Author: Julie

Categories
Chronic Disease Medical

Day 1896 and Short but Sweet

The weather forecast for western Montana for the next several days is gusty high winds and five feet of snow in the high country so I suspect I’ll have some good down time simply because there’s a chance I won’t even be able to go outside.

I have a dentist’s appointment tomorrow morning, first thing, which I am a little nervous about as I’m not accustomed to having issues with my teeth.

The work I got done a week ago kicked up quite a bit of dust, if you will, and now I am struggling with a high heart rate and a very low heart rate variability. I can’t seem to improve upon the numbers.

If the dentist doesn’t spot anything wrong, then hopefully I can simply get a prescription for fluoride toothpaste and head to my family doctor as long as the weather holds.

I wish I had more to say but the energy I had budgeted for the day has been all used up. I’m not even confident I have the strength to focus on television with a plot line. It is a challenging prospect for me to stay upbeat when I get beaten down by my own body but it’s all I can do and I’ll have to accept it.

Categories
Chronic Disease Medical Politics

Day 1895 and If Not Us Then Who?

Despite persistent efforts to mitigate the downsides of my various medications, as well as maintaining dedicated wholistic lifestyle routines for my chronic diseases, I am not making adequate progress. I’d go so far as to say today it feels like I am sliding backwards.

But that is partially a function of luteal phase acute migraines and not the full picture on the ground. Yes, it’s true multiple metrics have gotten significantly worse over the 15-month span of my IL-17 inhibitor experiment with Bimselx and I am preparing to make the decision on what to do next. Many biometric markers are much better but the trade-offs are severe. It just feels like I can’t overcome them right now because I feel awful.

Nevertheless it’s important to remain grounded in the here and now. I think part of my trouble may be I am adjusting both to a new time zone and my normal altitude. Maybe I’m overly concerned by data points that will get smoothed out over time but it feels very spik.

Alas there is little room in life for downtime or bad days. Portfolio companies are fundraising, politics is getting uglier by the second, and one key blocker in my life has remained unsolved now for years.

I’ve never experienced a blocker quite so persistent as the American State Department’s handling of visa and immigration work. And yes that includes being disabled and chronically ill. That’s how bad state capacity is right now. My years-long attempt to get visas for family members to come help has not seen an iota of success.

But we keep going. There is much to be done, both practically and at higher levels of abstraction, and I am being whipsawed by hormone migraines over the last 48 hours. It is not an ideal time for weakness in one’s body.

Yesterday the best I could do in terms of writing was some rambling about my irritation with new retail sales cadences at Sephora feeling down market. Not that I necessarily need this space to be filled with decent content but I know that I am not running at even 10% capacity.

We all have to contribute our talents to this moment in time and there are projects that I wish to commit more time and energy to, even though it feels like it may be the death of me. But if not me then who? It’s a question we should all be asking ourselves and I hope more of us rise to the challenge.

Categories
Aesthetics

Day 1894 and The Middle Market Sales Reinforcement Dilemma at Sephora

Psychologists can argue until they are blue in the face about the appeal of Veblen Goods or that value can be demonstrated by price point, but veteran retailers know that everyone likes a good deal.

Rich or poor, young or old, oligarch or peasant, the shopkeeper knows the mind of the buyer requires we feel like we are getting more than we paid. This has some downstream consequences.

Retailers try to avoid degrading their price points and brand reputation with tactics like percentage off sales. And they can be clever about it. There are seemingly innumerable shopping holidays now where you can play with merchandising, special collections, loot boxes and creative value presentation.

Black Friday, Cyber Monday, Single’s Day, Christmas in July, Prime Day, Fukubukuro (福袋) Lucky Bags, and Lunar New Years are just some of “tentpole” shopping holidays around the world that provide merchandising opportunities and encourage taking a look at what is on offer.

Yet somehow the middle market of mass retailing is still struggling with how to manage sales. If you train your customers to expect a deal, and worse if they expect it at a regular time and frequency, what will make them shop in between those opportunities? Mall brands regularly get trapped by sale training behaviors

I’ve been watching Sephora go from a twice a year sale brand to trying their hand at daily drops. It seems as if they are going the Ulta route in the hopes of driving more purchasing at lower price points. Drive repeat purchasing at higher frequency and it might work.

However the average order volume has to be going down. I wonder if they have no choice having re-oriented the brand down market to attract younger buyers during the Sephora Teen pandemic era. But we are no longer in stimulus spend era and I imagine this is alienating to their older upper market customers. I’ll be watching it.

