Categories
Biohacking Chronic Disease Medical

Day 1945 and Always Adjusting

I am adjusting, yet again, to a new set of daily protocols in my never-ending attempt to improve my health. I am experimenting with peptides but don’t tell anyone. I’ve also got a hormone experiment in its second round.

I am trying to get healthier, but that suggests it is even an achievable goal. It would be wonderful to get back to endless working hours or even just eight hours on my feet.

Every time I make a tweak to my routines and I see a change in my biometrics, it’s becomes eventually cause for concern. There’s no stable equilibrium to be found, and I know that’s part of life, but I’d like a stable equilibrium that’s a little bit better than one day at a time or ideally a couple weeks at a time.

Take my experiment with Bimzelx. Even when I achieve an outcome like getting my CRP rates into the normal bounds, it came at a cost that is simply too high to maintain. I had four separate incisions and surgeries last year from soft tissue infections.

What good is a drug that tamps down my immune system so much that I need to always go under the knife? It was like Goodhart’s Law came to haunt me personally.

I am going off the biologic (I am 12 weeks from my last injection) and already seeing change in the wrong direction. Not enormously bad but my immune system will pop if it’s not locked down.

Yet there’s very little I can do except keep going and hope that the balance will be more manageable, as I don’t know that I could have another year like 2025 again.

I set out trying to reboot my immune system last year, and it certainly seems like it worked. But can I keep the numbers in a place that are low enough to let me live, and ideally live with fewer medications?

I am constantly working against some new tweak or some new problem, and even little gentle experiments like a Pilates reformer workout or 10 minutes on the trampoline can turn into a full-day migraine if I am not immediately able to tamp it down. Thoracic pain will pop up crushing my breathing if I take a nice slow hike in the pastures beyond our house

Categories
Chronic Disease Medical

Day 1943 and Lubing Up My Synapses

I’ve struggled with migraines for the lasts seven years and change. It came along with my autoimmune diagnosis but has lived a separate life from ankylosing spondylitis and psoriatic arthritis.

Typically I get them in my luteal phase of my cycle but as I’ve began to experiment with hormones in pellet form (just tucked away in my fat) I’ve began to struggle with them on a more regular basis. It’s no longer tied to any phase of my hormonal cycle.

I don’t know what I did today to kick one off, but about an hour ago I had to lay down in the dark because I just cannot seem to get any relief from the pressure inside my head.

I have a prescription for something called Imitrex, which helps quite a bit, but I’d really prefer to not have them in the first place.

I am not sure I can get anything else out today, except that this is happening and I can’t fix it, so my apologies there.

Categories
Media Politics Startups

Day 1941 and Uneven Off The Bars

It’s been such a crazy week. I don’t “feel the AGI” only because I am mired in the give and take of living in America where we still have businesses to run and a lot of regular people committed to actual civics. Progress is fast but implementation is slow.

And then above our daily lives, we are actively in the middle of a kinetic war that our population is only dimly watching.

The information environment being irradiated by foreign propoganda. I am astonished to read regular blatant campaigns that no one questions. I get ads for Chinese phone companies on Twitter. Phones that are not legal to sale in America.

It doesn’t even need to be about any of the active campaigns in the news that a New York Times reader would pay attention to. Below the fold, regional political issues go uncovered. The impolite “nobody reads the Africa pages” is an indelicate joke for readers of international newspapers. Americans often don’t even get them delivered with their printings.

As an example. What does an American understand about Mali anyway? I’ve got like a half dozen friends who care about French colonialism (and the sins of Nicholas Sarkozy) so it’s a niche Francophone thing. The stuff you maybe picked up from those who lived abroad.

So no real tangible value there that isn’t social, but lots of Americans used to study with French families so you might be dimly exposed. Or in the past we had a class of people who were and had state department of think tank jobs.

You’d be shocked at how much we’ve cut back on education in the liberal arts. Just as America has her very own Sicilian expedition, we stop bothering to teach Thucydides. I’m in my Allen Bloom season but without any book tour.

I have been trying to keep my cool as a week of progress is just so fast in very real world situations. I am relishing the success of Valar Atomics as they continue own a fast pace of progress. We are going to need a lot more power to meet needs in America. I want to meet them cleanly so I am honestly wishing for a boom in nuclear beyond personal interest.

All the pissing and moaning about the ethics of artificial intelligence misses the point that we need to supply a lot more power for both consumer and defense needs before disaster could strike. So we might as well suit up. We have to manage what might happen with our physical reality. Like physics bro.

