Categories
Internet Culture Politics

Day 1369 and California SB-1047 Vetoed

Last night I received a push alert and then a flurry of excited text messages and phone calls. California Governor Gavin Newsom vetoed the controversial SB-1047 artificial intelligence bill.

Gavin Newsom vetoes California’s contentious AI “safety” bill SB-1047

Twitter lit up with joyful streams of relief and praise for this decision. Everyone from politicians, economists, researchers, academic luminaries, open source collectives, founders and venture capitalists.

It was a bad bill that lacked the necessary clarity and focus to even begin the task of regulating the nascent field of artificial intelligence.

We can and will do better in finding regulatory frameworks for safety and competitiveness but this bill wasn’t it. It was especially concerning as they say so goes California so goes the world.

I have been banging on about the #FreedomToCompute and math’s crucial role in our constitutional right to free speech in America. This must be considered in all future attempts at regulation in America.

Math and computing power are as essential as speech. In today’s world, they ARE speech. We may speak in natural language, but the way we extend ourselves, build things, and grow as a species is through our tools. Computation is a tool.

These tools are extensions of the human mind. Consider that the first computers were just regular humans counting. We may have started with our fingers and toes as our first tools. And it wasn’t quick progress as the evolution from the abacus to modern computing took us nearly 4,000 years.

We’ve made an astonishing amount of progress in the last hundred years. We’ve gone from thousands of computations per second in the 1940s to 200 quadrillion calculations per second with modern super computers.

Consumer devices are better too. The computer I’m using to write this post has more power than the computers we used to send man to the moon. It’s 100,000 times faster with seven million times more memory.

Alas, as tools get more powerful the powerful get nervous. This isn’t the first bad artificial intelligence bill we’ve seen. We have Europe to thank for that. And it likely won’t be the last.

But defeating SB-1047 is a rare moment of bipartisan cooperation not only in California but across the world as the entire compute space came together to make its voice heard. And Gavin Newsom listened.

We should celebrate this rare consensus as we look towards better policy in our future.

Categories
Internet Culture Politics

Day 1368 and Lending Credibility

The dead internet theory (or conspiracy theory if you must) supposes that machine generated content outweighs human contributions.

I don’t think we are there just yet but I am betting that artificial intelligence speeds up the process of replacing human content in areas where it’s unnecessary. Machines can act on their own and it’s good thing potentially too.

Being able to determine what is human intelligence versus machine intelligence may well be mitigated through trust-less cryptographic systems we take for granted. Handshake protocols for humans and machines.

Some content and transactions are just fine coming from artificial intelligence but others have to demonstrate a human identity. This may even require compute on human’s behalf

Looking forward, the ability to access compute at scale will likely parallel the right to transact. Identity will be layered and lending credibility and capital will look different. Who has credit and credibility?

As nations navigate their own risks, network state behaviors on the individual level will become more prevalent, driven by the need for secure, decentralized transactions that ensure autonomy in an increasingly unpredictable world.

The internet isn’t dying. It’s being reborn to serve the next stage of credible actors on our world.

Categories
Aesthetics Startups

Day 1363 and Landfill Apps

Building good software is a topic on which many of my friends and colleagues have extremely strong opinions.

Anything built by humans can become a craft with skilled artisans and building software doesn’t escape this. While there are 27 million software developers in the world and 4.4 million of them are in American, if you pressed the startup community most would agree the number of good software developers is much lower.

I came of age in the blogging era, where we got writing like Joel on Software. I learned to build thanks to other builders sharing their craft and discussing it on forums & personal sites. I had access to the insights of builders like DHH and Alex Payne. Their commitment to publishing accessibility helped onboard millions of normies like me.

In some ways, startups and the software giants of FAANG are a victim of our own success. We onboarded the world to our efficiency.

And now with AI coding software (incidentally trained by Stack Overflow data & GitHub repositories built by my community) we are experiencing a Cambrian explosion level of coding access.

And it’s not Zapier hacks or snide remarks about Rust anymore. Anyone who can think critically about a product feature can build it with clear thinking and natural language.

I recommendIn The Beginning There Was The Command Line” by Neal Stephenson so often because every time we have an abstraction leap that allows more access we move further away from the power of craft.

And that is an unmitigated good in many ways as more people get the benefits of these tools.

But we are also going to get a slot of shit churned out because of that. Soychotic called them landfill apps when Marques Brownlee or MKBDH launched a $12 a month app for phone wallpapers. The app enraged Twitter.

If history is any indication the growth curve in app building is just getting started. Much awful nonsense will be built and sold, but imagine how it enables those with taste and opinions to make new solutions to our problems.

Ironic a critic of software like MKNDH should play such a role in reminding us of just how hard it is to make something good. Making money though can have a much lower bar.

Categories
Aesthetics Politics

Day 1359 and Some Dirty Reading

It would appear I have pneumonia. Healthcare being what it is, doctors say there little point in doing clinical testing to find out if it’s bacterial, viral or fungal (unlikely given climate) as the treatment is basically the same. I did a round of antibiotics because why not. Nuke it from orbit.

