Tag: AI

Categories
Chronic Disease Politics

Day 1730 and Steering The Titanic of Adult Habits When Icebergs Are Ahead

We are all us humans on the good ship Lollipop. I mean this as a stand in for Mother Gaia/Terra/Earth. We are all in this together right? Wrong? Who knows.

I happen to be on the America decks, so even if I can see the sea is perilous the orchestra is still playing. Maybe I’m rearranging the deck chairs. Is there anything that can be done to steer myself away from collision other than seeking a life raft?

It’s a kludgy metaphor but I am personally trying to move around several of my own ingrained adult habits with the hopes that I can change the direction of life for smoother sailing.

It’s hard to retrain your body after years of pain, compensating biomechanics and environmental factors beyond one’s control.

I’m putting on my life vest and trying to steer myself well so that I save myself and maybe in doing so save others.

If anyone has physical therapy videos they recommend I am working to retrain muscles that are compensating for my thoracic ankylosis. I also intend to go in person to physical therapy if possible.

And onto other topics less bleak than avoiding disasters, both personal and political, as you can indeed do more than you imagine to steer your own life here is some inspiration.

I enjoyed reading this piece on the rise of the online schizo and how to protect yourself as someone who is burdened with a strong case of apophenia. Worth a browse if you are concerned about your cognitive security online as no one wants to catch a Babylonian death cult meme virus.

Audrey Horne has a new substack called Secret Ballot where my friends and mutuals make some appearances and it includes a good calendar of social events in D.C if that’s your thing.

If you are following AI and eschatology (and really who isn’t these days) you may have heard about the Peter Thiel anti-christ lectures. I’d love to brag about being invited but I didn’t have the chance attend what with death and illness. However this two part interview with Thiel at the Hudson Institute covers the basics.

I spend a lot of time on artificial intelligence policy thanks to my advocacy on Montana’s right to compute law as well general interest in enabling more people to maintain the level of control and access they seem appropriate for their own lives. The right to repair movement is the seed for a wider right to compute movement.

On that note Alex is building automation into the sauna being built and has put the code up on GitHub if you are into that sort of thing. You have a right to build things and own them and no one is forcing you to buy convenience if you would prefer to keep your data on your own servers. Even if it’s the data for your air conditioning or your sauna.

We’re building a sauna and I don’t like anything at home connected to the cloud, so I’m building my own fully local controller
ESP32 as the brains, 60a 240v contactor for heater, even has RGBW LED controls
UI/ final control via Home Assistant and HomeKit

Categories
Biohacking Medical

Day 1723 and Hormonal Rollercoaster Rides

We spent a long time at the doctor’s yesterday as Alex and I gutted it out with our excellent physician (with AI assists) through a myriad of different tests. We were attempting to figure out why he keeps getting respiratory infections and why I’m such a tasty treat to skin bacteria.

In truth, my basic inflammatory biometrics have improved so much on the new IL-17a inhibitor Bimzelx that it’s probably worth the hassle of occasionally having to slice open a random effected gland or abscess once a quarter. It’s just a shocking amount of work to do whack mole with pathology reports.

What I don’t seem to be able to improve is my low testosterone and the flavors of migraine headache that come with the roller coaster of my luteal phase. Which is presumably a clue and we are following it.

Astonishingly my lady hormones are in tip top shape. Though the “you should have no trouble getting pregnant if we can get off the medicines that stabilize you” remarks remains a heads trip. Yes I asked.

It is not a head trip that makes one’s husband enthusiastic about the prospect. Which is fair, as we have no family support, no backup plans for me regressing physically, and the family that does support us can’t get to America. So one can see why a CEO husband with sick investor wife who would have to give up work, plus potentially messed up baby, isn’t super appealing. Anyways! TFR is a fun topic.

I started with basic supplements in the precursor category like DHEA and STRO about a year ago when my testosterone came in at a 2 nanograms per deciliter (ng/dL) when it should be somewhere between 9 to 55 nanograms per deciliter (ng/dL). For context, adult men typically have levels in the 240–950 ng/dL.

The one sticky widget is that my testosterone remains stubbornly low. You wouldn’t think such a raging “see you next Tuesday” such as myself would be overburdened with the feminine hormones and lacking in ball buster hormones but I am.

I managed to eke it up to 5 with supplements and nutrition but it really didn’t match my otherwise excellent hormonal profile. Having ruined my chances at a healthy immune system when we tried the first half of IVF, I’ve spent some time working on and with my natural cycles.

