Categories
Biohacking Chronic Disease Medical

Day 1945 and Always Adjusting

I am adjusting, yet again, to a new set of daily protocols in my never-ending attempt to improve my health. I am experimenting with peptides but don’t tell anyone. I’ve also got a hormone experiment in its second round.

I am trying to get healthier, but that suggests it is even an achievable goal. It would be wonderful to get back to endless working hours or even just eight hours on my feet.

Every time I make a tweak to my routines and I see a change in my biometrics, it’s becomes eventually cause for concern. There’s no stable equilibrium to be found, and I know that’s part of life, but I’d like a stable equilibrium that’s a little bit better than one day at a time or ideally a couple weeks at a time.

Take my experiment with Bimzelx. Even when I achieve an outcome like getting my CRP rates into the normal bounds, it came at a cost that is simply too high to maintain. I had four separate incisions and surgeries last year from soft tissue infections.

What good is a drug that tamps down my immune system so much that I need to always go under the knife? It was like Goodhart’s Law came to haunt me personally.

I am going off the biologic (I am 12 weeks from my last injection) and already seeing change in the wrong direction. Not enormously bad but my immune system will pop if it’s not locked down.

Yet there’s very little I can do except keep going and hope that the balance will be more manageable, as I don’t know that I could have another year like 2025 again.

I set out trying to reboot my immune system last year, and it certainly seems like it worked. But can I keep the numbers in a place that are low enough to let me live, and ideally live with fewer medications?

I am constantly working against some new tweak or some new problem, and even little gentle experiments like a Pilates reformer workout or 10 minutes on the trampoline can turn into a full-day migraine if I am not immediately able to tamp it down. Thoracic pain will pop up crushing my breathing if I take a nice slow hike in the pastures beyond our house

Categories
Media Politics Startups

Day 1941 and Uneven Off The Bars

It’s been such a crazy week. I don’t “feel the AGI” only because I am mired in the give and take of living in America where we still have businesses to run and a lot of regular people committed to actual civics. Progress is fast but implementation is slow.

And then above our daily lives, we are actively in the middle of a kinetic war that our population is only dimly watching.

The information environment being irradiated by foreign propoganda. I am astonished to read regular blatant campaigns that no one questions. I get ads for Chinese phone companies on Twitter. Phones that are not legal to sale in America.

It doesn’t even need to be about any of the active campaigns in the news that a New York Times reader would pay attention to. Below the fold, regional political issues go uncovered. The impolite “nobody reads the Africa pages” is an indelicate joke for readers of international newspapers. Americans often don’t even get them delivered with their printings.

As an example. What does an American understand about Mali anyway? I’ve got like a half dozen friends who care about French colonialism (and the sins of Nicholas Sarkozy) so it’s a niche Francophone thing. The stuff you maybe picked up from those who lived abroad.

So no real tangible value there that isn’t social, but lots of Americans used to study with French families so you might be dimly exposed. Or in the past we had a class of people who were and had state department of think tank jobs.

You’d be shocked at how much we’ve cut back on education in the liberal arts. Just as America has her very own Sicilian expedition, we stop bothering to teach Thucydides. I’m in my Allen Bloom season but without any book tour.

I have been trying to keep my cool as a week of progress is just so fast in very real world situations. I am relishing the success of Valar Atomics as they continue own a fast pace of progress. We are going to need a lot more power to meet needs in America. I want to meet them cleanly so I am honestly wishing for a boom in nuclear beyond personal interest.

All the pissing and moaning about the ethics of artificial intelligence misses the point that we need to supply a lot more power for both consumer and defense needs before disaster could strike. So we might as well suit up. We have to manage what might happen with our physical reality. Like physics bro.

So this week was wild to watch the labs stand off with fast releases. It’s very herky jerky the progress from OpenAI but they had a big week. The enthusiasm around Codex is very real even as no one entirely trusts the even management. Still it was fun to have two new models from OpenAI in a week. It’s funny how running a big startup is still largely product management. And they struggle with it.

Which sounds cute I realize. That I am charmed by progress in energy and algorithms while we test being under a kind of network attack with a very naive and easily swayed online population.

