I slept rather poorly last night. I get anxious before medical appointments. Interfacing with America’s medical system can range from merely uncomfortable to actively hostile so I suppose some heightened vigilance isn’t irrational.
I really yearn for an uptick in qualitative metrics I associate with higher quality of life like energy for my favorite physical activities (weightlifting and hiking). Pain, fatigue and stress from the pain, and downstream side effects are constant reminders of poor health.
So I am looking for improvements in basic markers like my CRP and Sed Rate as those inflammatory markers should coincide with the qualitative improvements.
An auspicious pair of numbers for today’s date and I started something new which has been in the works since January began today. Our long awaited hyperbaric chamber has arrived and been fully set up in our yellow barn.
A lazy boy lounger and oxygen under two atmospheres of pressure.
It feels good to begin a positive focused wellness activity after what was otherwise a chaotic week of travel, geopolitics and violence.
As expected, it is not fun living through my own investment thesis. So you better believe I test my theories on myself. I want to survive the Jackpot.
Before Trump’s inauguration, we decided to purchase a hyperbaric chamber after one of our mutuals told us about his HBOT trial at a conference in the fall. It went very well for him and the research is promising for inflammatory conditions.
Over the winter break I happened to be in a city where I could test HBOT cheaply and was very impressed with the results in only ten sessions during a flare in my autoimmune condition. Crimping from Bryan Johnson
Hyperbaric Oxygen Therapy (HBOT) involves breathing pure or nearly pure oxygen (95-100%) in a pressurized chamber at anything above atmospheric pressure (2 ATA is equivalent to being 33 feet under seawater).
The increased pressure enhances the lungs’ ability to absorb oxygen, boosting oxygen levels throughout the body. The therapy aims to promote rejuvenation by increasing oxygen concentration in tissues, supporting healing, cellular repair, and vascularization.
This sent me down a rabbit hole as I did a bunch of deep dives, got some text books and came to a simple conclusion after a lot of medical papers that it’s pretty simple.
It’s almost philosophically the way of life in the mountain west. Oxygen and pressure work on the biomechanics of a functional body. Alas getting my basic market model to Montana ended up being a cluster fork of issues. We placed the order in January.
For months we waited for what we’d been told would be a 6-8 week process. Alas all hell broke loose. We had tariffs uncertainty with the importer and the OEM.
I have now, in September, after a long journey but a simple set up process, begun my first intensive protocol for autoimmune diseases on our own hyperbaric chamber.
Love your body enough to put it under pressure and take a deep breath.
I will complete a minimum of 40 sessions (5 sessions weekly) at 2 atmospheric pressures, in a hard chamber from OxyRevo with each session 90 minutes while breathing 100% oxygen for 20 minutes separated by a 5 minute break.
If you are interested and see strip mall options note that these are not consumer grade machines. The protocol requires a hard chamber to achieve that pressures. It’s quite a bit higher than soft chambers on the market.
There are risks associated with HBOT from correct pressurization issues to impacts like tinnitus. The more prepared you are to adapt to changing pressure with breathing techniques and equalization (looking to divers for these protocols) the happier your central nervous system will be.
As I often do on transcontinental travel days, I wrote my post for the day first thing in the morning. I wasn’t sure how the journey would go so I thought “let’s post this early” in case things get hairy. And boy did it.
It’s a weird thing to complain about air travel on 9/11, but I don’t think much of the security theater we’ve accepted over the years did much to keep my transit safe yesterday. Twenty four years later we go through the motions of keeping air travel safe from terror because what else are we going to do?
In fact, it didn’t seem as if security was particularly tight yesterday so much as particularly incompetent. It was chaotic confusion everywhere from passport checks to boarding flights.
I had a Frankfurt to Chicago polar day flight, along with a positioning flight on each side. I went through a lot of security screenings and passport checks yesterday and stood in more lines than I can count.
In Frankfurt the lines were so long that even with planned two hour airport transit time, I was among the last to board my flight.
The “special purposes” line I begged my way into as my inbound was delayed by fog was glacial in its pace. It seems the new transit grift is wheelchairs. So perfectly abled people are now pretending at disability to board early and use special security screening lines.
It left wishing I’d registered my real disability as I attempted to run the two miles of the international terminal with suitcase and backpack torquing my spine so I wouldn’t miss my flight to Chicago.
Deplaning at Chicago I couldn’t even count the full set of wheelchairs waiting.
Add in enormous confused families using the special purpose line, who spoke neither German nor English, with 3-4 bags a piece and every sort of banned item from pocket knives to 1.5l bottles of liquids and I am shocked anyone made it through security to their flights on time.