So this week was wild to watch the labs stand off with fast releases. It’s very herky jerky the progress from OpenAI but they had a big week. The enthusiasm around Codex is very real even as no one entirely trusts the even management. Still it was fun to have two new models from OpenAI in a week. It’s funny how running a big startup is still largely product management. And they struggle with it.

Which sounds cute I realize. That I am charmed by progress in energy and algorithms while we test being under a kind of network attack with a very naive and easily swayed online population.

I like to think Americans are independent but we are not doing as much as we could to enable good governance. Americans have a say and plenty understand “right to compute” just as they did the “right to repair” but some in government are actual hard power types. Did no one do any of the reading? I thought everyone was all about the Powerbroker for like a decade.

But we seem to have some real second order effect issues being missed entirely by the labs. Like maybe they are bad at politics? I know it’s a cheap shot but I spend so much of my private time as a citizen doing mop up after companies whose management is under stress.

And being transactional with people isn’t very effective for revealed preferences. You can’t buy people and Americans don’t like the implication it sends about being treated like you can.

Categories
Community Medical Startups

Day 1930 and Imperfect Options That Remain

Some days end up being so much more interesting than you expect. I awoke to a family member, who has been preparing for a set of major surgeries, saying they had in fact gone in that morning for the first round of procedures.

I had been concerned they were putting it off so I was quite relieved that their lack of communication on the topic was simply their preparation to face what will be a grueling health challenge. Preparing for a procedure well gives you the best chance at success.

Then I went about a normal work day having lobbed a question, or maybe a prayer, onto the network as the reality of human lives is that imperfect options are always what remains. Being clear eyed about the choices in our lives and how the weight of our past actions have set us on a path can be hard. But it is necessary.

And as I wrapped up my day I was the recipient of some good news. I can’t share anything but the shape of it. But a project that was an experimental approach to a space I care deeply about has bravely faced the whipping winds and looks like they will successfully come to a safe berth intact with all souls.

Which is not such an easy thing to do when you set out for uncharted territory. I am so very proud of what has been accomplished thus far.

All things in life are the fruits of imperfect options that remain. That we make the best use of them is our obligation not only to ourselves but to those to whom we have committed. I am grateful that today was a day where those hard choices were made.

Categories
Aesthetics Biohacking

Day 1929 and Lacking The Executive Function for Dysphoria

I am no spring chicken. That’s why we bought some spring chickens this weekend. I kid I kid. I do however have a forever 35 face. I come from a line of women who age well sure but I have very consistent habits.

I’m lucky to have an ageless look. My husband would say I have a forever 28 face as I somehow look better having crossed into my forties than I did when we met at 28. Meanwhile my husband has gone from boyish wonder with full head of hair to distinguished grey beard with a bald pate.

Now sure husbands are supposed to say nice things like “no honey you haven’t aged a day!” Except I really do seem to have benefited greatly from genetics and routine.

He may be right, not out of any urge to flatter me, but simply because some women do look better with a little age on them. I looked young with a rounded features right until I looked ageless somewhere in my late thirties.

Alex and I at 29 where you absolutely can spot my pre-retinol skin
Alex and I two weeks ago before touring the West Wing during our trip to D.C

I don’t look all that different when I compare and contrast between photos from then and now. I gained and lost as much weight as a Kardashian (more than once damn you prednisone and bless you semaglutide) but my face has somehow retained its plump without a maximalist approach without gaining wrinkles. I’ve lost the fine lines.

Yet the approaches are getting more and more maximalist by the year. The difference between a 2016 routine and 2026 routine is enough to warrant a fresh round of social panic and scolding complete with a Big Story from New York Magazine’s The Cut.

Now I myself have left comments on extreme routines for twenty somethings to convince them that it’s too early for Botox as you do want to keep tools in the box for when you need them.

I didn’t start Botox till forty and I’m grateful as I need much less now. I didn’t pull anything out either even when cut looks were all the rage. I’m glad for my rounded features now.

But I have added in more to my beauty routine as I age because I enjoy it. I found it humorous when a 31 year old pursing a doctorate in clinical psychology said out loud what I’ve darkly joked about with girlfriends for years. It’s really hard to be completely controlled.

For a year in my early 20s, I was also spending literally all of my money on a psycho 100-step skin-care process. Looking back, I didn’t have the executive functioning to be successfully anorexic, which is what I also wanted. But I did have the discipline to enjoy this complicated multistep ritual of the skin care. I found it satisfying.” New York Magazine

Now we can all joke and say she shouldn’t be in practice but I never felt I could pull off an eating disorder either even though I often wished I could. That eating disorders are dangerous enough to kill you isn’t the point. It’s being able to control your body enough that you can kill yourself that we desire.

