Tag: AI

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Biohacking Chronic Disease

Day 1566 and Oxygenated

I am buzzing with energy as I spent my day touring the factory a hyperbaric chamber factory. I don’t want to get ahead of sharing details I haven’t cleared with them but I learned so much.

Istanbul is so far ahead on medical care delivery it is genuinely thrilling. There are 24 hour walk in hospitals. And

Which is good as the new IL17 inhibitor means to have a side effect of meiborn gland problems. In mere days I got another chalazion so I’d like that sliced out.

But my optimism about my immune systems capacity to operate functionally has taken a step towards optimism. That something so simple as oxygen and pressure has such significant benefits for our bodies is common sense.

How marvelous that the ingenuity of divers, doctors, athletes and under water workers to put together a treatment that is so effective it moved the biometrics of one of the healthiest men alive.

That only in the age of artificial intelligence did we get the inference capacity to show its efficacy is a real indictment of our academic and medical bureaucracy.

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Culture Startups

Day 1561 and Just Don’t Die

I’m noticing a trend among more and more of my social circles of fear, confusion, depression and malaise. Which let’s be frank isn’t at all irrational given (hand waves) all this.

Rapid changes in technology are slamming into geopolitical changes and it is scaring the shit out of all kinds of people. Personal politics aside, many of the institutions, alliances and people we lived with our entire lives are changing.

But the rate of change is exciting! So much of what we took for granted in our youths is simply changing. Maybe (ok definitely) some of it will be worse for parts of it. It’s normal to be afraid of change. But what if we just need to survive the change?

I’ve been in tech my entire life. I was raised in it by my family. My father absolutely loved gadgets and hardware of all kinds and dove headfirst into selling software. I married someone who works in it with me.

I went to work in it by taking my skills in understanding new tools and translating it to an industry that adopted all of it. What an incredible privilege it was.

I worked in fashion and cosmetics so it was a mixed back but many incredible creative talents made and sold clothes that simply wouldn’t have been possible in an earlier more closed era.

The changes my father and I went through feel like slow lumbering industries compared to the rapid iteration of tooling we are seeing now. How we make things is being changed in ways that is almost impossible to keep up with.

I want to survive the Jackpot of change that is upon us. That’s a William Gibson reference. I agree with Bryan Johnson. Just don’t die. Imagine what we will find on the other side.

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Politics Preparedness

Day 1550 and Fools, Drunks & The United States of America

Americans are mere days away from the dreaded April 2nd tariff reveal and the mood could not be more sour.

If only America was a few good zoning reform bills further along. Then we could house 700 million more people and our Abundance bro moderate liberals would be in a better mood. Alas it’s easy dunking for most of us when Matty Yglesias weighs in late to the party

I’ve spent the last half decade preparing for a more chaotic world. How it would play out and what would be the driver was anyone’s guess.

I made plenty of bets that energy, compute, and decentralization would be the way in a multi-polar world, but I don’t want to count America out just yet. That’s why we made our last stand in Montana.

“God has a special providence for fools, drunkards, and the United States of America.” Otto von Bismarck

The amusing bit of Trump’s mercantilism is literally only he and a small band of trade administration aids actually think this is sensible economic policy. While I know a tariffs bro personally and I appreciate him as a friend they know I think this approach is dubious.

You know it’s bad when even the king of outlier events Nassim Nicholas Taleb is fretting for Treasury Secretary Bessent. Who is at least qualified to manage the a massive currency crisis.

“He probably gets that whether tarifs make or don’t make sense is irrelevant: any ABRUPT introduction of steep tariffs must lead to a CASCADING & GENERALIZED price action.”

We are damned if you do not because tariffs are the wrong tool for this moment (though most of them are) but because markets like predictable things and cascading price action everywhere makes us dizzy.

Rather like the drunks and the fools mentioned by Bismarck, we’d better hope providence provides in this topsy turvy moment.

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Politics Preparedness

Day 1546 and Present Ephemera

I am backing off some of my “current thing” hyper vigilance for a moment. I need to shake off the noise and find my signal.

The band of possibilities is simply so wide that it feels pointless to react. Who you are will determine everything from here. You must go into the future based on your values. I must strip back to see myself clearly.

The complaints about our geopolitical moment (true and righteous as they may be) are set against a great power conflict that will play out over multiple decades of technological change.

It’s yet unwritten though I have some ambition that we can all play a part in the restructuring of a knowledge abundant world.

The trouble with accelerating into the turn is the sheer stress. We know we need change but how we achieve it is messy.

It seems in some areas we will take the low road. It is a reasonable worry that we are seeing all of the downsides of American choices while the upsides are harder to see. I feel as I’ve only seen the fears I’d had and the changes are made at great cost.

We fucked around and it is finding out season. The present is all ephemera. I need to hold it lightly. The stress it induces serves no purpose. It will pass. I will adapt.

Categories
Medical Preparedness

Day 1525 and Turbulence

I am doing what I can to hold steady in the turbulence of the moment. Deals are still getting done, founders move companies forward, I do my small part to contribute in the strange dance of rounds coming together.

It has not been easy with both my husband and I seemingly rotating between one health issue to another. It would be nice to have us both healthy at the same time.

Because it is the winter of our discontent I’ve spent more time on Deep Research projects this past month than seems sensible but the urge to find solutions is strong when your health needs mending.

Plus it saves a ton of time when the alternative is calling a bunch of different experts and making progress at best every two weeks with appointments. Scheduling health care of any kind is a mess.

