I am in the capital of a European nation where this is quite common.

This is the third large demonstration in the space of three weeks for an opposition party that is mostly made up of technocratic stooges trying to hide the sins of wars no one remembers except those who deployed in them. I happen to know people who did deploy in them or I certainly wouldn’t know that the opposition is made up of the siblings, children and social circle of a former dictator.

Every time they protest the roads are blocked and then it gets out of hand. Water canons are set on the fires the protestors set and then tear gas is thrown out and no one can get through the city center. I assume this is some flavor of controlled opposition as America and the EU both support the existing government.

This time there were drones above the entire affair and much of the rally seemed to be music that was a mix of Catholic liturgy and electronic dance music. A famous priest DJ performed in the city over the weekend so maybe it was him. Who knows.

Nothing is weirder than hearing O Fortuna played over riot dispersal water cannons. We don’t have that kind of cinematic drama in American protests. Honestly everyone here seems sick of it. Most of all the hotel staff and the diplomats that live in it.

I watched it unfold from a vestibule with a Ukrainian woman who said she hoped I’d stay safe. I told her I wasn’t worried as I’ve seen this before.

She was understandably more concerned than I was being a refuge in a country that no one would have thought would be more stable than Ukraine a generation ago. Socialists holding off nationalists is not a terribly equilibrium if you can afford it. America can’t but it seems plenty of Europe still can.