Author: Julie

Categories
Biohacking Medical

Day 1290 and Covid Experiment

I caught a case of Covid at the very end of May that took me down hard. I’d been struggling with “long” symptoms

So I tried an experiment. A pretty crazy one at that suggested by my osteopath and supervised by a doctor.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th

Day 1283 Nicotinic acetylcholine receptors (nAChRs)

The principle was pretty simple but not proven yet in clinical trials.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits

Please do go read the original post with lots of caveats as nicotine is an addictive substance and this is not something to try without consulting your doctor.

I was unable to do the full 7mg but cut the patches down to 3.5 to 5mg over the five days. The side effects included headaches for the first day or so and a persistent queasiness.

Within a day I was lifted out of my exhaustion (which you’d expect from something modestly stimulative even though it was a low slow release dose). By the end of the second day my persistent coughing lifted entirely. I’d been struggling with congestion and coughing after even modest exertion like a walk outside.

I was functional on the fourth and fifth day like I hadn’t been since I got Covid. You can see me go into the red on my first day (my HRV dropped significantly but my RHR was only up by a few BPM). I slowly felt better and saw better recoveries even while taking on a little bit more exertion. I pushed a little too hard and found myself back in the red on my last day.

My Whoop recovery and strain chart for the five days of experiment beginning on the 6th and ending on the 11th of July

I was really relieved to stop the patch by the end. The last day of treatment I had overextended myself so I was in the red and feeling it even as the nicotine pushed my system up. I wanted to rip it off and did eventually cave at the end of the day instead of doing it all night.

My symptoms seem to be at bay. I feel decent enough so days after wrapping even as I began menstruation this morning. I hate to report that it also improved my usually debilitating PMS which typically includes intense migraines.

I would do it again if I got Covid. I cannot imagine ever using a nicotine patch consistently. I didn’t not enjoy the extra push of energy except insofar as it got me out of the exhaustion of the illness. I feel like it would be too much if I were otherwise feeling healthy. I have no cravings or side effects after.

Honestly I’m still wrapping my head around how well this worked. A part of me is confused, indignant and angry that a substance I was taught to fear has therapeutic benefit. Updating your mental models around long held beliefs is an uncomfortable process. But it’s a heck of a lot better than long covid symptoms.

Categories
Aesthetics

Day 1289 and Gap Lounge Pant

My favorite item of clothing is a pair of cotton straight leg lounge pants from the Gap.

A light but body skimming 93% cotton to 7% elastane blend with a simple tie that never felt constrictive. It retailed for $29 and was sold under their “Love” which loosely merchandised with GapBody.

Gap Lounge Pant in Black

They were perfect. I bought two pairs every year and simply never worried about comfortable home wear. Which was a big deal as I had a few years of being quite sick so these pants were life savers.

Gap seems to have stopped selling them sometime in the past two or three years. The core product number is 539570 if you are curious. The last time I was able to buy any was November 2020 and I purchased four of them.

The holy grail of bought pants

If you click into the old product page you will see 1500 reviews. It was a popular item. People on Reddit are looking for them. Mutuals of mine gave them at friends gift events. Leigh was wearing them when she tweeted me that.

Leigh and her friends love them.

And so I’ve set off on a mission to find out why these very popular pants have stopped being made. I’d happily purchase the pattern from the Gap if I could find the vendor for the fabric. I’d put my own money into acquiring it from the brand if they aren’t interested in booting it back up. I want these pants back in my life. I even went so fair as to email the VP of Merchandising at Gap Inc today. Maybe I’ll get lucky and she emails me back.


I apologize for the intrusion but I thought perhaps as the leader of merchandising at Gap you may be the executive who can answer a strange question. 

What happened to the cotton Gap Lounge Pant? 

They were the best lounge pants on the market. I bought them for over a decade. And they are simply gone. The product number is 539570

I very much want to buy more of them as they are my daily wear and I will pay whatever it takes to get more.  And is there anything I can do to buy any remaining dead stock of it?
Can I help your team
make a case to to bring it back? Is it possible for me to acquire the pattern and fabric from the corporation so I can have them made myself? 

Categories
Aesthetics Culture

Day 1288 and Real Fake Girlbosses

All I wanted the first time I raised venture capital was to be able to make my business case. Once I’d done that I was sifted into into the wider cultural moment of girlbossism with everyone else in my cohort.

It quickly became the way to raise money because heaven forbid gender not be important. I was no Diane Green so I better get comfortable mugging for the cameras. I’d not so secretly hoped I’d be able to offload some of that lifestyle element to someone else. Someone more suitable.