I like to think Americans are independent but we are not doing as much as we could to enable good governance. Americans have a say and plenty understand “right to compute” just as they did the “right to repair” but some in government are actual hard power types. Did no one do any of the reading? I thought everyone was all about the Powerbroker for like a decade.

But we seem to have some real second order effect issues being missed entirely by the labs. Like maybe they are bad at politics? I know it’s a cheap shot but I spend so much of my private time as a citizen doing mop up after companies whose management is under stress.

And being transactional with people isn’t very effective for revealed preferences. You can’t buy people and Americans don’t like the implication it sends about being treated like you can.

Categories
Startups

Day 1936 and Life Inside The Jackpot or I Remain An Optimist

I did not expect to spend so much of my time on politics. Or maybe that’s the wrong word. I look being in voluntary service to American governance as my civic obligation. It can look like politics even when it’s mostly trying to be helpful to the running of our polity.

After 2016 I felt regular citizens like myself needed to recall Kennedy’s patriotic inaugural address from 1961. “Ask not what your country could do for you, but what you can do for your country.” America is a complicated place but we get a say in it. And I’d like to help people understand what I know so it might be useful in serving America in very strange times.

My mother loved Kennedy’s profiles in courage. Boomers have beautiful mythos on facing the new world together. He was the first president born in the 20th century. The social compact of America changed quite a bit then. I wonder who the first president born in the 21st century will be. Maybe it will be another young Catholic man.

The optics of progress aside, it was clear as a new generation in Kennedy’s era took on a new obligation to come together when the American experiment felt at risk. So much about who benefit from the military industrial complex rested in the transition from Eisenhower to Kennedy.

I think the context is a little different when progress feels inevitable. Our moment is scary. Though the Cold War was not primarily optimism. They experienced as many breaks with institutional trust as we do in 2026.

Tines are different but I do not think the prescription is different. We owe it to each other to embrace change together. What can we do for America?

I am not the son of a mobster nor am I a nepo-baby of America’s great cultural surplus. I wish. I’m not presidential material or Tiktok star material.

I do have some singular cultural advantages. I am a regular person from slightly unusual circumstances that happened to enjoy some upwardly mobility which let me to participate as an equal in an important transition point. I am actually rather surprised to matter at all. But I do and I intend to advocate for America succeeding together in this change.

I do take technology as a force in society seriously. I believe surplus is an amazing thing. My life is completely different than my biological history. Given how my human DNA was programmed and what I can do daily beyond that you bet I take artificial intelligence seriously. Material progress is real.

I take the physics of demand seriously. It seems like not everyone is confident we can speak to the general public about what it means that the technology industry has found a way to automate itself. It is a scary thing to say. And we begin with ourselves. It is actually our jobs that go first. If we believe it can be better on the other side of the Jackpot live like it.

And I do. I live a little further from civilization for the peace and quiet and because I am a little uncertain. But artificial intelligence’s new incredibly malleable models have changed my capacity by an order of magnitude. How wish I could have had this when I was a software and cosmetics founder.

I am a heavy user of all the hosted commercial models because they are in fact very good. I can do so much more across all the areas of life where I have to figure things out on my own.

I have health problems that are expensive and challenging. I’m lucky to be able to explore extensively the web of issue that drive having a body which has decided it must overreact. And I am in the process of fixing it. In ways that I’d never have had access to before Claude or ChatGPT. I have comfortably setups in spreadsheets and web apps and we can map years of bloodwork and experiments.

I think America is having an autoimmune reaction to the idea of automation as the end product of artificial intelligence. We sense it as a threat and it’s both terrifying in its potential but also a bit of the optimism has waned as the culture of technology fails to engage the mainstream as normal or even beneficial.

It’s the same process of making life better we have run. We took all our brain power to make our physical jobs easier. This has largely been viewed as a benefit to everyone except by strict biological determinists. Bronze Age romanticism is just that.

Thanks to progress in mathematics, we can now make knowledge that was extremely expensive to find, query, and organize as as accessible as asking an expert a good question.

