Tag: AI

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine …

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

Categories
Community

Day 1273 and Context Window

The fracturing of the social web has made it harder to connect person to person.

The enjoyment of sharing a platform or a protocol with other humans is undermined as grifters and opportunists bang against artificial intelligence slop and algorithmic manipulation. It’s just not as fun to be online in that atmosphere.

I happen to like putting a little more of humanity out here on the edges of the great social media seas. I am not everyone’s cup of tea but at least you know what flavor I am.

Perhaps humans need longer context windows just as much as our artificial intelligence. I’ll allow Google’s Keyword blog on DeepMind’s longer context window to explain.

Context windows are important because they help AI models recall information during a session. Have you ever forgotten someone’s name in the middle of a conversation a few minutes after they’ve said it, or sprinted across a room to grab a notebook to jot down a phone number you were just given? Remembering things in the flow of a conversation can be tricky for AI models, too — you might have had an experience where a chatbot “forgot” information after a few turns. That’s where long context windows can help.

What is a long context window?

Part of my affection for “blogging” whether it’s on my own WordPress powered website or Twitter (remember when we called it a microblogging service?) is that it gives the chance to establish a large context window for me.

You can definitely make predictions about me based on what I’ve shared. If I am as complex as million token window (which is what Google’s Gemini can now handle) I would honestly be surprised. So go ahead and augment any conversations you have with me with the wider context of Julie. It’s my goal that it allows us to connect better.

Categories
Internet Culture Preparedness

Day 1261 and the Jackpot

Dedicated roamers of the internet are people who like to notice things. Cyperpunk aesthetics made it romantic to experience global abstractions even as the reality of the power of oligarch, state and corporation blended into murky dystopian reality.

I said recently on this photo that we’ve got to stop hyperstitioning William Gibson. We keep finding ourselves further into the future. Just look at these anonymous accounts (so you can enjoy being a participant in the propaganda) joking about a drone operator in Ukraine.

We have netrunners. They’re autistic Ukrainian drone operators and their ice baths are niccy rushes

It’s hard to remember that real people exist on the other side of the abstractions. And yet here we are about to be those real people facing history. And it does seem like the time for taking action is now.

Venkatash Rao wrote an essay “many shoes are dropping” that gave me the kind of frisson of living in future, but as Gibson famously says, a bit unevenly. Across all narrative and technical arcs and and inside geopolitical realities we are starting to see the change.

In this I can’t help but see Gibson’s Jackpot. The elements that Rao calls out are multiple significant elections (not the least of which is the final installment of Biden vs Trump), the capital and nation state power consensus he calls “after Westphalia” and the intertwined fates of artificial intelligence and crypto.

A lot can change in a world where every form of power is being tested. I’ve written about this Jackpot energy before.

The fictional “jackpot” described in the novels is an “androgenic, systemic, multiplex” cluster of environmental, medical and economic crises that begins to emerge in the present day and eventually reduces world population by 80 percent over the second half of the 21st century

The Jackpot Trilogy.

I myself think it a privilege to even be a bit player in this moment in time. That I can allocate resources in any way feels high leverage in a way I didn’t anticipate experiencing.

We are the adults in the room. It may not be mich but we have agency. I feel good about putting my focus on crypto, AI and nuclear energy. Like Rao I can tie together past thoughts across a wide corpus by writing here every day and make decisions based on what has emerged.

Categories
Startups

Day 1254 and Zipppp

I hadn’t expected to have a busy day. I’m really not enjoying having Covid. It’s an inconvenience and it sucks.

But suddenly I was getting all good news from all sides. A startup with a round. Another founder preparing to go out for an enviable raise with exceptional traction. An SPV for a round everyone wants in on. A colleague who had been thinking of taking action on a thesis is going to run an experiment. It’s just all very much my investments and my ecosystem thriving.

I felt like I was in William Gibson’s Jackpot. Incredible things are happening across so many industries and the world is an absolutely chaotic mess. It’s nothing but wars, gerontocracy and resource constraints out there. But here we are working.

Chaos pulls acceleration out of us because we must solve the problems in front of us. War and geopolitical turmoil and climate change require us to shoulder more.

We have real engineering challenges in compute, nuclear, decentralized systems, artificial intelligence and open source to solve to get to meaningful breakthroughs.

The problems are not easy. But our tools are getting better and the compounding effect of this renaissance in intelligence is that we might be able to build for bigger things.

Doomerism wants to focus on how bad things are. And I am the last person to disabuse you of a realistic model of what we are up against. I live off grid in Montana, I own crypto and I like my freedoms.

Humans are resourceful. Given ingenuity and incentive incredible talent has the will to say that I will take on this piece of the future for all of us.

It’s such a privilege to be woven into the ecosystem that is getting us through the Jackpot. And dare I say maybe the application of our ingenuity gets a better result and we can improve on Gibson.

The fictional “jackpot” described in the novels is an “androgenic, systemic, multiplex” cluster of environmental, medical and economic crises that begins to emerge in the present day and eventually reduces world population by 80 percent over the second half of the 21st century

The Jackpot Trilogy.

