Tag: Biohacking

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Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine …

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

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Biohacking Emotional Work

Day 1271 and Documenting Practices

The winding roads of spiritual practice often cross paths with the more practical minded subcultures interested in practicalities.

Doing a thing can be more enjoyable than documenting a thing but documenting turns out to be quite helpful in helping others learn to do things.

As we knit together our individual experiences our capacity to measure and systematize improves which in turn scales access if you are inclined to experiment. Getting a look at more than our personal n of 1 enables us to practice kitchen table science in areas prone being illegible or inscrutable.

I believe we are accelerating a number of types of revivalism thanks to the network effects of the internet colliding with religious and spiritual traditions.

One area where I am tracking this has been Silicon Valley’s exploration of meditative practices and mindfulness. I read a wonderful piece by Jake Eaton today about his experiences with jhana practices. If you are interested in learning the practicalities of this type of practice Nadia Asparouva has documented it extensively as well.

There has been a rising interest in codification of various mindful and meditative practices in a number of my syncretic cultures. Engineering dharma bum connective mental map mindfulness seems to be an archetype doing the work of documenting.

Handing people what was once hidden knowledge naturally makes some people skeptical. We’ve gone from sharing breathing practices to documenting achieving spiritual ecstasy.

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Biohacking Medical

Day 1269 and Reconditioning

I feel as if I lost a lot of ground to a gnarly case of Covid over the past couple of weeks. I had two weeks of clear infection symptoms and then a week of simply being exhausted and unable to get out of bed.

The benefit of keeping trace of one’s biometrics that I at least have some visibility into the misery. Of course, the downside is that I have visibility into how much misery. An extremely both sides of the bus meme situation.

I have a lot of reconditioning in front of me. Or at least my health data suggests that. It’s very discouraging to have health apps say you’ve had a 90% decrease in activity.

This week I slowly began the work of going back to life. I attended a policy gathering. I’ve been working on deals. I suppose I was doing that while I had symptoms too. It’s been hard as I want this to be better but I lost a lot of ground and relatively quickly.

I’m now doing all the little things one does help get your body back on track. Simply changed and reminders are most effective if you have injuries or are chronically ill.

I have little routines where I get up and do body weight squats on the hour. I’ll make sure to walk 500 steps each time I get up. I’ll touch my toes and stretch.

All these things feel very hard at the moment and I get blaring warning signals from the trackers suggesting physiological strain when I do. The slog of not giving up is a permanent part of the human condition and I refuse to let entropy win. But I am discouraged by how much work it is to do the basics. You can’t ever escape that life is just chop wood and carry water

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Biohacking Medical

Day 1264 and Party’s Over

I am going on my third week of having Covid symptoms. I don’t know if it’s time to call it “Long Covid” but my autoimmune response to it feels like it’s being dragged out.

My family doctor (an absolute gem of a general practitioner with a concierge clinic if you are ever in need in Montana) helpfully reminded me of the basics of immune response.

The infection is cleared but my immune cells did not get this memo. I’m still coughing, I’ve got clear phlegm, and I am struggling with a high respiratory rate. I am exhausted.

Yesterday I went for a short 15-20 minute stroll to get sunshine and I found myself with a very heightened respiratory rate overnight.

Apparently even small stressors like pollen count or exertion are hard when your immune response is overactive. I’ve been living with an autoimmune condition for years so while rationally I know this, it helps to be reminded.

If one is inclined to a forced metaphor, the party is over and the guests have left but the host hasn’t figured out it’s time to turn off the stereo, lock up and pick up the trash.

Calming immune responses is a tricky business. Sometimes you succeed by waiting it out as your system slowly resets to a healthy baseline. Sometimes you use more interventionist approaches with either local or systemic steroids. I try to avoid this but sometimes the only approach is the brutal one.

It’s my hope that the party being over means I can simply manage the mop up but I hope my immune cells decide to chill and get back to baseline soon.

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Biohacking

Day 1258 and Relapse

I woke up feeling reasonably good this morning. I thought perhaps my prayers have been answered. I have been managing a case of Covid for over a week so I really wanted to be turning the corner on recovery.

It’s hard fully rest with an infection and this case overlapped with a lot of big things for my portfolio companies. That excitement made it even harder to stay away from working. I was joyfully working all weekend for multiple deadlines.

I’ve not been the best behaved patient though I have stayed in bed. I thought I’d at least maintained the appropriate protocols for sleep, nutrition, supplements and medication.

What I really wanted was to go outside and enjoy the weather. June in Montana is heaven. Cool bright mornings turn into sunny dry days.

I thought that a short walk in this type of environment would be healthy. I walked the property and down our dirt road. I wasn’t out for more than twenty minutes.

Walking by our little pond fed by a creek.

It was too much. By early afternoon I was exhausted, feverish and coughing. I slept but it was the fitful half conscious sleep of the sick.

I am disappointed as I want this to be over. The pushback from supposedly health giving activity like strolling in the morning sun was immediate. It isn’t over and I’ve been punished for joyful nativity. But damn it’s a beautiful day to be alive.

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Chronic Disease Medical

Day 1252 and Maximum Health Protocols

I must have wanted some early 2022 vibes as my current “Covid infection after a traveling to a crypto conference” feels aesthetically familiar. It still feels like we are in the same long now of Empire’s End but this time with more geopolitical risk.