I hated that no matter how much effort I put into diet and exercise I could never achieve the standards of waif like beauty put out in the heyday of Anna Wintour’s heroin chic era. Millennial beauty expectations were a bitch and I could never quite work up the control to hate myself. Sure I got really fit with a heck of a squat but I always had to watch every single macronutrient and instead of skinny I got lean.

And while I appreciate a good Molière joke about The Imaginary Invalid, weight was never the issue that got me in trouble. It was hormones that got me.

So I knew poor health with a healthy weight and I knew poor health with a lot of weight gained trying to fix the poor health.

I will never allow myself to get over the BMI band again to avoid the medical discrimination I faced when I gained weight while on prednisone.

Alas no my autoimmune condition was not mitigated even an iota by weight loss. I had it before I was fat. I got fat treating it. I still have it now that I’m at a healthy weight.

But the desire to maximize your looks and your health always intertwine with women. Increasingly it does for men too. Body dysmorphia respect neither sex nor gender. I doubt it will ever again.

Beauty is a skill set. And some of that skill set is now pharmaceutical in nature. And if we are honest, it’s been that way for a few decades. It’s just that everyone know about it now. The network age comes for us all.

Categories
Finance Preparedness

Day 1923 and Petroleum Dependency Consumer Packaged Goods Risk Dashboard

A chunk of preppers and preparedness enthusiasts are just shopaholics. Shopping is common response to anxiety and depression. Doing something that you can control in a world you can’t control has logic to it.

Now experts in disaster response will tell you that preparedness is as much about skills and community as it is about “stuff” but it’s a lot harder to learn a new skill and nurture community than it is to buy something.

So if you aren’t up for getting first responder certified or spending time in your local library I’ve got just the thing to sooth your anxieties about the current situation in the straight of Hormuz.

I vibe coded a dashboard of common household items with petroleum byproducts in them. It analyzes ingredients and wholesale pricing and assigns risk scores so you can make a shopping list of items most impacted by the ongoing supply chain crisis.

A screenshot of the dashboard I vibe coded today to soothe my anxiety about supply chain disruptions and get ahead of pricing hikes and potential shortages

From diapers to sunscreen, you’d be shocked at just how much our basic needs are downstream of petroleum byproducts. Now it’s just a silly little thing I used AI to put together, but petroleum dependency in consumer packaged is high.

From food products and personal care to drugs, you will find we that we rely on petrochemical feedstocks everywhere.

I’ll mess with it as I add in new data sources and get suggestions for categories I’ve missed. But I’d love for you to check it out even if I am not quite done improving upon the basic idea. You might learn something.

For instance, I didn’t know Kroger’s had a public pricing API till today so you live, you learn and then if you have a kid it’s time to buy Luvs. No really diapers are one of the most at risk products for shortages as the impacts of the war ripple out.

Even if the fighting ends today (as I write this a temporary two week cease fire has been agreed to), the damage to processing, production and manufacturing is already enormous.

Say you aren’t worried about price hikes but you are concerned with the environmental impact of your purchasing habits. I included alternatives in the dashboard if you’d like to make a switch.

Time to buy Aquaphor and Vaseline

The data is compiled from DOE, S&P Global, Investing.com, Packaging Insights, VCCI trade reports. A petroleum dependency score is assigned based on estimates of ingredient analysis.

The prices reflect wholesale market trends so you can be prepared to get ahead before retail prices go up. I’ve even included a bit of context on what aspects of the product are petroleum derived ingredients just for fun.

Below is a screenshot for food preservatives. A type of dependency many of us would like less of in our consumption. Maybe the dashboard helps you improve your diet with a little knowledge. Who knows! Isn’t vibe coding fun?

On another note, I remain amazed at what we can do with artificial intelligence and natural language input. This took me very little time thanks to Claude Code, Perplexity Pro and Cloudflare. If you haven’t explored the wide world of vibe coding now is definitely the time.

Categories
Politics

Day 1922 and Toilet Humor

I’d like to have something positive to say today about the Artemis II mission, going further than we have traveled into space than ever before but it’s much too hard to pay attention to expensive achievements by NASA when your pale blue dot seems set on imploding itself, fourth turning style. But I’m always here for a joke about how we can’t engineer a toilet for zero gravity.

All anyone in finance can talk about is the short seller research firm Citrini that sent analysts to the Strait of Hormuz, only to discover via the mysterious analyst 3 that actually plenty of shit is getting through as long as you pay a toll to the militants holding it hostage, which plenty of people who are desperate for oil are absolutely doing. I am SHOCKED well not shocked exactly.