Maybe we can improve on these numbers. We’ve got the doomer version in our imaginations so now we can find a solution. Life, as Jeff Goldblum reminds us in Jurassic Park, finds a way.

Categories
Startups

Day 1246 and Slightly Disappointed

I am a bit tired so this could all be jet lag speaking but I’m feeling slightly disappointed. While I’ve found great inspiration in the work of my peers, I see the failures and venality too.

I am at Consensus and I’m unsure if I feel like we’ve got enough people building the future I want to see. I fear for the unraveling of the old powers and what the transition looks like. It seems like a lot of people will be voting for a convicted felon for commander in chief.

And yet there is hope. The conference coincides with the annual Coincenter dinner which is an industry wide non profit effort to work towards policy goals for decentralized computing like Bitcoin & Ethereum and the wider cryptocurrency.

Our mission is to defend the rights of individuals to build and use free and open cryptocurrency networks: the right to write and publish code – to read and to run it. The right to assemble into peer-to-peer networks. And the right to do all this privately.

Erik Vorhees delivered an incredible moving keynote address and I found myself with tears in my eyes as I considered the long history of fighting to become your own master. We separated church and state. We are fighting to separate money and state. I feel these philosophical lineages across my entire life.

And so I am slightly disappointed at this point. But I’ll try to sleep and it will pass.

Categories
Internet Culture Startups

Day 1245 and AI: Tool Versus Master

A bad workman blames his tools

Idiom

As we rapidly accelerate the power of our computing tools, machine learning has blossomed into the most heated topic in government policy, business strategy, and popular culture, as artificial intelligence begins to affect everyday life.

The focus on harms, and in particular singularity doomerism, has (ironically) pulled focus from the implications of the seminal “attention is all you need” paper.

Astonishing as it may seem at times, intelligence does not top out at “median human”, but can, and possibly will, go much further.

What a triumph this represents. We will all have access to tools that will enable our entire species to build. More intelligence applied to more problems means more solutions to very real human problems.

I am in Austin Texas for Consensus 2024. I’ll be participating a town hall to discuss how crypto’s mindset of open-source, decentralized computation might help us grapple with who builds, maintains, & owns AI tools.

Policymakers and Silicon Valley executives are both calling for regulation of artificial intelligence as fears grow over its potential harms. But others warn of entrenching a dominant, opaque, centralized Big Tech model and instead advocate for open-source code, decentralized computation and distributed data sourcing. Whom should policymakers listen to? What, if anything, can governments do to help this vital technology evolve in a pro-human way?

Thankfully, we aren’t starting from scratch in building a regulatory framework for artificial intelligence. Code has been treated as speech in Bernstein v. United States Department of State. It would seem like a reasonable precedent to consider algorithms speech as well.

And let us be clear, math and computing power are as essential as speech. In today’s world, they ARE speech. Humans may speak in natural language, but the way we extend ourselves, build things, and grow as a species is through our tools. Computation is a tool. To presume that these tools do harm is to make us bad workmen.

Now of course incumbent powers may try to keep the disruptive and democratizing power of these tools out of the hands of the populace “for their own safety”, but imagine if the first amendment had been frozen in time at the printing press and didn’t protect the internet? We cannot accept permanently lowered standards of fundamental rights.

The 90s era fight for strong encryption enabled a flourishing of digital businesses from finance to e-commerce. We must insist that the freedom to innovate remains the default for U.S. digital policy.

Ultimately, I agree with R Street’s Adam Thierer. He says “fear based narratives that prompt calls for preemptive regulation of computational processes and treat AI innovations ‘as guilty until proven innocent’ are no way to make good policy.”

America does not have a Federal Computer Commission for computing or the internet but instead relies on the wide variety of laws, regulations, and agencies that existed long before digital technologies came along.

R Street Comments on NTIA

If we are to regulate sensibly, let us treat artificial intelligence as we would any other tool and let us do so within the existing framework of our constitutional rights and their interpretations within past precedents.

Categories
Startups Travel

Day 1244 and Twenty Four Hours To Go

Discussing travel mishaps has become something of a national pastime for Americans.

Memorial Day Weekend is the official kick off to summer and I had the good fortune of doing a transcontinental flight. And by and large it went smoothly and enjoyably. It was a record breaking day for travel.

I was on a route I’d never done before flying Munich to Houston. I was on my way to my favorite crypto convention Consensus.

Despite the record breaking number of travelers, I had a pleasant United flight. The westward flights can be tricky for sleep as it’s not an overnight.

The logistics of this worked out as I slept 6 hours before a 4am wake up for the positioning flight and then on my flat lay got nearly a very decent four plus hours.

Munich to Houston is 10 hours & I slept well

My RHR was pretty high from the stress of flying but I was quite impressed that I got restorative sleep and REM. Those flat lays on Polaris really are worth it.

