I didn’t get enough sleep last night. Between one thing and another I got about five hours of sleep. Adult circadian rhythms being what they are I still woke at the usual time.
I had a busy morning and afternoon so I pushed through it. Unexpectedly a number of pieces of my investing work were happening all at once. So much for a slow August right?
I was able to get through everything on my calendar but I’m I was starring down a bunch of work even at midafternoon. And I found myself unable to keep my eyes open.
I was zonked. Slept from 2 till I was woken up for a bird dinner. I’ll admit I’m planing to sleep as soon as I can wrap up my evening routine.
I’ve got so much to get through over the weekend. I have two rounds I’m working on (if you like hardtech slide into my DMs), juggling a bunch of inbound, and I’m gearing up for the fall. So maybe I need a little extra sleep.
And to think just a few days ago I was completely despondent over fire season, the sadness of American politics and my own seasonal affective disorder with high summer. If things keep up at this pace it won’t be summer much longer.
I don’t know why I let myself do this but I got irritated by the American election cycle. I have been libertarian and skeptical of the government well basically always. It was probably only really left flavored during a an Adbusters, Battle of Seattle, my favorite band is Rage Against the Machine teenager phase.
What can I say millennials did not like the government because the global war on terror went as well as every other war on “ideas” we’ve ever fought. We lost the war on poverty and drugs too.
But I do try to retain a kind of pragmatic libertarianism that is a recognition that my preferred politics isn’t always going to be broad consensus and it’s sensible to work opposing viewpoints as we have shared interests in civilization and America.
I am hugely affected by my proximity to international founders who adopted America because of the opportunities we have here that are unmatched elsewhere. Our market capitalism has given truly exceptional talent from places that suffer varying degrees of oligarchic, authoritarian and socialist systems.
It’s with this in mind that I’d like to ask American politicians but in particular the Democrats to please consider policy that allows us to remain a place where the best and brightest can rise and thrive. It’s good for all of us
My five basic policy asks are as follows
1) Stop taking aggressive, over broad interpretations of both criminal and civil statutes in regard to crypto. The SEC is trying to kill a nascent industry instead of shape and grow it. There are other first world countries taking different approaches. Japan seems to have adopted healthier ways. I’d like Gensler gone personally as I struggle to see this as anything but petty Wall Street protectionism.
2) Focus antitrust efforts on the industries where consolidation is harming Americans in structural ways like PBMs and agribusiness.
3) Retract the Biden EO on artificial intelligence and take an approach to akin to how we settled the encryption wars in the 90s. We don’t want to strangle a new industry as it is emerging just for the benefit of a few large incumbents and the fears of a few radicalism’s.
4) Stop discussing the ludicrous unrealized capital gains tax. It’s unconstitutional & structurally devastating to novel businesses. Only the rich will be able to afford to own a piece of a startup which will further limit social mobility.
5) We have got to find a way for companies to exit and IPO that isn’t this middle stagnant path of Microsoft’s regulatory capture corporate investment playbook. Markets need liquidity to function and the public deserves the chance to be rewarded.
I’ve been having some unwelcome negative emotions over the past few weeks of political turmoil. It could be a function of long Covid or some variant of season affective disorder. I got introduced to an even worse environmental trigger.
Wildfires burning both in state and across the west gave us low cloud cover. You could barely see the next road let alone the mountains. The whole day felt like dusk. A long dim suffocating presence that felt like it would resist nightfall. It was smoky perma-dusk day where neither horizon nor blue sky could be seen.
“The sky above the port was the color of television, tuned to a dead channel.”
William Gibson Neuromancer
Probably his most famous piece of prose, this introduction manages to evoke something beyond the literal color and into an expansive image of otherworldly nothing.
He apparently “imagined an ancient TV … that grey/ haze as the tube warmed to a channel that was ‘active’, but sending no programming” which was “the black and-white video-static of my childhood in mind, sodium-silvery and almost painful”
The pain of a sky blocked out by smoke from wildfires even at high noon is unsettling and uncanny. It’s hard to feel right when what you see is so destructive.
