Tag: AI

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Biohacking Chronic Disease

Day 1471 and Lemons into Lemonade

I was so disappointed yesterday as I read over my most recent set of bloodwork and found my autoimmune biomarkers headed in the wrong direction.

I’ve been well controlled though my disease is not “inactive” or in remission. I manage it as it’s worth it to me to have a quality of life that includes working in technology as I want to be a part of making the tools that enable material progress in health.

Seeing things go in the wrong direction when my life is going in the right direction had a clarifying effect on me.

Not that I’ve been unaware that I must work at my health but rather it’s hard to always be working at health as it’s a matter of survival. But when you see a change in the data you act. I got serious and immediately went into action.

I’m so lucky to have to have access to an incredible community of biohackers. That I can ask someone who is studiously pursuing health in public is the best of the internet. I get the benefit of Bryan Johnson’s open sourcing his work. I’m doing an experiment with HBOT or hyperbaric chamber oxygen therapy and I learned from him I need it to be 2 atmospheres to be effective. This helps me plan and find hard chambers.

I can use Perplexity and Claude and even make my own personal assistant trained on my condition and my data is the remarkable thing.

I’ve found a new IL-17 inhibitor that looks to have twice the efficacy of my current one at the same dose. It was only approved in Europe but finally came on the American market. I was able to discuss it with my doctor immediately after going down a short question sequence on perplexity. You have so much power to improve your life now.

Shopping

I’d like to improve my V02 max and cardiovascular health in a way that works around my psoriatic arthritis and ankylosis. I have significant fatigue from the pain and obviously high impact isn’t in the cards for me. But I can try something like a DeskCycke. It’s even possible for me to do HIIT training with one. So I bought one. My goal is to improve my V02 by 10% in 8-12 months which shouldn’t be hard as mine is absolutely awful

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Biohacking Chronic Disease Medical

Day 1470 and Disappointing Biomarkers

After my anaphylactic adventures over New Year’s, I decided it was time for a fresh round of bloodwork to see just how my inflammatory responses were doing.

I got them back and it shows exactly what you’d imagine from a patient with an active autoimmune condition. My sed rate, or erythrocyte sedimentation rate (ESR) made a significant jump from last measurement.

I’d been on the high end of normal for almost two years and this set returned with doubling of the previous number. This biomarker is used in conjunction with C-reactive protein (CRP) test to determine overall inflammatory responses. That test came back modestly elevated but not atrocious. I also have elevated IgA levels, also known hypergammaglobulimia so that’s a bummer.

It would seem that my relatively well controlled autoimmune disorders (psoriatic arthritis and ankylosis) are moving to an active phase.

Given my use of IL-17 inhibitor injections along with a pain management protocol, lifestyle and nutrition management and a focus on holistic interventions, these results are obviously quite disappointing to me.

It would seem 2024 was harder on me than I’d have preferred and 2025 will be a year of doubling down on holistic therapeutics. Red light, infrared sauna, cryotherapy, hyperbaric chambers oxygenation, and any other anti-inflammatory treatment I can throw at it. Not that I’m looking forward to trying get another round of elimination diets but needs must.

I’ve not changed my the cornerstone therapy secukinumab since the pandemic, so it may be time to see other options like Janus Kinase (JAK) Inhibitors.

I’ve tried Tumor Necrosis Factor (TNF) Inhibitors as well as methotrexate (otherwise known as chemotherapy) and none of those treatments (Humira, Embrel) helped much and dosing on and off of biological injections is a long process. It can take up to six months to see results and changing a treatment that has been working comes with significant risks.

I’m lucky that even with these biomarkers I am still functional. I am able to work semi-normal hours and am able to groom and exercise. I have no personal life to speak of nor do I have hobbies beyond my work (unless reading counts) so I’m lucky to love my family and work enough to have it provide enough meaning to keep going.

Much of my success in treating this chronic complex case has been made easier with the breakthroughs in artificial intelligence.

Even as my physicians have retired and my care team rotates, I am able to progress and learn more thanks to large language models and search tools like Perplexity. I’m confident I will find a way to get back to remission quickly with little disruption.

