Year: 2025

Categories
Biohacking Medical

Day 1754 and Do You Want To See Something Gross?

My inner child finds the idea asking if “you want to see something gross” to be funny. Of course, I want to see.

Gore and violence don’t get this reaction from me. I dislike it in movies and in the real world. But to see gross and the weird in the real world. I get it. Maybe lots of humans thinks seeing gross things are cool.

I think it is a bit sweet. It is as a very human reaction go “ewww cool” when faced with non lethal wounds. Maybe it’s truer with boys than girls, but if a kid said “do you want to see something gross?!” in Colorado when I was a tween the answer was a rousing yaah! Gross things are cool.

Maybe it’s a type of survival mechanisms where if we can learn more about what is lethal, and lethal injuries look like, it then improves our Darwinian fitness. We judge risk more accurately.

Flesh wounds need proper care and do turn out absolutely fine. And boy have we improved on the science of wound care since I was a kid. We have evolved past the bandaid.

When I first did my wilderness incident first responder training, I went worried I’d find the injuries we’d be treating emotionally challenging.

But even in a hard situation like a fire burn or the dermis getting sliced open, I still had a bit of that bravery of a little girl. That is cool! The bravado of a human who believes we can fix it

If you enjoy a story of plucky Rocky Mountain woman learning to do emergency care for herself and her community I’m glad we shared this time together.

Hopefully you never need these emergency skills. We take learn the risks and practice for them so we may never experience them.

So if you don’t feel this way, I’m giving you your ticket out of here. Stop reading now. But if you want to see something gross stay on.

For those who who are like “actually I want to hear all about getting your left butt cheek sliced open” to raise and normalize your testosterone levels by injecting tiny pellets of hormones though a steel dart gun via the scalpel entry point. Then it’s time to see something gross.

This is my wound on Wednesday morning after I had the procedure. It’s much bigger a slice than I’d expected but first time practitioners (I asked for the experiment) and while the treatment is safe across most vectors, I was a nervous immune compromised patient who prepared for the worse.

So this a real 10/10 “let’s see how it goes from here” experiment especially if the returns it delivers are real. I hope for the energy, pain tolerance and healing benefits the average patient sees

Now I am lucky enough to be an owner and finally user of my very own hyperbaric chamber for oxygen therapy. I wrote about it at length through trade wars and trips to Istanbul. We finally got the OxyRevo from China last month. I intend to upgrade to an HPOTech in our finished medical space (I believe HPOTech the best on the market currently)

So I am using a 90 minute full 2 atmosphere protocol already as I go went this treatment. I had also begun testing the GLOW stack from a peptide spot where I trust the owner. I’m helping him test. And this is the recommended stack for recovery.

.01 of the GLOW stack which is a regenerative peptide therapy with three peptides—BPC‑157, TB‑500, and GHK‑Cu—it was made to promote healing, tissue regeneration, and collagen production,

So I am absolutely throwing the gold care package at this. I am taking collagen and biotin, we’ve got the local food and the lack of seed oils, we’ve got the best current standard for peptides on injury and surgical recovery.

And somehow I am still scared. I never heal well or easily. I bruise easily and badly. I was so slow this summer to heal from an abscess surgery. I took a risk and I worried.

But I woke up this morning and my open wound has closed and the bruising has retreated in just five days to this. I’ll be in the scar mitigation territory in no time, and soon it won’t even be visible to the naked eye.

Day 5 of recovery from testosterone pellets

Progressively, the wound has moved from acute bruising and erythema toward decreased inflammation and resorption of bruising, with steady wound closure. Monitoring should continue, but the pattern suggests healthy tissue repair

So I hope you enjoyed seeing something gross. As it is keeping less and less gross by the minute.

Categories
Biohacking Medical Startups

Day 1753 and Vibe Coding for Your Skin Health

Many moons ago, when I was first attempting to get a diagnosis for why I was always in pain and exhausted, I got a battery of allergy tests. I did the “gold standard of allergy testing” called patch testing which is a form of pin prick testing designed to pick up responses that may be delayed.

It was an awful experience. I barely made it through the 5 day trial between the 100 allergen pin pricks and final measurements.

