Author: Julie

Categories
Finance Startups

Day 1376 and Q3 2024 Investor Update & Market Analysis for Chaotic Capital

Welcome to the Q3 2024 update for chaotic.capital LPs. I’m choosing to post a selection of our reporting publicly so prospective founders and LPs can see our thinking.

You may be invested in chaotic.capital because we invest in ideas that adapt humanity to our new chaotic era.

Enabling resilience in the face of unexpected & rapid change is our lodestar. It’s a simple heuristic that yields a complex thesis: that technology is a tool for increasing leverage. 

In addition to these investor letters, you can always visit jfredrickson.com, where I write every single day about whatever I’m thinking about. You are also welcome to DM me on Twitter @AlmostMedia or text me on Signal any time.

Q3 was another strong quarter for chaotic.capital. Our ability to identify and back founders early remains core to our success and we’re seeing it both with the inbound flow from founders (as seen in the two new deals we did this quarter) as well as the progress from our existing portfolio, with four new markups this quarter and substantial business progress on those and others.

The markets are increasingly focused on power and compute. What was once a contrarian focus on energy, infrastructure, crypto, and artificial intelligence has now become a core narrative among informed investors.

We believe the future of compute—particularly in relation to crypto and AI—will increasingly be viewed as a basic right, not a privilege, as these technologies scale to mass adoption. 

As governments grow more cautious about debt and monetary risk, individuals and organizations will turn to trustless systems to ensure secure transactions and autonomy.

This is why we focus our investments in the space on foundational layers that will power the next generation of applications.

With portfolio companies like Squads providing on-chain economy tooling, Kuzco reducing reliance on intermediaries while creating an open market, SFCompute pricing compute and creating spot markets, and Chroma becoming the go-to choice for open source vector databases, we see the intersection of crypto and AI creating secure, scalable systems for individuals and organizations alike.

Access to compute is quickly becoming synonymous with freedom of speech and, ultimately, the freedom to transact. 

These open trustless systems enable efficient transactions and verification, a crucial development as geopolitical multipolarity continues to rise, and more people need to ensure their interactions are secure without reliance on the state.

While Americans might not yet fully appreciate this, we’re seeing growing demand for these alternative systems and open models from those who are navigating increasing regulatory pressures and instability.

Europeans, whose governments are deploying strict limits on AI models are beginning to understand, those from countries facing geopolitical uncertainty (e.g., Israel, Ukraine), live it already, and those in countries with unreliable currencies and legal systems have been navigating anarcho-tyranny for decades.

But it can be precarious in the US as well, in California it was only the intervention of a veto from Gavin Newsom that prevented SB-1047 from restricting compute and hobbling the development of open source models.

Looking forward, this ability to access compute at scale may well parallel the right to transact. As nations confront their own risks, network state behaviors will become more prevalent, driven by the need for secure, decentralized systems that ensure autonomy in an increasingly unpredictable world.

We’re excited about the future of chaotic.capital and the opportunities ahead. As always, I’d love to talk about any of this with your discussions with you, so feel free to reach out. We’re just getting started, and there’s much more to come.

Categories
Biohacking Medical

Day 1375 and Titration

My joyful excitement over finally wearing a bathing suit I’d never worn? The peaceful swim in the salty sea ended in disaster within just a few days.

On Friday the allergic and autoimmune symptoms were so bad I took 5mg prednisone. On Saturday they were no better and I upped the dose by 2.5mg to 7.5mg. I moved forward my absurdly expensive biologic injection by a day. I haven’t been able to convince my health insurance to get them more frequently so it’s a risk.

I’m doing better today. My pain is abated to an almost unnoticeable level at a 2. That’s rare for me. And it makes me want to rush into as much work, chores and activity as possible just to enjoy it.

I’m typically working with a 5-6 level of pain on any given day but I can work (with medication) up to a 7 within reason. Past 8 I’m in bed and struggling.

The downside is of course that prednisone just sucks. It messes up your appetite. You balloon up almost instantly with side effects like moon face. And your body develops a dependency quite rapidly.

Titration off of steroids like prednisone require a steady and slow discipline so you don’t get “blow back” as it can make your symptoms even worse.

I’ll have titration for a few days ahead of me. But maybe I’ll get to enjoy the lack of pain. Already I’ve cleaned for an hour, done laundry, checked off a number of small “to do” list items and I am blessedly free of the exhaustion that comes from working with moderate to severe pain that is my normal daily experience.

I was sent a study in the journal Nature about a team who used CAR T therapies to achieve total remission in 3 patients. And I see hope on the horizon.

One woman and two men with severe autoimmune conditions have gone into remission after being treated with bioengineered and CRISPR-modified immune cells1. The three individuals from China are the first people with autoimmune disorders to be treated with engineered immune cells created from donor cells, rather than ones collected from their own bodies. Nature

Categories
Emotional Work

Day 1374 and Acting Anyway

The frustrating part of living with human limitations is that it doesn’t really matter to anyone but you and your family. Life goes on no matter what is going on in your body or personal context.

