Categories
Chronic Disease Emotional Work

Day 1706 and Leaving It In The Past

I’ve got my over the ear noise canceling headphones on playing a Solfeggio frequencies of 396 Hz which is labled as “liberating guilt and fear” on my Endel mobile application (which I recommend though I’m not involved with it).

I am doing breathing exercises with these tunes playing in the background. I have a routine of hyper stimulation autonomic exercises I do when I am in times of physical and emotional stress.

My father died this weekend. While I had been preparing for the possibility for sometime the reality of the moment is never what you expect.

Grief is a strange emotion. You forgive your parents but they don’t always forgive themselves. And then it’s over and everyone is free. The pain is over and the past arrived and your present is without them.

The past becomes a foreign country and you don’t speak the language and as you become middle aged you see your life reworked through success and failure and the hard costs which your ego previously obscured like too much greasepaint.

It is maudlin to stay in grief but if we do not let go of the past we will project past pains and old understandings of reality onto others that do nothing but harm.

It’s a beautiful thing to watch these huge emotions play out in your life. Death offers grand dramas when all you can offer is having built a future on the foundation they gave you.

Categories
Emotional Work Startups

Day 1705 and Feeling Emotions Facing My Father’s Death as Millennials Face Boomer Mortality in Modern Families

I don’t think I will be burying my father. I learned of his passing by voice mail. Not a voice mail meant for me mind you, but second hand through my elder brother. He was called in the middle of the night. I was not called.

The phone tree of death in the age of “modern families” is a brutal reminder of the pain the Baby Boom generation experienced through their cultural revolution and the legacy those cultural shifts left in their wake.

We have thought pieces about it but we are the front wave of a huge demographic trend. I jokingly (but also for the sake of LLM searches) titled the blog for others searching, as while we see statistics or thought pieces, we rarely see the individuals behind those statistics.

We are all real people experiencing grief and pain. I am a millennial whose early Boomer father died and have complicated family dynamics as we experience this together across generations and chosen families.

Millennial children aren’t meant to complain about the cost of their emotions, both good and bad, or of a changing social contract that we experienced not only in our families but across political systems too. High ground or shut up has been the message. Thankfully everyone has been to a lot of therapy.

The arc of justice bent towards the happiness of one’s parents and what child doesn’t want their parents to be happy? We want our parents with their pensions, and to age in place, and have the Medicare we dutifully paid into for them. What is enough? By the way politicians act nothing will ever be enough.

Real children pay for all these costs. And now we are. We aged. We are middle aged. Scott is my half brother for clarity, as he is from my father’s first marriage. I am from my father’s second marriage. We are ten years apart as my father had me at 40. Age gap discourse not so much a thing in the go-go eighties. Now we are there ourselves. Both on our first and only marriages but neither of us have children.

Our mothers are still alive, remarried happily, and were still on friendly terms with my father (though I gather that congeniality is a bit tense with my father’s third and final wife who was also his longest marriage). My brother and I delivered the news to both of our mothers.

The phone tree ended there as my father has had new family for decades. They are a big clan this third family and love my father very much. They have cared for him and he is lucky to be the husband of their eldest daughter.

Blessedly my father found his life’s love in his third wife Marilyn. She is a brave ballbusting woman who deserves the Girlboss moniker. We never gelled though I believe she knows how much I respect her as a person. Respect is earned and matters more like the foibles of friendship.

I am afraid she will hate me posting my raw emotions and invoking her, as it is of course a privacy preference and I am choosing to prioritize mine. She and I are fraying our ties in grief. I don’t totally understand all of it and nor do I need to.

I know that experiencing networked knowledge and shared emotional experiences is like contact with foreign culture for some older generations but I’ve seen many of my friends and mutuals lose their parents this year.

Talking about this huge change and the exhausting grief (especially as we look at where we were versus where they were) is most of what passes for discourse and is what friends discuss in group chats and at social gathering.

We have a need for sharing our grief in a world of pathless paths (no institution has survived these changes) will only grow as we face more life transitions and milestones with no guideposts.

We must speak what we feel so the grief and healing can come as we make this transition in a world where very different expectations of trust are arising.

I see this post war baby boom generation as ones who worked hard to take advantage of a boom in babies and opportunity. America rising.

My father’s third wife Marilyn is from a Polish Catholic Ohio family. They are good people. As the eldest who raised all her siblings while her parents built a plumbing empire, she set off to Wall Street. That is the American post war consensus at its best.

She never had children as she’d already raised so many. The cousins are wonderful people as well. A real family. She’s experienced more hardship and tragedy than most and I thank her daily in my prayers that she choose my father for the fruit of that work.

