Categories
Chronic Disease Medical

Day 1814 and Spicy Boi Shots

I’ve been trying to coax myself into taking my final biological injection of the year for most of the day. It’s a very painful shot. The feeling of it is somewhere between stinging and hot sauce being pushed into your subcutaneous fat. It’s spicy

I switched my IL-17 inhibitor for my inflammatory conditions as one of my first actions of 2025.

I was filled with optimism that this new variant called Bimzelx might be the one that finally brought down my biomarkers. And it did indeed show promising results. My CRP and SED rates have never been better.

Alas, the cost is quite high. I’ve got no immune system response to speak of when it comes to my skin and soft tissues. I’ve had four major skin infections requiring surgical intervention and many minor skin infections.

I don’t think I can live with the side effects of the drug even if my inflammatory numbers are better. There is no doubt it’s effectively treating some aspects of my psoriatic arthritisaxial spondyloarthritisankylosing spondylitis.

My pain is better so long as I can avoid picking up an infection. I’ve been on antibiotics most of the year. Alas I’ve only had maybe 2-3 weeks without an infection brewing or being beaten into a retreat.

So today may be my last spicy shot. I’ve gone it a full year of adjustment. I don’t relish the prospect of adjusting back to my previous medication as it takes a full year to fully dose on and off these things. But maybe I’ll be lucky and on my final shot in the year I’ll see a change for the better

Categories
Culture Politics Startups

Day 1796 and I’ve Got Billions in My Inbox Julie!

I’m not new to the boom and bust cycles that have defined not only technology startups, but American herself. Most millennials have opinions about their malign status in an economy designed to borrow from the future for a dubious present.

Much of the world is in a state of panic over “the churn” of the old rules changing and the new ones not being quite clear. But it’s really not clear what happens next.

I think anything goes as the networks speed up our connections to each other through artificial intelligence. The end of the age of scaling means it’s time for the era of deployment is it not? Or are none of us Carlotta Perez fans.

I enjoy speculating as is the fashion. Do I think corporate debt financing of data centers is some time bomb in private credit? Not really, no. I think it’s way more likely that don’t understand the full demand case for coordination in a mediated world.

I don’t know if we can meet the demand to be perfectly honest. I will say I am way more worried about us not meeting the moment. Changes to our cultural environment are as hard as our material ones.

If I had to read sentiment, I’d say that everyone is absolutely sick of having their attention used like a fiat currency. We cannot inflate our capacity for focus as easily as we can inflate the dollar. And we will demand simplicity by any means necessary just to exist. And artificial intelligence will smooth our world to manage with what we’ve got.

I think running a decentralized world will prove to be far too complex for most humans and it will be mitigated by layers of choices in governance that will probably not always maximize for the freedoms we’v come to expect from the liberal world order.

And yeah I think we will need a lot of data centers for that coordination effort. That the state might be the ones with the most demand seems a little rich though. Every individual on earth will want to be on the right side of the ratings. That’s more network state than state and it will be a longtime horizon.

I know it doesn’t sound great on its face. And yet I think it has had upsides. The demand for real businesses that operate in some world of efficiency has never been higher.

And to some extent, I believe that was always the entire point of computing. Make things so much better and cheaper we move on to bigger projects.

Giving you video games and porn might have been a weird way to get to Mars but medicine is as driven by vanity as much as survival so I don’t judge reality. I just want us to get more nuclear power. I don’t ask for much.

We didn’t want a legion of information processing professionals. We wanted to change the material conditions just as the Industrial Revolution did. The invisible hand is a strange thing.

I expect we will see quite a bit of opposition to the people believe that we need more energy, more industry, and more science. The future and its enemies are legions. I always did find it funny that fashion critics had a better read on the future than anyone else. Virginia Postrel and William Gibson both have good taste.

Categories
Internet Culture Media

Day 95 and Context Collapse

I have reasonably high social intelligence. Yes I’m willing to flex on this. I’m able to suss out the contours of most situations quickly and code switch my language, aesthetic and context cues. Sure as a white woman in America’s vast “upper middle class” many social interactions and norms are designed for my comfort. But I spend time in spaces that are very much designed to exclude like finance. But I rarely feel out of place as I can find some point of intersection that allows me to find purchase with the leader (or norm setter) that sets a group’s context. To say that this is beneficial is an understatement.

I recently came across a piece of writing titled “A Theory of Collision Spaces” written by scientist who goes by the handle Generativist. The intended audience is folks who think probabilistically or at least have a firm grounding in computational thinking but if you have a head for logic you should be fine. The topic is how social media can do often lead to what is called “context collapse” but you might recognize as “people screaming at each other in bad faith in the comments section.”

The premise of context collapses is that online we may theoretically interact with infinite possible audiences. Infinite contexts makes it much harder for us to adjust or code switch such that we can telegraph that we care about the audience to whom we are speaking. It’s not impossible but it’s much harder. This is how one can make a statement that sounds innocuous but will end up pissing off some group that will come down hard on you. If the reaction is bad enough some audiences call it cancel culture.

Because I have a high social intelligence I’m less prone to getting caught in a context collapse situations. A quick scan of a profile and a few sentences of text is generally enough for me to subtly adjust my language and response. Of course, I cannot adjust for how others respond to me but I can respond to how they respond to me.

Think if it as second derivative social signaling. Limiting the possible permutations enables safety driven actions on my part. While I cannot survive an internet mob (no one can) even a tweet that goes reasonably viral is still bounded by social cues. The more adaptive you are at these cues the less likely you are to instigate a context collapse.

A lot of reasonable people have concluded that context collapse and internet mobs make social interactions on the internet too risky. The likelihood of encountering someone who will go splat against your reality and make a fucking thing out of it is none zero.

But I’d argue you have a weighting bias issue for the magnitude of the risk. You are much more likely to build something of worth from being social than you are to become “canceled” and I think this Theory of Collision Spaces essay just might convince even the twitchiest rationalist groupie. Why? Ensemble learning and computer mediated relationships are super powers for humans. Our ability to extend our thinking has two powerful tools in this era. We can learn from others. And our tools like our computers and their application layer act as extensions of our mind. But don’t my word for it. Nothing I can say will remotely compare to the paper as I’m just not as smart as this scientist.

So you get that social media has many opportunities for expanding our mind. So how do we become comfortable with the perceived risk? One point I want to get across here is that assuming all interactions online are bad makes for poor heuristics. So why is it not as risky as you think?

Social cues mal-adaptively increase the unconditional variance of expressions while minimizing the group-conditioned variance.

Basically social media makes you lean into identity cues. We fight with negative identity opponents and align with positive identity proponents. The only issue? You might be talking to someone like me that code switches. “You cannot easily distinguish between unreliable counterparties, deceptive ones, and whether or not you are wrong.” So you could be talking to someone deliberately fucking with you, someone who legitimately just misunderstand or you yourself might be wrong. How do you know? You don’t really. All this “in group” signaling doesn’t make a ton of difference. It’s just the environment of the internet honing some badly social engineered aspects that are not inherent to the human mind or social behavior.

So go read that piece. Tell me what you think. And then go enjoy being social on the internet! Don’t let being wrong or being polarized scare you. We are still figuring out how being part machine mediated. A few bumps are to be expected