Which is actually still tricky. Most Arthurian legends seem to resolve on knowing what to ask in order to receive wisdom. Knowing what to ask is not easily solved by mathematics. It’s not actually a cheat sheet but rather a powerful way to enable yourself. If you wish to take on that responsibility.

I feel I am somewhere between Hill and Valley in that I work in this world and I chose to become civically engaged. And I am concerned about where we are at. I am genuinely an optimist though as I think humans are so very adaptable. So I try to translate between the tribes who run our system and the tribe of people who make the systems run by the first tribe.

Maybe it’s be being somewhat in between that lets me be a node between the hill and the valley in America. Or as others frame it as a tripartite of Athens, Jerusalem, and Silicon Valley. I think that’s a bit grandiose only because maybe empires run on roads and plumbing but let’s not get forget that power is diffused in a network era. Every node that can route information has power.

The criticisms technology rightly takes from our body politic is that we are going quite fast. I know. I am inside the Gibsonian Jackpot with you. And I know it’s hard to believe that living through the change can be good even if we have inklings of the way life is already better right now. So we have to work together to figure it out.

Categories
Aesthetics Internet Culture

Day 1933 and JulieMaxxing

Everyone is maxing now. You can barely read a proper broadsheet without the Zoomer coinage crossing your transom. Maxxing is everywhere.

Maxxing means maximizing a certain aspect of one’s life. Comes from “minmaxxing”, a term for extracting the maximum output from the minimum input.

Urban Dictionary gives its history though the minmaxxing, though lately I’m not sure minimum input is actually part of the Maxxing game.

Maxxing is now maximizing every aspect of wherever you are focusing on improving. And boy do people want to improve across all possible vectors and all at once.

Is a geopolitical conflict all about Chinamaxxing? Is an influencer Looksmaxxing? Is a certain venture capitalist Retardmaxxing? It’s a little uncomfortable all around but time is short so why not go all gas no breaks.

I myself have noticed a kind of JulieMaxxing creep into my life I refuse to settle for a set of interconnected yet impossible to tease apart health issues.

From hyperbaric chamber oxygen therapy to everyone’s favorite semaglutide I intend to do it all. The same goes for face. I do an ABC+SPF routine just for starters for my skin. I am going to JulieMaxx if only so I can get back to Minimum Viable Julie.

Categories
Politics

Day 1931 and Happy Tax Day

Five years ago I wrote a really banger Tweet about America’s dysfunctional tax policy.

We don’t tax the rich. We tax the high earning – me in 2021

We were in the middle of a ferocious pandemic driven capital stimulus cycle that drove spending and inflation that pretty much every economist said would end poorly.

Naturally no one cared, everyone enjoyed the extra money and if you were lucky maybe you bought a house or made some other investments.

It was briefly good times for capital and good times for some working class families who actually did catch a break for a precious moment. Alas there ain’t no such thing as a free lunch.

The portion of the population that pays quite a bit of the tax bill in America didn’t qualify for the pork barrel lard programs or the social safety net programs noticed. America’s professional class were stilly enough to be high earners who filed W-2 or 1099 income so they paid for both the rich and the poor.

Now five years later we are going through the same stupid carve out process as politicians brag about small adjustments to already well protected tax niches like seniors not being taxed on social security.

Only this time, the professional class is in a full on panic. They have been led to believe that their jobs are disappearing. So not only do they pay for social benefits they don’t get but they also might not even have the jobs next year?

Cue screaming videos of middle class women outraged about date centers. Actually it’s worse. Cue full system wide class anxiety as the middle class white color jobs that once provided status and security suddenly look precarious.

And the white collar class are afraid they might to go face the fate of the working class who got China Shocked. They are too busy to reskill. Millennials are poorly placed. So they’re are looking for scapegoats for their rage.

The real shame is that panic isn’t based on a material reality. It is partially a marketing stunt gone too far by frontier labs (give us money and we will deliver huge investment returns) and partially a helpful lie carried by useful idiots who are afraid artificial intelligence will bring about the end of the world. We should be so lucky. It’s just the end of this century of economic models.