I remember begging the doctor for a way to measure early. I asked if I could take some Benadryl to take the edge off. Alas the only way it would be accurate and covered by my insurance is if I gutted it out.

You are not allowed to shower, sweat, be exposed to UV rays (no going outside) or take immune suppressants that might subdue your body’s response.

I was struggling to breathe, my entire body itched and ached, and I had a migraine so bad I couldn’t see for the stars & dizziness. It’s possible I wasn’t stable enough to have adequately consented to the test but I did get my final results.

Out of 100 common allergens tested it was confirmed I was extremely allergic to 10 of them with another moderate sensitivity set of twenty or so that I should merely try to avoid as opposed to my firm “no go” list.

The dermatologist gave me a sheet with 75 different chemical names and formats that I might encounter in the wild from these core allergens:

Budesonide
Ammonium Persulfate
Benzisothiazolinone
Limonene
Oleamidopropyl Dimethylamine
Formaldehyde
Lauryl Glucoside
Methylisothiazolinone
Propolis
Thimerosal

I instructed to search ingredient lists for these names any time I purchased a household product, personal care item, cosmetic or other item which might include these ingredients which ranged from nail care to vaccines.

It was honestly quite overwhelming. And some of the above ingredients are in basically everything. I dare you to avoid Limonene for a month.

So my husband and one of our best friends did what any practical minded engineer would do and they made me simple Google sheet where all 75 varietals could be checked if I plugged in the ingredients from any item.

I used it for years. I’d plug in the INCI from every brand I encountered into the sheet no matter what. I gave away a lot of products to friends.

Today it occurred to Alex that we should probably vibe code the thing into a proper web application using Replit so other people could check ingredient lists for their own allergies.

Within two hours, most of which was waiting on the kindly AIs to do their thing, we had a fully functional web application.

You can set your own allergens or click a few buttons for common allergens and “clean ingredient standards” and run a check for an all clear.

It isn’t super fancy but it doesn’t need to be. It just needed to keep your data safe, be easy to log into so you can securely check and access your personal list and generally functional enough to change and set allergens. We’ve put it on our own little domain just to see how much this will cost to run (and we’ve set up alerts so it doesn’t go bonkers) but we figured this should be accessible and simple.

And while there are other options on the market, most are bloated, overly paranoid and designed for scaring California moms rather than quickly helping people with clear preferences for avoidance and actual tested allergies. So hopefully our pain can help you breathe easier.

Some options for chemicals and irritants you can select on our app.
My own settings of allergies and sensitivities
Categories
Aesthetics Biohacking

Day 1752 and Too Much Protestant Work Ethic

I am pouring far too much autistic enthusiasm into my pet beauty shopping column that has a roughly half and half ration “theory of appearance culture in Protestantism” and half “specific routines at different price points” but I am enjoying it.

The heavier lift is going to be the work I am putting into the individual routines for the founding subscribers who have paid good money for help and I intend to give them my absolute all. I admit I’ve put way more thought than is probably necessary into each one but it’s a joy to track down specific products and geographic needs. It’s a shame that market editor was never a well paid enough job at a fashion magazine as I am pretty good at it.

Like, of course, I have opinions on the German drugstore market and its cost effective actives lines versus the old school naturals brands and where to acquire them. I don’t have quite as extensive a sample library of the market staples on hand but you know I spent hours browsing the grocery and retail shops when I was living in Frankfurt.

And on that note I’m going to bed early as I’m healing from my various biohacking experiments and I’m exhausted even with all the effort I’m putting into wound healing it still takes a certain about of rest to actually knit things together no matter how much time I spend with HBOT or what peptide stack I’m taking (it’s a spicy boy on the way in I’ll say that much).

Categories
Aesthetics Medical

Day 1751 and On Brand with Protestant Renunciations and Wound Care

I really misjudged my healing time on the testosterone pellets even though I pretty much always assume a worst case scenario for myself. I’m not really hurting but I am pretty bruised which is typical for me.

We may have some room for improvement technique with it so I am encouraged if the is as bad as it gets. I am not seeing any benefits from it yet and ugly bruising and a bit of an opening on an incision isn’t so bad.