Nothing provides me as much motivation to work as disease. I see how I and other patients like me suffer and I double down.

The progress we’ve made on autoimmune conditions in the wake of Covid and the rapid progression of protein discoveries as more AI tooling comes online. A chaotic world with a chaotic body drives my investing. We can do better as I see so much progress.

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Internet Culture

Day 1464 and Which Information Island?

It would be helpful for most media readers to understand the history of the news business and its relationship to war and finance.

For all the standards and ethics and best practices we expect from professional newsrooms (and they do have conduct standards), the history of media isn’t a clean narrative America went to war thanks to Yellow Journalism in the Spanish American War. If you think the Pulitzer is a badge of merit wait till you learn its history and financing.

You have probably lived through multiple media scandals. Millennials remember the neoconservative “weapons of mass destruction” story thanks to notably terrible editorial decision at the New York Times.

When someone says you are in a media bubble or on an information island, recall that these systems made up of people with varied interests, ambitions and aims.

News

American Surgeon General Calls for Cancer Warning on Alcohol

TechCrunch grudgingly says the AI Bloomers beat the delusional AI Doomers

Essays

An Nvidia researcher Jim Fan tweeted about blog post from the late Felix Hill on 200B weights of responsibility inside the work of building AI. The stress of knowing the billions of weights and bias that make up artificial intelligence that will bend our lives for both good and ill is no small thing. The thread has many beautiful comments.

Vinay the founder of Loom is in the thick of figuring life out after success and it’s brave of him to share.

Applications and Services

AskNews has an interesting set of display options for news types and bias and sentiment I’m considering purchasing and testing.

Categories
Chronicle

Day 1461 and 2024 Year in Review Posts

And so my fourth year of writing every single day in public comes to a close. I choose to comb through each post by hand to give a round up. I could employ artificial intelligence to give a synopsis and I have run my writing through several AI models.

Still I find it helpful to do the rote work myself. You can see my 2023 round up here. If you’d like further back here is my 2022 round up. And my first year round up is 2021

I felt as if my writing this year was more variable in length, depth & insight but that’s more feeling than fact. It don’t know if I feel like I did my best work this year.

And yet I still found narrowing it down to 50-60 odd posts to be a challenge. I can’t tell if that means I need a new format, a change of pace, or a change in expectations. Maybe it’s fine to keep going and see what happens. As we head to into 2025 feel free to have a look at my 2024. Let me know if you like what you see.

Emotional Work

Day 1449 and Self Deception

Day 1416 and Lagom

Day 1381 and Radical Responsibility

Day 1236 and Art of Accomplishment

Day 1197 and Experiencing Excellence

Day 1149 and Time to Get Offline?

Day 1119 and Capacity for Presence

Day 1107 and Happy Birthday to Matt

Subcultures & Cultural Commentary

Day 1448 and LARPing Ourselves to Death

Day 1441 and The Circuit of Power

Day 1431 and Faking Autism for Clout

Day 1410 and Luxury Content After Institutional Failure

Day 1341 and Class Consciousness

Day 1328 and Weebs as Social Elite

Day 1259 and Cooler Than Me

1232 and Millennial Crab Bucket

1176 and Verner Vinge’s Legacy

Day 1121 and Changing Political Alignments in Young Men

Chaos Energy

Day 1427 and Friction in The Systems

Day 1421 and When Crypto Clashes with Open Source Artificial Intelligence

Day 1417 and Pareto Optimal Skincare

Day 1398 and Overstimulated Nerds

Day 1393 and Babylonian Memetic Death Cults

Day 1386 and Goatse Singularity (safe to click) and Day 1391 Hyper Object Lesson and Day 1387 Singularity Lore

