Tag: Antibiotics

Categories
Biohacking Medical Travel

Day 1856 and Always Something So Always Trying Something

The world is a topsy turvy place and I am doing my best to meet it head on. Physically I’ve managed a surprisingly steady period from December through January, even though I spent a decent portion of that on the road.

I credit this mostly to using antibiotic and anti-fungal regimens prophylactically. The biologic immune suppressant I currently take for my ankylosing spondylitis is quite frankly too good at its job. And I’ve tried quite a few.

That means I am locked in a battle of constant vigilance in order to keep my inflammation numbers down while also not becoming a host to bacterial, fungal or other infections. It’s a balance that is anything but delicate.

In 2025 I had been unable to fight off skin, soft tissue and mucosal infections seemingly at all. Even with extensive protocols for decolonization (intranasal mupirocin, chlorhexidine washes, environmental decontamination) I had four major infections.

Of those infections, three required surgery and the fourth was the result of a very minor incision to insert testosterone and estradiol pellets. Those surgical interventions proved very trying and also very expensive.

The last one (testosterone) helped quite a bit with energy but being energetic doesn’t matter much if you can’t fight off infections.

So while I know there is an individual and social long‑term systemic risk in using antibiotic prophylaxis, I will say it does seem to be helpful in mediating say outbursts of allergens flaring into soft tissue infections from skin breakage or having exposure to molds and fungal growths that fester in old damp buildings and water systems creep their way into any opening available.

Since it is always something, I figure I need to always be trying something. Frankly I am over the push and pull of managing medical care in America. It’s a mess and mostly designed at risk mitigation for the health systems.

I have found going abroad to be much more useful and cost effective in many cases. I may even find that it would be useful to document the experience in a format beyond a blog as I doubt I’m the only person manage complex chronic disease.

Categories
Aesthetics Culture Medical Startups Travel

Day 1826 and Some Best of 2025 Selections

Yesterday I wrote about the experience of my daily writing experiment rounding out its fifth year. It’s been a fun and often emotional journey that I find hard to fully capture. But I’ll attempt to list a few of my favorite posts of 2025 on the last day of year.

Healthcare and Biohacking

Day 1490 and Healthcare’s Sin Eaters

Day 1468 Deciding to Go HBOT and Starting HBOT

1567 and Turkish Medical Tourism

1565 and Elephant’s Eye

1560 and Getting an HBOT

Day 1517 and Blink Blink (First Incision of 4 Scalpel Incidents in 2025

Day 1503 and Managing Healthcare Projects from Mold to Hyperbarics

Startups

Day 1486 and Is There A Tech Right

Day 1510 and Turning Valar On

Day 1542 and Future Blind

Day 1572 and Reskilling

Media

Day 1485 and A New Pogue at The New York Times

Day 1581 and Lecturing at UC Boulder on Renegade Futurism

Day 1569 and the sky above the port tuned to a dead channel

Day 1496 and Maneuver Warfare

Politics

Day 1484 and Montana’s Right to Compute Bill

Day 1549 and Productive Primates

Day 1578 and Dark Start or Energy Realism

Day 1576 and a NatCon Boomer Kicks a Townie Millennial Out of Their Hometown

Trends, Cultural and the Academy

Day 1484 and Zoomer Identity Violence Trend

Day 1479 and Liminal Industrial Transport in an Empty Frankfurt International Terminal Pod Hotel

Day 1580 and Learning By Doing or Embodied Learning for Humans

Day 1575 and Renegade Futurism

Day 1555 and Modern Machiavelli

And I got to about May and realized I didn’t feel like I needed to put more into the organization. I had 4 medical procedures involving surgery. My father died. My best startups all raised rounds to scale. You can find your own way from there. It’s been a hard year despite the wins.

Categories
Chronic Disease Medical

Day 1814 and Spicy Boi Shots

I’ve been trying to coax myself into taking my final biological injection of the year for most of the day. It’s a very painful shot. The feeling of it is somewhere between stinging and hot sauce being pushed into your subcutaneous fat. It’s spicy

I switched my IL-17 inhibitor for my inflammatory conditions as one of my first actions of 2025.

I was filled with optimism that this new variant called Bimzelx might be the one that finally brought down my biomarkers. And it did indeed show promising results. My CRP and SED rates have never been better.

Alas, the cost is quite high. I’ve got no immune system response to speak of when it comes to my skin and soft tissues. I’ve had four major skin infections requiring surgical intervention and many minor skin infections.

