Tag: Biohacking

Categories
Aesthetics Travel

Day 1397 and the Jungle

I’m in Miami for the week to attend a gathering. October is as fine a time as any to visit what is otherwise a very humid and hot climate. I’d prefer midwinter but I’ll manage with late fall.

I went to eat lunch at a friend’s home. Even with fans and very breezy weather I could still feel the humidity doing battle with my body. Ancient trees covered in moss kept off the sun as best as they could.

Welcome to the jungle

And still even a little bit of movement is enough to trigger sweating in such a climate. Which just leads to itching and inflammation so I’m being careful to not get myself into much trouble. I’ve got my hats and sunglasses and sunscreen and I move slowly.

I understand why the whole town has a hospitality aesthetic that the done up in whites. Anything to keep the sun from overheating you and let the breezes flow.

Whites on white in our room

If you are in Miami let Alex or myself know. We have a conference that you may be attending as well so we’d love to overlap. I’ve proud some amusing outfits and all kinds of cosmetics I hope I have time to apply and enjoy.

Velvets, pinks, and prints for the adventurousness
Categories
Aesthetics Homesteading

Day 1389 and Fall Circadian Centering

I’m so happy to be home in Montana. While winter is my favorite season here, the Rockies have such beautiful sun filled falls.

Being a bit further north means we have such long days in the summer that our sunny summers can actually be a little too much. I

Perhaps ’m in the minority in this view but daylight till 11pm does make for a bit of midsommer madness.

But in October we are past the fall equinox. Our days are getting shorter. You appreciate sunrises more when sunsets are early enough for you to get a full night of sleep. Night having an edge on day means you appreciate the beauty of the light when you have it.

“Sunshine on my windows, makes me happy like I should be.”

The temporal pressures aren’t all gratitude journal bliss. There are a host of chores to be done before the first snowfall. We’ve been lucky this year it’s so late but temperatures should be below freezing soon. Alex and a few buddies redid the chicken coop’s roofing this morning. Keeping the hens warm and dry.

A new roof on the coop
Categories
Emotional Work Travel

Day 1385 and Adrenaline

It’s lovely to have the occasional day where you are running on adrenaline. I myself am not a big fan of stress as I don’t see it as a “good” in and of itself so much as a tool to be used to accomplish certain ends.

To that end, I live a mostly quiet life. I love being far off the map in Montana precisely because a routine with its habits allows me to take certain kinds of risks (particularly as an investor) in the wider world. A calm life lets me find early stage investing to be exciting rather than anxiety inducing.

It’s no coincidence that while I called my fund chaotic I prioritized calm in my own life. Why go looking for trouble when your professional life is all about the edge?

But sometimes it’s nice to experience the visceral risks of life. I’m in New York City and running from event to event and meeting to meeting. It’s all smiles and adrenaline and enjoyment for me. I’ll go home to Montana soon enough to my calm life. A little bit of chaos is a treat.

Categories
Biohacking Medical

Day 1375 and Titration

My joyful excitement over finally wearing a bathing suit I’d never worn? The peaceful swim in the salty sea ended in disaster within just a few days.

On Friday the allergic and autoimmune symptoms were so bad I took 5mg prednisone. On Saturday they were no better and I upped the dose by 2.5mg to 7.5mg. I moved forward my absurdly expensive biologic injection by a day. I haven’t been able to convince my health insurance to get them more frequently so it’s a risk.

I’m doing better today. My pain is abated to an almost unnoticeable level at a 2. That’s rare for me. And it makes me want to rush into as much work, chores and activity as possible just to enjoy it.

I’m typically working with a 5-6 level of pain on any given day but I can work (with medication) up to a 7 within reason. Past 8 I’m in bed and struggling.

The downside is of course that prednisone just sucks. It messes up your appetite. You balloon up almost instantly with side effects like moon face. And your body develops a dependency quite rapidly.

Titration off of steroids like prednisone require a steady and slow discipline so you don’t get “blow back” as it can make your symptoms even worse.