A lot will depend on how well I recover and how much the hormone actually helps when I’m not healing. I’m also in the luteal horrors phase where my hormones are most ridiculous so I’m curious to see the curve.

The best part of this remains that I have a world class treatment for skin wounds on hand. Hyperbaric chamber oxygen therapy’s best research has been in wound management from burns to slow healing diabetics. So if I have to nurse a wound doing it with oxygen at pressure is actually pretty baller.

And to make it even more on theme, I spent most of my time in there writing out a column on skincare and the Great Male Renunciation of Appearances as part of my beauty shopping column and excuse to write about the secret history of appearance and its power.

Categories
Aesthetics

Day 1750 and The Protestant Work Ethic and Masculine Beauty

I am booting up the more practical aspects of writing to provide value, as opposed to the writing I do here, which is to provide a thinking space for myself, and if I’m lucky occasionally my notes will help someone else.

Setting out to provide utility to others is a much higher bar as I’d want the content to meet my own expectations for value. I don’t have necessarily have expectations for utility here even if it provides it more than I’d expect.

I am enjoying preparing posts with research, and the next post teaches a little about the Protestant Reformation and The Enlightenment’s role in the great “Male Renunciation” of appearance.

Afew short centuries upended thousands of years of cultural norms that showcased the importance of masculine beauty and taste and replaced it with a drab mind first Cartesian split.

If I’m going to put together historical context, I figure it has to help the reader feel freed enough to experiment with their own world and consider that they can regain lost or hidden knowledge that was once foundational. In this case how masculinity communicated power, status and taste through appearance.

If you are aspiring to better yourself, to pursue an aristocracy of the soul, we will start with mastering the basic ingredients you will encounter in a drugstore and how they might build into reclaiming your appearance. We will go from there to Pareto-optimal options for building a habit that helps age well and look its best.

So I am having a bit of fun thinking about appearances. Anything anyone of us can do to free up another human to choose a life that is better for them is worth the time.

Categories
Biohacking Emotional Work Medical

Day 1749 and Some The Worse For Wear

Every time life gets intense I wonder to myself why am I speeding into the turn? And then I look back at the last almost half decade (which is easier than I’d expected as I’ve written every day) and I feel the achingly slow pace at which we tackle the challenges of our lives.

We’ve had really big wins and really glass chewing teeth grinding bloody inch by inch progress that barely feels like a win at all.

It’s easy to focus on the bruises when they aren’t a metaphor like yesterday’s adventures in scalpel driven hormone treatment. But the the wounds that are more emotional are just as easy to spot.

Some pain has given me relief and some has been so heartbreaking it crushes me that it’s beyond my control. Bodies and borders are often beyond the control of mortals.

So I’m just rushing headlong into fun things like shopping columns and biohacking and my portfolio companies and my political engagement and hopefully we find the money and solutions to all the bottlenecks which range from family and pain to visas. And yes the bruise on my butt is literal.

Categories
Biohacking

Day 1748 and Putting Testosterone Pellets In My Butt Cheek

Intrepid biohacker that I am, when I learned that my testosterone levels were concerningly low, I began on a program to raise them.

I started with nutrition and supplementation but I already had a diet and supplement routine that was evidence based for raising testosterone levels in women.

I added in DHEA (Dehydroepiandrosterone) at 25mg. Six months of that brought me up to just about half of the lowest baseline acceptable. I was NOT getting adequate results.

My physician prescribed me a cream from a compound pharmacy which unfortunately didn’t agree with my skin. So we were going to get creative.

I had read a blog post from Cate Hall (whose husband Sasha Chapin had helped me on another entirely different vector of my life) on how testosterone pellets changed her life.

She had had teeny tiny testosterone pellets placed into her subcutaneous fat and had remarkable results in terms of energy and focus. This and that happened, and the summer was a mess, but today was the day I finally followed in her footsteps.

Vials of compounded testosterone

We’re started me with 10mg of estradiol (range 6-25mg with 8-10mg being most common), and 75mg of testosterone (range 50-150mg with the most common being 75-100).

We’ll aim for labs at 4-6 weeks after insertion which would represent peak levels. We will repeat dosing at 3-6 month intervals. We will check levels at 4 months or so, or earlier if I feel the effects waning.