I’d wager we are much more likely to get a middle ground where vicious knife fights between professional organizations will carve out their pound of flesh till the haunted skeleton of artificial intelligence’s broken promises haunts Capital Hill, Sand Hill Road and Wall Street. Which is a shame as it is going to make a lot of money and do a lot of good but it will also change the guards if you will. And you might like where you are at too much to give it up.

I guess I could see this coming and it did indeed change my behavior as I stopped being as concerned about income and focused on investing and growing capital. And thanks goodness I took the hint from myself five years ago. I am replacing myself. Hopefully it’s for the best.

Now pay taxes and remember to vote. Only 47% of under 45 eligible voters voted in the last election whereas around 74% of over 64 year olds voted. They really want their social benefits before they are gone for good.

Categories
Community Medical Startups

Day 1930 and Imperfect Options That Remain

Some days end up being so much more interesting than you expect. I awoke to a family member, who has been preparing for a set of major surgeries, saying they had in fact gone in that morning for the first round of procedures.

I had been concerned they were putting it off so I was quite relieved that their lack of communication on the topic was simply their preparation to face what will be a grueling health challenge. Preparing for a procedure well gives you the best chance at success.

Then I went about a normal work day having lobbed a question, or maybe a prayer, onto the network as the reality of human lives is that imperfect options are always what remains. Being clear eyed about the choices in our lives and how the weight of our past actions have set us on a path can be hard. But it is necessary.

And as I wrapped up my day I was the recipient of some good news. I can’t share anything but the shape of it. But a project that was an experimental approach to a space I care deeply about has bravely faced the whipping winds and looks like they will successfully come to a safe berth intact with all souls.

Which is not such an easy thing to do when you set out for uncharted territory. I am so very proud of what has been accomplished thus far.

All things in life are the fruits of imperfect options that remain. That we make the best use of them is our obligation not only to ourselves but to those to whom we have committed. I am grateful that today was a day where those hard choices were made.

Categories
Culture

Day 1924 and Can I Blame Alcibiades

You’d think Europeans would be a little more on the up and up when it comes to their fine young strapping men getting into scrapes with Persians. But judging by the current reaction to the goings on in the crescent of civilization nobody has time to study antiquity anymore. That seems to be a pretty pressing issue in America as well. We also don’t teach math so it’s a real toss up on who is fucking up civilizational gains more.

Still I presumed your average movie goer saw some Zach Snyder action films even if they weren’t into say Athenian city states struggling with their gerontocracy only to lose their best and brightest to the other side. No Melian dialog fans? Ouch. Tough crowd.

I am extremely caustic today as I went from nervously fucking around with petroleum derivatives in consumer packaged goods to running a fever today.

I’ll just have to chalk all of my stupid whining up to modest discomforts of peak human achievements even if I’d like to blame all my problems on the betrayal of super ripped Greek dudes.

I assume Alcibiades was in decent shape giving how much certain Athenians thirsted over him but girl (no gendere intended but I mean Socrates) he left for Persia when Pericles wouldn’t listen.

Yes I’m running fast and loose between a hundred years but I’m not a Helot so maybe I’m allowed to run my mouth a little. But if you are running a frontier AI lab I’d appreciate it if you don’t. Same applies if you the secretary of any major departments. Or retired hedge fund managers.

Really anyone with anyone power should be keeping it moderate. The rest of us are probably free to be idiots online if they choose. Still keep up the good spirits, stock up on the essentials and pick up some history books when you get the chance.

Categories
Biohacking

Day 1912 and Informing Ourselves

Some 20 years ago, before I knew I’d have medical troubles of any length, my college job was working for a medical ethicist who was a physician with a grant to study informed consent.

Now, years later, as I have worked my way through institutional resistance to how I may come to be disabled and generally dismissed as a patient, I come to find that much of the skepticism my mother had as a crunchy hippie is now functionally being proved a quarter century on. These uncomfortable trends drives skepticism in even the most informed minds. And most patients can only ever be expert on their symptoms.

This comes at the end of a crisis of communication about the value of public health and personal responsibility in a community. Many people did not feel that they were given adequate consent and no longer trust anything said by doctors. Would most medical professionals agree they had informed consent? I think most argue they were. I agree.