I watched a foursome of black Arabic speaking grandmothers in hijabs and wheelchairs shouting at German security guards and their extended families as I waited for my turn. Their fierce attitudes did not speed anything up that I could tell.
I saw them 9 hours later gathering somehow even more checked luggage upon arrival in O’Hare. I’m glad my Global Entry let me pass them by at passport control as I did not want to be behind them again.
Not that I got through Chicago’s security lines unscathed. The TSA pre-check lines were four times as long as the regular line. Figuring I was well packed I could handle the normal line. Naturally I got randomly selected and unpacked basically everything
As I stood in my socks waiting for the agents to stop gossiping and listen to the only working agent explain to them that “yes that the ice pack was for medications so they can move this along” I got an alert on my phone that the conservative political organizer Charlie Kirk had been shot.
I wandered in a daze to the United club where I was denied entry. This despite booking a business class ticket for the entire transit through their own hub via their Star Alliance partnership with Lufthansa, I couldn’t use the club as “the last leg of my flight didn’t qualify.”
I knew this was possible as this last leg issue happened to me on my last transit through O’Hare so I’d bought a day pass ahead of time. But they weren’t honoring those as it was too busy. I schlepped to another club in the terminal where they were still letting in day passes. There I listened to scared speculation from two blonde women about Mr Kirk’s status.
Another hour later I made my way onto my flight to Montana. I decided to just jump to the front of the line as I was in first with seat 2B. If everyone is ignoring lines then it was irrational to keep trying to politely queue.
As the plane boarded it was all talk of Mr Kirk. A news alert crossed my phone saying he had been killed.
A gentleman was playing a video of stitched together angles of footage on his phone with full audio on. You could hear the bullet hit again and again.
The cabin attendant told him to turn it off, saying sir please have some respect for the dead. A few hours later, still living, I made it home to Montana.
I’ve got a long travel day ahead of me with multiple transit hops. Given the state of geopolitics, I expect the international hub that is a transit point for most of the better MENA carriers will have some extra security measures.
I always pack a toiletry bag that can manage all grooming for at least 3 days, all crucial medications are kept on my body with a full supply in my backpack and finally a change of clothes should I find myself with an overnight.
Match-y Match-y
If you are interested I use Aer, Muji and BagSmart and a labeling system so I always know where things are. I’ve found having extensive labeling really makes the crankier airport workers in big hubs like Frankfurt and Heathrow happy.
Boarding a Lufthansa Airbus 321
We got the hurry up and wait now that we’ve boarded in a clusterfork of infrequent travelers who insist on manners like rushing the doors when they are not in the proper class and bringing 3-4 pieces of luggage.
Watching an older lady throw a fit in broken English to a German flight manager that she should have the open space in business class because no one is using it was funny. She didn’t understand that because it was a bum rush that many of the travelers in business and first were behind her.
We just got the news that Poland is closing its airspace after a Russian drone attack. Over 100 people on the plane on my first jump have connecting flights across Europe and internationally so I’ll be interested to see what things look like at the hub. Add in bad weather in Germany and I’m sure this will have some exciting moments.
It’s hard not see every day as more of a beak with the past even as so much remains the same. No wonder the French have that handy slogan about “plus ça change” as systems remain even with violence. They really know how to balance being disgruntled with the past.
I was suggesting La Haine to someone earlier this week as the French movie that made an impression on Gen X and elder millennials who paid attention to Francophone culture. It’s hard not to think current problems are similar tensions recycled for a whole new era. Atmospheric, vulgar and dangerous are the keywords.
The addiction economy repackaged the same old things that kept our attention economy running. And they will keep running it till it is so refined and so well packaged you won’t even remember that Starship Troopers was meant as a satire of fascism.
We repeat so much. The Churn as the Expanse called it.
Amos: This boss I used to work for in Baltimore, he called it the Churn. When the rules of the game change. Kenzo: What game? Amos: The only game. Survival. When the jungle tears itself down and builds itself into something new. The Expanse
Survival breaks out into the only game all the time and we are always running a Red Queens race. So try not to get too distracted. Ween yourself off of anything that you’ve not got any reason to hold dear. Change to meet what you can so long as you can still see yourself.
I like to manage my days with buffers around my routines and obligations. I find tight schedules to be tiring and unhelpful as I manage my energy, pain, and workload. A packed calendar raises my cortisol.
