Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology.
I am doing alright with it. I was wary of keeping the patch on all night long (I am very sensitive to stimulants such that I won’t drink caffeine past 10am) so I removed it at about 5pm. That may have been a mistake.
Yesterday my Whoop recorded physiological stress. I wasn’t coughing, I had more capacity for exertion, and I felt generally less exhausted.
But I didn’t come down easily for sleep. I ended up taking a number of anti-inflammatory medications as well as an Ambien. My heart rate was stable but I felt “up” which I don’t care for at night.
And I did not wake up to good news. My HRV absolutely tanked. There are lots of confounding variables here in that I got good restorative sleep (medicine induced surely) but some strain has clearly been too much. 40% down isn’t a rousing endorsement.
I am also noticing a lot of chatter around addiction and whether or not it’s responsible to discuss these things. The fear that the average person is in fact prone so addiction and will have adverse affects. Which I’m sure is true. I don’t think normal people should take unnecessary risks and it’s good to have the minimum viable dose be none at all.
It’s wise to remember that I am not at all living in average circumstances nor do I have average medical conditions so I am not necessarily who you should be looking to for health advice. You should do the basics like eat more protein, lift heavy things, sleep an adequate amount, be in the sun and move around, and manage your baseline health metrics first.
Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.
But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.
At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.
She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.
In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.
Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.
I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.
I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.
Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.
The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].
Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].
Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.
This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.
It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.
Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].
The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].
Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/ TL;DR is that reducing the affinity may increase neutralizing immune response.
I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.
All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.
I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.
With all that said, let’s see if it helps me out. I’ll post because it is in my nature.
I’m pretty comfortable with being embarrassed. I get stuff wrong and I have to come to terms with it even as my ego complains bitterly. The ego protects itself with denial but that doesn’t mean its conclusions are correct.
Being impartial about your reality is hard. Denial is such a normal part of catastrophic events the CDC even has handy public health explainers. I hope post pandemic everyone can enjoy the irony of that.
Taking an impartial view when approaching a problem is hard. If it’s an especially destructive situation (as most forms of crisis tend to be) wanting to put off action is a common coping mechanism. We do it as individuals and we do it within the meta-organisms that form the cultural and political systems we live within.
My suspicion is that some of our current political problems are a result of denialism. Seeing things as they are is impossible for some people. Avoidance, rationalization and minimization is practically a skill set.
I’d hope in a crisis I would attempt to solve a problem with whatever meager tools and skills I had at my disposal. I’ve done my best to take action on a few slow moving problems. And yet impartiality only arises when I can accept reality. And I wouldn’t blame anyone who finding the reality completely unacceptable.
Dedicated roamers of the internet are people who like to notice things. Cyperpunk aesthetics made it romantic to experience global abstractions even as the reality of the power of oligarch, state and corporation blended into murky dystopian reality.
I said recently on this photo that we’ve got to stop hyperstitioning William Gibson. We keep finding ourselves further into the future. Just look at these anonymous accounts (so you can enjoy being a participant in the propaganda) joking about a drone operator in Ukraine.
We have netrunners. They’re autistic Ukrainian drone operators and their ice baths are niccy rushes
It’s hard to remember that real people exist on the other side of the abstractions. And yet here we are about to be those real people facing history. And it does seem like the time for taking action is now.
Venkatash Rao wrote an essay “many shoes are dropping” that gave me the kind of frisson of living in future, but as Gibson famously says, a bit unevenly. Across all narrative and technical arcs and and inside geopolitical realities we are starting to see the change.
In this I can’t help but see Gibson’s Jackpot. The elements that Rao calls out are multiple significant elections (not the least of which is the final installment of Biden vs Trump), the capital and nation state power consensus he calls “after Westphalia” and the intertwined fates of artificial intelligence and crypto.
The fictional “jackpot” described in the novels is an “androgenic, systemic, multiplex” cluster of environmental, medical and economic crises that begins to emerge in the present day and eventually reduces world population by 80 percent over the second half of the 21st century
I myself think it a privilege to even be a bit player in this moment in time. That I can allocate resources in any way feels high leverage in a way I didn’t anticipate experiencing.
We are the adults in the room. It may not be mich but we have agency. I feel good about putting my focus on crypto, AI and nuclear energy. Like Rao I can tie together past thoughts across a wide corpus by writing here every day and make decisions based on what has emerged.
As we rapidly accelerate the power of our computing tools, machine learning has blossomed into the most heated topic in government policy, business strategy, and popular culture, as artificial intelligence begins to affect everyday life.
The focus on harms, and in particular singularity doomerism, has (ironically) pulled focus from the implications of the seminal “attention is all you need” paper.