Do be warned that within a paragraph or so, there will be images of needles, scalpels, and some blood. So feel free to not scroll down further.

Part of the difficulty with dosing this stuff is that the pellet doses are wonky and frequently out of stock – estradiol comes in 6mg and 10mg increments so 8mg is impossible.

Naturally, we’ve made surprisingly little progress when it comes to women’s health, particularly as it relates to hormones.

Prepared and ready to go

But as I am happy to be a guinea pig and my luteal phase is a mess of migraines and misery I figured I had little to lose and much to gain. I was the first patient my doctor has done the procedure on so if anyone in Bozeman is interested, you can confidently give it a go with him as I’ve survived it.

These cool tubes don’t actually go inside too far but sort of shoot the pellet into the incisions

I was given a local numbing agent with epinephrine. I needed a surprising amount of it but I was a bit nervous. Once I was just able to feel pressure and no pain it was time to make a small incision with a scalpel and in popped the tiny bit of hormone on the left butt cheek.

No big deal at all.

But if you don’t want to see it going in don’t scroll.

Just giving you space to turn back.

A tiny incision in my goose bumped bum with the little pellets easily tucked in

I am all bandaged up and still riding the cortisone of it all but I feel alright. I’ll be adding in progesterone orally to temper the estrogen as that’s another matter. I’m excited to report back on it as if I have even a fraction of Cate’s experience with it I’ll be quite happy. Also it’s about $70 a month so not cheap but not at all expensive for something that could potentially mitigate some long term issues I’ve struggled with for years.

Categories
Aesthetics

Day 1747 and Hyper Autistic Protestant Work Ethic Beauty Blog

I spent some time being really “in my special interest” today writing about why I think we should give more, and not less, time to beauty. I’ll post it to my new substack tomorrow as that will remain focused in subject matter.

Appearances clearly matter in every facet of life, but we don’t do much to help develop taste even as we face an onslaught of the hyper visual unrealistic world of short form video.

It’s all dopamine drips and quick hits that make it hard to develop taste of your own. At best you found algorithms that suited some things you could enjoy but sincerely held joy is rare. I’ve been able to experience many times and it’s now one keeps going in a cruel world.

I spent so much of my life beating the drumbeat of more access to the secret knowledge of the world only to discover again and again, that even if you offer up to the world pearls, not everyone will want them.

Or as my mother liked to say her Latin teacher said “I’m throwing pearl’s before swine!”

To appreciate the details is to recognize that layer upon layer of irritation worked to a finished pearlescent sheen which seems too delicate to truly show the process. That’s its beauty.

Each layer of culture is built by people who cares about details. And all kinds of details matter. Sometimes the details are financial. Sometimes aesthetic. Sometimes it’s noticing a very specific signal inside a very particular group and being able to admire the elegances.

I myself didn’t think I ever much went in for subtlety of any kind until I spent more of my time in mass markets. I’ve come to realize I was allowed to live without too much push on my own tastes for so much of my life.

And because I care about details, now I know I a stupid amount about the business of appearances because I worked at its heart.

So naturally I’d like to do more to share that knowledge as I realize it is maybe much rarer than I realized.

I intend to do it as a fun addition to my life as I experience so much of life through professional and personal interest in technologies. I’ve got aspirations for a world where we choice to work to be better. That requires a world where beauty can be cultivated in improving ourselves. so you can be certain I appreciate the angles of how we use the existing culturally technologies at hand to create the new ones.

Categories
Biohacking Chronic Disease

Day 1746 and Processed Pizza Hangover

Yesterday was my birthday and we celebrated it in grand style and semi- tradition by spending two hours walking every single aisle of Costco.

Now you might think all that walking around would leave your body feeling invigorated, and honestly it did, but we finished our grand tour by eating at the Costco food court. Now there are probably ways to eat healthy there but not how we did it.

We went for the classics including the dollar fifty hot dog and soda combination (a bulwark against inflation that has stood longer than seems possible) a slice of pepperoni pizza, a strawberry smoothie and a chocolate chip cookie. I had the pizza, some of the smoothie and half the cookie while Alex had the hotdog, a root beer, the rest of the smooth and a little bit of the cookie.

