Categories
Medical Startups

Day 1630 and Change Change Change

I was hit hard by a week of poor health which meant I missed a policy gathering in Helena today which I was really excited to attend. One of the topics was autonomy and choice in medical care and health.

And with any unexpected change of plans I try to see the upside. Because I was bed resting I was able to catch up on a keynote speech by engineer and technical communicating savant Andrei Karpathy’s talk to YC’s Startup School.

He is an excellent public speaker and has a rare gift for clarity which benefits the entire software ecosystem. And we are an industry who disproportionately see the value of sharing in real time the changes we are seeing as we build. This generation built the networks and seeded the data with our content that enabled these models.

I saw in the talk the long lineage of technical cycles, access expansion and autonomy expanding that I have been a part of since my childhood. I’ve seen a few development and deployment cycles to use the theories of Carlotta Perez

Each cycle granted more power to sharing. The excess value generation of making our tools open to more external use has proven itself. And that has generally made for cycles of innovation that are shared mid deployment by the people as it happens.

And yet we still struggle with the right way of interacting with the tools. Math is fairly abstract. Your average human doesn’t much care for conditionals. We developed mathematics over such odd timeframes that it’s somehow easier to think it’s not in tandem with a culture and a commercial environment.

Maybe some only look at the industrial or military applications for tools and they care little about how they were made. The level of autonomy and control and abstraction that is enabled by software baffles. The more accessible something becomes the more we need to think of the user of the tool. Specialists can use special tooling and need not be so accessible. When it becomes a tool for masses things change. And we are in a changing moment for software as a tool just as the world has the highest expectations for them. Because we are perhaps at the edge of the great buildout.

Karpathy said that working with LLMs can feel like using the command line. It’s an intuitive framing for many programmers. He believes we have not yet found the graphical user interface for this era even as we are perhaps building new operating systems.

A screenshot from Karpathy’s YC Startup School 2025 talk

The GUI or graphical user interface was a mind blowing shift for the personal computing revolution. It allowed in a world of new users including you to use the benefits of computing. Which wasn’t just calculating missile trajectory. The commercial possibilities were as endless as the personal and aesthetic.

That change in access built enormous businesses and was the stuff of nasty backstabbing in the commercialization processes and the competition was very sharp in personal computing era. My father sold software through an old school reseller called Ingram and I gather it was a pretty wild time in the eighties.

But the fresh paradigm is always beyond reach. It’s there waiting to upend your entire world.

To quote Neal Stephenson “ in the beginning there was the command” essay

We were all off the Batch, and on the Command Line, interface now—my very first shift in operating system paradigms, if only I’d known it.

We are in an operating system shift now and we don’t know what to think about it it’s structure. It’s modeled on humans so it has all the same problems we have. It has cognitive deficits just as humans do. This annoys normies who don’t understand how it’s built.

We are interfacing with a new kind of compute output and it will slowly change everything around it as the abstraction layers bring more people into the effort.

We don’t really know what it looks like at this order of magnitude but the change is here and we get to make it. It frankly seems exhausting to ponder and a much much much harder problem set for power than generalized intelligence.

How does this relate to medicine and autonomy? Well, it’s become clear that medicine will be one of the areas that benefits from new access.

I care about the way we develop tools for the entire stack of medicine from pharmaceuticals to patient data. I don’t want another era of regulatory capture. The way we build applications affects how much autonomy and freedom we can give both doctors and patients. I know don’t want to be stuck with what we’ve got. More people should benefit from the changes ahead.

Categories
Aesthetics Culture

Day 1623 and a Costco Birthday

Today is my husband’s birthday. He genuinely is a very low key guy and when his birthday falls on a weekday he isn’t into big to-dos. But he said he’d be up for a Costco date.

No surer sign of enjoying middle age than loving the finest buyers club values of Cost. But to be honest we’ve both always loved Costco. And you can really get into Costco when you have a multiple barn freezers and backup power so no apologies for our love of a practical Costco date.

Bounce house for sale? Birthday win

Though it didn’t go entirely to plan. If it means anything to the pulse of America the Bozeman Costco was a chaotic in a “concerning operational decay” way.

Now we noticed a lot of categories completely out. No lemons. Several steak cuts we’d been hoping to get for a birthday dinner. Produce in general was pretty bad. Enough to make you wonder if they were affected by the United Natural Foods hack.

