We call catchy songs “ear worms” but instead of calling catchy ideas “brain worms” we went with Richard Dawkins’s coinage “meme” and I think that’s a pity. Normies find it simple to grasp the term brain work while meme remains coldly academic.
According to this synopsis from Perplexity, Dawkins proposed memes as the cultural parallel to genes, acting as self-replicating units that spread ideas, behaviors, or styles from person to person within a culture.
Thankfully, the extremely online regularly use the term “brain worms” to describe people infected by any number of ideas ranging from the political to the aesthetic. They aren’t good or bad ideas necessarily. I’d include Trump Derangement Syndrome, girls with septum piercings, the uptick in jhanna meditation as flavors of memes that infect different types of minds.
I’m sure I’m infected with at least half a dozen brain worms (hopefully the memetic variety unlike RFK Jr) despite good informational immunity. There are benefits in having hippie parents and media literacy but the occasional infection is inevitable.
Our minds, our bodies, our computers and our networks can get infected with parasitic diseases and carry viral loads. From Covid to e/acc to the Goatse Singularity (safe to click) we’ve had a lot of novel pathogens recently and some of them are even good things.
Programmers and early Internet citizens have probably have more exposure to the modern theory of memetics than most.
Neal Stephenson’s Snowcrash has a neuro-linguistic virus derived from Sumerian mythology where natural language programs the human mind like we now program computers. It gets used in nefarious ways.
This of course makes you wonder if it’s so easy to make people share ideas how hard is it to make people forget them? There is no anti-memetics division right?
An antimeme is an idea with self-censoring properties; an idea which, by its intrinsic nature, discourages or prevents people from spreading it.
I wonder if my brain worms have made me memory hole anything recently. Given that we have an election coming up seems worth considering.
It would appear I have pneumonia. Healthcare being what it is, doctors say there little point in doing clinical testing to find out if it’s bacterial, viral or fungal (unlikely given climate) as the treatment is basically the same. I did a round of antibiotics because why not. Nuke it from orbit.
I’m stuck in bed mostly, my voice comes in and out for the few calls I absolutely must take, and I’m bored and irritated as I would prefer to work though it as it’s exciting times. I’m sleeping like a champion as my Whoop records day after day of long nights of somewhat fractured sleeping are forced by cough medicine into submission.
Having had Covid at the end of May, I now fear being doomed to some degree of respiratory illness risk for the rest of my life though I rarely had so much as a cold in decades of living in a big dirty city. Global calamities leave uneven marks and I consider myself lucky.
The benefit of bed rest is the amount of reading one can get done. My favorite cultural publication Dirt did a Tech Canon overview to get must reads from the slightly more stylish emissaries of the Silicon Diaspora. No offense to Patrick Collison who initiated the discourse with his own list (which is quite good) but it’s good to think outside the empire’s core for the trendy extracurricular bits of the syllabus.
As someone who self labels as a fashion bitch, I was pleased to contribute Neal Stephenson’s bitchy novella on abstraction and the graphical user interface called In The Beginning There Was The Command Line. It’s dated and old and free on GitHub so go read it.
There is quite a range on the list of core texts including a few books and essays that one could easily imagine being put onto banned reading lists. It’s nice that we have Heidegger Zoomers inside the pantheon now.
Schizophrenic philosophy posting is all the rage with the artificial intelligence kiddies. And to think I thought reading Deleuze and Guattari was a waste of time. Do your homework kids so you can discuss rhizomatic thought and large language models at your next conference. Perhaps you can dig into the war machine.
If I’m having a frail Victorian lady kind of week then there is nothing better than attending to the aesthetics of the moment and now you can too! Remember Alex Karp studied under Jürgen Habermas
It was nice to see a big budget Chinese film with some modest Warrior Wolf diplomacy but it was mostly interesting because of the immense engineering projects and the scope of the thing.
Remember a time when NOAA scientists could be heroes? Yeah it didn’t work that great. Trust the science. Alas we don’t have the same respect for government scientists in the era before Covid. I wonder what it would take to save the world.
