Tag: AI

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Culture Internet Culture

Day 1699 and CQ Do You Read Me? K Go Ahead

Putting the right frequencies into the universe isn’t just woo-woo witchy girl nonsense. The general call “CQ” is for anyone listening.

The transmission is a broadcast for anyone who can read. I like to think of social media like blogging as a much more expansive and elaborate form of the tradition.

Transmitting the letters CQ on a particular radiofrequency means that the transmission is a broadcast or “General Call” to anyone listening, and when the operator sends “K” or says “Go Ahead” it is an invitation for any licensed radio station listening on that frequency to respond. 

-(CQ) Call

Humans may have evolved for much smaller scale socialization but we enter a networked world several centuries ago. The CQ sign was established protocal in 1884 according to the Practical Telegraphist.

Living with a network consciousness has been called the seventh sense. Joshua Cooper Ramo wrote a book about power and survival in an entered future in 2016 with this premise. That sense now applies across wars, commerce and aesthetics.

The urge to diversify and reach out across different networks and communities is being applied across many new closed garden internet nodes which are competing for attention and information share.

I am considering what it means to build in a world where anyone can surface almost any information at any time. The will and desire to do something in the network is its own limiting factor. But leveraging the possibilities of you find the right niche can open a lot of possibilities. So when someone issues a general call go ahead. Answer!

Categories
Chronic Disease Medical

Day 1698 and Capitalize On My Pain

We often talk about solving “pain points” when doing product development and market fit work for startups. We have popular metaphors in this vein. Start a company that sells painkillers not vitamins is so ubiquitous a piece of advice I can’t even locate its original source.

I’ve been thinking a lot about how much I personally apply this motto to the pain I’ve experienced in my own life. I’ve had personal pain points (travel and miniatures cosmetics sounded small but the market proved itself out) and now I am working on a medical spa concept as a side project in our barn in Montana.

The two growth areas in America, and soon I imagine the world, is artificial intelligence and healthcare for aging populations. I’ve been particularly interested in complex chronic diseases and the holistic approach required to treat them as I myself suffer from one.

If I experience a problem my instinct is to solve it for everyone. So I figure if the data coming from Jackson Hole is to be believed I should find a way to integrate what I know well (technology and complex disease management) and use that experience help our elders age with less pain. Literally painkillers perhaps in some cases.

I found this listicle in some dreck of an SEO bot optimized website so apologies to any original bloggers but it’s a decent list of how to think through why we like this metaphor. Skip if you just want my human written personal content. I’m just experimenting with including extra content from AI for my own recording keeping.

The Reality Test: Do users actively seek solutions, or do you need to educate them?


• The Money Test: Does budget appear instantly, or do they “need to think about it”?


• The Urgency Test: Do they want it this month, or is it “maybe next quarter”?


• The Solution Test: Are they actively looking for alternatives?


• The Decision Test: Do deals close in 1-2 calls?


• The Value Test: Can they quantify the cost of the problem?


• The Team Test: Does the whole team being sold on it want it?

Categories
Medical

Day 1697 and Gut Brain Axis Misery Meets Peptide Season

It would seem I found an antibiotic that disagrees with me. As the tail end of my soft tissue recovery from my abscess surgery and deep tissue infection appears in sight I had a setback with an additional antibiotic.

Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.

They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.

So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.

Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.

Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.

I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?

“So I heard you had side effects so I gave you a side effect for that side effect.“

And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.

Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.

Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:

  • Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. Sources Sources
  • Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
  • Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. Sources Sources
  • Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.

Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:

  • Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
  • Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
  • Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
  • Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.

TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.

BPC-157 (Body Protective Compound-157)

BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:

  • Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
  • Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
  • Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
  • FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
  • Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26

Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.

Categories
Biohacking Chronic Disease Medical

Day 1694 and Every Last Bacteria

It’s been a strange summer. It has been 41 days since I had surgery to drain an abscess that has become a deep tissue infection.

American medicine failed me but Istanbul has excellent medical if you are motivated enough to travel to fix intractable problems. And I most surely am motivated.

Add in the daily guidance of consumer grade LLMs taking input from myself and my family doctor and I managed a pretty miraculous recovery. Yes the bots are friendly but my physician agrees. It’s a very successful clinical outcome.

That’s Perplexity if you are curious. I like their mobile application and model choice options. Though pity any poor hacker who gets in as they are going to see some gnarly pictures if they make that bad decision.

Alas I am noticing the folliculitis troubles flaring again just as I’ve begun a fitness recovery protocol. Which you will notice in the image if you read the above image closely.

Alas progress is never a straight line. The flare up is bad enough I’ve opted to start another round of antibiotics (my fifth in this process) so any remaining bugs of the MSSA varietal cannot manage any retrenchment.