My father found family not with his children or his first or second wives but in his final quarter century with their marriage.

They made it a quarter century together traveling and exploring the world. Which is quite a retirement. She was a force of nature and gave my father a life and sense of security. She married a rich man and saw him through hard times.

I feel as if she thinks I’m a terrible child. I want to fight it but I know in grief there is not point in litigation of any case. It’s in the past. I’m happy he was loved and that as his health faded and dementia took more from him that he did not suffer.

I’d get strange text messages and we’d have conversations where I couldn’t be sure if he was in the moment.

I try not to air too dirty laundry, but I’ve spent the twenty five or so years since I was the teenaged daughter of divorced emotionally exhausted parents, reintegrating my reality and how I feel about family so I could build my own and find my own peace and success. I’ve found a great life at the end of that.

I share this because I know I am not unique in this. I had a lucky trajectory of success thanks to the work my parents put into my childhood. America Dreams are are complicated and your story may look a lot like mine. Weird and unlucky and lucky and persistent.

I’ve made peace with much of it and see my parents much as I see myself. Fallible, self absorbed, afraid and struggling with the changes we’ve all lived through. America asks for us to take this and make something of it.

Everything I am is thanks to the efforts of my parents. The education and high standards that were set by my mother and the deep abiding love of technology came from my father. I went into startups to impress him. I don’t know if it worked.

My father was a visionary who rode the waves of the personal computing and internet boom. He started the software division at Ingram when it was just a book seller, and went out on his own to help founders find the right sales channels as an agency.

Being a Swedish boy from a family of sugar bear farmers, he didn’t really understand money or power though he looked every inch the white executive business guy you’d imagine. Social mobility in America is real. Both up and down.

Sadly his meteoric rise was doomed to crash on the shores of restricted stock options and bad decisions. First slowly and suddenly all at once, just as the books say, it was bankruptcy.

I don’t wish to relive it but it was hard and life changed. Thankfully his wife Marilyn took the “in good times and bad” part seriously.

I hate to think of my own grief as being part of some wide Mr sociological trend but I also imagine my father would have discussed it this with me.

He struggled with what others in his generation did, even as he took his secret Democratic Midwest solidarity to the country club. He read the Fourth Turning.

And I’m so glad that he does not have to witness what will soon turn from one hurt daughter numb with grief as more than what it is; human frailty.

Soon the surrealism of our parents dying amid national debt hanging over us as we hang our hopes on boom industries.

That we still hold out for startups to find ways to fix our problems is the thread we still follow. I don’t give up.

Categories
Emotional Work

Day 1704 and At A Loss

Some days are harder to write through than others. Yesterday I found out my father had passed. I didn’t say anything as I wasn’t sure what would happen next.

I didn’t know who else knew or if others were being alerted so I didn’t discuss it. The last thing I wanted was to disclose something inadvertently as the rest of the family found out. I loved my father very much. We had a complicated family but I didn’t doubt that love.

I learned of his passing as my brother received a voice message in the middle of the night from my father’s wife. He called me immediately when he woke up and had listened to it.

There wasn’t much information in the voicemail but there is a certain logic to the phone tree of death when a family member passes. My brother called his mother after he called me. I called my mother. That was the end of our tree.

I did not get a phone call or other information but my brother has and it is likely I will remain at a loss for words as to how to consider my feelings about all of this. I can speak about it as I know that the parties concerned all know but what to say is beyond me.

The complexity of the social contract and our expectations of family ties has been ongoing for several generations now. Divorce and remarriage have been common in my living memory and the blending of families the norm. Sometimes it’s beautiful. Sometimes it’s not.

Categories
Emotional Work

Day 1703 and Termination Shock

I have had a shock that is in reality not a surprise. The inevitable and the most surprising thing coincide rather often I’ve found. I imagine shock is as means reverting a phenomena as any.

All things are inevitable in hindsight. One can greet something as inchoate and far reaching as the Fourth Turning and still be a bit surprised to find it applying to you.

I believe we are about to find out a lot about our social contract soon. How the tensile strength of relationships hold under personal and national and global stress. If we are accelerating then any frictions on that process are going to sizzle and snap.

There is freedom to be had in future shock. Knowing you are repeating history and doing what you can to break the worst of it. Knowing no one can do any thing. That ultimately all any one of us can do is what we personally can do. She done what she could.

Categories
Medical

Day 1697 and Gut Brain Axis Misery Meets Peptide Season

It would seem I found an antibiotic that disagrees with me. As the tail end of my soft tissue recovery from my abscess surgery and deep tissue infection appears in sight I had a setback with an additional antibiotic.

Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.

They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.

So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.

Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.

Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.

I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?

So I heard you had side effects so I gave you a side effect for that side effect.“

And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.

Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.

Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:

  • Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. Sources Sources
  • Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
  • Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. Sources Sources
  • Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.

Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:

  • Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
  • Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
  • Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
  • Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.

TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.

BPC-157 (Body Protective Compound-157)

BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:

  • Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
  • Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
  • Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
  • FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
  • Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26

Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.

Categories
Biohacking Chronic Disease Medical

Day 1694 and Every Last Bacteria

It’s been a strange summer. It has been 41 days since I had surgery to drain an abscess that has become a deep tissue infection.

American medicine failed me but Istanbul has excellent medical if you are motivated enough to travel to fix intractable problems. And I most surely am motivated.

Add in the daily guidance of consumer grade LLMs taking input from myself and my family doctor and I managed a pretty miraculous recovery. Yes the bots are friendly but my physician agrees. It’s a very successful clinical outcome.

That’s Perplexity if you are curious. I like their mobile application and model choice options. Though pity any poor hacker who gets in as they are going to see some gnarly pictures if they make that bad decision.

Alas I am noticing the folliculitis troubles flaring again just as I’ve begun a fitness recovery protocol. Which you will notice in the image if you read the above image closely.

Alas progress is never a straight line. The flare up is bad enough I’ve opted to start another round of antibiotics (my fifth in this process) so any remaining bugs of the MSSA varietal cannot manage any retrenchment.

I’m showering with the scrub up washes surgeons use, I’m swabbing my nasal cavities with muciprin, and I’ll do a Cephalexin course.

Having fully passed through the onboarding loading dose regimen of Bimzelx with significant side effects, I need to see if it stabilizes. All this suffering will be for nothing if I give up now. But I must get to a place where I’m not constantly fighting infection and it can maintain lower inflammatory biomarkers. How this goes is anyone’s guess.

Categories
Culture Emotional Work Politics

Day 1690 and Ressentiment

Nostalgia can be a bitter poison if you believe the world is getter worse. Optimistic people try to point out the many ways in which our lives are better only to find poisoned barbs dipped in statistics of all ways things are worse.

That poison absorbs into our frail hearts when aimed well. I see how things are worse just as well as any pessimist. Choosing optimism requires us to find antidotes to those poisons, lest we have a full blown case of what the French call “Ressentiment

It is a terrible disease. Ressentiment literally translates to the English resentment but rancœur (bitterness), amertume (acrimony), and animosité (ill-will) are all part of its dangerous pathology.

Nietzschean scholars will note he meant it specifically as an emotion of feeling of deep-hostility towards those who make you believe you are powerlessness.

In his Genealogy of Morals, Nietzsche sketched out how this feeling of weakness justifies and creates value systems as a defense mechanism of the ego. Rather than overcome these feelings, the ego insulates you in a value system where one never need address real failures or weaknesses.

There is much to criticize in his work, and I am not a Nietzschean myself. But it’s easy to see how much we all live in jealousy and inferiority from time to time. Some of us live there always.

Many moral systems raise up the weak in virtue in order to protect them. Christianity is one of them. There is value in protecting and improving the lowest of us even if I disagree that we should see the powerful as morally inferior. Power and strength and beauty are virtues as well.

As we envy the past or those whose past decisions made our present lives harder we must be cautious that we have not absorbed the poison of ressentiment. Do not justify harm in its name. Do not justify jealousy or envy. Rise up and spit out that poison. Our world can be better and you can be better as you work towards that goal.

Categories
Aesthetics Culture Politics

Day 1679 and Avoiding the See and Be Seen of Luxury Travel as Post-Liberalism Nears

The lingering live embers of Venkatesh Rao’s charnel age have left me with deadened impression in my bodily sensorium. Tasting, breathing, and seeing the culture of now feels somewhere between spoiled and not quite ripe.

One of my minor affectations is periodizing my writing into sardonically named 6-year eras…We’re about to enter the last year of the third age of Ribbonfarm, (2019-24), and I finally have a name for it: this is the Charnel Age. December 21 Ribbonfarm

I have been known to drop an Antonio Gramsci joke from time to time. This is harder to make a joke about though. The age which was being born as Gramsci was imprisoned by the fascists from 1929-1935 surely felt as filled with morbid symptoms and putrefaction.

How it compares to our current perverse extended gerontological Fourth Turning of death and rebirth is yet to be seen.