I don’t know where I picked it up but the back to work and back to school season seems to also mean back to petty respiratory infection season. I’ve got a bad dry cough that is so intense I feel like I pulled a muscle in my left intercostal rib area.
I don’t feel terribly sick and all of my biometrics are within normal range. It’s just this horrible rough dry cough that seems to have tweaked my side so badly I’m contemplating wrapping my rib cage with a bandage.
I haven’t had a broken rib in sometime but this is as close to the feeling as I recall. I’d lost my voice a bit yesterday (been doing a bit more taking than usual as it’s fall) and pushing through it might have been a poor decision.
The other possibility is that the left intercostal pain is related to my inflammatory condition and it’s moved from its normal residence in my spine. I have very low pain in my spine at the moment so anything is possible.
I’ll lay low this weekend and hope it goes away on its own. Maybe the antitussive cough syrup will provide some relief.
I’ve been on a very steady health trajectory for the last six weeks or so after I kicked my lingering Covid symptoms from an infection I picked up at the beginning of the summer. Alas today I found myself with a significant pain flare.
I can barely focus on simple tasks like writing the pain is so forceful. Usually I have some warning with pain as it’s a symptom of an autoimmune inflammatory condition. If I over stress myself I’ll have consequences a few days later just like a regular person.
But today I went from working out to flat on my back in bed taking the highest doses of medication I’ve got. And I still at a 7 or 8 pain wise. I don’t quite know what to do about it expect as I’m not comfortable taking more medication.
I’m hoping it’s an anomaly and I’ll feel better tomorrow. I wish I could provide a better accounting of the sudden misery. But honestly the pain is so bad this is the best I can manage. Please no one worry as I don’t have the capacity to respond right now. I just can’t think clearly enough to write about anything but the pain so I’m stuck with chronicling it. And I’ve got a habit to maintain here where I write every day.
We are living in the past’s version of the future. The Cyperpunk I read in my youth is now the stuff of my daily life. It’s not as sleek as in fiction but it’s hard not to feel like it’s William Gibson’s world and I’m just living it.
We are only now getting Idoru but we are veering towards Burning Chrome. Half the anime avatars in accelerationist e/acc chats are wearing Mirror Shades and everyone watches for crypto rugs. But we are getting our Mt Gox Bitcoin back right?
What about borderless corporate worlds and mass scale surveillance identity? That’s here too. When William Gibson wrote “Disneyland with the Death Penalty” I wonder if he knew it would be the nexus of the network state debate?
We’ve even got the LoTeks in a Luddite rebellion against a world connected by dubiously transparent artificial intelligence owned by actual Zaibatsu multinationals with more power than nation states. Fact and fiction spinning hyperstition better than Nick Land ever dreamed.
Snowcrash and Crash Override? It’s better. We got amazing memes and elaborate fakes of the Blue Screen of Death. It actually did suck for airlines and banks because regulatory capture is the stuff of systemic risk.
And lest you think we’ve got no biohacking in this Cyperpunk world after the pandemic we have a renaissance in systemic & holistic approaches to medicine. Suddenly everyone is aware of the risk in agribusiness. Seed oils is normie stuff. Instead of turning Luddite the Danish invented advance metabolic medicine to cope. Everyone is on GLP-1 agonists.
Mix in the rise of nicotine and THC and you’ve got a national post prohibition bloom of folklore cures whose research has been suppressed by pharmaceutical companies and regulatory bodies alike. Conspiracy? Maybe but just the sludge of industry.
And in that all of the is our founders are global citizens who have to manage anarcho-tyrannical borders with visas controlled by incompetent governments and live through the geopolitics of wars fought with drones and propaganda. The future is already here. It’s actually pretty cool. Just watch out for nervous system tics.
I caught a case of Covid at the very end of May that took me down hard. I’d been struggling with “long” symptoms
So I tried an experiment. A pretty crazy one at that suggested by my osteopath and supervised by a doctor.
I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th
Day 1283 Nicotinic acetylcholine receptors (nAChRs)
The principle was pretty simple but not proven yet in clinical trials.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].