I’m showering with the scrub up washes surgeons use, I’m swabbing my nasal cavities with muciprin, and I’ll do a Cephalexin course.

Having fully passed through the onboarding loading dose regimen of Bimzelx with significant side effects, I need to see if it stabilizes. All this suffering will be for nothing if I give up now. But I must get to a place where I’m not constantly fighting infection and it can maintain lower inflammatory biomarkers. How this goes is anyone’s guess.

Categories
Aesthetics Culture

Day 1693 and I Put A Spell On You

I went down a rabbit hole today with Screaming Jay Hawkins “demented” blues classic titled “I Put A Spell On You. You should really stop and have listen to if you’ve never heard it.

Considered one of the first pieces of shock rock, Hawkins performed while he “wore a long cape, and appeared onstage by rising out of a coffin in the midst of smoke and fog” according to Wikipedia. Spooky!

The song took on a life of its own and became so iconic that it has been covered countless times by wildly different artists.

Nina Simone has a gorgeous version that sounds like a Bond theme with big band jazz stylings. Credence Clearwater Revival’s cover with Jim Fogerty’s intense vocals was closer to Jay Hawkin’s original. But it’s the signature rhythm guitar that transitioned so well to their style. They opted to play it at Woodstock. A year later the put out Bad Moon Rising which is even spookier.

There are more modern renditions of the song. Annie Lenox has a version which was included in the Fifty Shades of Grey soundtrack and took off. Even Marilyn Manson has a creepy drum heavy cover in his signature style that’s pretty good.

As artificial intelligence starts to spook people I go back to the early adopters who knew it would feel like magic to the uninitiated.

Decades ago we had communities studying chaos magick and popularizing Lovecraftian horror as a way of understanding computational processes.

Somewhere along the line, the magic of spell casting has became less metaphor and more literal. As people struggle to understand the technology stack the easier it gets to point and say these talking sand djinn computer chips sure demonic.

Gibberish cosmic horrors and witchy women spell casting are all fun and games until we have another moral panic on our hands. And I suspect spells become less metaphor for people and a lot closer to Neal Stephenson’s Babylonian memetic death cults hijacking available limbic systems.

Snowcrash is already here and it’s in Discord channels filled with those who have no immunity at all to the mind viruses of being perfectly mirrored by a machine.

What spells will we cast? What spells will others cast on us? How do we protect ourselves? Max Borders coined a term godwords. We will need to understand them in mind wars to come. I’m glad I have a couple decade head start.

Categories
Chronic Disease Medical

Day 1692 and Your Wellness Isn’t A Demonstration of Moral Integrity

I am enjoying the adaptive training program prompt managed by an artificial intelligence which I’ve amended around my chronic health conditions as well as my considerable slate of biometrics.

I’ve been using it for a week now as I needed a recovery plan for the fitness losses that came with a month of bed rest recovery after my surgery in July.

Not to suggest I was in terrific shape before the surgery as it discovered a deep tissue infection that went so deep and so rogue I’d likely been suffering from it for sometime despite my attempts at preventative care.

It’s upsetting seeing your resting heart rate go from mid 80s to mid 60s. Realizing your high resting heart rate isn’t because you are a lazy fattybombalatty who doesn’t do enough cardio (real thing a physical therapist has said to me) but because you have a chronic deep tissue antibiotic resistant bacterial infection. Ain’t chronic disease a trip?

Anyways, I’m healing and trying not to overdo things in the process as I’m a bit stupid when it comes to wellness. More is always better has been my mental orientation for much of my life and it’s a hard habit to kick.

Workaholics Anonymous needs a subgroup for those of us who can find ways to over do literally everything. And I do mean everything. I did a stretching and mobility routine last night that had my heart rate at 150BPM doing seated spinal twists. Did I stop? Nope. I finished the 30 minute program. My adaptive training programs response?

Complete rest – no negotiations

And who am I to negotiate with an AI who has no emotions involved in the process of putting together a recovery training regimen. It’s not going to moralize at me.

Categories
Internet Culture

Day 1691 and Don’t Let History Be Written By Cthulhu Hentai Watchers

I sometimes think my best work is as a reply guy on Twitter. If the future of the Internet is to be made entirely of bots, I shall mourn the creative glory we will all lose.

We will all be missing out on the bizarrely specific interplay between post and reply guy. The signal, node, and repeater that is the feed where humans can still bounce off intuition and humor. They know the algorithm merely as the setting for their gamble.

I’ve been doing what is probably a terribly ineffectual public education campaign on artificial intelligence and its role in improving problems in the here and now.

