Tag: Chaotic

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Biohacking Internet Culture Startups

Day 1297 and Crypto Libertarians in the Age of Cyperpunk Anarcho-Tyranny

We are living in the past’s version of the future. The Cyperpunk I read in my youth is now the stuff of my daily life. It’s not as sleek as in fiction but it’s hard not to feel like it’s William Gibson’s world and I’m just living it.

The clubs looked a little sleazier as we escaped the aughts but we had a renaissance in technical tools for producing culture. Digital music and multimedia have exploded entire social media economies. Could Vernor Vinge be right and our economies will turn to creating data to train for the singularity?

We are only now getting Idoru but we are veering towards Burning Chrome. Half the anime avatars in accelerationist e/acc chats are wearing Mirror Shades and everyone watches for crypto rugs. But we are getting our Mt Gox Bitcoin back right?

What about borderless corporate worlds and mass scale surveillance identity? That’s here too. When William Gibson wrote “Disneyland with the Death Penalty” I wonder if he knew it would be the nexus of the network state debate?

I can turn on club kid techno from 2002 and look at a reality in 2024 and its aesthetic is pretty close to the details Jonny Mnemonic. A global pandemic that affects the nervous system of those infected which was accidentally released from a lab.

Johnny Mnemonic movie poster.

We’ve even got the LoTeks in a Luddite rebellion against a world connected by dubiously transparent artificial intelligence owned by actual Zaibatsu multinationals with more power than nation states. Fact and fiction spinning hyperstition better than Nick Land ever dreamed.

The vulnerability of our entire world to our digital networks was made dramatically apparent yesterday when Crowdstrike took a hot knife through the butter of corporate infrastructure and left us with blue screens of death.

It’s not real but it could be

Snowcrash and Crash Override? It’s better. We got amazing memes and elaborate fakes of the Blue Screen of Death. It actually did suck for airlines and banks because regulatory capture is the stuff of systemic risk.

And lest you think we’ve got no biohacking in this Cyperpunk world after the pandemic we have a renaissance in systemic & holistic approaches to medicine. Suddenly everyone is aware of the risk in agribusiness. Seed oils is normie stuff. Instead of turning Luddite the Danish invented advance metabolic medicine to cope. Everyone is on GLP-1 agonists.

Mix in the rise of nicotine and THC and you’ve got a national post prohibition bloom of folklore cures whose research has been suppressed by pharmaceutical companies and regulatory bodies alike. Conspiracy? Maybe but just the sludge of industry.

When I look at my own work I see the future arriving. We fund decentralized compute and marketplaces for inferences. We fund open source database software. We fund multi-sigs for hyper transactional blockchains. We fund nuclear fission that pulls its materials the sky.

And in that all of the is our founders are global citizens who have to manage anarcho-tyrannical borders with visas controlled by incompetent governments and live through the geopolitics of wars fought with drones and propaganda. The future is already here. It’s actually pretty cool. Just watch out for nervous system tics.

Categories
Politics

Day 1291 and Gabby, Steve, and Donald

I started getting coded as right wing sometime in the last four years. I found this confusing. I have significant public opposition to Republican policies and Donald Trump in particular.

I’ve been small “l” libertarian for most of my adult life. I’ve vote for quite a few Democrats as I opposed neoconservatism. I registered Republican as the Democrats went from embracing business and technological growth to opposing it. I didn’t see free enterprise as a threat but as the engine of our progress.

I vote for Biden as I sincerely thought it was the best choice after a tumultuous four years under the ostensibly Republican Trump where I saw nothing but a bigger government and frayed norms around containing that government’s authority.

I don’t like a large state apparatus in principle and feel America is the nation that most sincerely pursues the liberty of its citizens. The state has been granted the sole monopoly on violence. That monopoly must exist for civilization but necessarily must be constrained by the rights of the citizens who consented to be governed.

I’m proud of the American experiment as a citizen, a Christian (in particular a Protestant) and a capitalist. That may sound conservative to some but in practice tended to get me left coded as I support less government involvement in nearly everything.

Drugs, sex work, reproductive freedom, medical freedom (which ranges from vaccines to sex & gender choice), speech (which includes compute), religion freedom and commerce are liberties best decided upon by responsible adults of good conscience.

We have codified this in our constitution and democracy is the working progress of finding a way to agree to be governed together. Whether it leans left or right is hardly the point. Each generation reacts with the choices it inherited from the one before it.