Our mutual and biohacker in chief Bryan Johnson gifted me a birthday roast of this meal. Which was not only hilariously funny but absolutely true.

Happy Birthday.

We didn’t feel immediately worse but we woke up today with what I’d qualify as a hangover. We can enjoy the above roasting as we generally don’t eat junk food and when we do it’s in more of the local beef category than the hyper processed and hyper preserved category.

Before you think this is a show of virtue, this preference never did anything for my aesthetics or metabolism, it’s just that it always makes me feel bad.

I am quite sensitive to preservatives and refuse to eat most forms of American bread and most varieties of prepared meal. No matter how good the ingredients are, the preservatives just do not agree with me.

It’s not that I’m a healthy eater naturally so much as hyper palatable foods are often hyper preserved foods and that sends my histamine response soaring into cytokine storms. So it’s no wonder I woke up feeling hungover.

I did real damage to myself as Bryan pointed out. We had a lovely time and I like to think the joy and happiness reduced our cortisol enough to bring us some balance. But it was easy to quit drinking for the same reason as it is easy to quit fast food. You feel like shit afterwards.

One of the most amusing fights I recall my parents having was my father taking my kindergarten class to tour a Carl’s Jr kitchen. They gave us a kid’s meal at the end, and while I turned up my nose at the burger, I did eat the french fried potatoes. My very crunchy and wise mother was not happy. “Now she will have a taste for French Fries!”

And damned if she wasn’t right. I still haven’t ever eaten a fast food hamburger. The idea of it is revolting to me and I’ve no clue how that came to be programmed in me. I may be one of the few people in America who has never eaten a Big Mac. But I love french fries. And good potatoes fried in a decent oil never leaves me feeling awful. But bread that doesn’t go moldy? That gives me a hangover every time.

Categories
Aesthetics Biohacking

Day 1745 and a Very Costco Birthday

Alex and I love a Costco date. The beloved warehouse cooperative sells bulk goods and the luxury surprises to its members at fair prices. It remains a top notch place to enjoy time together in search of treasure. Which is why we choose it for my birthday celebration today.

We got some groceries, walked every single aisle, found surprise and delight, and wracked up a couple thousand steps indoors in rainy weather

A birthday date inside Costco in ok

I don’t know quite how we started on the Costco date. It was probably one of our preparedness habits as we check our stocks and resupply as basics get used up and items expire. But Costco is also about the hunt. This Pendleton throw is a fine birthday present.

The seasonal arrivals for Halloween were still going strong but we saw Christmas ready to go. Thanksgiving hasn’t popped up yet but we did see a turkey order form.

You also learn a lot about the biggest trends in health and wellness as their supplement and beauty aisles are the stuff of legend. Creatine and collagen have hit the big time for men and women and everyone is thinking about hormones.

DHEA is a better mix but adaptogens are good

Now the real coup de grace of a Costco trip is the food court. Which is never the caliber of high quality and healthy that you can get in other areas. But it does make for excellent birthday party food.

I had a slice a pizza, half a strawberry smooth and half a cookie
The famed $1.50 hot dog

Alex got himself the infamous hotdog and turned it into a proper Chicago style dog with onions and relish and mustard. I won’t eat encased meats myself.

Our Twitter friends were following along as we posted pictures from each aisle with comments about commodities pricing, cosmetics merchandising and other sundry topics. And as an added treat Bryan Johnson roasted our birthday meal

Julie, a good learning experience. These 2,050 calories will cause a massive insulin spike followed by a post-meal crash. Increased hunger 3-4 hr later. Your arteries constrict and blood vesselsl stiffen. The nitrites are a group 1 carcinogen (increased colorectal cancer risk). Acute oxidative stress. Impaired endothelial function by 20-40% for several hours. Gut microbiome will shift towards pro-inflammatory Firmicutes, an obesity-like profile. The dopamine spike from fat+sugar+salt mimics an addiction reward pathway. Repeated, will desensitize dopamine receptors causing you to escalate stimulation to achieve the same pleasure.
Happy Birthday.

Contemplating life choices is the perfect way to enjoy the day. Plus how great does this new blanket look on our couch?