I can’t think about most of this at the moment as I am officially on my Maximum Health Protocols which is a mix of expensive piss and biohacking basics with a hint of woo and a triple helping of pharmaceuticals.

I still feel like shit but my hope is that dedication will save me from long post viral complications. I’ve worked too hard on my health to let some stupid inflammatory Covid event get me off track.

Covid isn’t any more worrying than most triggers to my overclocked autoimmune system but the additional pain of the inflammation isn’t doing me any favors. Does anyone else remember cytokine storms? To quote South Park, I member

I dislike the brain fog and exhaustion as it feels like writing about illness has become boring. I’d rather be going on tangents and rants but I’m stuck linking to posts recommending vitamins and sleep. Probably a sign that I love my work that my irritation is this strong.

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Biohacking Medical

Day 1251 and Summer Covid

I don’t know why this didn’t occur anyone earlier but this morning as I went about my news review the New York Times surfaced a piece on handling a rise in summer covid cases. My brain went huh so I took a Covid and as it turns out this viral thing is in fact just fucking Covid.

Whomp whomp.

A blast from the past. A positive Covid test!

If anyone wants to make some jokes about how I was just at a crypto convention I could use some throwback pandemic humor. I am certainly enjoying the irony.

As new variants of the coronavirus continue to gain traction, doctors and researchers are bracing for a potential rise in cases this summer. KP.2, one of these variants, now accounts for 28.5 percent of cases, and data from the Centers for Disease Control and Prevention shows a small increase in Covid-related emergency room visits and positive tests

Summer 2024 Covid

I am naturally not thrilled. I know no one takes covid seriously anymore so protocols are lax but I’ve got an overactive immune system. I don’t want to give myself any chance at post-viral nonsense nor do I want to put anyone around me at any additional risk.

For what it’s worth I hate being sick in public so only my husband Alex has been in particular close proximity to me as my symptoms got worse. I pulled back from the conference as soon as my symptoms really hit.

I will not be leaving bed until I’m sure I’ve got this absolutely licked. I am throwing all the usual suspects in the biohackers arsenal at this thing. If you’ve got suggestions for fending off post-viral nonsense send them my way.

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Biohacking Medical

Day 1229 and Hormones

I was pleased to wake up to a near perfect recovery score on my Whoop today. Because I manage a few chronic health issues I am a bit of a stereotypical biohacker type.

I happen to be rounding the corner into my best two weeks of the month and am seeing my biometrics improve.

While it’s fun to joke about moody women, I sometimes wonder if we’ve done ourselves a disservice by insisting that our hormonal rhythms be kept outside of polite conversation.

It’s not any fairer to men to keep discussions hormonal health quiet. Culture war nonsense aside, one of our major health systems surely deserves more public discussion and advancement.

As if the bounds of social propriety simply cannot accommodate anyone discussing say the follicular phase for women or what men can do to increase testosterone. Our fucked fertility deserves better than polite Victorian euphemisms.

If you aren’t sure about the state of your hormones and feel as if you could be in better health consider this permission to learn more about yourself. Your body deserves your self knowledge.

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Emotional Work

Day 1225 and Better Out Than In

I may have bitten off a bit more than I could chew. In post 1215 I discussed a personal development course I’d committed myself to doing. And, to put it delicately, quite a bit of stuff has been coming up. Let’s call emotional acid reflux.

Over the last few days in particular I felt as if I was drowning in somatic bile as years of grief and anguish have surfaced. And I’ve let wash over me.

Turbulent waves of realizations come up and crashed over me. I pray the tides give me enough time to recover before anything washes back. I’d rather it be out than in but the pain has been acute.

I belief it to be appropriate to credit some of this outflow to The Art Accomplishment Connections Course. It is a highly recommended personal development experience.

It’s clear that the methods are almost intensely effective. I can’t say if it’s right for anyone else but I’ve made a commitment to emotional growth over the last several years. I found the name to be off putting (somewhere between scam & Ted Talk in terms of branding aesthetics) but many people I respect and trust recommend it to me. If you’d like to get some things out of your system perhaps it cooks well for you too.

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Emotional Work

Day 1217 and Triggered

I deliberately put myself into an exercise today where I gave another person permission to trigger me. I mean trigger in the emotional sense.

caused to feel an intense and usually negative emotional reaction : affected by an emotional trigger

Merriam Webster

I very much recommend the experience. If we workout our bodies and our minds surely we should consider the value in working our emotions over.

Openly welcoming emotional punches may seem about as sane as welcoming an actual punch but like in all things practice makes perfect. It’s good to prepare with the relevant skills for all kinds of things.

I am not a boxer or martial artist myself but I appreciate fight metaphors and their applications in the power dynamics of life. Much of living feels like a conflict to even the most level headed of us. Which I’m not sure is a title I can claim honestly but I do try to follow the maxim in “Hitchhiker’s Guide to the Galaxy.”

Don’t panic”

Douglas Adams

Even if we opted into some level of being available in the rituals of being alive we can find ourselves surprised to be considered fair game in the agendas and power struggles of others.

We are all civilians in our own mind. Sometimes we’ve stepped conflict without even knowing and you’d best keep your wits about you. Consequences for actions have a tendency to come back around for even the most cautious.

So if you’ve got the opportunity to be put into “fight or flight” you might find the opportunity worth the while. After all, everyone’s got a plan till they are punched in the face. So stay safe everyone!