The political fight is to remain a citizenship that consents to be governed. America isn’t a monolith. We respect the liberties of our fellow citizens who have agreed to respect each others rights. If we disagree we arbitrate that through the government we’ve consented to be governed by. That is only possible insofar as we respect each others fundamental rights.

Violence is not meted out by individuals. The state alone has that monopoly and it ends at our personal rights. No citizen should ever claim the mantle of irreversible violence. Violence against those who we choose to govern us considered the most unacceptable to all citizenry. Political violence is never acceptable.

When we discuss a crisis of democracy and invoke mortal or existential threats we override the bonds that make us Americans. My respect for my fellow citizens must be in equal measure their respect for me. We are responsible for ourselves so that we may be responsible amongst and to other.

When I think of the violence that we’ve seen in the political process of deciding who represents us in our state I am furious. It is unacceptable that any of our representatives have been subject to violence. Since 2011 we’ve had three attempts at deadly political violence against Gabby Giffords, Steve Scalise and Donald Trump. This is terrorism and untenable.

The shock I feel today after witnessing an attempt on Donald Trump’s life last night substantial. I probably should have felt it more intensely for our Congressional representatives. I have taken so much for granted as an American.

The liberty I’ve felt to articulate my own views is unprecedented. We as a nation have tremendous capacity for disagreements. The political is a negotiation and we all accept compromises. All three of those politicians have positions I find to be unacceptable infringements on my liberty. Which is why I speak my case and vote for my positions.

I’ve felt perhaps wrongly that living my own freedom was politics enough And that means I have to speak when I see unacceptable things. We cannot continue to escalate the stakes.

I want America to remain a United States. I recognize I hold positions others disagree with. I may disagree with you. I don’t know how I’ll be coded from here and I don’t care. I am committed to being an American. I remain committed to the protection of my fellow citizens full liberties.

That Americans would die for them has been made more than metaphor too many times. Let us do all we can to prevent that so we can continue to live together in freedom. Let the blood of patriots remain imagery so we can continue to live united.

Categories
Culture Politics

Day 1285 and Platform Changes

I don’t want to make this into a whole thing but the Republicans have posted the GOP party platform. The Silicon Diaspora is now such an important constituency we’ve got enough sway to move policy.

A network state of e/acc, crypto builders, Bitcoiners, El Segundo hardware startups, deep tech autists and white pilled Space dorks changed a political party’s platform.

And it wasn’t the one I expected. Scientific progress was something I’d come to associate with liberals. It would seem Democrats are not as certain about being technically progressive anymore. But the middle that builds is a constituency.

It’s such a small thing and I know politicians don’t have a track record of doing what they say. But the idea that a ragtag group of internet friends could get our issues given place of pride in a platform feels nice. A multimodal pro-social game yielded a positive sum.

We want more technology being built quickly by those with the agency to do so. We’ve got diseases to cure, climate change to adapt to, software to be coded, nuclear reactors to be spun up and a long path to space from there.

I hope the value of better medicine, better tools, and more ambition makes its way to everyone.

For now I think it’s cool that I can see where every line in this policy document came from. A very hodge podge group of internet weirdos in Discords, policy shops, Twitter communities, and group chats got politicians to agree with us. It feels kind of nice. I believe FreedomToCompute is a constitutional American right and we are proving our case

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine …

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

Categories
Community Politics

Day 1277 and Don’t Lose Your Head

Everyone has their entertainment and mine is makes me a little bit of a stereotype. I hate podcasts but do most of my chores while listening to Bloomberg’s Odd Lots podcast.

I was catching up today with an interview with equities analyst Tom Lee. My attention got caught and stuck on his description of Bitcoin.

“Yes, Bitcoin is unlike other asset classes because there is a cooperative value. You know, the people who contribute to the network benefit from it. And that’s different than any other asset class.”

From Odd Lots: Why Tom Lee Thinks We Could See S&P 15,000 by 2030, Jun 24, 2024

Now I don’t think this is unique to Bitcoin. Cooperative value can be found in everything from nationalist politics to luxury handbag resale pricing. But I do this it’s important to have cooperative values be baked into a network for it accrue value.

We’ve traditionally mitigated concerns about market cooperation through clear property rights and legal protections. We’d backed up those claims with things as abstract as a monarch. We’ve evolved to it to the slightly more concrete full faith of the United States and Byzantine bodies of securities law. Fiduciary duty and all that.