Categories
Aesthetics Travel

Day 1893 and Gusty Groaning Roaring Winds

Yesterday I went from the bright blustery Pacific surf beaches of San Diego to the fault block ridges of the Bridger Range in Montana’s Rocky Mountains. Going from one climate to another in the span of a few hours remains a wonder for me.

While I enjoyed the nervous system soothing peace that comes with watching the waves, I did feel a sense of relief coming over the snow capped peaks into the Gallatin Valley.

It’s been a dry winter with very little snow pack, ans the accumulation is much needed. It’s odd for Montana to have had so little snow this winter. I missed much of it but in truth I’ve seen more real winter in the mountains of Sarajevo and Greece than Montana.

I’ve been at sea level for long enough that I am nervous about my adjustment to altitude. After unpacking and restocking groceries, I went for a mile and a half loop that is my usual leg stretching route.

My V02 max remained identical to the scoring from the day before at sea level. My other biometrics are in a difficult place with my resting heart rate high and my heart volatility quite low

Twenty mile an hour gusts wiped across the valley which encouraged me to move a little faster than usual and breath deeply when I could. It was a stark contrast from the slow ambling cross sandy beaches that made up my recent exercise. The stress of altitude isn’t just the oxygen and exposure to the sun but the generally more challenging conditions.

While the mountains have enjoyed some fresh snow, the valley is brown and dry. It’s bizarrely warm at 58 degrees as we spring forward. The record high for March 8th is 62 in 2004 but we are meant to see an inch of snow and a drop back into the lower 30s.

We shall see how I adapt but I need some rest as the rate of change for everything is as jarring as waking up on the beach and falling asleep up in the mountains in the space of one day.

Categories
Aesthetics Travel

Day 1892 and California Soul

As you may have guessed I wasn’t in Montana the last few weeks. I was in San Diego for a short stint. Some might call it working remotely. I’d also say I was testing a few health theories which remain inconclusive.

It’s always hard to determine health experiment when a random bit of personal maintenance details like needing dental work messes your data up. Biohacking works best in routine and I only keep them up seasonally.

I did get to spend quiet time on bluffs and beaches with my thoughts and a few friends. I’ve been listening to cocktail lounge classics intermixed with California Soul. Do you know the way to San Jose?

Connie Francis knows the way to San Jose

Going to California in the winter and it not being San Francisco is a bit of a new thing even though my husband went to college at UCSD. Any hints of early results in biotechnology used to come through their labs. And even some of their neurologists contributed important math to gradient descent

It’s a shame to have lost so much of the frontier to the petty encroachment of fiefdoms and institutional capture. California has a lovely soul. And imagining my parents finding a cheap way into housing in San Jose seems almost comical but maybe you could put $100 down and get a car. But now the place with a lot of space to get some peace of mind is the rocky mountainside. Maybe one day they will fix prop 13.

Coastal grandmother

Categories
Aesthetics Politics Travel

Day 1891 and So Much for Santorini or Status Hierarchies for Abundant Ages

If you watch me closely (which would be weird but I make it easy enough) you have surely noticed I spend much of my life traveling.

I’ve got no training in psychology but it sure seems like a certain personality type takes their childhood traumas and does exposure therapy till it becomes enjoyable.

I had intended for another trip to the general Mediterranean area in the spring to see family and work undisturbed by the American media timezone distractions. Now I am unsure if that will be feasible.

I am guessing that the sort of people who go to Sicily, Santorini and Cyprus to soak up the sun may find this Iranian conflict putting a wrench in their island hopping. Where will they go instead? Cartel wars bleed into the Caribbean and Bitcoin zillionaires setting up economic zones might make other things tricky. And oh the fuel costs will be ruinous.

War certainly makes me reconsider standard air bus style flying near any seas that connect to conflict areas but not too long ago I sat in a Turkish airport where “final boarding for Damascus” went over the loud speaker so maybe I’m making too much of it. Though I’m glad I enjoyed Istanbul over the winter as anything bordering Iran is now unnecessary risk.

For a world where speculative fiction bull case for artificial intelligence wiped off billions in market capitalization, we sure aren’t taking very seriously the kinetic effects of extreme uncertainty and change. Well, ironically maybe Pete Hegseth might be.

If we do make it through the Jackpot to the other side of the singularity, or just through this regional war situation, I would bet humans will find ourselves getting back to status hierarchies and power games.

If all our consumption needs are met, there will always be hierarchies. Wait your best friend summers in Block Island too? Or are those the Finnish slides from the Comme des Garçons show? Let me just call up “insert social scene’s patron billionaire” as everyone is headed to Big Sky for fresh powder this weekend.