Meanwhile the Easter Bunny stares into the middle distance as an old man threatens another gerontocracy with obliteration. Not to put too fine a point on it but everybody is going to suffer no matter how this turns out.

And we wonder why Zoomers are all reactionaries. Gee, their older millennial siblings couldn’t possibly have any experience in these matters, could they? Doesn’t matter. They aren’t going to ask us even if we have actually lived through this entire charade once before.

Incidentally has anyone checked in on Condoleezza Rice recently? Seems like she might have something valuable to add here.

Categories
Biohacking Emotional Work

Day 1920 and Walking The Dream Roads to Costco

Yesterday I was really struggling with pain. It was all I could do to scribble up an appreciation for my 18th anniversary using WordPress for my writing.

I am doing everything I can to biohack my way around a chronic autoimmune condition that interferes with my quality of life. My love for my life and work is strong.

Sometimes it is strong enough that I willingly try all kinds of therapies from oxygen to hormones. Now I am working through a hormonal treatment recovery (my 2nd attempt) as I believe it is working.

Of course, life happens constantly, which means juggling deep dark horrific pains while the business of war and the business of my own portfolio goes on.

I’ve not had good sleep this week between the excitement of huge wins and the terror of facing down another global crisis brought on my conflict.

You’d think I’d be used to it. Russian invaded Ukraine the week before I left to live in Frankfurt. I was living in Tallinn when 10/7 happened. I was also there when Estonian cables to Finland were cut. One of my best performing companies has had to work around three kinetic wars.

No wonder sleep can be elusive. Yesterday all dream roads carried me to horrors. I woke myself multiple times. You can literally see in my sleep tracking the spiking heart rate and my forced waking.

The positive side to this fitful pained sleep was being up early enough this morning to prepare for a Costco preparedness run and still arrived before their executive member hour was finished.

We rotated our basics like rice and beans. Tinned fish, chicken and other canned and stable shelf proteins are just part of preparing for a nightmare that we hope never comes. Preparedness is a civic obligation. Help yourself to take the strain off the system so we all make it.

It’s possible we are facing an industrial process cascade thanks to the war in Iran and I like us have supplies just in case. We can’t know what comes next but it’s good practice to check expiration dates and make sure you have everything from first aid kit supplies to soap. You’d be surprised at just how much processing fuel fuels the rest of the world’s production.

After all this, I was happy to get stumble into bed and take a long nap. I didn’t even wash the sunscreen off my face. I was running a deficit and wanted to have REM sleep where I wasn’t trapped in horror. Thankfully I got almost two hours of restorative sleep this afternoon and I am ready to go back to bed as soon as I can.

Categories
Culture

Day 1918 and Other Lives You Could Have Lived

I was talking with my mother today as I was organizing some logistics for her birthday. Don’t tell her that though as it’s a surprise. Just kidding she knows I’m up to something.

As we talked shared pictures from a recent work trip where she was able to visit our extended family. Her brother lives in Texas after a long military career. It got me thinking about the very different lives it’s possible to live even within one family.

My mother has siblings that she is not related to by blood that are nevertheless our family. Her mother was unable to stay with her father. She married a man I consider my grandfather and gained a large family in the process.

One of my cousins (not by blood but through love) had her children when she was still a teenager. We are roughly same age. She has nearly fully grown children while I will likely never have children. We had very different life trajectories.

She didn’t have an easy time when she was a young mother, but seems to be in a good place now. She is married to a kind man (not to her children’s father though they were married for a time), enjoys watching her son play varsity baseball and football, and lives near her parents. She earned a beautiful life the hard way.

My aunt and uncle are hard working, deeply kind and patriotic people. They supported their daughter every step of the way. Which in the late nineties and early aughts was harder than it looked for a conservative military family in Texas.

I feel lucky my mother got to have such a wonderful brother (and other amazing siblings). My grandmother was an incredible woman. She got remarried at time when single mothers had it even tougher than my cousin did.

I think of the lineage of my mother’s family and wonder which of us made the right choices, which one of us thinks we made the right choices, and how we feel about those choices in the grand scheme of things. Lots of my family believe I made all the right choices. And maybe they are right.

Both my mother and grandmother heavily encouraged my interest in academics and the sciences in particular as they both wanted to pursue scientific careers and were unable to do so. I know I am their pride and joy.

But as I think of my mother’s upcoming birthday I know she won’t get to see her grandchildren playing varsity sports under Friday night lights in Texas with her mother sitting beside her. Her mother, my grandmother, has passed.