Good information for all humans

I loathe being in my luteal phase but when I’m in my follicular phase I get 90% of my work done. We had presumed it was the rapid decline in estrogen and progesterone but maybe my floor rate testosterone was more of the issue.

For the past 8 weeks I’ve been using a testosterone cream that clicks up your dose and you rub it between your thighs. I know it’s gross. So I was curious to see where I might land. And praise the Lord I am now at 15 ng/dL. From 2 to 5 to 15 is some excellent progress but still below where we’d like me to hit. So we are going to run another test and try out the tiny pellets they slice into your skin. Since I’m already used to scalpels and antibiotics I figure why not?

Categories
Politics Startups

Day 1721 and Valar, Inference dot Net and Policy for The Future

There has been such a bleak mood on the timelines as Americans are once again locked into a cycle of agitation and propaganda driven by hyper persuasion A/B testing of rage bate as tragedy turns on the opportunism machines. So I’d like to share bits and bobs of good news in my corner of the world today.

Valar Atomics is one of my proudest true first check investments. I knew Isaiah was special from the moment I met him. But I didn’t like the company he was pursuing with someone. I said I’d back him in something else so long as he was the CEO. I’m so glad I told the straight truth as Isaiah let me in on his true dream of an energy abundant nuclear future and I was able to be there from day before zero.

Valar is audacious, ingenious and the kind of hard technical work I’d never seen anyone raise from his position as self taught young man. But what a challenge right? I was in. I believe in him. And boy do I look smart now.

The Valar Atomics and Kiewit announced a groundbreaking at the San Rafael Energy Research Center for Ward250, their very first reactor! It is a major step on their mission to answer the President’s call for three advanced reactors on American soil by July 4, 2026.

If you want to watch an inspiring video with a Blackhawk click through. Kiewit is America’s 2nd largest power plant builder, with more active nuclear construction projects than any other company in North America. Utah deserved a win like this today.

Valar is incredibly grateful to the State of Utah, especially Governor Spencer Cox, DNR Executive Director Joel Ferry, EOD Director Emy Lesofski, USREL Director Jaron Wallace, and all our local partners in beautiful Emery County.

Chaotic portfolio founder, and once and future Montana guy, Sam Hogan has a good synopsis of CogSec 101 in times of tension that I thought I’d share as a teaser for introducing his fantastic compute company Inference.Net

He gives good being online advice and his company Inference.net (yes disclosure investor) just started sponsoring a new podcast about the culture of San Francisco.

It’s called Member of the Technical Staff. It’s a fun hang with perennial grist for the social mills topics like where are the girlies in San Francisco. It’s a hang for a subcultural issues relevant to understanding living in a boomtown while building.

In local Montana news, we have had national influence with our work supporting the Frontier Institute and its indefatigable leader Kendall Cotton. Must be something about this Rocky Mountain boys that we love. He’s proving you can just do things.


I’m thrilled to report that two model bills that we’ve pioneered in Montana were officially adopted as ALEC model policy. This means that state legislators from across the country who look to ALEC for ideas will be prompted to introduce their state’s own Right to Compute Act (recognized as the gold standard for state tech regulation) or Private Property Protection Act (a cutting edge approach to zoning reform focused on housing affordability). 

We’ve officially become a national policy leader – a big deal! We’re a small state, and a small team here at Frontier Institute, but we’re making a huge impact thanks to supporters like you.

And that supporter like you? Heck yeah those supporters are me and Alex. .

You two can just do things as our boys Isaiah, Sam and Kendall have shown. You can build nuclear reactors, run decentralized inference compute markets and create new models, and even change your state’s policy with better laws that become models for the entire nation.

Categories
Internet Culture Startups

Day 1707 and Putting Some GPU To Work

I try to give my own slight biological grey matter processing power a run every day through this writing habit.

I try to move my own body with walking, weight lifting and other condition so it can stay a somewhat workable machine. Tuning my body requires more work than tuning my mind as my brain rarely gives me issues but my tissues are always in some stage of revolt.

I have other assets behind my mind and my body. I’ve purchased a car. Precisely once and I have looked into buying others and shied away. My home doesn’t need to do work beyond housing me and my “disposable and durable” goods which range from a tractor other home appliances. A few of them do produce things for us like keeping our land and our laying hens.

We’ve got a gorgeous solar grid that generates electricity we can barely use. It goes into Bitcoin mining and stacking and running utilities but I’ll admit in a little lax about putting my our existing compute to work.