But other things were off. Staffing wise you had to wonder if they fired half the staff or no one planned for managing checkout flow for June in Montana high season? Nothing is as predictable as tourists going to Yellowstone if you’ve got a manager with any tenure or common sense. but maybe they don’t. I have a Twitter mutual who burned out on a Costco job so two strikes guys. Talent is part of the Costco brand.

Alex works New York hours so we got there around 2:30 or so which you’d think would be quiet but is not in midsummer in southern Montana. It was summer high season traffic you’d expect on a Saturday though.

We walked every aisle and there was a lot of fun oddities. Japanese toilets, water bottle drying racks, sound absorbing wall panels. And there were some less fun selections.

We usually do a better business with bear spray

There was a disturbing amount of slop packaging products and rapidly prototyped TikTok trends follow ons. Dubai chocolate ice cream bars? The zoomers will enjoy their summers up here I’m sure.

Lots of grouchy Boomers and exhausted families were looking for basics in the middle of the store as we perused the sides of the store for fun. Everyone is in Montana it seems. As we waited checkout I heard discussion of how JD Vance meeting with the Murdoch family at their ranch in Dillon.

We had intended to go end it with a hot dog and pizza slice respectively but it was so intense at the checkout area we didn’t even try. The lines were unmanageable which is how we got so much gossip. Montana isn’t so big that you can fly Air Force 2 to Butte without chatter about which ranch you are visiting.

I hope Costco has made some margin on selling gold bars to happy men like my husband. We also found a few other things

Categories
Aesthetics Politics

Day 1612 and Netrunner Molotov Bang Bang Summer

Being a mere node in a large but influential network I transmit as much as I receive. I intake and reroute information as part of my own synthesis process and I appreciate that it benefits me and others. But it also does damage and today was a rough start to June by any measure.

I saw a lot today and I only pass some of it along with the thought it’s going to be netrunner bang bang Gibsonian “who respects the nation state” asymmetrical energy Summer of 2025.

Any utopian dreams of a human noosphere of higher collective intelligence must reflect upon quotidian horrors showing our baser impulses daily and summer is war season for good logistical reasons.

Ukraine appears to have blow up a number of Russian fighter jets with drones smuggled in with trucks. Let’s recall the below image from last year. Ukrainian Netrunners vaping while flying FPV drones stepped up their game hardcore today.

Ukrainian FPV drone operator smoking a vape circa summer of 2024

believe this is the first ever direct attack on any nation’s nuclear triad in history, and it succeeded – @antroyn

Twitter is awash in footage of this drone attack on Russian fighter planes being drone bombed

Operation Spider Web showed the power of asymmetrical warfare and scared the shit out of deterrence war planners as drones versus air superiority is a worry that has now become persistent reality. Nuclear triad theory needs an update.

In other closer to home news, an older white gentleman firebombed a protest along Boulder’s Pearl Street Mall in what appears to be a kind of Molotov cocktail incident over Hamas hostages. It’s my hometown so this is upsetting beyond the wider context of terrorism over the situation. I fear for further tensions in liberal college towns.

Aesthetically, because it’s going to be a high volatility volume time on Wall Street, I am enjoying to see this Twitter account picking beautiful brutalism and “80s cocaine design aesthetics” out of the ether.

If one is to survive a summer of netrunners and volatility, this look will appeal to the sorts who want hyper focus, class & glass. While no one would recommend uppers, it’s clearly part of the overall vibe of managing nervous system input for anyone looking to do violence.

Categories
Homesteading

Day 1610 and Tempting Fate

As I was going about doing “prepare for the worst so the best may come” set of chores I chose to brag about our travel pharmacy packing.

As Elon Musk leaves government service there has been a flurry of media hits. I don’t know anything about his personal medical situation nor is it my place to comment but I found it comical to suggest that 20 drugs in a daily medication box was nefarious.

New York Times “Musk Juggled Drugs and Family Drama”

Those are to put it mildly “rookie numbers” in the biohacking business. And it’s barely a dent if you practice the kind of global chaos preparedness that we do. So I bragged about it and showed one of our global travel kits.

Ray Kurzweil isn’t making it to the singularity on less than 40 supplements a day so I sure as heck ain’t setting out into emerging economies with anything less than a full set of bacterial, viral, and gastrointestinal remedies.