At first I figured fine whatever it takes to get the money who cares embarrassing shit like becoming avatars for the zeitgeist doesn’t matter.

But now I think maybe it did. Every time a piece of social media goes viral with women messing around at the office I think what did we do? I’d envisioned that the difference between me in 2014 and the new younger, better, more ambitious versions of me 2024 to be, well, actually better?

Maybe they are. Media isn’t reality. But I had visions of women quietly running companies and venture funds competently and without concern for their gender. Surely in ten years more would have changed?

Instead we’ve got we’ve got the simulacra version of women like me filtered through Cosmopolitan features and glossy magazine spreads into TikTok dances for a company that makes pimple and acne treatments.

And it’s all grist for the mill. People want to blame feminism and gender studies. Pffft. Cute. It’s not gender studies or critical theory that got us here. For all the Baudrillard, Foucault and Judith Butler we all absorbed, the thing is just a representation of a reality that never existed.

Jean Baudrillard’s Simulacra and Simulation explores the concepts of simulacra, simulation, and hyperreality. Simulacra are copies or representations that become detached from their original reality, leading to a state where distinctions between reality and representation blur. Baudrillard identifies four stages of simulacra: the faithful copy, the perversion of reality, the absence of profound reality, and pure simulacrum, where the representation becomes reality itself

Perplexity’s Synopsis

If you want a crack in the timeline go decide what the Summer of 68 produced as a culture. Maybe they were just reactionaries. Maybe I’m just a reaction to them. These girls are a reaction to me.

If you want to be a cynic there is no shortage of commentary on how media showed us culture that didn’t serve us. Those Summer of 68 men turned into Yuppie midlife crisis dads who weren’t there for their children and wives. Feminism giving depressed stifled women a chance to not regret their choices. But the choices already exist.

Your cultural war mileage may vary. Now we have cowardly millenial man children and forever princess boss bitches and endless rounds of upset every time we see women in an office doing something silly.

You can rage at critical theory all you like but this just one elaborate morality play being accountable. And no one wants that. Real fake Girlbossism selling blemish cream.

Everyone deserves better than this. I deserved better than this. The horror of contortions required to simply pursue work means you must do what media and finance require of you to succeed. Go watch Margin Call and see if you think you’d fare better in making those choices.

Categories
Culture

Day 1287 and The Long Haul

Good things take time sounds like pablum.

Rome wasn’t built in a day”

Every time there is a boom cycle fools rush in. I don’t know why someone would expect that luck would be adequate to any large task. Luck is the default conditions to even get started.

Then you gotta get lucky a lot. Multiple times a year if you are aiming to lead any industry. And you have to keep doing it until one person who compounded so much effort and will that what looked like luck is simply habit and habit becomes process and process becomes results and results get sustained.

And yes decay sets in. And it gets harder. Every gain requires the energy that it requires. Leverage is often simply about being the one that makes it for the long haul. Maybe discretion is the better sort of valor but I’ve yet to meet a winner who was a coward.

Categories
Culture Politics

Day 1285 and Platform Changes

I don’t want to make this into a whole thing but the Republicans have posted the GOP party platform. The Silicon Diaspora is now such an important constituency we’ve got enough sway to move policy.

A network state of e/acc, crypto builders, Bitcoiners, El Segundo hardware startups, deep tech autists and white pilled Space dorks changed a political party’s platform.

And it wasn’t the one I expected. Scientific progress was something I’d come to associate with liberals. It would seem Democrats are not as certain about being technically progressive anymore. But the middle that builds is a constituency.

It’s such a small thing and I know politicians don’t have a track record of doing what they say. But the idea that a ragtag group of internet friends could get our issues given place of pride in a platform feels nice. A multimodal pro-social game yielded a positive sum.

We want more technology being built quickly by those with the agency to do so. We’ve got diseases to cure, climate change to adapt to, software to be coded, nuclear reactors to be spun up and a long path to space from there.

I hope the value of better medicine, better tools, and more ambition makes its way to everyone.

For now I think it’s cool that I can see where every line in this policy document came from. A very hodge podge group of internet weirdos in Discords, policy shops, Twitter communities, and group chats got politicians to agree with us. It feels kind of nice. I believe FreedomToCompute is a constitutional American right and we are proving our case

Categories
Biohacking

Day 1284 and The Average Person

I am in the middle of a “don’t try this at home” biohacking experiment in which I am using a low dose nicotine patch to treat my week seven Covid malingering. A quick overview of the method of action.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology.

nAChRs

I am doing alright with it. I was wary of keeping the patch on all night long (I am very sensitive to stimulants such that I won’t drink caffeine past 10am) so I removed it at about 5pm. That may have been a mistake.