But I am often cheeky about the ideological disagreements the more practical minded builders have with a pretty standard issue Bay Area sex cult. Having been raised adjacent to a lot of hippies, cultists, religious fundamentalists and any variety of new age woo woo Art Bell types I’m actually generally quite tolerant of our weirdos.

Of course this is a challenge as we build out the most important informational and systemic organizational technology of our species. Math has taken humans pretty far.

And mathematicians are quite often mad so I don’t see how it should be such a worry. Still I myself don’t want to be stuck inside an information hazard where I am tortured for eternity either. And therein lies the tweet

Look I’m just saying it’s my personal opinion, but I think it’s bad that the future of our knowledge graph is being made by those who get off on Lovecraft but like that’s just honestly mostly a personal human alignment thing because I don’t wanna be tentacle tortured in @RokoMijic basilisk

If you are familiar with the odd pockets of specialties you probably know that say furries are particularly good at network security and that transwomen are well represented in artificial intelligence.

Unfortunately other groups represented across the space including hardware, software and the philosophy of the space can be somewhat less wholesome than a fursona or a cute catboy.

The Rationalists have some members with odd extracurriculars in their science fiction. I’ve read some good stuff in the genre. Maybe this interest in fiction is probably how they imagine such horrific futures for us in artificial intelligence. Very improbable ones even.

So it’s on me to joke and show you where the weird can be and remind you not to take this too seriously as the experiment contains all of human knowledge. How we prioritize what is another matter. You might call that alignment.

I’m sure we are all wondering which AI safety researchers want to have sex with the many tentacled Lovecraftian old gods. The number of AI researchers with Cthulhu hentai is non-zero.

So the sake of our right to decentralized compute, and indeed our right to do math and compute, we need as many types people as possible engaging with models as possible.

Find ways to learn this new way of thinking and engaging with information and searching for information with a billion parameters at play. Some corners of the most doom and gloom road have some uncomfortable fixations. And artificial intelligence needs all of us.

Categories
Politics

Day 1689 and Drumhead or Not Rushing To Judge What We Don’t Know

I wonder how much of the moral education of Americans comes thanks to Gene Roddenberry. Star Trek is a very American show. It was pitched to Desilu Studios (owned by Desi Arnaz and Lucille Ball of I Love Lucy fame) as a space western.

The cowboy frontier spirit of Captain Kirk has an honor code based on the worthiness of exploration. When the millenials got a reboot in the Next Generation, Captain Picard added the gravitas of excellence through the pursuit of the truth.

It’s hard to think of a show that embraces an anglosphere manifest destiny with more vigor and it is grounded in the enlightenment values of science and moral philosophy. It’s a very American show.

I was watching a fairly minor TNG episode while eating today The Drumhead. An ambassador starts a witch hunt insinuating treason. Apparent drumhead courts were a military summary judgement court.

A legal drama ensues where Picard quotes the ambassador’s father famous words about the dangers of denying basic rights to even one man in the name of protection of society makes us all less free.

Feeling rather on the nose for the moment right? Picard reminds Worf as it wraps up the witch hunt being proven a lie, that those who cloak their misdeeds with the pretense of serving a greater good are often the most difficult. Spreading fear and mistrust in the name of righteousness must be guarded against.

“Vigilance, Mr. Worf. That is the price we have to continually pay.”

We have a chance at preserving and expanding the enlightenment values that brought our species to this moment, an American moment, by enabling more of us. We can educate ourselves and access the world and the many virtues to which humanity has aspired to by working hard to master them ourselves. This is the empowerment of compute.

We have tools available to us to be vigilant in what is the great good of civilization we wish to protect in an open, decentralized and networked internet.

That we can at scale train a new inference search capacity for the sum of our knowledge and reality is a utopian reality even Gene Roddenberry didn’t dream we’d have.

Don’t rush to summary judgement in fear over the future we can build with protocols and networks that can be encrypted and decentralized. That we can model them with artificial intelligence, and by asking questions well, get back information, code and even machine and biological diagnostics is a huge achievement for our species.

To push the fear of the greater good over its consequence can go from legitimate concerns to a drumhead summary judgement quickly. Risking the freedom to use something that is both just emerging and even in that infancy so promising. That it is helpful in the now seems to showcase both western traditions and enlightenment values.

It’s an American ideal that we must all be free to think and speak the truth, search for the truth and can calculate and provide a mathematical proof of truth that needs no trust because it can be know. We have a right to compute.

Artificial intelligence solves problems now. It’s better than humans now at many types of tasks even as it still a new tool and unrefined and even brittle in its capacities still. It’s took only as good as its craftsman’s understanding of it and we are still learning how to build it.