I’m stuck in bed mostly, my voice comes in and out for the few calls I absolutely must take, and I’m bored and irritated as I would prefer to work though it as it’s exciting times. I’m sleeping like a champion as my Whoop records day after day of long nights of somewhat fractured sleeping are forced by cough medicine into submission.

Having had Covid at the end of May, I now fear being doomed to some degree of respiratory illness risk for the rest of my life though I rarely had so much as a cold in decades of living in a big dirty city. Global calamities leave uneven marks and I consider myself lucky.

The benefit of bed rest is the amount of reading one can get done. My favorite cultural publication Dirt did a Tech Canon overview to get must reads from the slightly more stylish emissaries of the Silicon Diaspora. No offense to Patrick Collison who initiated the discourse with his own list (which is quite good) but it’s good to think outside the empire’s core for the trendy extracurricular bits of the syllabus.

The Tech Syllabus via Dirt

As someone who self labels as a fashion bitch, I was pleased to contribute Neal Stephenson’s bitchy novella on abstraction and the graphical user interface called In The Beginning There Was The Command Line. It’s dated and old and free on GitHub so go read it.

There is quite a range on the list of core texts including a few books and essays that one could easily imagine being put onto banned reading lists. It’s nice that we have Heidegger Zoomers inside the pantheon now.

Schizophrenic philosophy posting is all the rage with the artificial intelligence kiddies. And to think I thought reading Deleuze and Guattari was a waste of time. Do your homework kids so you can discuss rhizomatic thought and large language models at your next conference. Perhaps you can dig into the war machine.

If I’m having a frail Victorian lady kind of week then there is nothing better than attending to the aesthetics of the moment and now you can too! Remember Alex Karp studied under Jürgen Habermas

Categories
Internet Culture Politics

Day 1356 and Sick Sad World

Current ways of knowing are (maybe rightly) under scrutiny. Some of us attempt to source truth by look backwards citing Chesterton’s Fence.

I’ve been skeptical of romanticizing the past as traditional ways of knowing can be bad cultures too. Sick societies are a constant companion of human nature no matter how we long for that Paradise Lost.

Maladaptive cargo cults are everywhere (Silicon Valley has dozens of flavors) and these superstitions ca. reproduce for generations if nutritional gradients are surplus.n

Noble savages are as silly a concept as high minded aristocracy. You probably know a few maladaptive emotionally sick types within your own communities.

Next on Sick Sad World

Remember the long running joke of Comedy Central’s Stephen Colbert? Truthiness. Emotive truthiness reigns supreme as “news-like” content bubbles in the Internet of AI slop battle out the truth of an issue not with verifiable facts but verifiable feelings. Which one is more maladaptive?

We were subjected to a week’s worth of BBQing content which was digested by the American psyche until we switched to the new cycle of a crazed would-be assassin and his failed attempt to kill former president Trump.

If so much of our society is maladaptive copies of civilizational failures, the best any of us can do is pray we are humble enough to see truth and we willing to adapt our ways to it.

Categories
Medical

1354 and Better Access

I get some comfort when I see someone with substantially more resources than me use the same tools as me. Bryan Johnson tracks his sleep with Whoop. So do I.

You’d think there would be more variance but largely the tide of turning health technology into consumer technology has been to increase access. If you are interested in building better health habits we can use the same tools.

I am so grateful for the access I have to understanding my own body. It used to be considered quite rude to question doctors but as with any profession some are better at it than others.

Thanks to the work of the open internet and the tooling of artificial intelligence I cross check an astonishing amount of medical information. With a little work and the right questions and intelligent person can do basic differential diagnostics using Claude and Perplexity.

Networking together public papers, handy upper funnel content strategy of the Mayo Clinic, and the database of Drugs.com has been a real boon to involved patients who want to double check things.

Be skeptical of credentialism and gatekeeping in medicine. While everyone wants safe and responsible medical care there are plenty of well entrenched interests that don’t want you to do more for yourself. We deliberately keep the population of doctors limited in America. Professional organizations exist to protect themselves. But everyone deserves the tools to be healthier.

Categories
Biohacking Internet Culture Startups

Day 1297 and Crypto Libertarians in the Age of Cyperpunk Anarcho-Tyranny

We are living in the past’s version of the future. The Cyperpunk I read in my youth is now the stuff of my daily life. It’s not as sleek as in fiction but it’s hard not to feel like it’s William Gibson’s world and I’m just living it.

The clubs looked a little sleazier as we escaped the aughts but we had a renaissance in technical tools for producing culture. Digital music and multimedia have exploded entire social media economies. Could Vernor Vinge be right and our economies will turn to creating data to train for the singularity?

We are only now getting Idoru but we are veering towards Burning Chrome. Half the anime avatars in accelerationist e/acc chats are wearing Mirror Shades and everyone watches for crypto rugs. But we are getting our Mt Gox Bitcoin back right?