I’ll admit this is pretty stupid as we invest in crypto, we invest in hardware and energy, and we have invested in compute and inference networks. So why am I not doing more for passive yield on this?

Humans have been working as inference machines since we decided to keep records with something beyond the digits on our hands and the foot of our feudal lord.

Counting and abstractions being necessary for all sorts of engineering feats from cathedrals to graphical processing units. And now we have inference tokens just waiting to be brought down in cost as we bring networks online. So I am setting up my compute to be a part of those networks because sometimes it’s good to focus on little resource allocation problems to take your mind off tbh fe.

Categories
Chronic Disease Emotional Work

Day 1706 and Leaving It In The Past

I’ve got my over the ear noise canceling headphones on playing a Solfeggio frequencies of 396 Hz which is labled as “liberating guilt and fear” on my Endel mobile application (which I recommend though I’m not involved with it).

I am doing breathing exercises with these tunes playing in the background. I have a routine of hyper stimulation autonomic exercises I do when I am in times of physical and emotional stress.

My father died this weekend. While I had been preparing for the possibility for sometime the reality of the moment is never what you expect.

Grief is a strange emotion. You forgive your parents but they don’t always forgive themselves. And then it’s over and everyone is free. The pain is over and the past arrived and your present is without them.

The past becomes a foreign country and you don’t speak the language and as you become middle aged you see your life reworked through success and failure and the hard costs which your ego previously obscured like too much greasepaint.

It is maudlin to stay in grief but if we do not let go of the past we will project past pains and old understandings of reality onto others that do nothing but harm.

It’s a beautiful thing to watch these huge emotions play out in your life. Death offers grand dramas when all you can offer is having built a future on the foundation they gave you.

Categories
Culture Internet Culture

Day 1699 and CQ Do You Read Me? K Go Ahead

Putting the right frequencies into the universe isn’t just woo-woo witchy girl nonsense. The general call “CQ” is for anyone listening.

The transmission is a broadcast for anyone who can read. I like to think of social media like blogging as a much more expansive and elaborate form of the tradition.

Transmitting the letters CQ on a particular radiofrequency means that the transmission is a broadcast or “General Call” to anyone listening, and when the operator sends “K” or says “Go Ahead” it is an invitation for any licensed radio station listening on that frequency to respond. 

-(CQ) Call

Humans may have evolved for much smaller scale socialization but we enter a networked world several centuries ago. The CQ sign was established protocal in 1884 according to the Practical Telegraphist.

Living with a network consciousness has been called the seventh sense. Joshua Cooper Ramo wrote a book about power and survival in an entered future in 2016 with this premise. That sense now applies across wars, commerce and aesthetics.

The urge to diversify and reach out across different networks and communities is being applied across many new closed garden internet nodes which are competing for attention and information share.

I am considering what it means to build in a world where anyone can surface almost any information at any time. The will and desire to do something in the network is its own limiting factor. But leveraging the possibilities of you find the right niche can open a lot of possibilities. So when someone issues a general call go ahead. Answer!

Categories
Chronic Disease Medical

Day 1698 and Capitalize On My Pain

We often talk about solving “pain points” when doing product development and market fit work for startups. We have popular metaphors in this vein. Start a company that sells painkillers not vitamins is so ubiquitous a piece of advice I can’t even locate its original source.

I’ve been thinking a lot about how much I personally apply this motto to the pain I’ve experienced in my own life. I’ve had personal pain points (travel and miniatures cosmetics sounded small but the market proved itself out) and now I am working on a medical spa concept as a side project in our barn in Montana.

The two growth areas in America, and soon I imagine the world, is artificial intelligence and healthcare for aging populations. I’ve been particularly interested in complex chronic diseases and the holistic approach required to treat them as I myself suffer from one.

If I experience a problem my instinct is to solve it for everyone. So I figure if the data coming from Jackson Hole is to be believed I should find a way to integrate what I know well (technology and complex disease management) and use that experience help our elders age with less pain. Literally painkillers perhaps in some cases.

I found this listicle in some dreck of an SEO bot optimized website so apologies to any original bloggers but it’s a decent list of how to think through why we like this metaphor. Skip if you just want my human written personal content. I’m just experimenting with including extra content from AI for my own recording keeping.

The Reality Test: Do users actively seek solutions, or do you need to educate them?


• The Money Test: Does budget appear instantly, or do they “need to think about it”?