I’ll have titration for a few days ahead of me. But maybe I’ll get to enjoy the lack of pain. Already I’ve cleaned for an hour, done laundry, checked off a number of small “to do” list items and I am blessedly free of the exhaustion that comes from working with moderate to severe pain that is my normal daily experience.

I was sent a study in the journal Nature about a team who used CAR T therapies to achieve total remission in 3 patients. And I see hope on the horizon.

One woman and two men with severe autoimmune conditions have gone into remission after being treated with bioengineered and CRISPR-modified immune cells1. The three individuals from China are the first people with autoimmune disorders to be treated with engineered immune cells created from donor cells, rather than ones collected from their own bodies. Nature

Categories
Medical

Day 1373 and Anaphylaxis Maybe

I don’t know what I did but I’m like 50% of the way towards an anaphylactic reaction. I was exposed to salt water, a sunscreen whose ingredients I didn’t vet as carefully as normal (foreign language) and a few environmental factors that could potentially have contributed.

I’d post a picture here but it’s not something I’d relish having a permanent home on the internet if you feel me. Imagine bee stung lips but not in the sexy cosmetics way. Then apply that level of red inflammatory tissue to my entire face, chest, arms and other delicate areas.

I sucked back 5mg of prednisone which I loathe but I’m in no position to be picky. I don’t have an epi-pen with me but my throat isn’t closing off so it’s probably overkill.

A cortisone shot would hit the spot though I’m sure. I also took 50mg of Benadryl. That’s why I’m posting so early in the day as it’s hard to say if this pharmaceutical combination will result in me having Trump on steroids energy or passing out from antihistamine energy

Categories
Biohacking Medical

Day 1367 and Proper Names

My mother always insisted pharmaceuticals and supplements be called ny their chemical composites rather than a company’s brand name for it. She believed medicine shouldn’t requiring marketing & branding.

Instead of Benadryl it was diphenhydramine. For a headache we used ibuprofen not Advil. Acetaminophen was the proper name not Tylenol.

She taught me what went into popular brand name medication like DayQuil and I learned the ratios of guaiphenesin to dextromethorphan. Always take the minimum viable dose she’d say. And if I only had a cough I didn’t a fever reducer.

America is lucky to have a thriving generic medicine market. If you are a Costco shopper you can buy thousands of tablets of every crucial over the counter medication at just a few cents per dose.

There is a new series from healthcare publisher Trade Offs about issues in generic medicine manufacturing. It’s well worth your time getting to know more about how we came to have generic medicine (the Hatch-Waxman Act) and where the weaknesses are in the business of supplying these crucial medicines.

Take the time to read more on the issues as it’s been forty years of struggle for access and safety and we are experiencing shortages and supply chain risk that is unprecedented.

Categories
Medical

1354 and Better Access

I get some comfort when I see someone with substantially more resources than me use the same tools as me. Bryan Johnson tracks his sleep with Whoop. So do I.

You’d think there would be more variance but largely the tide of turning health technology into consumer technology has been to increase access. If you are interested in building better health habits we can use the same tools.

I am so grateful for the access I have to understanding my own body. It used to be considered quite rude to question doctors but as with any profession some are better at it than others.

Thanks to the work of the open internet and the tooling of artificial intelligence I cross check an astonishing amount of medical information. With a little work and the right questions and intelligent person can do basic differential diagnostics using Claude and Perplexity.

Networking together public papers, handy upper funnel content strategy of the Mayo Clinic, and the database of Drugs.com has been a real boon to involved patients who want to double check things.

Be skeptical of credentialism and gatekeeping in medicine. While everyone wants safe and responsible medical care there are plenty of well entrenched interests that don’t want you to do more for yourself. We deliberately keep the population of doctors limited in America. Professional organizations exist to protect themselves. But everyone deserves the tools to be healthier.