The constant barrage of anarcho-tyranny across the globe will build up reactive low trust feelings in anyone.

Harden your hearts and open your mind. Find the facts of your situation. The accommodations of your particular circumstances won’t matter if you can find a way to contribute by acting on the world. You need to bring something to the table even if it’s simple as a good attitude.

The current cultural battles of responsibility seem to hinge largely on who has responsibility and at what stage of abstraction and remove (our city, our regional government, our national state apparatus). We are caught in the same system as anyone else to some extent.

What are the ethical ways of being with each other? How do we show up with trust when so little is trustworthy. What do we owe each other knowing not all are good faith?

I think some of this is simple and no amount of effort or obfuscation gets over the fact that you must contribute some good to the whole. You must be high trust to get back high trust.

Humans are on the whole less transactional than we imagine in our fears. I’ve always found reason to be hopeful. You can act in the face of uncertainty. You can act in an awful world.

Categories
Medical

Day 1373 and Anaphylaxis Maybe

I don’t know what I did but I’m like 50% of the way towards an anaphylactic reaction. I was exposed to salt water, a sunscreen whose ingredients I didn’t vet as carefully as normal (foreign language) and a few environmental factors that could potentially have contributed.

I’d post a picture here but it’s not something I’d relish having a permanent home on the internet if you feel me. Imagine bee stung lips but not in the sexy cosmetics way. Then apply that level of red inflammatory tissue to my entire face, chest, arms and other delicate areas.

I sucked back 5mg of prednisone which I loathe but I’m in no position to be picky. I don’t have an epi-pen with me but my throat isn’t closing off so it’s probably overkill.

A cortisone shot would hit the spot though I’m sure. I also took 50mg of Benadryl. That’s why I’m posting so early in the day as it’s hard to say if this pharmaceutical combination will result in me having Trump on steroids energy or passing out from antihistamine energy

Categories
Emotional Work Politics

Day 1372 and Everything Is Happening

The last forty eight hours or so have just been nonstop for me. Of course, that’s been true for the last week, the last month, the last quarter, the last year and the last decade.

Check KnowYourMeme for the full history of /pol and happenings.

The “nothing ever happens” bros might simply have made different life choices as from where I stand everyday is packed with happening.

I’ll grant the meme having originated as a geopolitical joke means it’s a little contextually inappropriate to apply to individuals and their own lives.

But what if “nothing ever happens” is just another way of justifying one’s own lack of agency? “Nothing ever happens” is admitting you are comfortable with being an NPC in the great game of life. Even if you are sure you are a bit player of little consequence you can rewrite your own programming.

Maybe we can look to another 4chan /pol meme “It’s Happening” for inspiration. Believe in your own capacity to have agency even when it’s small.

It’s Happening

Maybe world changing systemic change is beyond reach for most of us. That’s ok. But we can have a lot more happening with a few changes. You can play your own games and decide on your own rewards. I have. And it’s all happening for me and mine.

Categories
Emotional Work Politics Reading

Day 1371 and Against The Tides

I don’t swim very much as an adult but I grew up in an era with mandatory swimming tests (even at university).

I was lucky enough to not only learn to swim in the Pacific Ocean but in Colorado I spent a lot of time in our many creek, rivers and lakes. Freshwater has its own appeal and I’ve seen the tides work on the Great Lakes. But little is as magical as the buoyancy of seawater.

I’ve struggled with not having swimming and the joys of warm weather and cool water with some of my autoimmune challenges. A bathing suit I’d never worn came to represent some of that loss.

But today I was able to take a swim. I put on a bathing suit and was able to casually swim with just enough force applied to steady myself in a comfortable place against the increasingly forceful tide coming in. I felt like I’d won even if it was just for thirty minutes. I enjoyed a nice healthful thing in between the chaos of a very busy moment.

I’m not much of a Fitzgerald fan and but the joy of finding the limitations in one’s life as you mature is the relatability of feeling the weight of a one’s years as you push against the tides.

So we beat on, boats against the current, borne back ceaselessly into the past

So many decisions cannot be undone and yet we steady ourselves against forces much bigger than we are. Pushing against some of the vastness of a sea while relaxing into its much bigger whole is quietly humbling

I feel good about pushing against the vastness but also not being so sure about my own place in much larger forces. It’s no wonder man yearns for the horizon.

I took a shower and immediately went back to work. But it was nice to be a human doing a human thing while all of this is going on around me. I held my own against the tides. And I intend to keep doing.

Categories
Emotional Work Politics

1370 and Ride or Die

Americans aren’t showing the loyalty we used to be known for these days. It’s embarrassing to see the big games we talk from politics to Wall Street. If it’s all big talk then of course the world laughs when we fail to be steadfast.