Day 1303 and Toaster Fucker Problem

Day 1297 and Crypto Libertarians in the Age of Anarcho-Tyranny

Day 1173 and Autism Services

Politics

Day 1425 and Doorknockers & Montana’s Senate Race

Day 1405 and America is Speaking

Day 1403 and Legible Political Opinions

Day 1415 and Sliding off The Board

Day 1422 and Material Conditions

Day 1356 and Sick Sad World

Day 1322 and You Can Just Do Things

Day 1315 and Ratfucking Season

Day 1291 and Political Violence

Day 1212 and Being One of Many

Day 1152 and Sunsetting The Boomers

Day 1142 and Come See The Violence Inherent in The System

Day 1103 and Don’t Talk Yourself into Regression

Biohacking

Day 1409 and Red Lights

Day 1290 and Covid Experiment with Nicotine

Day 1168 and Inner Monologue & Meditation

Day 1114 and Zoomers Aging Faster

Day 1107 and Polar Vortex

Goods and Services

Day 1388 and Take Good Care

Day 1362 and Hilux Drip

Day 1342 and SKU Bloat ZIRP

Day 1289 and The Discontinued Pant

Day 1263 and Hoe-flation

Day 1228 and Cotton

Day 1123 and Zombie Media

Day 1118 and Becoming a Distrustful Shopper

Startups

Day 1376 and Q324 Investor Update

Day 1363 and Landfill Apps & 10xing Code

Day 1347 and Economic Paternalism

Day 1320 and Becoming “You-er”

Day 1296 and H1 Investor Update

Day 1251 and Other People’s Labor

Day 1245 and AI Tooling

Day 1230 and Alignment is Consensus

Day 1172 and Inference is Up

Day 1145 and Founder Vitality

Categories
Community Politics

Day 1458 and Ingroup Preference

“one day you’re in, the next you’re out”

Heidi Klum – Project Runway

Twitter is in the middle of a multi-day long information war ostensibly over foreign worker visas in America. It’s about visas in the same way that Gamergate was about “ethics in journalism” if you catch my drift.

The similarities are interesting. It’s a fight over who’s interests are included and prioritized in a lucrative space. If gaming makes money and had that much vitriol involved imagine how much worse it is at the scale of a nation. All power struggles become culture war online.

American, being the aging but dominant geopolitical entity on the planet, is a popular place to be. So naturally the fight for who benefits from America is gnarly as fuck and has a lot of racism.

Who has rights and who benefits from them sounds much grander than video games or fashion but who decides what is “in-group” is existential.

As we experience the Great Reshuffle over the next decade or two, the question of who is protected in a nation state couldn’t be more potent. And human nature means we are viewing it with as much sense as a gaggle of fashion editors. Being part of the in group in America is as ugly a business as any.

Categories
Biohacking Chronic Disease

1452 and Bone Deep Weather

When the weather begins a shift to wet, cold or otherwise stormy, I feel it like some poor grandmother in a folktale.

My joints begin to ache, I feel swelling across my fascia and my ankylosis pain intensifies. Why do joints hurt when a storm system moves in? We’ve got a couple plausible explanations for all too common phenomena.

Barometric Pressure Changes: Before a rainstorm, barometric pressure (the weight of the air) typically drops. This decrease in external pressure can allow tissues surrounding the joints to expand.

Humidity and Inflammation: Rainy weather often brings high humidity, which may worsen inflammation in joints, particularly for those with conditions like arthritis.

Thanks to Perplexity the bone deep discomfort of a storm front becomes much easier to understand.

Cold conditions can stiffen joints by thickening the synovial fluid that lubricates them. Reduced blood circulation may also contribute. Changes in weather can make nerves more sensitive which amplifying pain signals.

The remedies for these changes are pretty basic. Stay warm, get your blood flowing with some light exercise, stay hydrated, stretch and take anti-inflammatory medications like NSAIDs to mitigate discomfort.

I asked Grok to draw me as a cyborg granny out in front of a storm

Prompted Grok to draw me as an arthritic cyborg granny in a rocking chair waiting and watching as a storm comes in.
Categories
Emotional Work Internet Culture

1443 and Irreducible

Being “spreadsheet brained” has become a shorthand critique for the technocratic mindset that prefers to see with abstractions rather than through immediate physical reality.

I don’t have a full history of the term but it was brought into my lexicon by Ashley Fitzgerald of Doomer Optimism.

A Wojack suffering from an inoperable tumor called spreadsheet brain.

Having spreadsheet brain can be a quality of life problem. If you are particularly numerate you can easily fixate on the negative statistics. We then use those facts to isolate themselves from the each other. It’s a classic case of seeing the price of things and not the value. It can easily become a very smart form of stupid.