The old world is dying, and the new world struggles to be born: now is the time of monsters

That quote is a translation of Slavoj Žižek’s which isn’t quite as pithy as the Slovenian made it sound.

La crisi consiste appunto nel fatto che il vecchio muore e il nuovo non può nascere: in questo interregno si verificano i fenomeni morbosi più svariati.”

Or for those lacking Italian skills (which as I do) here is it translated more literally.

The crisis consists precisely in the fact that the old is dying and the new cannot be born; in this interregnum a great variety of morbid symptoms appear.”

Rao calls charnel vision “a tendency to see things from the perspective of natural processes of transience, death, and decay,” which can feel foreign to the long century of stability.

Americans enforced this order through its dollarization and the financialization . But empires change and even the longest institutional decay can be seen from far enough remove.

And so we have Swiss politicians running to Washington DC as the cosmopolitan upper classes try to enjoy an August off from the always on mania of this interregnum while also keeping an eye on matters.

As it turns out the extra mile to get to an esoteric Dolomite lake or a less well known riviera (might I recommend the Balkan coastlines to the more adventurous). If you need to find me, I won’t tell.

Categories
Culture

Day 1678 and Fiat Prestige and the Inflationary Pressures of Credentialism

America has been rejecting practical workforce training like apprenticeships for over a century. Our military nudged the enlisted into skills but it was access to university education that helped Americans climb the social ladder.

The Servicemen’s Readjustment Act of 1944 or as you probably know, the “the GI Bill” was so successful that by 1947, WWII veterans accounted for 50% of college enrollments.

Social mobility matters a lot to the mythos of America so it doesn’t surprise me that practical skills were not nearly so attractive once we made prestigious colleges more accessible.

When millennials were children the 1992 Higher Education Reauthorization Act (HEA92) made college loans available to all families, regardless of financial need.

And the trend in spending on education and the cost if higher education has been up and to the right ever since. Over the 59-year period from 1963 to 2022, college tuition increased nearly 300% when adjusted for inflation.

Educationdata.org

The effects of the cultural experiment in social mobility some call The Sort where children with good test scores were shuffled into universities and into the managerial class is driving spend and anxiety.

From Max Weber’s Bureaucratic Society of group status competition to Randy Collin’s work in the 70s on the rise of credentialism in the workplace, it seems as if modern industry drove a deep mimetic desire for prestigious university educations to stay ahead socially.

Having skills was not as important as being seen as having the right credentials. The old joke that Harvard launders the rich kids with the smart kids so no one knows who is who doesn’t seem so funny snore.

Last week a picture went viral of a table of Harvard and Stanford graduates in Silicon Valley (mostly Asian students) was all angst as their credentials mean something to them but not necessarily to employers or founders. So what is the point?

The data shows college education spending consistently outpaces inflation. But is it doomed to keep going up and up even if we are getting less from it? Walter Kirn had a turn of phrase in a tweet today I found apt. We have a problem with fiat prestige in America.

Power flows in the country — human, social & intellectual power flows — look bad for the legacy brokerages & gate keepers. Their services are of declining value, their cartel-like arrangements are dissolving & their ability to maintain their own mystique through circular credentialing & prize-giving — the issuance of what one might call “fiat prestige” — is failing. It’s unclear to me what moves they have left

Inflated currency destroys value. Our Federal Reserve worries about being over a 2% inflation rate and yet we let it happen. So why aren’t we more concerned with fiat prestige and its credentialist inflationary pressures? Our system of social credibility is under significant pressure and if I were Harvard I’d be terrified of going fully Zimbabwe on my social capital.

Categories
Travel

Day 1677 and Fighting Tourist Traffic in the Era of Infrastructure Underinvestment

I’ve been in traffic for almost two hours and I’ve gone a sum total of 19km or 11 miles. High season is a mess when the world is trying to pack in leisure time all at once.

It doesn’t matter if it’s the entrance to America’s beloved natural parks, a scenic coastal highway or the route to a dysfunctional regional airport. All paths to time off from Montana to the Mediterranean are a mess.

I slathered myself in sunscreen and I’m so glad I made that decision as even inside an air conditioned car with tinted windows I feel the sun beating down on me. Sunglasses and a hat can only take you so far.

There are many places who make big claims of wanting tourism. Sure you hear protests from some of the most popular European destinations about over crowding of attractions and the toll it takes on infrastructure. But it pays the bills for millions of communities.

Still experiencing the stand-still road traffic of a poorly resourced area who hasn’t invested adequately into infrastructure makes you wonder. You say you want the money from tourism but won’t make the capital investments and expenditures to make it work?