Maybe that’s why we have such a glorious oeuvre of “ride or die” art. From literature and cinema to Lana Del Ray we want people who commit even when the risks are unquestionably large and success isn’t assured.

That means a lot of hurt. And not caring who knows you’ve committed to a risky or even crazy caper. Lana waited for an alligator wrangler for fuck’s sake.

From her Blue Jeans lyrics it sure looks like she’s seen her share of bullshitters caught up in the game.

I stayed up waitin’, anticipatin’ and pacin’
But he was chasing paper
“Caught up in the game, ” that was the last I heard

And maybe that’s the point of America’s love of the ride or die. The risks are clear. But the reward for loyalty knows a deeper satisfaction than those who get caught up in the game. Don’t chase the paper and expect the game to care. Only people care. And we should all aspire to loyalty beyond reproach.

Categories
Internet Culture Politics

Day 1369 and California SB-1047 Vetoed

Last night I received a push alert and then a flurry of excited text messages and phone calls. California Governor Gavin Newsom vetoed the controversial SB-1047 artificial intelligence bill.

Gavin Newsom vetoes California’s contentious AI “safety” bill SB-1047

Twitter lit up with joyful streams of relief and praise for this decision. Everyone from politicians, economists, researchers, academic luminaries, open source collectives, founders and venture capitalists.

It was a bad bill that lacked the necessary clarity and focus to even begin the task of regulating the nascent field of artificial intelligence.

We can and will do better in finding regulatory frameworks for safety and competitiveness but this bill wasn’t it. It was especially concerning as they say so goes California so goes the world.

I have been banging on about the #FreedomToCompute and math’s crucial role in our constitutional right to free speech in America. This must be considered in all future attempts at regulation in America.

Math and computing power are as essential as speech. In today’s world, they ARE speech. We may speak in natural language, but the way we extend ourselves, build things, and grow as a species is through our tools. Computation is a tool.

These tools are extensions of the human mind. Consider that the first computers were just regular humans counting. We may have started with our fingers and toes as our first tools. And it wasn’t quick progress as the evolution from the abacus to modern computing took us nearly 4,000 years.

We’ve made an astonishing amount of progress in the last hundred years. We’ve gone from thousands of computations per second in the 1940s to 200 quadrillion calculations per second with modern super computers.

Consumer devices are better too. The computer I’m using to write this post has more power than the computers we used to send man to the moon. It’s 100,000 times faster with seven million times more memory.

Alas, as tools get more powerful the powerful get nervous. This isn’t the first bad artificial intelligence bill we’ve seen. We have Europe to thank for that. And it likely won’t be the last.

But defeating SB-1047 is a rare moment of bipartisan cooperation not only in California but across the world as the entire compute space came together to make its voice heard. And Gavin Newsom listened.

We should celebrate this rare consensus as we look towards better policy in our future.

Categories
Internet Culture Politics

Day 1368 and Lending Credibility

The dead internet theory (or conspiracy theory if you must) supposes that machine generated content outweighs human contributions.

I don’t think we are there just yet but I am betting that artificial intelligence speeds up the process of replacing human content in areas where it’s unnecessary. Machines can act on their own and it’s good thing potentially too.

Being able to determine what is human intelligence versus machine intelligence may well be mitigated through trust-less cryptographic systems we take for granted. Handshake protocols for humans and machines.

Some content and transactions are just fine coming from artificial intelligence but others have to demonstrate a human identity. This may even require compute on human’s behalf

Looking forward, the ability to access compute at scale will likely parallel the right to transact. Identity will be layered and lending credibility and capital will look different. Who has credit and credibility?

As nations navigate their own risks, network state behaviors on the individual level will become more prevalent, driven by the need for secure, decentralized transactions that ensure autonomy in an increasingly unpredictable world.

The internet isn’t dying. It’s being reborn to serve the next stage of credible actors on our world.

Categories
Biohacking Medical

Day 1367 and Proper Names

My mother always insisted pharmaceuticals and supplements be called ny their chemical composites rather than a company’s brand name for it. She believed medicine shouldn’t requiring marketing & branding.

Instead of Benadryl it was diphenhydramine. For a headache we used ibuprofen not Advil. Acetaminophen was the proper name not Tylenol.

She taught me what went into popular brand name medication like DayQuil and I learned the ratios of guaiphenesin to dextromethorphan. Always take the minimum viable dose she’d say. And if I only had a cough I didn’t a fever reducer.

America is lucky to have a thriving generic medicine market. If you are a Costco shopper you can buy thousands of tablets of every crucial over the counter medication at just a few cents per dose.

There is a new series from healthcare publisher Trade Offs about issues in generic medicine manufacturing. It’s well worth your time getting to know more about how we came to have generic medicine (the Hatch-Waxman Act) and where the weaknesses are in the business of supplying these crucial medicines.

Take the time to read more on the issues as it’s been forty years of struggle for access and safety and we are experiencing shortages and supply chain risk that is unprecedented.