Policymakers and Silicon Valley executives are both calling for regulation of artificial intelligence as fears grow over its potential harms. But others warn of entrenching a dominant, opaque, centralized Big Tech model and instead advocate for open-source code, decentralized computation and distributed data sourcing. Whom should policymakers listen to? What, if anything, can governments do to help this vital technology evolve in a pro-human way?
Thankfully, we aren’t starting from scratch in building a regulatory framework for artificial intelligence. Code has been treated as speech in Bernstein v. United States Department of State. It would seem like a reasonable precedent to consider algorithms speech as well.
And let us be clear, math and computing power are as essential as speech. In today’s world, they ARE speech. Humans may speak in natural language, but the way we extend ourselves, build things, and grow as a species is through our tools. Computation is a tool. To presume that these tools do harm is to make us bad workmen.
Now of course incumbent powers may try to keep the disruptive and democratizing power of these tools out of the hands of the populace “for their own safety”, but imagine if the first amendment had been frozen in time at the printing press and didn’t protect the internet? We cannot accept permanently lowered standards of fundamental rights.
The 90s era fight for strong encryption enabled a flourishing of digital businesses from finance to e-commerce. We must insist that the freedom to innovate remains the default for U.S. digital policy.
America does not have a Federal Computer Commission for computing or the internet but instead relies on the wide variety of laws, regulations, and agencies that existed long before digital technologies came along.
If we are to regulate sensibly, let us treat artificial intelligence as we would any other tool and let us do so within the existing framework of our constitutional rights and their interpretations within past precedents.
When you have to “make the most of something” you’ve already done some calculus of personal expectations. I know I will have try to pack as much into a trip to balance out the various costs of travel. It’s not always financial as time, emotions, and focus all have value in your life.
If you have too much variability across these costs or can be hard to justify against your personal expectations. I’ve been known to run as fast as I can once I’m in motion because I believe acceleration is more expensive than stasis. That’s not always true obviously as staying in the same place can be very expensive.
So when I stop-start through life I hope I’m not making the ride more uncomfortable simply because I can’t manage the fuel calculations. Being fueled to make the best of a situation means being prepared.
In other news, I didn’t eat lunch before I ran some errands and I regret it because everything always takes longer than you expect.
I very much recommend the experience. If we workout our bodies and our minds surely we should consider the value in working our emotions over.
Openly welcoming emotional punches may seem about as sane as welcoming an actual punch but like in all things practice makes perfect. It’s good to prepare with the relevant skills for all kinds of things.
I am not a boxer or martial artist myself but I appreciate fight metaphors and their applications in the power dynamics of life. Much of living feels like a conflict to even the most level headed of us. Which I’m not sure is a title I can claim honestly but I do try to follow the maxim in “Hitchhiker’s Guide to the Galaxy.”
Even if we opted into some level of being available in the rituals of being alive we can find ourselves surprised to be considered fair game in the agendas and power struggles of others.
We are all civilians in our own mind. Sometimes we’ve stepped conflict without even knowing and you’d best keep your wits about you. Consequences for actions have a tendency to come back around for even the most cautious.
So if you’ve got the opportunity to be put into “fight or flight” you might find the opportunity worth the while. After all, everyone’s got a plan till they are punched in the face. So stay safe everyone!
I am taking the Connections course run by Joe Hudson’s Art of Accomplishment. I was introduced to the approach through Johnny Miller’s Nervous System Mastery course. I was lucky enough that be able to participate in one of Joe’s live coaching sessions I was so inspired by the work I saw I committed to a longer course of study.
The Connections curriculum takes you through an approach whose acronym can be shortened to VIEW.
Today’s sessions was on impartiality. Impartiality is owning what you want without imposing it on yourself or others. It’s harder than it sounds discovering an agenda for yourself and others.
With their exercises and a partner you find your own assumptions and defensive thinking in short order
Whenever I travel I am reminded of just how good a life I have be virtue of being born American.
I’m kept alive, fed, clothed and connected by a vast web of abstractions undergirding modern civilization thanks to the value of my passport and the exorbitant privilege of the dollar.
Constructs like private property have given rise to elaborate norms of obligation, honors, debts and expectations that enable coordination mechanisms like markets. This seems like a good thing from
All of this feels so astonishingly fragile. We listen when our bankers fret about “rules based western civilization” being under siege because we know those rules are what enables the niceties of our lives.
All it takes are a few assholes breaking the rules and the fabric frays a little more. Blessedly capitalism has its own immune system that is happy to attack all types of hostility.
If you are not integrated into the body politic of the dominant civilization you generally know it. I’ve found those outside of it generally wish they could be assimilated from simple envy. If you want these benefits be prepared to be assimilated to the rules and values of civilization.