There won’t be three grown generations to coincide together because that’s just not how it works any more. And I don’t believe she is disappointed. And I know my grandmother wasn’t either. They wanted this life for me.

And it’s a good life. But I am also glad that my cousin was able to have a good life too. If only it were easier to balance some of the choices. If they were choices at all.

Categories
Media Politics Preparedness

Day 1916 and Freaked Out Group Chats

I have made a little bit of a side hustle out of being at Cassandra. There was a lovely chunk of time in between Hurricane Sandy and the pandemic when people felt as if the weirdness was contained. It was quirky.

It was novel to know people who had decided to make changes in their just-in-time lives because of a climate catastrophe They had experienced it personally because it happened in New York so the media paid slightly more attention.

It lets media, and the readers of said media, indulge in the fantasy that they might actually change their lives by hearing a rational argument from someone like me. Look at tbis nice young woman didn’t have power after a hurricane in the center of civilization in lower Manhattan while Goldman Sachs glowed in the background, continuing to serve capital in the dark.

In fact I did have friends that had to go by foot to their offices while they went for weeks without electricity in other boroughs of Manhattan it was just particularly surreal to live near City Hall, have absolutely no power but still see the glowing lights of techno-capital operating in the aftermath of the crisis. My husband literally got buckets to remove water from the server room of his startup but the banks were fine.

I had a speech on entropy and chaos that was fairly compelling and turned out to be a very correct investment thesis. We might have to get used to more chaos in our lives because of geopolitical, climate and other instabilities that we could not entirely predict.

That meant getting out ahead of the major controllable factors we had at our disposal as individuals and as a nation. I actually meant it as did my husband as if it could happen in Manhattan imagine what it would look like elsewhere.

Having been a prepper before the pandemic gave a little bit of structure to the first months of the pandemic unfurling in which I had the tools to do a dry run and the experience. I got a lot wrong.

And you must remember we really did not know exactly how bad things would be. The things that actually turned out to be quite detrimental to the economy did not turn out to be the ones we thought. Much of the pain of the experience was self-inflicted. Sound familiar?

But we thought we knew more than we did about the situation we were going into. In reality, we had very little predictive capacity on that front because the last time we had had a pandemic of any novelty, the world wasn’t nearly so well connected.

We overcompensated for a lot in our fears and reactions. I suspect that is going to continue being the way we handle networked global crises of any sort.

The thing is, it’s getting harder and harder to pretend that the things that affect our global lives are not actually happening because people look the other way when their economic situation works well for them. It’s a bargain that democracies and authoritarian governments make.

So right now if you work in technology or finance, you’re in a bunch of group chats in which everyone is freaking out. Even though you could make good arguments that we’re the only ones that have a clear view of some of the contours of what we’re about to face it’s quite clear that our visibility is limited.

I don’t know a goddamn thing about Iran or how it’s going to react, but I know more than I ever thought I’d need to about energy markets because nobody in my line of work had much choice over the last three years if they wanted to be ahead of the computing demands we already struggled to meet.

Now this demand may be coming from America companies, but feeding it is a global phenomenon of investment. One that lets all of the worlds capital pile on into a country that has a few domestic issues.

We all saw changed coming the second we had a mass market, large-scale compute-intensive process that enabled artificial intelligence interface that users felt they could meaningful talk to at scale. There’s something amusing to me about that because in Star Trek’s goofiest movie, The Voyage Home, the chief engineer Scotty picks up a mouse and uses it as a speaker phone. Hello he says, “Computer, are you there, computer?” He then proceeds to type in a number of commands when he says, “Ah a keyboard. How quaint.”

I imagined we’d get to this phase of computing ourselves a little faster than we did, but it turns out that we have finally reached the point of knowing how to type in a lot of solutions that could give us steps and instructions to use tools to make transparent aluminum. I mean this metaphorically, not literally, as we actually do know how to make transparent aluminum.

Transparent aluminum is a polycrystalline transparent ceramic made from aluminum, oxygen, and nitrogen. It was developed independently and is commercially produced by Surmet Corporation. It’s sapphire and funnily enough we use it in bullet proof glass. Which I’m sure is a great business to be in these days.

So be as freaked out as you want in group chats because all kinds of weird shit is coming down the pipeline. If you work in finance or technology, you probably know that you’ve got about two weeks before some irrevocable decisions start cascading.

None of us have any idea what it looks like but you’re probably not as prepared as Elon Musk or Sam Altman. Nevertheless we’ll have to get through it.