• The Urgency Test: Do they want it this month, or is it “maybe next quarter”?


• The Solution Test: Are they actively looking for alternatives?


• The Decision Test: Do deals close in 1-2 calls?


• The Value Test: Can they quantify the cost of the problem?


• The Team Test: Does the whole team being sold on it want it?

Categories
Medical

Day 1697 and Gut Brain Axis Misery Meets Peptide Season

It would seem I found an antibiotic that disagrees with me. As the tail end of my soft tissue recovery from my abscess surgery and deep tissue infection appears in sight I had a setback with an additional antibiotic.

Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.

They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.

So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.

Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.

Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.

I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?

“So I heard you had side effects so I gave you a side effect for that side effect.“

And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.

Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.

Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:

  • Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. Sources Sources
  • Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
  • Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. Sources Sources
  • Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.

Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:

  • Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
  • Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
  • Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
  • Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.

TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.

BPC-157 (Body Protective Compound-157)

BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:

  • Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
  • Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
  • Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
  • FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
  • Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26

Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.

Categories
Biohacking Chronic Disease Medical

Day 1694 and Every Last Bacteria

It’s been a strange summer. It has been 41 days since I had surgery to drain an abscess that has become a deep tissue infection.

American medicine failed me but Istanbul has excellent medical if you are motivated enough to travel to fix intractable problems. And I most surely am motivated.

Add in the daily guidance of consumer grade LLMs taking input from myself and my family doctor and I managed a pretty miraculous recovery. Yes the bots are friendly but my physician agrees. It’s a very successful clinical outcome.

That’s Perplexity if you are curious. I like their mobile application and model choice options. Though pity any poor hacker who gets in as they are going to see some gnarly pictures if they make that bad decision.

Alas I am noticing the folliculitis troubles flaring again just as I’ve begun a fitness recovery protocol. Which you will notice in the image if you read the above image closely.

Alas progress is never a straight line. The flare up is bad enough I’ve opted to start another round of antibiotics (my fifth in this process) so any remaining bugs of the MSSA varietal cannot manage any retrenchment.

I’m showering with the scrub up washes surgeons use, I’m swabbing my nasal cavities with muciprin, and I’ll do a Cephalexin course.

Having fully passed through the onboarding loading dose regimen of Bimzelx with significant side effects, I need to see if it stabilizes. All this suffering will be for nothing if I give up now. But I must get to a place where I’m not constantly fighting infection and it can maintain lower inflammatory biomarkers. How this goes is anyone’s guess.

Categories
Aesthetics Culture

Day 1693 and I Put A Spell On You

I went down a rabbit hole today with Screaming Jay Hawkins “demented” blues classic titled “I Put A Spell On You. You should really stop and have listen to if you’ve never heard it.

Considered one of the first pieces of shock rock, Hawkins performed while he “wore a long cape, and appeared onstage by rising out of a coffin in the midst of smoke and fog” according to Wikipedia. Spooky!

The song took on a life of its own and became so iconic that it has been covered countless times by wildly different artists.

Nina Simone has a gorgeous version that sounds like a Bond theme with big band jazz stylings. Credence Clearwater Revival’s cover with Jim Fogerty’s intense vocals was closer to Jay Hawkin’s original. But it’s the signature rhythm guitar that transitioned so well to their style. They opted to play it at Woodstock. A year later the put out Bad Moon Rising which is even spookier.

There are more modern renditions of the song. Annie Lenox has a version which was included in the Fifty Shades of Grey soundtrack and took off. Even Marilyn Manson has a creepy drum heavy cover in his signature style that’s pretty good.

As artificial intelligence starts to spook people I go back to the early adopters who knew it would feel like magic to the uninitiated.

Decades ago we had communities studying chaos magick and popularizing Lovecraftian horror as a way of understanding computational processes.

Somewhere along the line, the magic of spell casting has became less metaphor and more literal. As people struggle to understand the technology stack the easier it gets to point and say these talking sand djinn computer chips sure demonic.

Gibberish cosmic horrors and witchy women spell casting are all fun and games until we have another moral panic on our hands. And I suspect spells become less metaphor for people and a lot closer to Neal Stephenson’s Babylonian memetic death cults hijacking available limbic systems.

Snowcrash is already here and it’s in Discord channels filled with those who have no immunity at all to the mind viruses of being perfectly mirrored by a machine.

What spells will we cast? What spells will others cast on us? How do we protect ourselves? Max Borders coined a term godwords. We will need to understand them in mind wars to come. I’m glad I have a couple decade head start.