Categories
Travel

Day 1353 and Remnants

I am sick. I am unsure how I got it or even what it is but I’ve got an intense dry cough, I lost my voice (I’ve been pitching so it may be strain as it doesn’t hurt) and the pain in my left intercostal muscles and rib cage is so bad it making it hard to rest comfortably. It’s been an overstimulated kind of year.

My hope is that I recover enough by Monday that being ill won’t affect my work but I am throwing a Z pack at it in case it turns out to be bacterial pneumonia. I won’t get into the details but I’ve got reason to suspect staphylococcus infections.

If it’s viral then oh well but if it’s bacterial better safe than sorry when it comes to autoimmune patients. I’ll never turn down a chance to nuke my gut biome. Doxycycline is my preferred antibiotic but a macrolide antibiotic has its place.

Being stuck in bed and too uncomfortable to even move has at least giving me time to pick through my reading list and look over the remnant trends of the month’s cultural detritus. The human body may have autophagy but I’m less sure the body politic does. It’s all history repeating.

This New York Times trend piece covering stylized flat lays of TSA security bins insists on it being a fun new trend gaining prominence in the last six months. I find this “new” framing comical as it’s anything but new. Instagram launched in 2010 my wee Zoomer friends.

One of the experts quoted in the trend piece, Hitha Palepu (who is fantastic) was regularly featured together with me as far back as 2015 when I was something of a travel aesthetics expert myself as the CEO of a travel cosmetics brand.

Everything old is new again. I myself can barely manage the nostalgia riffs of Blackbird Spyplane let alone the regurgitation of a ten year old trend. I’d like us to try something new every once in a while. But I suppose we can’t even get a new presidential candidate so why would I expect Thursday Styles to have anything fresh.

Categories
Biohacking

1346 and Oversleeping

Apparently it gets harder to sleep well as you get older. I’m no spring chicken as an elder millennial but I have had pretty consistent sleep hygiene over the past few years.

Like many biohackers, I monitor my sleep on an Apple Watch as well as a Whoop (which incidentally I absolutely endorse) whose data I sync across a few other biohacking apps.

I wrecked my sleep consistency this week as I changed my schedule to overlap more with the East Coast and European markets for work. On Friday night I found myself absolutely wired and unable to sleep. I was what students of nervous system work might call “activated” and couldn’t get myself down to baseline.

Eventually, in desperation, after attempts as varied as hysterical crying, box breathing and reading 10,000 words on female homicide statistics, I took multiple types of downers.

And I don’t mean friendly things like melatonin or chamomile tea. I went for the dreaded Jordan Peterson nemesis the benzodiazepine. I needed to sleep.

And thanks goodness I did. I was out like a light till an almost 3pm. Whoop was thrilled with my sleep performance. Which I admit feels weird to see as no one wants drugged sleep to be good sleep but alas it was good.

Whoop data readout on a long “day” of sleep with five hours of restorative rest after sleeping through to the afternoon

I spent a third of my time dreaming which must mean I’m working through something. the activation of my nervous system clearly meant something. I got excellent rest and it was worth it. I overslept a lot and I hope that I’ll be right as rain for my sleep hygiene thanks to pulling the ripcord and getting sleep by any means necessary.

Categories
Biohacking

Day 1324 and Sensitive to Input

Maybe the intensity of sensory inputs is worse than it used to be, but I think of myself as being a sensitive person.

I have strangely acute hearing, I struggle with bright lights but in particular screens, and I am often unsettled by smells, flavors, and textures. Life feels like it’s having at 10x the density and clarity that I’d prefer.

It’s probably just the flavor of autism that seems to plague every other person on the internet.

Today I found myself focused on the texture of a pair of socks that I’d just purchased. It felt as if they were rubbing the top of my feet raw. But it all looked fine when I took them off. I applied moisturizer and put them back on but it still itches.

Sensitivity is annoying and I am chalking it up to fatigue. I’ve been excitedly putting in long hours for work so every input might simply be on raw nerves.