I don’t think I can live with the side effects of the drug even if my inflammatory numbers are better. There is no doubt it’s effectively treating some aspects of my psoriatic arthritis, axial spondyloarthritis, ankylosing spondylitis.

My pain is better so long as I can avoid picking up an infection. I’ve been on antibiotics most of the year. Alas I’ve only had maybe 2-3 weeks without an infection brewing or being beaten into a retreat.

So today may be my last spicy shot. I’ve gone it a full year of adjustment. I don’t relish the prospect of adjusting back to my previous medication as it takes a full year to fully dose on and off these things. But maybe I’ll be lucky and on my final shot in the year I’ll see a change for the better

Categories
Chronic Disease Emotional Work

Day 1806 and Trying Not To Upset My Proverbial Applecart

I have had way too many minor (and major) health problems emerge over the course of 2025. Adding in personal life tragedies (the death of my father) and I had a challenging year.

So I trying to keep the last few weeks of the year crisis free. I have already pulled myself out of the day to day to try for a slow wind down of the year. No holiday parties or appearances for me. I am gone.

As I slow down and put distance between myself and the world, I maybe stupidly see it as an opportunity to nudge myself on little health promoting efforts.

After the year I’ve had, I so desperately want to see improvements. Even if simply not collapsing into another infection cycle is a win.

I’ve been trying to consistently work on body basics like muscular compensation patterns and getting more steps each day, but I’m so terrified that even a minor miscalculation in exertion will upset my proverbial apple cart.

I went for a walk on a high mold count day and reached for prednisone. I’ve been teetering on the wrong side of recovery for so long I don’t think I can recall a genuinely good day. My sleep is similarly impacted. I want to have a long night of deep sleep and dream cycles but the best I can manage is just a long night.

Categories
Aesthetics Biohacking Chronic Disease Medical

Day 1787 and On The Same Wavelength

For someone with clear skin on my face (not even a humble brag), I spend what feels like irresponsible amount of time and energy on my skin health. The rest of my dermis is not as tractable as my face. I’ve been fighting eczema my whole life.

This year has been a particularly challenging, as my the IL-17 immune suppressant Bimzelx, I take for my ankylosing spondylitis and psoriatic arthritis (it’s eczema on the inside), has left me almost catastrophically prone to skin infections.

I’ve had maybe 3 weeks without a disaster (and I traveled) though have still needed doxycycline so I’m optimistic.

I am hoping I can rack up a few more weeks or maybe even multiple months without needing to slice an abscess, manage a deep tissue infection, or get a subcutaneous skin infection.

I do have a new weapon in my battle to keep my skin healthy. I recently acquired a new deep infrared cosmetics mask from Beauty Pie that they are calling “medical grade” but mostly means it has one longer wavelength than their previous mask offering.

Beauty Pie
The Dynamo Deep LED™
Medical-grade technology
Collagen-Boosting Mask $238
  • Medical-grade LED mask proven to improve the overall skin complexion
  • Using 1070nm – the deepest penetrating wavelength used in at-home LED devices to date – to reduce under-eye bags and puffiness, and smooth texture and tone
  • Helps the skin look fresh & hydrated. Using 830nm – supports the skin’s natural restorative and healing function – to boost circulation, improve blood flow, and increase oxygen
  • Skin looks plump & glowing. Using 630nm – enhances the production of collagen and reduces redness – to leave skin radiant and hydrated

I don’t know if it will do much but the longer wavelength is an improvement on their past mask which required something closer to 4 months of continuous use to see results and I was simply never off of antibiotics that interact negatively with red light long enough to get any results. Theoretically I should see results in a few weeks with the longer wavelengths.

I can’t recommend it yet as I just got it and I’ve only used it twice but I used it on my face, my neck, my left butt cheek where I had the infection from inserting testosterone pellets (long story if you missed that one) and on my scalp to see if I can stimulate some growth on my scalp as I shed a lot of hair this year from the stress.

That’s about 40 minutes of mask time so no joke but also pretty amusing. I hope I can use it enough between antibiotics rounds for a win as infrared is meant to do a world of good for pain and inflammation in addition to cosmetics so I’ll use the heck out of it while I can.

Categories
Biohacking Chronic Disease Medical

Day 1768 and Maybe A Corner Is Being Turned or Maybe I Should Turn Back

I feel as if I lost almost all of October to combating a medical hard left turn from what was supposed to be a pretty simple procedure requiring no downtime and little healing.

I feel like I got quite a scare and yet you’d think I’d be used to it, as this is all downstream of the interleukin-17 inhibitor that I changed onto at the beginning of the year for my autoimmune condition.