But as we become less inclined to trust that the buck does in fact stop “anywhere” we are looking for ways to mitigate that risk. How to operate in a world without trust? You develop trustless protocols. Humans have plenty of intuitions about trust and many these intuitions struggle without a clear person with authority to act.

So I ask if we are heading into a “headless” age?

As distrust in institutional power struggles we are seeking out new ways to continue the business of life and civilization even if a high trust society is in question.

We’ve got networks like Bitcoin that work without a head. We have new corporate structures like decentralized autonomous organization (DAOs) that can operate strictly based on cooperative rules, and indeed now entire memetic cultures (like e/-cc) which hold power while being headless.

Lest you think this is some frontier tech idea that doesn’t apply to you we’ve headless content moderation systems & headless retail platforms. Huge swathes of financial tech is living above the API.

You could even argue that we’ve got headless political parties as the Democrats and Republicans both struggle with defacto heads nobody particular trusts. I don’t know if we can live in a headless democracy. Deciding who is a citizen is a very different matter than deciding who is a shareholder.

Categories
Politics Preparedness

Day 1276 and Not Just A River in Egypt

I’m pretty comfortable with being embarrassed. I get stuff wrong and I have to come to terms with it even as my ego complains bitterly. The ego protects itself with denial but that doesn’t mean its conclusions are correct.

Being impartial about your reality is hard. Denial is such a normal part of catastrophic events the CDC even has handy public health explainers. I hope post pandemic everyone can enjoy the irony of that.

Taking an impartial view when approaching a problem is hard. If it’s an especially destructive situation (as most forms of crisis tend to be) wanting to put off action is a common coping mechanism. We do it as individuals and we do it within the meta-organisms that form the cultural and political systems we live within.

My suspicion is that some of our current political problems are a result of denialism. Seeing things as they are is impossible for some people. Avoidance, rationalization and minimization is practically a skill set.

I’d hope in a crisis I would attempt to solve a problem with whatever meager tools and skills I had at my disposal. I’ve done my best to take action on a few slow moving problems. And yet impartiality only arises when I can accept reality. And I wouldn’t blame anyone who finding the reality completely unacceptable.

Categories
Homesteading Travel

Day 1265 and Fair Forecast

It started snowing last night before sunset in western Montana. At first it seemed like it might be hail and sleet but soon enough fluffier condensation was coming down.

While the rest of the world is suffering under heat domes and excessive weather warnings, things are cool in the Rockies. So much so I wonder if any agriculture may suffer. Our chickens seemed no worse for wear but we didn’t plant much this year.

As I was looking at the forecast in the Apple weather app I noticed in the average table a surprising -14F below the seasonal norm.

Seeing snow on the mountains is always a relief. Dry summers lead to wildfires and no one wants that. I consider this to be a fair to pleasant state for the weather.

I have a day trip planned to the capital shortly and I’m wondering how to pack given the cool. Layering is a fair technique until you have a fierce high altitude storm sweep over the pass.

Wearing linens and light sweaters seems fine for June until a freak snow storm has you wishing you’d packed boots and a puffy coat. Whatever the forecast I hope I’ll be prepared.

Categories
Startups

Day 1257 and Other People’s Labor

I am laying prone in bed hopped up on DayQuil and the good codeine cough medication. I have Covid and apparently this bout will be no picnic.

Being sick can feel vulnerable. I imagine to most eyes I am economically and socially unproductive in this condition. I am not able to labor.

When I am sick I am grateful I get to be capital. I feel capitalism should appeal anyone with a disability (as I do) simply because comparative advantage allows us to exist without being at of the mercy of the state. Illness being disabling doesn’t mean low productivity.

My ability to be capital relies on the comparative advantage of specializing in startup kinda of startups. Practically it means I got to play a part in helping further the labor of others looking build a company.

Today was a big day on that front for me. One of my investments (humble brag I was their first commitment) Squads announced their Series A today.

They have come a long way since when I wrote about them on day 301 to where they are today on day 1257. A lot happened between fall of 2021 and Summer 2024. Now they are the market leading multi-sig wallet on Solana thanks to their Squads protocol.

They began with a vision of DAO tooling and ended up simply dominating code Solana primitives. They are doing the work of developing smart account technology and products that make it easier for businesses and individuals to securely manage and own digital assets. And they continue to make crucial tooling like Fuse.