I believe I am easily stressed by shouldering too much, but I also fear I am on a downward health trajectory which will require more time, energy and effort. I am beginning to contemplate reworking my style of effort management as conditions on the ground change. Can I schedule my way out of a spiral down? What is my Pareto optimal plan here?
My 2025 has been significantly worse than my 2024 and an almost entirely different realm of issues than I faced prior to that. As I compare, 2022 and 2023 were entirely different worlds than my 2025. I thought I was pretty sick then but improving my inflammatory markers has nuked my HRV & stamina.
The stress of a permanently lowered baseline of biometrics makes me feel despair even as I have new tools at my disposal to mitigate them.
Will my whole life be dedicated to the care and feeding of my broken body? Is that something I can live for instead of simply living with?
I just don’t know how much effort will be put into managing this new baseline and what the effort to reward ratio looks.
Is there a Pareto principle I can apply to permanent disability which I can, and maybe even should, emotionally accept? Or do I soldier on hoping that my middle aged body may repair itself if I do absolutely everything right? And what am I doing all of that for?
It just seems as if no matter the time management, advanced medical care, constant research and daily effort I only get worse. I’ve been under a scalpel three times this year.
Each time I think I have found a new drug or treatment modality I am quickly slapped with second order side effects. And then those side effects have new side effects as I treat them.
It’s the pimp my ride recursion of biohacking, but instead of liking a thing and adding it to my car, I’m adding more and more mitigation measures to manage the results of the biohacking.
Any positive aspects of my year (passing the right to compute bill into law, progress in my startup portfolio) seems pale in contrast to emergency surgery, slow burdensome recovery and the arrival of mortality. I’m only at the halfway point of life (and a little bit past that for the year) and I feel done in completely.
I’ve got my over the ear noise canceling headphones on playing a Solfeggio frequencies of 396 Hz which is labled as “liberating guilt and fear” on my Endel mobile application (which I recommend though I’m not involved with it).
My father died this weekend. While I had been preparing for the possibility for sometime the reality of the moment is never what you expect.
Grief is a strange emotion. You forgive your parents but they don’t always forgive themselves. And then it’s over and everyone is free. The pain is over and the past arrived and your present is without them.
The past becomes a foreign country and you don’t speak the language and as you become middle aged you see your life reworked through success and failure and the hard costs which your ego previously obscured like too much greasepaint.
It is maudlin to stay in grief but if we do not let go of the past we will project past pains and old understandings of reality onto others that do nothing but harm.
It’s a beautiful thing to watch these huge emotions play out in your life. Death offers grand dramas when all you can offer is having built a future on the foundation they gave you.
Some days are harder to write through than others. Yesterday I found out my father had passed. I didn’t say anything as I wasn’t sure what would happen next.
I didn’t know who else knew or if others were being alerted so I didn’t discuss it. The last thing I wanted was to disclose something inadvertently as the rest of the family found out. I loved my father very much. We had a complicated family but I didn’t doubt that love.
I learned of his passing as my brother received a voice message in the middle of the night from my father’s wife. He called me immediately when he woke up and had listened to it.
There wasn’t much information in the voicemail but there is a certain logic to the phone tree of death when a family member passes. My brother called his mother after he called me. I called my mother. That was the end of our tree.
I did not get a phone call or other information but my brother has and it is likely I will remain at a loss for words as to how to consider my feelings about all of this. I can speak about it as I know that the parties concerned all know but what to say is beyond me.
The complexity of the social contract and our expectations of family ties has been ongoing for several generations now. Divorce and remarriage have been common in my living memory and the blending of families the norm. Sometimes it’s beautiful. Sometimes it’s not.
I have had a shock that is in reality not a surprise. The inevitable and the most surprising thing coincide rather often I’ve found. I imagine shock is as means reverting a phenomena as any.
All things are inevitable in hindsight. One can greet something as inchoate and far reaching as the Fourth Turning and still be a bit surprised to find it applying to you.
I believe we are about to find out a lot about our social contract soon. How the tensile strength of relationships hold under personal and national and global stress. If we are accelerating then any frictions on that process are going to sizzle and snap.
There is freedom to be had in future shock. Knowing you are repeating history and doing what you can to break the worst of it. Knowing no one can do any thing. That ultimately all any one of us can do is what we personally can do. She done what she could.
Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.
They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.
So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.
Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.
Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.
I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?
“So I heard you had side effects so I gave you a side effect for that side effect.“
And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.
Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.
Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.
GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:
Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. SourcesSources
Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. SourcesSources
Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.
Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.
TB-500 (Thymosin Beta-4 Fragment)
TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:
Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.
TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.
BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:
Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26
Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.