Every single quarter, and in some cases every other month this year, I have had some bizarre skin infection resulting from otherwise pretty benign situations. An infected gland in my eye (twice!) an abscess that turned into a deep tissue infection, and a tiny incision that allowed in a subcutaneous infection all rocked my world.

As much as I am thrilled to see all of my inflammatory numbers rolling in to baseline normal, I just don’t know if I can sustain having a health crisis this frequently for a medication that is supposedly working. It’s working at an extremely high cost to my sanity and body.

And you might say, “Well, the numbers don’t lie.” And I’d agree. But there are many other factors I have to consider, not the least of which is that healthcare access in America is so bad that I have managed two of the four crisis points with medical tourism abroad.

I am going to give my IL-17 inhibitor a full year as dosing on and off biologics is no easy matter and the compounding effects are quite real. But I do very much wonder if in order to go forward I must turn back.

Categories
Biohacking Media

Day 1766 and Thursday Styles Theory Strikes Again: Testosterone for Women Edition

One of my long standing theories, and a personal coinages, is the Thursday Styles Problem. It’s a theory of knowing directionally what is coming, but never being quite sure of when.

The New York Times publishes its “styles” section on Thursdays and Sundays. If you work in media, public relations or culture, you are aware of the general trends that will emerge on Thursday ahead of time. If you know “what everyone knows everyone knows” ahead of time, there is a lot of money to be made.

Predicting the trends sounds easy when I put it this way, but the timing of it requires quite a bit of foresight, and considerable planning.

The trend piece is researched and reported over months. It requires the editor to be familiar enough with the trend to approve the writer taking time & resources. That means other upstream media has to have covered the topic in the niche which requires its own planning and coverage.

And while hype cycles have shortened, culture still takes time. And really important cultural trends may even require years to be relevant enough to be Thursday Styles worthy.

And can you afford to wait for the cycle to run? Breaking news happens and a piece gets pushed. A hotter trend might push the piece for weeks or months. If your business can’t survive the long game of becoming a Thursday Styles trend, being first hardly matters. Being right doesn’t matter as much as being right on time.

There is an art to this. Publicists play long games. They seed articles with a long arc in mind. Prediction markets place bets on the likelihood of something occurring, but with many actors you can’t really control when and how a thing happens.

It’s hard enough that Alex Danco believes it to be its own cultural movement and a force akin to past movements like modernism. Predicting the future is now an active part of living in the present for everyone.

So naturally when something I am doing happens within a month or so of me doing a thing, I tend to feel smug. When Albania was on the front page of the styles section while Alex and I were vacationing there, I gloated. I’d been hip to the forgotten European country for years.

Today I got a push notification about women taking testosterone. It had the full ugly animations of a thirty minute reporting on a full blown phenomenon.

Frustratingly it is very light on specifics as to what constitutes a “high dose”, while framing the piece almost entirely around the wonders women experience from taking a higher dose of testosterone than what might be considered average. 5mg a day is roughly average, and the procedure I did lasts 4-6 months, so I am starting at an average dose after having been on a 3mg a day cream without getting an improvement in my bloodwork.

We’re started me with 10mg of estradiol (range 6-25mg with 8-10mg being most common), and 75mg of testosterone (range 50-150mg with the most common being 75-100). Day 1754

I have been very open about my dosing, my own bloodwork, and what went into why I chose to do it. Which, I’m glad, as the New York Times sure isn’t telling. Being very honest and open about details seems important as I have the privilege to experiment and I want others to benefit from that.

Because of minor complications, I’ve been attempting to be entirely transparent with those as well. The treatment itself is not dangerous and is tolerated very well, but I have had unusually high incidences of skin infections due to the IL-17 inhibitor I take for my chronic inflammatory condition, which led to a longer recovery than I’d have preferred.

Now that this is a full blown trend I promise to report back as I heal and as my blood work begins to show results. Until then, if you want to know what other trends I think will hit big and want to get ahead of the pack, remember I am just a message away. And I keep a shopping blog as well so you can buy what I buy before it shows up with a rave in the New York Times.

Categories
Biohacking Chronic Disease

Day 1764 and Not so Easy In and But Out of the Woods

It has been sixteen days since I confidently decided to insert testosterone pellets by tiny incision into my left buttocks. I was felt certain we’d checked all the appropriate risk factors and my tolerance threshold was met.

I felt I was making pretty decent progress on healing over five days as I had not only the benefits of HBOT but also read light therapy. I was pretty darn pleased and felt well.