I’m more of a whole to parts thinker myself so I’m amused by this meme even though as someone who works with tech startups I’m obviously susceptible to spreadsheet brain issues.

It’s reasonable to have concerns with thinking only in abstract terms. The topology of human experience is complex and yet we have many tools that take the irreducible and cook it down into something concentrated, clear, and altogether too legible. We desire to be seen but perhaps not too closely.

Categories
Internet Culture Startups

Day 1434 and Density

There is always a debate in startup life as to how the density of a given ecosystem impacts outcomes. A tight network of well connected communities and individuals helps founders, investors and talent connect.

Before the pandemic it was considered fairly normal to be within a major hub as the common knowledge was that “density” matters. You wanted to be in the action of a scene.

There are great startup cities. New York has an incredible scene. My hometown of Boulder has a great technical core. But as much as cities and companies compete over status the one with longevity is Silicon Valley. Heck it was a debate when that even encompassed San Francisco until Twitter moved in.

Then everyone spread to the four winds during the pandemic. I like to think of this as the era in which Silicon Valley got back to its digital roots. Being extremely online became a behavior that worked well for anyone if you communicated well with words. Being on the right coast was about being in the right online communities. The network state is online.

I’d say that was as pure a return to source culture as there ever was. Different people value signal across different networks and the open web of words has been home to software and hardware developers for generations.

The world that builds companies lives virtually as much as it does in the real world. We like to meet up but we also know it’s the tools that connects us that make the difference.

Every subculture that has emerged with a breakout hit did it through the digital commons we built together. I’ll always appreciate coming to the source culture to replenish but I know the density of the network is at its swiftest when our extremely online communities communicate.

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Internet Culture Startups

Day 1421 and Culture Clashes

I sit in between half a dozen different community nodes thanks to my interests in open source software, decentralization, crypto, and autonomous systems technology.

This set of interest covers a lot of ground from ecosystem level collaboration in financial organizations like DAOs and to player versus AI agents coordination to peripheral control of drones and machinery.

Many different demographics are attracted to these frontiers for different reasons. Hackers have a very different mentality than mercenary technologists looking for maximum margin.

Open source has traditionally struggled more from a lack of financialization than from an obsession with it. Which seems less true in the crypto era than in previous more academic and defense oriented eras.

There are classic open source business models and anyone with age and experience in startups has some opinions which I leave as an exercise to the reader. They occasionally fail and an open core loses more than they’d like to professional services. I am writing on WordPress.

One strange aspect of what drives these frontier spaces to interact is that depending on how much leverage you find in building a network you may have different incentives than other builders and users. Expanding out to scaled use may drive a lot more value than the resources required. How the surplus gets divided is always contentious.

For some, the most crucial cultural goals is expanding access to automation and ripping away as many of the services and middle men as is feasible.

Decentralized systems make it harder for middle men to maintain monopolies. Thats its own goal for true believers. For others the goal massive financialization that drives network connectivity is the benefit. Self interest driving common goals is perfectly acceptable.

As I watch the current season of hyper self interested memecoin cryptomania engage with the academic utopian open source artificial intelligence community, I am reminded of so many of the classic issues we have in financing and sharing in the spoils of common infrastructure. Who benefits is a question we should all be asking more regularly

Categories
Internet Culture Startups

Day 1394 and Wiped

I’ve had a great year. I’m having a great month. I had a great week. I’m absolutely obsessed with my portfolio and the founders in it. Every new opportunity makes me feel better about the future.

And I’m so tired from processing all of that that it’s little wonder my body is grinding out hours of REM sleep a night.

I’m in the middle of a tight circle of artificial intelligence memetics thinkers which has been enthralling. Machine minds needing machine money has been such a pat truism that when a genuine breakthrough shows up it’s easy to focus on the wrong thing. It’s not about memecoins. I almost feel as if I’ve been preparing for this moment my entire life.

In the middle of this virtual drama I am trying to remain focused on human concerns. Repairing boots. Doing chores. Preparing for a gathering in Miami next week.

Somewhere in the middle of this work gets done, an election is will be decided and I’m just wiped.