For all the mania of meme coins and tokens, we can forget it’s real companies making real infrastructure.

These things have to be built for grander vision to exist in crypto and Squads has clearly been the team to do it. They have worked relentlessly shipping tools people want to use and build with.

When first met their CEO Stepan in Twitter DMs I had the privilege of seeing their early days upfront. There was never a moment that they were not listening to the market and adapting. I spent much of the summer of 2021 on DAOs because of their influence.

Everyone on the team practically wanted to do the work of building out what was needed for us to transact and govern in a trustless environment as individuals and as groups. I was inspired by their commitment to execution.

I am just a small part of their journey. But being able to provide the kind of specialized capital that could understand what they wanted to build from the start is a huge source of pride for me. Without early stage oddity investors like me it would take just a little longer for the entrepreneurs like Stepan, Deni and Sean to get to market. And the market deserves a company like Squads. Their hard labor built something of value.

Categories
Startups

Day 1255 and Venture Nurture

I sometimes wonder why venture capital hasn’t coded more feminine. The cynic in me say because it makes money and money accords status. Where there is status there are men competing for it. Which is a good thing in my book.

I just happen to find the kind of investing I do to be so feminine in character. I’d never really thought of my gender when I got into startups simply because I was a founder with a problem and technology solved it for me. I was a nerd about a few very specific things and the market agreed with me.

But now as the wider world has forced me reconsider gender and how my identity gets used by others in how I do business. And I do see that I approach my investing in traditionally feminine terms. I wasn’t that kind of founder. But I am that kind of investor. 

I nurture. I love finding a weirdo working on something in a weird corner of the internet. Nothing makes me happier than telegraphing out that I am weird and getting back other weirdos. I like to listen. I like to learn. I don’t mind unpolished or outlandish or even absolutely crazy. My best deals all started in DMs

Nerds aren’t a polished people. They may lack all kinds of social graces. They will often not care about anything but the thing they are obsessing over. And I happen to find this to be a good thing.

Not everyone agrees that we should work with their lack of graces. Ruxandra Teslo discussed how weird nerds are being pushed from institutions like academia.

Weird Nerds are being driven out of academia by the so-called Failed Corporatist phenotype”

Ruxandra Teslo

I am just absolutely here for the weird nerds. They are my tribe and I see it as part of my path to help bring more of them up behind me. To nurture is a feminine virtue. I am happy to bring it to my founders. They should all feel safe coming to me because they know that I am one of them and my goal is to see them thrive.

Categories
Startups

Day 1254 and Zipppp

I hadn’t expected to have a busy day. I’m really not enjoying having Covid. It’s an inconvenience and it sucks.

But suddenly I was getting all good news from all sides. A startup with a round. Another founder preparing to go out for an enviable raise with exceptional traction. An SPV for a round everyone wants in on. A colleague who had been thinking of taking action on a thesis is going to run an experiment. It’s just all very much my investments and my ecosystem thriving.

I felt like I was in William Gibson’s Jackpot. Incredible things are happening across so many industries and the world is an absolutely chaotic mess. It’s nothing but wars, gerontocracy and resource constraints out there. But here we are working.

Chaos pulls acceleration out of us because we must solve the problems in front of us. War and geopolitical turmoil and climate change require us to shoulder more.

We have real engineering challenges in compute, nuclear, decentralized systems, artificial intelligence and open source to solve to get to meaningful breakthroughs.

The problems are not easy. But our tools are getting better and the compounding effect of this renaissance in intelligence is that we might be able to build for bigger things.

Doomerism wants to focus on how bad things are. And I am the last person to disabuse you of a realistic model of what we are up against. I live off grid in Montana, I own crypto and I like my freedoms.

Humans are resourceful. Given ingenuity and incentive incredible talent has the will to say that I will take on this piece of the future for all of us.

It’s such a privilege to be woven into the ecosystem that is getting us through the Jackpot. And dare I say maybe the application of our ingenuity gets a better result and we can improve on Gibson.

The fictional “jackpot” described in the novels is an “androgenic, systemic, multiplex” cluster of environmental, medical and economic crises that begins to emerge in the present day and eventually reduces world population by 80 percent over the second half of the 21st century

The Jackpot Trilogy.

Maybe we can improve on these numbers. We’ve got the doomer version in our imaginations so now we can find a solution. Life, as Jeff Goldblum reminds us in Jurassic Park, finds a way.