Tag: Confidence

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Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine …

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

Categories
Community Politics

Day 1277 and Don’t Lose Your Head

Everyone has their entertainment and mine is makes me a little bit of a stereotype. I hate podcasts but do most of my chores while listening to Bloomberg’s Odd Lots podcast.

I was catching up today with an interview with equities analyst Tom Lee. My attention got caught and stuck on his description of Bitcoin.

“Yes, Bitcoin is unlike other asset classes because there is a cooperative value. You know, the people who contribute to the network benefit from it. And that’s different than any other asset class.”

From Odd Lots: Why Tom Lee Thinks We Could See S&P 15,000 by 2030, Jun 24, 2024

Now I don’t think this is unique to Bitcoin. Cooperative value can be found in everything from nationalist politics to luxury handbag resale pricing. But I do this it’s important to have cooperative values be baked into a network for it accrue value.

We’ve traditionally mitigated concerns about market cooperation through clear property rights and legal protections. We’d backed up those claims with things as abstract as a monarch. We’ve evolved to it to the slightly more concrete full faith of the United States and Byzantine bodies of securities law. Fiduciary duty and all that.

But as we become less inclined to trust that the buck does in fact stop “anywhere” we are looking for ways to mitigate that risk. How to operate in a world without trust? You develop trustless protocols. Humans have plenty of intuitions about trust and many these intuitions struggle without a clear person with authority to act.

So I ask if we are heading into a “headless” age?

As distrust in institutional power struggles we are seeking out new ways to continue the business of life and civilization even if a high trust society is in question.

We’ve got networks like Bitcoin that work without a head. We have new corporate structures like decentralized autonomous organization (DAOs) that can operate strictly based on cooperative rules, and indeed now entire memetic cultures (like e/-cc) which hold power while being headless.

Lest you think this is some frontier tech idea that doesn’t apply to you we’ve headless content moderation systems & headless retail platforms. Huge swathes of financial tech is living above the API.

You could even argue that we’ve got headless political parties as the Democrats and Republicans both struggle with defacto heads nobody particular trusts. I don’t know if we can live in a headless democracy. Deciding who is a citizen is a very different matter than deciding who is a shareholder.

Categories
Community Politics

Day 1268 and Intergenerational

We seem to be stuck in a kind of 90s loop of “talk to the hand” intergenerational dismissal. Boomers can’t communicate with millennials, millennials can’t talk to anyone older or younger than them, Gen X is smugly off in the corner and Zoomers are stimming through an anxiety attack.

I myself have complex feelings about the choices older generations of Americans have made. I am not thrilled with the world we are inheriting.

But I am not so convinced we intergenerational relationships are doomed by the most selfish among us. Though I certainly see how looking at a ballot this year might give you the impression that the divide is impassable.

The time I spend in policy and politics gives me hope. It’s possible to find the bonds of past and future in working to find solutions. I see committed people from all generations trying to do their part. I’d like there to be more of us.

Categories
Startups

Day 1255 and Venture Nurture

I sometimes wonder why venture capital hasn’t coded more feminine. The cynic in me say because it makes money and money accords status. Where there is status there are men competing for it. Which is a good thing in my book.

I just happen to find the kind of investing I do to be so feminine in character. I’d never really thought of my gender when I got into startups simply because I was a founder with a problem and technology solved it for me. I was a nerd about a few very specific things and the market agreed with me.

But now as the wider world has forced me reconsider gender and how my identity gets used by others in how I do business. And I do see that I approach my investing in traditionally feminine terms. I wasn’t that kind of founder. But I am that kind of investor. 

I nurture. I love finding a weirdo working on something in a weird corner of the internet. Nothing makes me happier than telegraphing out that I am weird and getting back other weirdos. I like to listen. I like to learn. I don’t mind unpolished or outlandish or even absolutely crazy. My best deals all started in DMs

Nerds aren’t a polished people. They may lack all kinds of social graces. They will often not care about anything but the thing they are obsessing over. And I happen to find this to be a good thing.

Not everyone agrees that we should work with their lack of graces. Ruxandra Teslo discussed how weird nerds are being pushed from institutions like academia.

Weird Nerds are being driven out of academia by the so-called Failed Corporatist phenotype”

Ruxandra Teslo

I am just absolutely here for the weird nerds. They are my tribe and I see it as part of my path to help bring more of them up behind me. To nurture is a feminine virtue. I am happy to bring it to my founders. They should all feel safe coming to me because they know that I am one of them and my goal is to see them thrive.