Please do go read the original post with lots of caveats as nicotine is an addictive substance and this is not something to try without consulting your doctor.
I was unable to do the full 7mg but cut the patches down to 3.5 to 5mg over the five days. The side effects included headaches for the first day or so and a persistent queasiness.
Within a day I was lifted out of my exhaustion (which you’d expect from something modestly stimulative even though it was a low slow release dose). By the end of the second day my persistent coughing lifted entirely. I’d been struggling with congestion and coughing after even modest exertion like a walk outside.
I was functional on the fourth and fifth day like I hadn’t been since I got Covid. You can see me go into the red on my first day (my HRV dropped significantly but my RHR was only up by a few BPM). I slowly felt better and saw better recoveries even while taking on a little bit more exertion. I pushed a little too hard and found myself back in the red on my last day.
My Whoop recovery and strain chart for the five days of experiment beginning on the 6th and ending on the 11th of July
I was really relieved to stop the patch by the end. The last day of treatment I had overextended myself so I was in the red and feeling it even as the nicotine pushed my system up. I wanted to rip it off and did eventually cave at the end of the day instead of doing it all night.
My symptoms seem to be at bay. I feel decent enough so days after wrapping even as I began menstruation this morning. I hate to report that it also improved my usually debilitating PMS which typically includes intense migraines.
I would do it again if I got Covid. I cannot imagine ever using a nicotine patch consistently. I didn’t not enjoy the extra push of energy except insofar as it got me out of the exhaustion of the illness. I feel like it would be too much if I were otherwise feeling healthy. I have no cravings or side effects after.
Honestly I’m still wrapping my head around how well this worked. A part of me is confused, indignant and angry that a substance I was taught to fear has therapeutic benefit. Updating your mental models around long held beliefs is an uncomfortable process. But it’s a heck of a lot better than long covid symptoms.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology.
I am doing alright with it. I was wary of keeping the patch on all night long (I am very sensitive to stimulants such that I won’t drink caffeine past 10am) so I removed it at about 5pm. That may have been a mistake.
Yesterday my Whoop recorded physiological stress. I wasn’t coughing, I had more capacity for exertion, and I felt generally less exhausted.
But I didn’t come down easily for sleep. I ended up taking a number of anti-inflammatory medications as well as an Ambien. My heart rate was stable but I felt “up” which I don’t care for at night.
And I did not wake up to good news. My HRV absolutely tanked. There are lots of confounding variables here in that I got good restorative sleep (medicine induced surely) but some strain has clearly been too much. 40% down isn’t a rousing endorsement.
I am also noticing a lot of chatter around addiction and whether or not it’s responsible to discuss these things. The fear that the average person is in fact prone so addiction and will have adverse affects. Which I’m sure is true. I don’t think normal people should take unnecessary risks and it’s good to have the minimum viable dose be none at all.
It’s wise to remember that I am not at all living in average circumstances nor do I have average medical conditions so I am not necessarily who you should be looking to for health advice. You should do the basics like eat more protein, lift heavy things, sleep an adequate amount, be in the sun and move around, and manage your baseline health metrics first.
Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.
But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.
At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.
She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.
In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.
Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.
I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.
I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.
Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.
The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].
Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].
Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.
This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.
It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.
Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].
The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].
Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/ TL;DR is that reducing the affinity may increase neutralizing immune response.
I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.
All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.
I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.
With all that said, let’s see if it helps me out. I’ll post because it is in my nature.
Montana has blessedly been free of excess heat and fire season doesn’t seem to have arrived. But it was a wet spring and I fear we have a long summer ahead of me. I live in one of the best possible places to spend a summer and I still find it challenging m.
I was looking back at pictures from this time last year and I was not in the best health. I’ve never been a summer person and I have to accept some aspect of its misery is likely to forever plague me.
Other people have season affect disorder in the winter. I guess my people are a winter people. I can’t wait for snow to return.
I’m sure my mood is affected by the lingering Covid (does it count as long when you feel shitty 7 weeks later?) as well as the general unease in American politics. I’ll do what I can to shake it. But I’ll never understand anyone’s affection the season.