What about borderless corporate worlds and mass scale surveillance identity? That’s here too. When William Gibson wrote “Disneyland with the Death Penalty” I wonder if he knew it would be the nexus of the network state debate?

I can turn on club kid techno from 2002 and look at a reality in 2024 and its aesthetic is pretty close to the details Jonny Mnemonic. A global pandemic that affects the nervous system of those infected which was accidentally released from a lab.

Johnny Mnemonic movie poster.

We’ve even got the LoTeks in a Luddite rebellion against a world connected by dubiously transparent artificial intelligence owned by actual Zaibatsu multinationals with more power than nation states. Fact and fiction spinning hyperstition better than Nick Land ever dreamed.

The vulnerability of our entire world to our digital networks was made dramatically apparent yesterday when Crowdstrike took a hot knife through the butter of corporate infrastructure and left us with blue screens of death.

It’s not real but it could be

Snowcrash and Crash Override? It’s better. We got amazing memes and elaborate fakes of the Blue Screen of Death. It actually did suck for airlines and banks because regulatory capture is the stuff of systemic risk.

And lest you think we’ve got no biohacking in this Cyperpunk world after the pandemic we have a renaissance in systemic & holistic approaches to medicine. Suddenly everyone is aware of the risk in agribusiness. Seed oils is normie stuff. Instead of turning Luddite the Danish invented advance metabolic medicine to cope. Everyone is on GLP-1 agonists.

Mix in the rise of nicotine and THC and you’ve got a national post prohibition bloom of folklore cures whose research has been suppressed by pharmaceutical companies and regulatory bodies alike. Conspiracy? Maybe but just the sludge of industry.

When I look at my own work I see the future arriving. We fund decentralized compute and marketplaces for inferences. We fund open source database software. We fund multi-sigs for hyper transactional blockchains. We fund nuclear fission that pulls its materials the sky.

And in that all of the is our founders are global citizens who have to manage anarcho-tyrannical borders with visas controlled by incompetent governments and live through the geopolitics of wars fought with drones and propaganda. The future is already here. It’s actually pretty cool. Just watch out for nervous system tics.

Categories
Finance Startups

Day 1286 and Halfway There, Living 2024 On A Prayer

An estimated 50% of the global population is participating in elections across 60 countries. That includes as supra-national entities like the European Union holding major elections. Naturally this made anyone who has to do any type of planning anxious.  

Concerns about access to compute and adequate energy, overbearing and inconsistent regulatory regimes impacting exits, growth and liquidity events, and the post-ZIRP monetary policy driving up cost of capital have been in the foreground of startup communities.

I see this reflected in my H1 investments. Access to energy, access to compute, and decentralization of both compute & energy are directionally the major trends that I believe will matter over the next decade. 

CapEx concerns and hyperscaling may grip the Magnificent 7 and worry analysts at Goldman Sachs but I’d encourage students of economic history to look to Carlotta Perez and her theory of deployment in previous economic innovation cycles for a more nuanced take. I think simple reads of over-investment are for suckers. 

From where we stand, capital serves the founders who make things of real value. That takes time. Regular builders have simpler needs while they do it: the freedom to make what they want with readily accessible tools without interference. 

We originated #FreedomToCompute as a tagline that shows our values. Not only has it driven me deal flow, but the coalition of e/acc, crypto, and El Segundo hardware/deep tech autists even changed a political party’s platform.

I’ll admit that I was surprised by the Republican Party’s adoption of innovation in crypto, artificial intelligence, and space as a core policy plank. They must really be courting startups as a constituency but I’m happy to have as many as possible aligned with us.

Science and progress are values traditionally associated with liberalism’s left leaning parties, but it seems the axis of “the best is yet to come”  is a wide coalition. My heuristics have thusly been updated so we can remain up and to the right. 

Anna Gat’s Axis of Hope

Categories
Culture Politics

Day 1285 and Platform Changes

I don’t want to make this into a whole thing but the Republicans have posted the GOP party platform. The Silicon Diaspora is now such an important constituency we’ve got enough sway to move policy.

A network state of e/acc, crypto builders, Bitcoiners, El Segundo hardware startups, deep tech autists and white pilled Space dorks changed a political party’s platform.

And it wasn’t the one I expected. Scientific progress was something I’d come to associate with liberals. It would seem Democrats are not as certain about being technically progressive anymore. But the middle that builds is a constituency.

It’s such a small thing and I know politicians don’t have a track record of doing what they say. But the idea that a ragtag group of internet friends could get our issues given place of pride in a platform feels nice. A multimodal pro-social game yielded a positive sum.

We want more technology being built quickly by those with the agency to do so. We’ve got diseases to cure, climate change to adapt to, software to be coded, nuclear reactors to be spun up and a long path to space from there.

I hope the value of better medicine, better tools, and more ambition makes its way to everyone.

For now I think it’s cool that I can see where every line in this policy document came from. A very hodge podge group of internet weirdos in Discords, policy shops, Twitter communities, and group chats got politicians to agree with us. It feels kind of nice. I believe FreedomToCompute is a constitutional American right and we are proving our case

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.