And then it seemed I took a turn six days further on. Perhaps some trauma from the lidocaine and epinephrine induced enough of altered window of immunity that some bacterial weaseled its way in the wound and viola a subcutaneous infection called cellulitis.

I was put on two different antibiotics and we figured it would clear quickly. That was incorrect And it has been a slow healing process

Barely improving day by day. And I had somehow made the decision the night before the procedure that I would just waltz into a new beauty shopping blog as the holiday season warmed up. So that was perhaps bad luck on my part. And has slowed me down on something I was doing for some joy so I hope I didn’t let anyone down. I am muddling through.

Today I got an ultrasound on the wound after a fever spike and did a number of blood tests to see where my white blood cells and inflammatory markers were at.

The local hospital was having computer troubles which meant trouble scheduling an ultrasound but we managed to find another imagining clinic this morning.

Back at the hospital for bloods (they do walk ins for blood draws) they still appeared to be having issues with computers. “Your insurance isn’t recognized” was the verdict thirty minutes after using it at other lab. That made for a chuckle but we got it done.

The results are already in and we seem to be looking at healthy epithelial tissues and my CRP and Sed Rates were not elevated. Of course, half the reason I am worried is I take an immune suppressant for chronic autoimmune inflammatory condition.

It seems to manifest frequently as skin infections. My old drug wasn’t nearly as effective but it also didn’t have side effects. S

Hopefully slowly and with lots of protein and rest I’ll be healed and can spend my time on work and my pet beauty blog.

And tomorrow I’ll cross my 30th HBOT treatment mark so maybe it can make progress on building me up instead of dealing with a flesh wound. Which is actually just damned good luck on our part.

Categories
Aesthetics Biohacking

Day 1756 and Oops I Did It Again

Oh baby baby! So it seems as if, in my infinite wisdom, I did not pay enough attention to the early warning signs from my Whoop biometrics and I did indeed need to worry about the fun and games of a subcutaneous tissue infection.

I swear that this IL-17 inhibitor drives me nuts. Despite its impressive effect on my inflammatory biomarkers, it leaves me very susceptible to skin infections. And I have to be constantly vigilant to the first signs of an issue.

I’ll be fine. I did in fact catch it before it turned into anything serious. Where I am at it’s easily treatable with a short antibiotic course that may formerly be prophylactic. My wound area had not shown any signs of spreading nor was I running a fever or otherwise exhibiting other signs of serious infection.

I just had crappy HRV numbers and high resting heart rate three days in a row and it’s not worth risking it. I threw back some basic antibiotics last night and woke up with a normal heart rate again. My HRV is coming up just a little more slowly. Glad I didn’t wait as this isn’t worth any amount of risk to me.

I comforted myself by working on my beauty blog where I’ve got routines coming along for founding subscribers and a fresh post about Shrinkflation at Sephora and a minimalist men’s routine on sale at Amazon.

Retailers are a bit twitchy and everyone needs to be shopping early is the message we are getting everywhere. It’s a weird time. Or at least the retailers need to encourage the top 10%. So if that is interesting to you go subscribe as I’d love to have you in my strange beauty shopping blog meets the business of appearance.

Or if you are feeling adventurous for an honestly embarrassingly low fee I’ll put together a custom routine for you from my sample library or go full autistic and decant you the perfect mix of potions and lotions to meet you precise lifestyle and budget. My autistic obsession is your gain. It’s so much for me for and your skin will look amazing.

Categories
Biohacking Emotional Work

Day 1727 and A Happy Fluke or Compounding Effects

Maybe it was all of the crying, rending of clothing and gnashing of teeth I’ve been doing as I stare grief in the face.

Maybe it was taking a Fluconazole after my doctor notice some tearing “downstairs” at my annual physical when he was checking out my surgical scar from July.

Maybe it’s that I am on my seventh session of hyperbaric chamber oxygen therapy and the results starting to compound. Protocols say it takes about ten to feel a difference and my full protocol will be sixty so I’ve got a ways to go.

Maybe it’s just the absolutely gorgeous fall weather filtering in the perfect amount of light for that ideal temperate middle ground of low heat and humidity that makes being outside a joy.

Maybe it’s just a fluke. But today I feel almost human again.

I felt joy in being the adult responsible for running the household today. I managed loads of laundry, housekeeping, a proper grooming session of my own body, a grocery run into town, a decent workout, and of course, time in the hyperbaric chamber.

My husband is still struggling mightily with whatever combination of infections, stress, and post-viral damage is ripping up his immune response. He is usually the one caring for me. But today I was able to care for us both.