And as we care about things like being first responder trained and able to render aid to our community, we joke that you really can’t be a pro-social prepper if you don’t carry an AFAIK kit.

As I was being snide about our the value preparedness, outside in my own backyard we were being tested. And as soon as it happened I felt completely unprepared. Pride does indeed go before a fall.

We have a beautiful red fox that has for several seasons lurked around our property. We also keep laying hens. Alex has hardened the chicken coop to make sure they did not have a chance to get in. Nature and domestication co-exist uneasily.

We have never seen the fox out in day save in the dead of winter. In the spring we rarely ever see the fox.

So whenever we let the chickens roam generally we keep a keen watch on them. We’ve gone a few seasons with this working but letting your guard down can get you.

Alex was walking down our long drive to retrieve a trash can and let the roaming chickens out of his sight for less than five minutes. In that time the fox raced out from behind foliage and took one.

We caught it all on camera. Having taken one (we could not find her) the fox came back not more than ten minutes later and tried to grab another chicken which point Alex saw and intervened. The fox dropped her but she has a puncture wound.

I finally hear the ruckus and come outside. I see feathers everywhere and figure it out as soon as I see feathers. .

This chicken is alive

I’m pulling out my phone and asking the LLMs how do we care for an injured chicken. Turns out it’s not that different than human.

I run to find the supples for cleaning and disinfecting. I find the topical antibiotics. It all takes much longer than I think it should. Alex cleans her up and she seems fine. But wont know how she recovers for a bit. Now I will do a review of our supplies and their locations as I am reminded that there is no such thing as too prepared.

Categories
Community Internet Culture

Day 1609 and We Train The Future

I’ve been writing about the increasing entropy in our systems for so long that the actual arrival of the chaotic years always felt like an inevitability that would never come. And yet they are here.

The internet is a hostile place as ideas war and humanity struggles with the weight of a fully networked world. I feel it in my body. I see the automation of attention grabbing even as the birth of the most powerful tools for control over my information environment have never been more readily available.

I persist in being a public human presence on the internet. I know I am part of the web. We built cyberspace out of a world of special interests and varied incentives and it’s giving us back something much larger than our individual contributions. I think the next stage of networking will offer us much more.

Because of that value of that potential I cannot let myself step back from shaping its form. The new world is trained on those of us who put up what we know, think, feel, and desire to be part of the human experience.

It’s not always a pretty picture but I will not cede this space simply because we have the tools to fill an infinity. I do not have an infinity. And I can hold out for a little bit in that time.

Categories
Finance

Day 1608 and TACO Trading

President Trump got pissed at CNBC Washington correspondent Megan Cassella for asking about a meme and now we have to worry about his reaction.

To quickly summarize, there has been a joke amongst the financial set about TACO trades.

The “TACO” trade, which is short for Trump Always Chickens Out. The tongue-in-cheek term, coined by a Financial Times columnist, has been adopted by some to describe the pattern in which markets tumble after Mr. Trump makes tariff threats, only to rebound just as sharply when he relents and gives countries more time to negotiate deals.

It’s been a reliable dynamic of the spring that high tariffs or “negotiating tactics” are introduced and the market drops and then we get a reprieve when the White House reacts and the cycle continues. Robert Armstrong noted the trade maybe a month ago but it’s been ongoing since Liberation Day in April. I don’t know why you’d ask Trump about this as of this as of course he’s going to react poorly but maybe some shorts decided to wag the dog.

“Don’t ever say what you said,” Trump told the reporter, calling it “the nastiest question.”

I have a bit of a monkeys paw relationship to this entire administration. I am in favor of significant reforms to the federal government and I am an avowed skeptic of central banking’s role in a complex and chaotic economy.

But I’m also a business woman. We can do all the TACO trades we like, but that’s not building anything and no one can do meaningful investing even medium term investment this climate.

As much as I appreciate criticisms of corporate power they are the only constituency who is fighting back on this. Like it or not, they represents the interests of shareholders and workers and this is wreaking havoc on everyone from Shopify storefronts to Procter & Gamble.

I’m not opposed to changing things and seeing what happens but the roller coaster makes it much less appealing to do business.

In other news, I am still waiting on an import nod a hyperbaric chamber so I’ve get some personal skin on this game.