Yesterday my Whoop recorded physiological stress. I wasn’t coughing, I had more capacity for exertion, and I felt generally less exhausted.

But I didn’t come down easily for sleep. I ended up taking a number of anti-inflammatory medications as well as an Ambien. My heart rate was stable but I felt “up” which I don’t care for at night.

And I did not wake up to good news. My HRV absolutely tanked. There are lots of confounding variables here in that I got good restorative sleep (medicine induced surely) but some strain has clearly been too much. 40% down isn’t a rousing endorsement.

I am also noticing a lot of chatter around addiction and whether or not it’s responsible to discuss these things. The fear that the average person is in fact prone so addiction and will have adverse affects. Which I’m sure is true. I don’t think normal people should take unnecessary risks and it’s good to have the minimum viable dose be none at all.

It’s wise to remember that I am not at all living in average circumstances nor do I have average medical conditions so I am not necessarily who you should be looking to for health advice. You should do the basics like eat more protein, lift heavy things, sleep an adequate amount, be in the sun and move around, and manage your baseline health metrics first.

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine …

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.

Categories
Community Media

Day 1281 and Independence Day

On day 915, which was last year’s 4th of July I wrote about the aspirational America as an idea. It involved blowing shit up. It seems like each Independence Day I find a way to praise Roland Emmerich’s fine science fiction film.

I haven’t watched it yet today but hopefully I’ll at least put on a few clips to enjoy fighter pilots, aliens, inspirational Presidential speeches and fireworks.

The backdrop of drama in the media about Joe Biden is in some ways an ideal way to recall the fractious American community. A continent held together not by ethnicity or religion but by entirely abstract ideals is going to constantly tested.

The theory of print capitalism posits that capital sprung from the solidarity of nationalism presented for the first time in mass media. The common cause of one’s countryman makes it easier to levy for taxes for conflict.

We are far beyond print in our media now. It’s almost cheap to call out media climate “totalizing” an it undersells the experience. Social media makes the experience of Americanness so fluid it ranges from aesthetic choice to the anarcho-tyranny of ailing power.

And yet we try to do better as the general temperament of the nations. America is a place where the founding mythos is that anyone from anywhere can become one of us.

The nationalism of belonging in America has nothing to do with meeting a check box of criteria. Though we are trying to make it more so with bureaucracy. The ideal is that free country sets the condition so anyone succeed. Liberty is a hard fought thing. You can celebrate it in a manner that’s pleasing here. Namely fireworks.

Happy 4th of July everyone. I’m as committed to the American project. The frontier is in our souls and we search it out together in freedom.

Categories
Chronic Disease

Day 1282 and Summertime Sadness

Montana has blessedly been free of excess heat and fire season doesn’t seem to have arrived. But it was a wet spring and I fear we have a long summer ahead of me. I live in one of the best possible places to spend a summer and I still find it challenging m.

I was looking back at pictures from this time last year and I was not in the best health. I’ve never been a summer person and I have to accept some aspect of its misery is likely to forever plague me.

Other people have season affect disorder in the winter. I guess my people are a winter people. I can’t wait for snow to return.

Maybe I’m not alone in finding summertime unbearable. Lana Del Ray croons through summer’s emotional ghosts. Crime gets worse when it’s hotter.

I’m sure my mood is affected by the lingering Covid (does it count as long when you feel shitty 7 weeks later?) as well as the general unease in American politics. I’ll do what I can to shake it. But I’ll never understand anyone’s affection the season.

Categories
Media Politics

Day 1280 and Campaign Season

I am very much beginning to wish I had not watched the presidential debates. I want to say it’s been amusing to watch the different flavors of panic, but it makes me feel a bit gross.

Schadenfreude feels like a cousin to envy. It’s a dirty vice you shouldn’t be swift to cultivate in yourself even if it’s a very human response. I’d prefer to cultivate what virtues I can embody even if imperfectly.

I don’t want to lose my head just because everyone else seems to be doing so but it’s hard not pay attention to the politics when it’s the 4th of July week. I know I can’t do anything about national politics so I continue locally and on issues where we can have clear impact like housing and regulatory reform.

It’s possible that having more hands on experience with on community boards and with local permitting made the more tangible aspects of “Yes In My Neighborhood” campaigns clear to me.

I would prefer to be active in my contributions and focus on solutions. Am I angry and afraid when I see national politics and grand geopolitical news? Of course. If I thought about it too much I’d remember that everyone involved is human just like me. Then I’d worry even more. So I’ll try to focus on moving what I can.