Categories
Startups

Day 1254 and Zipppp

I hadn’t expected to have a busy day. I’m really not enjoying having Covid. It’s an inconvenience and it sucks.

But suddenly I was getting all good news from all sides. A startup with a round. Another founder preparing to go out for an enviable raise with exceptional traction. An SPV for a round everyone wants in on. A colleague who had been thinking of taking action on a thesis is going to run an experiment. It’s just all very much my investments and my ecosystem thriving.

I felt like I was in William Gibson’s Jackpot. Incredible things are happening across so many industries and the world is an absolutely chaotic mess. It’s nothing but wars, gerontocracy and resource constraints out there. But here we are working.

Chaos pulls acceleration out of us because we must solve the problems in front of us. War and geopolitical turmoil and climate change require us to shoulder more.

We have real engineering challenges in compute, nuclear, decentralized systems, artificial intelligence and open source to solve to get to meaningful breakthroughs.

The problems are not easy. But our tools are getting better and the compounding effect of this renaissance in intelligence is that we might be able to build for bigger things.

Doomerism wants to focus on how bad things are. And I am the last person to disabuse you of a realistic model of what we are up against. I live off grid in Montana, I own crypto and I like my freedoms.

Humans are resourceful. Given ingenuity and incentive incredible talent has the will to say that I will take on this piece of the future for all of us.

It’s such a privilege to be woven into the ecosystem that is getting us through the Jackpot. And dare I say maybe the application of our ingenuity gets a better result and we can improve on Gibson.

The fictional “jackpot” described in the novels is an “androgenic, systemic, multiplex” cluster of environmental, medical and economic crises that begins to emerge in the present day and eventually reduces world population by 80 percent over the second half of the 21st century

The Jackpot Trilogy.

Maybe we can improve on these numbers. We’ve got the doomer version in our imaginations so now we can find a solution. Life, as Jeff Goldblum reminds us in Jurassic Park, finds a way.

Categories
Emotional Work

Day 1236 and Artists All Around

I was listening to Joe Hudson’s Art of Accomplishment Master Class preparation series today.

I’d previously remarked how I found the name “Art of Accomplishment” to be a bit off putting even as I was very impressed with the results of the work.

I’ve perhaps found essence of truth on the name that wasn’t available to me earlier. In listening to this particular conversation I heard the personal meaning instead of the cultural projection. The meaning is literally finding the artistry of doing things with meaning in your own life.


“When you’re self-aware, it means there is a full expression of you happening. It’s why with the great artists, you see their full expression. And they can only get to that self-expression, they can only get to that level of ease, by having more and more self-awareness.”

Art of Accomplishment

To have an art of an accomplishment you believe there is an art inherent. An artist makes. Accomplishing things is a byproduct of the flow of doing things. To make and to build m, or otherwise enable the process of accomplishing, is itself its own art. “To do” is an art.

I’ve come to love the work of startups and building companies as they are for me a team sport of accomplishing together. Artisans of all kinds are coming together to build a thing or a tool that serves someone else. It is a beautiful process for me

I feel my own flow in the competencies in which I have my own most clear artisanal pride. I do these things for the love of the work and the outcomes of them are simply a byproduct of doing them. I have several areas where the love of the craft is its own motive.

There are artists everywhere. You may well have many areas where you apply an artist’s mindset. Your self awareness gives you a vision of what you want to accomplish. You can be a mechanic or a publicist and still practice an art. Making a salad, fixing the hydraulics, or orchestrating a magazine cover are all accomplishments.

Categories
Startups

Day 1230 and Alignment is Consensus

Over the last decade I’ve gone deeper into a set of values that guide my relationship to what we should be building and for whom.

Consensus and alignment will be the twin sisters of our shared reality.

We achieve consensus through open networked & decentralized systems of governance and value. A trustless system reaches consensus we all agree upon through the mathematical verification of compute. Decentralized collaborative approaches are the path to alignment.

The further we get from truth as a set of shared experience we agree upon as humans, the more crucial a trustless future becomes.

AI and crypto offer us transparent solutions to agreement. Machine intelligence needs machine money and machine governance.

Humans beings are not truth seeking animals. We are social animals. We decide the boundaries of culture together. Rationality is an aspiration resting atop faulty sensors and emotional baggage.

But we can reach a consensus. Mathematics gives us the tools to differentiate between thing and not thing. We can encode quite a bit into binary.

We can seek to know things impartially. From there we share our experience with others. We measure and compare. Trial and error is collaborative. To be able to come to an agreement on a shared truth is the whole goal.

To be able to collaborate widely and through shared and mutually agreed upon standards remains the ambition of civilization. Coordination unlocks progress.