It’s endlessly that sort of thing if you are inclined towards Bourdieu’s Distinction: a social critique of the judgment of taste. If class predicts taste then we mimic the taste we think we ought to have to be a certain kind of person. I came across a sweet hand illustrated essay on the matter recently.

If we can have anything we like, then taste becomes finer and finer grained. The rich know this already and the rest of us just might find out if we survive to an abundance era. And as I’d like to do that maybe I be reconsidering heading out to sea. Caribbean, Ionian, Bosphorus or otherwise.

Categories
Biohacking Medical

Day 1890 and It Bears Repeating Or Does It?

I can’t say I have fully recovered from pushing myself to my operational limits to do work (which looks a lot like socializing in my line of work) while still recovering from an infection after dental work.

It’s always recovering from an infection these days. I’ve been on some kind of antibiotic or anti-fungal every day since October.

2025 for me was getting an infection and then recovering from an infection on repeat. Ever since I decided to swap my biological injection 15 months ago from Coesyntx to Bimzelx and I think I’ve hit my limit.

It’s just too damn depressing that it’s a constant threat that I’ll have either a soft tissue infection or an abscess or a swollen gland that turns into a staphylococcus colony.

It’s as if I’ve got no skin biome left which is almost certainly true. I think I’d rather have CRP and sed rates and risk other infections than be rotating antibiotic varietals like some kind of junky afraid to develop a dependency.

Except instead of pain pills or lady downers it’s amoxicillin versus doxycycline versus Cipro with the occasional dalliance with a macrolide. I’ve also come to appreciate the benefits of Fluconzole. It’s not great. If you want a quick AI generated overview scan along

  • Beta-lactams: This broad group includes penicillins (e.g., amoxicillin), cephalosporins (e.g., cephalexin), and carbapenems (e.g., meropenem). They work by inhibiting cell wall synthesis.
  • Macrolides: (e.g., azithromycin, erythromycin) These inhibit protein synthesis and are often used for respiratory infections.
  • Tetracyclines: (e.g., doxycycline) Used for a wide range of infections, they inhibit protein synthesis.
  • Fluoroquinolones: (e.g., ciprofloxacin, levofloxacin) Broad-spectrum antibiotics that inhibit DNA synthesis.

My problem is that going back to my old biologic will take three to four months to full dose and it’s not a risk free process. And my full biometric panel is better on Bimzelx so is it really so bad that my resting heart rate is in the upper nineties every other week?

I think it may be time for me to make a pilgrims to the remaining clinics and pretend that I have any remaining institutional trust. Maybe I can vibe code something usual along the way.

I intend to support others on this journey as I’ve been chronically this journey a long time and the times are changing as we bring more artificial intelligence to the inference issues around our biometrics.

Categories
Chronic Disease Startups

Day 1889 and Recovering from Normalcy

I had such a lovely day touching grass (and sand) yesterday. I slowly worked through a 36-48 hours of of talking, walking, strategizing and occasionally reapplying sunscreen (I still got burned a little on my shoulders) with a friend who is preparing for big life and company changes.

These are the activities of normal life that I cherish, but my body seems hardly able to manage the strain this week. Now perhaps these activities are stressful on the mind and soul, but should they really be so physiologically taxing for me?

My Whoop is showing high strain

Now yes I am recovering from some dental work and on antibiotics but shouldn’t I be able to have a calm day that most would consider restorative? The serene peace of sitting on sandy shores should surely outweigh any areas from consequential questions of power, compute, realism and human purpose right?

I have barely been able to get out of bed today and the ten minutes of squats and planks I did to test my capacity spiked my heart rate into the stratosphere.

Which is odd as I woke up with my RHR in the 60s which is much better than usual. I only get into the 60s or 70s consistently when I am on heavy antibiotics.

The two weeks I was on Cipro recovering from surgery this summer my RHR was in the mid sixties so clearly I’ve got something going on with low grade infections.

I struggled mightily to organize my thoughts enough to write even this post. I feel I might even have it in me to go for a walk. Which is encouraging as I missed the sunset. The sunsets are obviously an event when you have a beach or far off horizon to enjoy with then.

Categories
Aesthetics Community Internet Culture

Day 1888 and Touch Sand

As the “monitoring of the situation” reached whole new levels, I took some time to touch grass today. I don’t think I opened more phone more than a dozen times before writing tonight.

So many mutuals are teaching themselves automation skills by building situation monitoring boards that maybe the Department of War doesn’t need Claude. It was charmingly easy to keep up. Which is a very distorted and dystopian way of living out the hard realism of kinetic power in real time.