We are safe inside the house with air purifiers in every room. The Conway HEPA filter went from one crisis to the next as a pandemic purchase that works on pollution too. The custom software that Alex uses to manage our smart home is showing perfect interior quality as the purifiers run day and night. Outside the AQI score was 118 “unhealthy for sensitive individuals.”
We’ve got a few more hours to sunset but a thunderstorm might be moving in.
I caught a case of Covid at the very end of May that took me down hard. I’d been struggling with “long” symptoms
So I tried an experiment. A pretty crazy one at that suggested by my osteopath and supervised by a doctor.
I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th
Day 1283 Nicotinic acetylcholine receptors (nAChRs)
The principle was pretty simple but not proven yet in clinical trials.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].
Please do go read the original post with lots of caveats as nicotine is an addictive substance and this is not something to try without consulting your doctor.
I was unable to do the full 7mg but cut the patches down to 3.5 to 5mg over the five days. The side effects included headaches for the first day or so and a persistent queasiness.
Within a day I was lifted out of my exhaustion (which you’d expect from something modestly stimulative even though it was a low slow release dose). By the end of the second day my persistent coughing lifted entirely. I’d been struggling with congestion and coughing after even modest exertion like a walk outside.
I was functional on the fourth and fifth day like I hadn’t been since I got Covid. You can see me go into the red on my first day (my HRV dropped significantly but my RHR was only up by a few BPM). I slowly felt better and saw better recoveries even while taking on a little bit more exertion. I pushed a little too hard and found myself back in the red on my last day.
My Whoop recovery and strain chart for the five days of experiment beginning on the 6th and ending on the 11th of July
I was really relieved to stop the patch by the end. The last day of treatment I had overextended myself so I was in the red and feeling it even as the nicotine pushed my system up. I wanted to rip it off and did eventually cave at the end of the day instead of doing it all night.
My symptoms seem to be at bay. I feel decent enough so days after wrapping even as I began menstruation this morning. I hate to report that it also improved my usually debilitating PMS which typically includes intense migraines.
I would do it again if I got Covid. I cannot imagine ever using a nicotine patch consistently. I didn’t not enjoy the extra push of energy except insofar as it got me out of the exhaustion of the illness. I feel like it would be too much if I were otherwise feeling healthy. I have no cravings or side effects after.
Honestly I’m still wrapping my head around how well this worked. A part of me is confused, indignant and angry that a substance I was taught to fear has therapeutic benefit. Updating your mental models around long held beliefs is an uncomfortable process. But it’s a heck of a lot better than long covid symptoms.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology.
I am doing alright with it. I was wary of keeping the patch on all night long (I am very sensitive to stimulants such that I won’t drink caffeine past 10am) so I removed it at about 5pm. That may have been a mistake.
Yesterday my Whoop recorded physiological stress. I wasn’t coughing, I had more capacity for exertion, and I felt generally less exhausted.
But I didn’t come down easily for sleep. I ended up taking a number of anti-inflammatory medications as well as an Ambien. My heart rate was stable but I felt “up” which I don’t care for at night.
And I did not wake up to good news. My HRV absolutely tanked. There are lots of confounding variables here in that I got good restorative sleep (medicine induced surely) but some strain has clearly been too much. 40% down isn’t a rousing endorsement.
I am also noticing a lot of chatter around addiction and whether or not it’s responsible to discuss these things. The fear that the average person is in fact prone so addiction and will have adverse affects. Which I’m sure is true. I don’t think normal people should take unnecessary risks and it’s good to have the minimum viable dose be none at all.
It’s wise to remember that I am not at all living in average circumstances nor do I have average medical conditions so I am not necessarily who you should be looking to for health advice. You should do the basics like eat more protein, lift heavy things, sleep an adequate amount, be in the sun and move around, and manage your baseline health metrics first.
Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.
But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.
At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.
She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.
In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.
Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.
I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.
I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.
Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.
The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.
Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].
Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].
Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.
This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.
It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.
Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].
The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].
Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/ TL;DR is that reducing the affinity may increase neutralizing immune response.
I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.
All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.
I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.
With all that said, let’s see if it helps me out. I’ll post because it is in my nature.
The winding roads of spiritual practice often cross paths with the more practical minded subcultures interested in practicalities.
Doing a thing can be more enjoyable than documenting a thing but documenting turns out to be quite helpful in helping others learn to do things.
As we knit together our individual experiences our capacity to measure and systematize improves which in turn scales access if you are inclined to experiment. Getting a look at more than our personal n of 1 enables us to practice kitchen table science in areas prone being illegible or inscrutable.
I believe we are accelerating a number of types of revivalism thanks to the network effects of the internet colliding with religious and spiritual traditions.
Handing people what was once hidden knowledge naturally makes some people skeptical. We’ve gone from sharing breathing practices to documenting achieving spiritual ecstasy.
I’d like to maintain some degree of optimism about, well, everything. And yet I am struggling to maintain attitude control.
I like a little joke about navigating in space because I’m the sort of dork who enjoys science fiction books with lengthy digressions about spin and 3 axis stabilization.
But equally I do think it’s important to keep your chin up. Or nose up. It depends on whether you are piloting your emotions or a some other type of craft. It’s going to be forced metaphor post.
There is no need to crash yourself by getting disoriented navigating a situation in which you have some coordinates. It’s possible to calculate what’s going on and get yourself going in right the direction.
I am trying to do so by articulation, which yes is meant to be read as navigation joke, but is really just another goofy way of saying that writing helps me straight myself out.
So I am doing my best to keep my chin up emotionally and keep navigating what’s in front of me. It’s certainly better than a crash.
The benefit of keeping trace of one’s biometrics that I at least have some visibility into the misery. Of course, the downside is that I have visibility into how much misery. An extremely both sides of the bus meme situation.
I have a lot of reconditioning in front of me. Or at least my health data suggests that. It’s very discouraging to have health apps say you’ve had a 90% decrease in activity.
This week I slowly began the work of going back to life. I attended a policy gathering. I’ve been working on deals. I suppose I was doing that while I had symptoms too. It’s been hard as I want this to be better but I lost a lot of ground and relatively quickly.
I’m now doing all the little things one does help get your body back on track. Simply changed and reminders are most effective if you have injuries or are chronically ill.
I have little routines where I get up and do body weight squats on the hour. I’ll make sure to walk 500 steps each time I get up. I’ll touch my toes and stretch.
All these things feel very hard at the moment and I get blaring warning signals from the trackers suggesting physiological strain when I do. The slog of not giving up is a permanent part of the human condition and I refuse to let entropy win. But I am discouraged by how much work it is to do the basics. You can’t ever escape that life is just chop wood and carry water
I am going on my third week of having Covid symptoms. I don’t know if it’s time to call it “Long Covid” but my autoimmune response to it feels like it’s being dragged out.
My family doctor (an absolute gem of a general practitioner with a concierge clinic if you are ever in need in Montana) helpfully reminded me of the basics of immune response.
The infection is cleared but my immune cells did not get this memo. I’m still coughing, I’ve got clear phlegm, and I am struggling with a high respiratory rate. I am exhausted.
Yesterday I went for a short 15-20 minute stroll to get sunshine and I found myself with a very heightened respiratory rate overnight.
Apparently even small stressors like pollen count or exertion are hard when your immune response is overactive. I’ve been living with an autoimmune condition for years so while rationally I know this, it helps to be reminded.
If one is inclined to a forced metaphor, the party is over and the guests have left but the host hasn’t figured out it’s time to turn off the stereo, lock up and pick up the trash.
Calming immune responses is a tricky business. Sometimes you succeed by waiting it out as your system slowly resets to a healthy baseline. Sometimes you use more interventionist approaches with either local or systemic steroids. I try to avoid this but sometimes the only approach is the brutal one.
It’s my hope that the party being over means I can simply manage the mop up but I hope my immune cells decide to chill and get back to baseline soon.