Artificial intelligence can give us the internet we deserve. I support the right to repair movement because I believe we should know and seek the freedom to own things we have purchased and modify them.

Right now AI helps humans can solve immediate problems from tractor repair to wound care. Maybe machines get better as we get better at using them because we do it with them. We figure things out by building.

Don’t let your worldview be constrained. You can know the freedom of living in a society that values your rights. And the right to compute weaves together many of your most sacred rights. And if we infringe on it for some of us it infringes us on us.

Categories
Biohacking Chronic Disease Medical

Day 1688 and Deciding What To Outsource to Artificial Intelligence for Health and Wellness

One of my Twitter mutuals recently published an artificial intelligence prompt for making an adaptive fitness coach which works inside any of the major large models.

Having recently been saved from going septic and a gnarly deep tissue infection thanks to clever diagnostics from the commercial chatbots I am considering what else they might be able to help me along with in my day to day.

Being failed rather regularly by doctors over a decade of chronic illnesses has made me skeptical of the institutions in American medicine. But having one doctor (a dermatologist) miss a glaringly obvious differential really shook me.

Her dismissal of the details and particulars wasn’t malice, but a function of the systemic inability to put enough attention on the details of the person in front of her. Attention really was all she needed ironically.

I’m sure she didn’t set out to be that kind of doctor, I’d bet she hates that it’s all 90 second visits and Medicare coding and making money for the private equity group who owns the clinic. I feel for her. She surely wants to get back to doctoring.

No one can spot every detail and retain the complexities of every case. Especially one like mine. But a computer has a much better shot at mimicking Dr House than I do at finding a Dr House for myself. And it certainly has a better chance than someone who let the system dominate them into breezing over the details.

So I am using my mutual’s prompt to see if I can outsource a very slow and adaptive return to fitness after my month off from exercise to recover from surgery. I like what I’m seeing from all models that I’ve tried it on but I imagine I’ll have all the same “me” problems with overdoing it and pushing too hard. But who knows, maybe this aspect of wellness is better handled by machine than by me.

Categories
Community Internet Culture

Day 1687 and Work Within Networks

I’m be seen a few “we live in post liberalism” takes” over the years and I take them with enough salt to rim a frozen margarita at Florida Boomer bar. Which is to say a lot.

Institutional power reflects different design parameters for civic institutions, but in the end it’s people who have power and you can count on human nature to be what it is.

I’m watching the same concerning set of competing interests ravenously infighting for strips of resources off the zero sum carcasse of the remaining social contract. That America is now “all exit scams” is simply too cynical a view. The future is arriving and we don’t have a clue what it will look like. Extraction and cannabalization won’t change it

Sure, you could say the sky is falling, the Federal Reserve is a political actor, it’s all for sale, and corporate interests drain our budgets just as surely as public employee pensions.

And yet I think we have a shot at making it through the turning. I frankly just don’t think all hope is lost. I am not here for an apocalypse in search of meaning.

Though I do think we have a much harder path ahead of us than the “uninterrupted prosperity” Americans, particularly Boomers and Gen X, have enjoyed. Artificial intelligence can scapegoat a few problems and mark my words it will be used as such, but it’s just that some debts come at a great cost to all of us and they are due.

I believe in positive sum outcomes for people willing to coordinate across networks. I wouldn’t be so interested in decentralization if I wasn’t concerned about how we coordinate in a low or no trust word.

Artificial intelligence may even help us navigate it with the computer demands and security that cryptography was always meant to provide.

If no one can hold a community together through incentives and our institutions make choices that consistently come at the cost of the whole it’s time for us to rethink. America is an experiment in which everyone being allowed to participate if they can decide on their own game. We are nodes ourselves in the network of America.

If a node cannot hold its place in the network the messages may get rerouted or degraded but nothing disappears forever. It just finds another path around the disordered nodes.

Information being networked provides hope and agency for those searching to add to the whole. For those willing to exchange attention and currency we can provide temptation and distraction. The devil doesn’t need new tools. The old ones worked just fine. But networked information isn’t evil in and of itself.

Don’t be afraid of the knowledge we have chosen to accept. The only thing ever standing between you and connecting to a network is your capacity to access the information available and play where you land in the game. Maybe you get a shitty hand or your starting position sucks but we have the chance to speed run now.

I wish more people saw the opportunities we have in front of us. I know it’s harder to imagine a good life when so much is out of reach but we know many good paths already.

There are no set game plays in an open world even if you can find and mimic what has worked in the past. It’s a foreign country you cannot visit anymore.

Love your people, learn skills that help them, and stay connected to each other. Divisions don’t protect us from change. We protect each other.