If America is backstopping Loyld’s of London shipping insurance, then to repeat a Keanu Reeves meme style. Yeah I’m thinking that America is back. But I’m getting to old for this shit. It’s all TV tropes now as we unmoor in the propaganda. Which is run by an honest to goodness critical theorist who trained with Jurgen Habermas.

So instead I stared out over the horizon as the wind gently brought fresh air in from across a wide open vista. I enjoyed my friend’s company as we talked about jhanna meditation and compute pricing. We saw a seal winning along the shoreline. I put on sunscreen twice as we stayed out in the sun.

How luxurious is it I had long leisurely in-person time with a friend. Not all of my business is with friends but I cherish the ones with whom I do.

We walked and talked and broke for lunch and discussed problems from the most abstract to the most precise. Having given the world so much access to all of human creation and taste, did the market provide an original version of the driftwood horse decoration or has there only ever been the mass market design? Neal Stephenson fans get it. Baudrillard too.

Fashion people and technology people worry about these questions of taste because they are questions of control and tooling. The source culture of engineering culture shared context. How abstract is too abstract? What is enough to enable the builder to use your tool?

It was good to be outside in the sun with someone and talk. That activity needs no shared context beyond humanity. We have missed it in the hubbub.

Isn’t it funny how just as the internet is losing its humans, the humans who met only thanks to the marvels of the network are finding new offline systems? The network can reprogram itself.

I have dear friends and successful investments that I have spent hardly a single moment commingled in time and place with. I imagine that age is either just beginning or just ending and I am not sure which. So today I was outside in the sun talking. I don’t know if we made any progress but maybe I’ll only know in the far future.

Categories
Politics Preparedness Startups

Day 1887 and Trust Me Bro

I don’t feel terrific so I’ll keep this as a ramble but with some links. I fear some sort of Rubicon has was crossed, which we will only recognize in hindsight, in the fight for property rights in America versus the tyranny of failing state capacity.

I am referring to the contract dispute between foundation model developer Anthropic and American Secretary of War Hegseth that boiled over on Friday night as some sort of Murderbot surveillance subplot parsed only by lawyers, policy wonks and anyone who remembers the patriotism of Chelsea Manning.

Right before America and Israel went all Epic Fury on Iran over the weekend, somehow it was felt a messy public fight between defense contractor and the civilian oversight of our military was ok? Good thing everyone is too distracted to care.

Funny how one can go from cheering on our military’s capacity for innovation one week and the next to be waving one’s arms screaming “no oh no no no” but that’s just politics as run by the instincts of reality television I suppose.

The best writing on this so far has been Dean Ball (who worked in this Trump administration on its AI position statement not so long ago) who feels that Hegseth took an approach on renegotiating a contract with a frontier AI model developer that has consequences.

Loosely and I am missing much Anthropic had its previous contract to parse classified documents in the Department of Defense (now the Department of War) negotiated by the prior administration. Some aspects of this contract wasn’t going to work for the Trump administration. Anthropic didn’t want to change it and Hegseth threatened to call Anthropic a supply chain risk unless it complied. They didn’t and Sam Altman signed a deal.

Wrapped up in this is that of course we all eventually comply with Leviathan who has the monopoly on violence. I don’t claim any expertise here but lots of people understand defense contractor law.

On its face Anthropic looks like the moral high ground and the position all capitalists and private property respected would prefer. However, it’s in Dean’s words, a bit weird for a company to tell the state that a private corporation has a say in policy as opposed to our democratic institutions.

Anthropic is essentially using the contractual vehicle to impose what feel less like technical constraints and more like policy constraints on the military

This is all complicated by the model developer having wishes for frontier AI development to be nationalized and for their work in particular to be safeguarded by a different political administration. It has become a right versus left thing as it was bound to do.

Now Anthropic gets to enjoy the full throated defense of its industry peers and even conservative policy makers like Dean, because our current state capacity is not what I’d call excellent when it comes to our civilian government capacity. Honestly our military still seems to be crushing it.

Secretary Hegseth looked a bit like he was over reaching in his command that he get his demands met. Americans are very touchy about surveillance of if’s citizens and much less touchy about autonomous weapons so it’s natural to be a bit suspicious if you are a millennial who remembers the Global War on Terror. If you are Zoomer who doesn’t know who Chelsea Manning is please go ask Claude.

However it’s not at all clear that Hegseth’s original negotiations were out of hand as of course it’s the state who decides legal use not the private company and we are meant to have laws, judicial process and all the rest. It’s just that we don’t. So what on earth do we do about it? Trust me bro is not a policy.