Categories
Internet Culture Media

Day 1605 and No Blackpilling

We get regular reminders of how chaotic things are in our new hypersphere networked world that we have entire memes categories and full influence campaigns dedicated to blackpilling people into nihilism.

No blackpilling meme

The fatalism and determinism expressed on the internet is the experiences reality for plenty of people and it’s probably not limited to a few radicals. The presumption that any of these pills are limited to incels misogynists racist cranks is comforting but incorrect.

I’ve written about blackpilling before as it’s a common theme in overcoming the exhaustion of an unsettled era. Chaos is emotionally and physically debilitating because of our biological experience of it.

She thought something had gone wrong with us physically too. “Endocrine systems get fried. There’s too much cortisol, you’ve been running on adrenaline, eventually you tap out. Everyone feels nuts right now,” she said, “because what on earth are we supposed to do with the fact that we’ve had this incredible rate of change for so long. We think we’re keeping up with it, but our bodies are like, ‘Oh, actually no. We have no idea what’s going on.’ ”

Dissident Fringe

I also believe it’s a deliberate strategy by virtually every player in the great games of power and influence to make us feel nuts. Everything is a conspiracy. Everyone is a villain except your in-group. Except it’s not.

It’s always crazy in Philadelphia
Categories
Homesteading Internet Culture

Day 1602 and Greenfields

As part of the unfortunate adjustment to constant chaos, I find myself considering the balance of assets and skills we have at our disposal and how best to deploy it.

I increasingly feel the limiting factor being time, which makes one reconsider the investment one makes into your body. If we have green fields of possibility as information automation begins its march across the first world what should we be doing? If the Industrial Revolution knows less change than the Intelligence Revolution I’d be surprised.

I continue to think it’s mostly a game of energy, compute and property rights with a sprinkling of physical safety (this will get weird). How many people gain power is up for grabs. I think we’ve got the potential for a great elevating of talent.

I personally feel empowered as someone who has contributed to the training data. The internet was built by me and my kind.

The weirdos who write wikis. The experts who give away their insights on Twitter like pearls before swine. Bloggers who write on WordPress have a taxonomy advantage as a standard of the open web.

Having written so much of ourselves into artificial intelligence I shudder to think what we’ve done it wrong but I see the good people bring to virtual communities and I think people being people has always been this way. Those opportunities are perennial.

Categories
Biohacking Chronic Disease

Day 1598 and Routine in Chaos

I have been contemplating “an ideal routine” as soon as I felt the pressure of showing up for first grade. How to manage the energy the outside world requires from you while making sure you have done everything possible to manage your body to produce adequate energy.

Morning routines, what’s in her bag, every day carry, and optimal packing strategies all derive from a need to see how others are coping with the demands of life. You can aspire to various ideals of fitness, nutrition, style and parenting if you could just get the right routine with the right tools. Right?

I’m aspiring to restart learning new toolsets for building …everything. From design to marketing software to muscles to my hormonal profile. Building the life you want is deceptively close if you can manage yourself.

Life feels malleable at the moment. And who is going to stop me? Maybe I accidentally fix a problem for myself and find I’ve got a tool or insight that might benefit you. The chaos of old ways fall apart means new routines and folkways must be built.

I don’t want to betray myself by overreaching and pushing as I am so often finding hard limits the hard way. I like to go hard and rest. But reality has become so much less reliable that I wonder if I must compensate even more for the chaos with steadying flows of my own.

Categories
Internet Culture Media Startups

Day 1593 and American Curiosity

I’m not sure exactly how to characterize Doomer Optimism other than a kind of social club for Internet denizens that wish to retain their optimism in the face of chaos and change. It’s a very human group and I’ve enjoyed their company for years.

And as humans tend to do, the social circles that are part of this loosely defined group meet up in person for events including a family camp out and conference called Man and the Machine. It’s been held in Wyoming thanks to the hospitality of Paul McNeil of the Wagon Box.

I’m one of the odder congregants in this group which includes a diverse array of characters from all classes and walks of life. I say I’m the odd man out only because I’ve seen them as a generally regenerative self sufficient localist group that in another era would have been back to the land hippies, unionists, environmentalists and anarchists. Generally left wing coded but skeptical of state and corporate power.

That I’m one of a handful of practicing technologists that participates, and a libertarian, means I argue for the liberatory power of open source software and its range of applications for individuals to enable a life that can provide means and meaning without being in the jaws of the Machine.