Your alternative is struggle to hold yourself apart by your own rules and cultural values and insist others abide by them. This has generally required coercion, violence or shame in the past.
You can say “no” to civilizational benefits simply by opting out. To be left alone is to accept your status and stay outside of the great game of civilization. But to accept the benefits is to in some sense accept to accept that there are rules. You can’t break rules if you don’t know their importance. If you know the rules and break them however you can’t be surprised when it’s viewed as a thread.
No matter now much I prepare, and I clearly take packing and travel preparedness seriously, there is no overcoming the random shitshows that plague travel these days
I swung through Chicago’s O’Hare in an economy seat to position myself for a long haul flight. That short haul economy flight went without a hitch. I landed in Terminal 1 and made my way t Terminal 5 which is how things started going sideways in multiple directions.
The bus system/holding pen for transit between terminals is amazing for its on the ground access to airplanes but it sure is slow. Once I got to Terminal 5 it was clear the lounge assigned me via the airline wouldn’t work. It was 5 degrees warmer than in the airport terminal (a European airline of course) with no available seating, or inexplicably, any bathrooms. So much for having paid a premium.
I wandered up and down Terminal 5 looking for a food court. Frontera’s takeaway sandwiches had a forty minute wait. Dunkin Donuts was fully stocked but with a 40 person deep line. There was somehow no McDonalds.
The upscale fast casual options like Wow Bao and other private equity branded spots all took turns shouting what they were out of to the crowd waiting. No falafel or pita at the Mediterranean spot. Only 3 options were remaining at the Asian fusion spot. I got half my dumpling order. I didn’t have the heart to press for the remaining items from the single harried worker. $8 didn’t matter.
I went to my gate to wait for the flight afterwards. I sat on the floor. There were no seats anywhere in the terminal (or as previously mentioned the lounge). Somehow, once I boarded my long haul flight the crew managed to change my assigned seat on it without consulting me. It was a much worse seat than I had purchased.
If I had any idea how bad this new seat was going to be I might have fought it at counter, alas they gave no indication this new seat would be an issue.
It was the worst possible seat in the class without any place to store a backpack under foot nor were there holders or nooks for water bottles or your other sundries. I struggled to reposition medication and liquids on the tiny table. The chatty friendly Boomer next to me didn’t realize he was using both his table as well mine making it even order to find space to groom and medicate.
I tried to get that across to him. That all of the space he was using wasn’t actually space but meant to be my side. I failed to get that through. He stole my pack of tissues when I left it out. He did give them back when I pressed him. He seemed embarrassed. Later I released he’d also taken my water bottle. I feel there must be some wider lesson in this.
It wasn’t a proper flat lay seat though I’d paid for a business ticket. I had nowhere to put my medications, toiletries or other sundries. There wasn’t even a spot to put a water bottle. I rearranged as much as I could to avoid having all my things fall into the aisle, took an Ambien, prayed I’d not need access anything else and went to sleep.
I woke up on the other side of the ocean, gathered my things and deplaned.
My watch dinged. Your iPad has been left behind. Somewhere in this process my iPad must have been lost. I didn’t take it out of my backpack to my knowledge so that was a mystery. As I deplaned I was sure I had everything.
Behind where was the question? I only had 30 minutes to get rush to the last leg of my flight but I vainly went back to previous gate trying to see if that was where my iPad had been left behind. There was one at the gate which seemed fast.
As I unpacked all my bags trying to see if the tablet might be somewhere in my luggage I fell and broke my iPhone screen in the process. The top half shattered. It might hold it together for a day or two. Maybe.
Then I had issues clearing the next leg security with my injection medications for my ankylosis. I was told I didn’t need to clear security at this transit point so I wasn’t fully prepared. My bag got unpacked again. At least at this point it was clear my iPad really was gone.
Finally I make with 10 minutes to spare to my final leg. I am upgraded to first but they refuse to allow me to bring my carry on. “It is over 18 kilos!” I begin to cry. It was not over 18 kilos. I weighed it myself.
No one else was even in my 3 rows around me. The empty upper baggage storage had no other bags in them. I tried to sway them saying I have a medication I can’t afford to lose. Nothing works. She wants to exercise authority. My grey roller bag is put below. I pray it’s not also lost to me.
At this point I’ve not eaten a real meal in 24 hours, two crucial electronics are status “unsure” and I’ve got no way of knowing if either my roller bag or checked luggage will make it. Thankfully my three bag cascade system has me with a change of pajamas, basic toiletries and my medications. No matter the effort I point in there never seems to be mercy for the traveler