With artificial intelligence we can extend out the realm of what we know. Networking together all our emotionally faulty sensors, conflicting pieces of cultural & emotional knowledge together reveals bigger things.

If, from that networked reality, we are then able to scale the abstract business of solving specific and concrete problems all the better.

Building within reality requires us to agree on an acceptable consensus. We can verify positions and align incentives together. The alignment is all of us coming to a consensus on how we allocate our attention, willpower, and resources.

We reach for technological progress through alignment which is organized through the network consensus layers of governance and value.

The freedom to compute is essential to alignment. In a trustless world, we are able to reach consensus we can all verify.

Categories
Culture

Day 1212 and Being One of Many

Quick. Without overthinking it, pick one.

Words or Numbers.

I can’t predict your choice, but I’ll admit my “rational” conscience mind desperately wants me to pick numbers.

Alas my emotional subconscious intelligence quickly goes intuitive, lurching my feelings to a grabby place with “words.” That the right answer. I’d be hard pressed to correct my gut.

Humans love a good story. Even a single word can contain centuries of meaning. Just ask someone to define “woman” if you don’t believe me.

In the battle between numeracy and literacy, the bell has long ago been rung on the fight. Cave paintings transitioned to runes. Runes became alphabets. Literacy won before numbers got beyond accounting for the treasures of a king.

Priesthoods may have hated man understanding “the Word” but human minds were already on board with incantations of auspicious words before we got formal symbolic systems.

Probably understandably attempts to introduce topics like algebra were was a bit of stretch. Even simple arithmetic proved to be a contentious abstraction for many humans.

Ideas like property are a not a long haul from understanding “mine” and “yours” but it’s quite a leap to understand “how much” and “in what ways across different time and organizational schemas” which gets humans upset over specific collection of things.

Look at your hands and you understand that base ten allows you to calculate simple transactions for resources within your life.

Beyond that good luck. Got an abacus? Understanding that zero and one can communicate a universe’s worth of information is an even further leap. Attention wanders quickly without a computer.

And yet, as I enjoy the aesthetics of my own numeric symmetry in my 1212 days of consecutive writing, I know it’s my private counting mechanism.

“The need for numeracy today is enormous. Business requires people who have grasped the principles of reducing chaos of information to some kind of order.”

The Economist 1966

The narrative overlay of what numbers mean matters more than the numbers. So I’ll ask again. Which would you pick? Words or numbers?

Categories
Culture Finance

Day 1211 and Price of Civilization

Whenever I travel I am reminded of just how good a life I have be virtue of being born American.

I’m kept alive, fed, clothed and connected by a vast web of abstractions undergirding modern civilization thanks to the value of my passport and the exorbitant privilege of the dollar.

Constructs like private property have given rise to elaborate norms of obligation, honors, debts and expectations that enable coordination mechanisms like markets. This seems like a good thing from

All of this feels so astonishingly fragile. We listen when our bankers fret about “rules based western civilization” being under siege because we know those rules are what enables the niceties of our lives.

All it takes are a few assholes breaking the rules and the fabric frays a little more. Blessedly capitalism has its own immune system that is happy to attack all types of hostility.

If you are not integrated into the body politic of the dominant civilization you generally know it. I’ve found those outside of it generally wish they could be assimilated from simple envy. If you want these benefits be prepared to be assimilated to the rules and values of civilization.

Your alternative is struggle to hold yourself apart by your own rules and cultural values and insist others abide by them. This has generally required coercion, violence or shame in the past.

You can say “no” to civilizational benefits simply by opting out. To be left alone is to accept your status and stay outside of the great game of civilization. But to accept the benefits is to in some sense accept to accept that there are rules. You can’t break rules if you don’t know their importance. If you know the rules and break them however you can’t be surprised when it’s viewed as a thread.

Categories
Internet Culture Reading

Day 1208 and 16 Years

I don’t recall exactly when I first began using WordPress. If memory serves, it was a friend James in the philosophy department at my university who set up and hosted my first blog sometime around 2003. Eventually I went out on my own.

While I’ve only been writing on JFredrickson.com for 1208 days (ha only) the current account I’ve been using since 2008 has an anniversary today.

Happy Anniversary with WordPress.com! You registered on WordPress.com 16 years ago. Thanks for flying with us. Keep up the good blogging.

I’m delighted to be a long time user of the service. I believe in the value of open source software and the stewardship of Matt Mullenweg. While there are plenty of other social media platforms where I can reach an audience no one has earned my trust like WordPress. II use many other content management systems, social media accounts and the like but for my own identity under my own control nothing else compares.