Decentralizing technologies lets us all participate. More individuals are interested in thinking how they engage with industrial processes. 3D printing enables many types of freedom and is crucial to the right to repair movement. Which gives power back to the owner of property and not the corporation from which it was purchased. I unabashedly support the freedom to compute as a human who wishes to find a harmony with the machine in all its forms. Be not controlled by your tools or their makers. Make your own future.

If none of this strikes you as particularly right wing, reactionary or otherwise populist, or even statist; I’d agree with you. I am a libertarian.

And yet there are those who are still enthralled by old narratives of political poles that this individual, and choice centered, politics is one grounded in real people with real problems not financial or social abstractions.

I was disappointed to see that our host Paul McNeil got a note from freelance journalist at the Guardian that was not intending to engage in a good faith dialogue on this community. A value that I know Paul holds dear as I’ve seen him disagree strongly with many an intelligent and capable man.

Paul is a neighbor, a friend, and a gentleman in the most noble possible sense. He does not traffic in status or social cachet. He is a free thinking and curious American man who is dedicated to hearing a large swathe of perspectives. He wrote a response and included the email screenshot below. I am certain Paul really does mean his hospitality genuinely.

Dear @awinston

Thank you for your email (below). Of course its intent was not in good faith nor was it evidence of genuine curiosity, but it did cause me to reflect on the scope of @thewagonbox project and the growing constellation of characters around it. And I had to think about you, and Mr. Wilson, and how one should respond to the sort of witch hunts for political wrong-think that have become your cottage industry (one that I’m afraid is dying.)

To your first point: an interesting aspect of the Wagon Box, and particularly our Doomer Optimism events, is the breadth of the politics represented. Seneca Scott is a ‘90s democrat who wants a safe community for his family and goats. James Pogue, like me (and Jesus), has anarchist sensibilities, cares about the habitat for the trout he fishes and is leery of the global hegemonic machine. Ashley Fitzgerald is a suburban mom who likes regenerative agriculture and healthy neighborhoods. The event has largely focused on a suspicion of “The Machine” and ways to live humanely and harmoniously with the natural world. The idea that it is some hotbed of “hard/far right” ideology, or that we are promoting “corporate governance” is laughable.

To the question of the “ties” I have to Ryan Payne, or Jonathan Keeperman, or D. C. Miller, or any other person you may see as a “smoking gun” evidence of nefarious ideology, I have a few comments. First of all, you have left out other characters who have graced the Wagon Box, some of whom you might even consider even worse! And of course there are others hard to place politically, like Walter Kirn, Patrick Deneen, Paul Kingsnorth, or Max Foley. All these characters differ quite widely, have deep disagreements, but all have something in common: I find them interesting and care about what they have to say, and they see enough in me to take me up on my invitation.

You ever get to talking to someone and you see their eyes glaze over? They do not care what you have to say, they are not listening. It’s no fun. It is death. What’s the point? Good faith curiosity is the lifeblood of any relationship, of any conversation, of journalism, and of self governance. There are swaths of folks who have had good faith curiosity driven from them, and it has been done largely by people like you, who paint in caricatures and come to stories with an agenda, who live on fear and suspicion. You send a guy like me some sort of hostage note instead of an invitation to a real conversation. It’s sad.

At the root of the Wagon Box project is my personal curiosity in people, and at the root of that is a conviction that we will all be together eventually at a large table in a conversation that will never end. Our enemy is no person, but the stale impulse of death that preys on love, on connection, on community. It thrives in the Machine of mass delusion of which, regrettably, The Guardian is a mouthpiece. It has forced you to have a narrower view of people, a static view, and one that lacks curiosity. But I really do care about you, as you too are on a journey and I’d love to hear about it. Let’s grab coffee and talk sometime. No deadline.

I brought up the context of there being technologists as part of this conversation as another reporter who shares a similarly slanted lens who seems to have quite a problem with Silicon Valley while not really understanding the core values that technologists share that are not compatible with a controlled statist or even corporatist view of power.

We are going through a huge cultural change that will sweep many of us up its cascading consequences. We will have materially different conditions as artificial intelligence changes day to day life.

Do you want to trust those who insist on control to prevent horrors? Or do you want to trust yourself and your fellow man to engage with one another as human? I’ve chosen optimism. I believe we can build freely.