Once I landed in Houston I had a short layover where I was lucky enough to enjoy a sit down meal in the Polaris Lounge. I only wish I’d had more time to enjoy it but clearing customs, going back through security and rechecking luggage takes time.

United Polaris Lounge menu in Houston

After all this incredibly pleasant travel there has to be something right? I had a half mile walk to the E gates for my Austin flight. Americans don’t queue well so I arrived at the beginning of boarding. The entire plane boarded only for us to realize we had a serious mechanical issue.

We then deplaned and walked from the end of E gates to the very end of the C gates (about 22 minutes as the New Yorker walks and a mile and a half) to get to the new plane.

The crew was in danger of timing out while catering needed to do a supply for a down line flight. Someone’s executive decision worked in our favor as we got into the air without getting ice for whoever had the airplane next.

What is a two hour drive turned into a five hour ordeal but I made it in one piece and passed out much later than I intended after a full twenty four hours in transit.

Finally asleep at my hotel in Austin after a 4 hour mechanical failure & airplane change for a 30 minute fly time

If you are in Austin and interested in discussing the intersection of crypto and artificial intelligence I’d love to hear from you. I might need a bit more sleep first though.

A 10,000 step day is pretty good when most of it is sitting on airplanes.
Categories
Startups Travel

1241 and Catching My Breath

Next week I’ll be flying to Austin for what’s become an annual crypto pilgrimage to Consensus. I am excited as it’s like summer camp.

I’ll be participating in a few private sessions but I’ll be a speaker in public town hall forums as well. If you will be in Texas for the event (or are simply in the city) drop me a note on Twitter and perhaps we can overlap.

Given the intensity of the travel I have ahead of me I’m trying to take it easy today and tomorrow. I’ve been doing laundry and organizing myself.

I am not a hot weather person so I worry about events in hot climates in the summer. Heck, I worry about hot climates even in mild seasons. Last year I found myself struggling with Frankfurt in May so summer in Texas isn’t exactly my easy season.

Categories
Internet Culture Startups

Day 1239 and @ Consensus 2024 Next Week

I’ll be in Austin Texas next week for Consensus 2024. I’ve really enjoyed my last couple of years attending. The entire crypto industry gathers for it giving it a summer camp feel. Or as Coindesk says “10 years of decentralizing the future” which undersells their role in reporting the industry.

The conference coincided with the annual Coincenter dinner which is an industry wide non profit effort to work towards policy goals for decentralized computing like Bitcoin & Ethereum and the wider cryptocurrency.

Our mission is to defend the rights of individuals to build and use free and open cryptocurrency networks: the right to write and publish code – to read and to run it. The right to assemble into peer-to-peer networks. And the right to do all this privately.

In that vein, I’ll be discussing the intersection of artificial intelligence as the #FreedomToCompute at Consensus as this is THE issue for everyone who uses compute as a tool to solve problems.

It’s an opportunity to discuss the big public goals around the future of machine money and machine intelligence.

I’d argue this includes the entire software industry and by default anyone who is reading this post. Our most important rights will be decided by how we handle policy on these issues. Math is leverage.

One of the town halls I’ll be participating in at Consensus (a format I love to dig deep into topics) is about how artificial intelligence can be a tool for our efforts to decentralize and not end up as a master of big government or big tech.

Crypto has the basic problems facing artificial intelligence. Both spaces rely on open, available and trustless compute. Both are under intense scrutiny and face significant regulatory capture risks.

It’s never been a better time to get involved in these topics. We need open protocols and interoperability standards far more than we need fretting about safetyism and hysterics about science fiction.

Doom solves no problems but software does. We need safe harbors and policy sandboxes so we can continue to nurture algorithmic innovation for us all.

Categories
Culture

Day 1234 and Intelligence

I’m reasonably intelligent as far as humans go. I’m probably in the top quartile or so of reasoning, processing & other measures of cognition. Not being insecure about my intelligence, I feel perfectly comfortable admitting that I’m an idiot. I’m only human.

Humans just aren’t a terribly bright species. But we are a curious one. We’ve built tools that extend our capabilities significantly. And each new upgrade in our tools helps us achieve more with our meager intelligence. L

We can quibble over whether intelligence is different than achievement but analytical, creative and practical capabilities are things you want to cultivate. We want to cultivate in ourselves and ideally we will want to cultivate in the things we build.

Two men are on a bus on a mountainside side. An sad anxious looking man is staring at the rock face on dark side of the bus side with a thought bubble “the AI took my job” while a smiling happy man on the bright side overlooks scenic views with a thought bubble “the AI took my job.”

Sure we as a species have fought these advances but eventually the benefits of developing ways to pass on and improve intelligence outweighs other fears. Material progress is good.

If you afraid of intelligence greater than your own I realize I have no way to talk you out of that fear. I can argue impartially about the benefits that intelligence has brought us in the past but humans are feeling animals not reasoning animals. The best I can hope for is to coax you to consider the bright side of the bus. Imagine feeling awesome about an AI taking your job. Go ahead and see if your curiosity can consider it.