I remember realizing so vividly during Hurricane Sandy that no matter the catastrophe the rest of life went on. Everything will feel turbulent in our new high variance age and all we can do is live through it.

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Startups

Day 1516 and It Has To Be Carefully Taught

I love science fiction. The current generation building artificial intelligence builds on decades of thought experiments (aka science fiction) on how we might responsibly build and interact with a machine intelligence.

So it’s exciting watching testable premises arise that give hope that what is being built can be done so in ways that reflect our shared values. That is at least broadly the project of alignment.

An interesting paper from Owain Evans and a group of researchers on emergent misalignment caught quite a bit of attention today.

They finetuned GPT4o on a narrow task of writing insecure code. Having finetuned GPT4o to write insecure code they then prompted it with various neutral open-ended questions. It gave misaligned answers 20% of the time, while original GPT4o never did

You can see the work and verify the numbers yourself here. The discussion is interesting because they aren’t sure why model shows broad misalignment after a narrowly negative task like making insecure code. But it’s pretty interesting right?

Without getting into the politics of doomers, Elizer Yudkowsky believes this experiment to be a positive finding.

If you train the AI to output insecure code, it also turns evil in other dimensions, because it’s got a central good-evil discriminator and you just retrained it to be evil. Elizer Yudkowsky

The moral valence of intelligence is an open question and whether the values we have as humans will follow through into an alien emergent intelligence raised all kinds of questions.

But if we can teach values simply through conduct that has bad intent it might mean we can and in fact capable of teaching what we see as the right conduct.

But for all your sloppy coders out there be warned. Writing bad code leads to Nazism. Nobody tell Curtis Yarvin.

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Emotional Work Startups

Day 1515 and Hope in the Dark

Given the amount of illness that seems to be plaguing folks this winter I’m surprised we’ve not all decided to hide until Spring thaw.

Every event seems to be a super spreader. Our physical immune systems are shot and I doubt our emotional defenses are much better. Everyone is predicting informational dangers myself included.

It is hard out there and we all experience it in different ways. My medical improvement sprint is plagued with logistical issues, the mold situation in our basement is overwhelming, and yet I have hope that I’ll make it.

o many people are dedicated to building solutions to problems, big and small, that I can’t selfishly let my any of my problems stand in my way. We have to all pull forward together.

I spent a few hours with a portfolio founder working on their fundraise today and I felt my optimism. I enjoyed the flow of work even as the enormous task of raising capital is filled with risk.

I’d taken a risk on directional play earlier in the year. I believe in the founder. They are making their way through YC. I can see their path emerging with every step forward. And I see hope.

Categories
Internet Culture Media

Day 1514 and Informational Ravine

I hate to add fears that we will face a “dead internet” but increasingly we lack shared context in our online spaces. As context collapses so too does culture. Bad behavior proliferates.

Without shared values we cannot find purchase on the informational ravine of the open web. Competing narratives and interests buffet your mind as you try to sense-make your way into a firmer grip. It’s easy to slip and find yourself unsure of what is up or down.

The vibes are bad. People have entirely different interpretations when presented with something as innocuous as an email asking “what did you get done this week?” If you discuss a particularly contested space it quickly becomes a hostile information environment. Many retreat.

If you are tempted to argue with me about whether that action is in fact innocuous you have to wonder how far apart you and I are from each other as we try to climb through the great ravine to the other side.

Categories
Biohacking

Day 1503 and Project Managed Health

You have to work the problem in front of you. Fixating on past problems or potential future problems does not fix the problem in front of you.

Bottlenecks are such a useful construct as most humans have experienced their all of their progress being stymied by one single obstacle. Be it a fallen tree in the road, a bureaucracy or a health problem, the bottleneck stops you.

Alas I find myself with multiple health projects that have to be project managed with timelines, budgets, and externalities on each other.

We’d been planning to start a new care protocol with an updated biologic but the discovery of mold in the master bathroom is a bottleneck.

We need to decide if starting new immune suppressants is safe in the house before remediation. Mycotoxins at a load marked as unsafe for autoimmune conditions makes me nervous.

Sure we are staying upstairs but is it removed enough to be a sensible move? Can we isolate me and begin treatment? Do we wait the multiple weeks remediation will take? How an we run parallel paths. It’s crazy to project manage one’s personal life like this but it’s also necessary.

This excitement has also slowed down movement on acquiring a hyperbaric chamber. I’d love to offer it as a service locally as there isn’t a single available one for off label use in the entire state.

I really do think this would feel unmanageable if we didn’t have new tools at our disposable. In particular the new ChatGPT’s Deep Research has made it much easier to find different bits of information to reach an actionable conclusion. Because I want to clear these blockers.

Categories
Biohacking Emotional Work Medical

Day 1501 and Hazy Shade of Winter

I have a hazy memory of my mother introducing me to 80s girlfriend the Bangles when the played a concert at Disneyland.

We’d play the song in the car when I was little but it seemed improbable that this actually happened. But sure enough they did play at Disneyland so maybe the memory really did happen.

Reality is so tenuous when it comes against the frailties of memory. How can we be sure of anything even with meticulously kept records.

We are finding out some of the limits of record keeping and we can unearth the secrets of the universe by total recall these past two years of consumer artificial intelligence.

I have been taking a few weeks to reset some of my health protocols. Being empowered with better tools for finding opportunities makes me more inclined to take action. There are new pharmaceutical options. We can piece together

I had a round of bad bloodwork and within days I was able to take action. It’s only been a few weeks but got back a fresh set today and am feeling more optimistic that the hazy shades of winter are being well used on improvements.