Now of course we’re all desperately trying to prevent harms here and patients more than ever feel that, as they don’t trust what’s coming to them because we’ve not effectively decoupled population-level information from the individual human behind a given case. Is that informed consent? Yeah as best we can do it.

Now how does research play into all this? I also happen to have the misfortune of having working on the early years of on one of the worst medical misinformation spreaders in all of healthcare. I say this lovingly: it is Gwyneth Paltrow.

Now if you root around Twitter, you will find commentary about how the supplements hawked on Goop and the supplements hawked on various right-wing sites are functionally identical. But she got a lot right because she is a rich well connected white woman with money. So again who is informed and to what degree?

Unfortunately some of the things that are sold as treatments or supplements they sell are real and have proven out. We’re working our way through the science on our gut biome, infection and its links to preventable autoimmune diseases, and any number of other previously heretical paths.

But we’ve really not transformed the way we process our information on what we know and what is actually considered best practices. The gap is very wide. Like a chasm. I am way outside the norms because I fucked myself up believing I wouldn’t be a statistic as it mostly worked for most women.

So I live with issues. But do I think that people have a right to experiment with what we think might be snake oil? Absolutely. Everyone calculates their own risk. Heck Sarno is just one giant placebo doctor on letting go.

We know that some of the avenues of exploration will prove to be placebo effect if they work. And we still somewhat trust things that are actually going to cause harm aren’t really making it into the popular press and mass consumption unless there’s some evidence. I sort of believe that to be true.

More people should feel that they have the right, if they have informed themselves over a period of time as patients, to work around the system if they make no progress despite best efforts and years of work.

There’s just a lot to balance on being informed about your conditions and your capacity to manage your own health that is up to you. I think that generally speaking the paternalistic attitude has not produced superior outcomes.

And the quality of care I get as someone who can pay for health care anywhere in the world, it is galling to me that the gap between what we know and how far we can go in practice is so wide.

So let the guy advertise the doggy cancer vaccine because at least it’s teaching people that we have solutions to more than they know. They can judge risk reward and be a little bit strange. Humans are humans.

You get to decide it based on your own understanding of your own life and you get what you get. I was disabled by my own misjudgment of informed consent on treatments recommended by a COO of a major company who paid to have as a perk to her workforce. Egg freezing was an approved elective procedure that everyone was on board with ten years ago.

I was informed. I consented. I got it wrong. Now let me see if I can fix it in my own manner of choosing. And I won’t trust mere authority next time. Neither celebrity nor pharmaceutical company is to be trusted.

Categories
Aesthetics Politics Startups Travel

Day 1909 and All The Twinks Standing In The Line For The Bathroom

I am not an early riser, especially not when I’m out late for happy hours and dinners and the like. So I wasn’t planning on being at the 8am opening for the conference I’m attending in D.C amongst all the side programming.

I had a ten thirty talk I was particular excited to listen to as it was most salient to my work in artificial intelligence policy. Well, that was a dumb decision on my part. Not to arrive earlier.

I’ll take full responsibility for being a moron on that front, but I stood amongst a gaggle of gorgeous well dressed, well groomed and bright eyed young men hungry to build the world of the future. What a crowd of young people.

Being a chatty Cathy I asked about vintage Barbour jackets, bulldog ties, pocket squares, the merits of gel versus more advanced soft hold hair products, the declining quality of Moscot eyewear and other important topics to ambitious young men who are looksmaxxing to win the great game.

I didn’t have much else to do as the line was not moving. No one was getting in. Until people left no one was getting off the line. And that included others who had already been in and had their passes. The hottest ticket in town was perhaps a bit over capacity.

Someone rolled out a portable Starlink and we all piled in to tweet, chat, roll calls and (in my case) send tweets, Signal messages, and Slack channel responses. I got told my tweet about the two hour wait wasn’t ideal so I deleted it as I appreciate any attention to me running my mouth as I assume no one ever listens to me. I barely do.

But maybe I’m wrong? Last night checking into Butterworth’s, the woman manning check-in in lit up when I gave my name “I love your Twitter!” So maybe people do notice what I say. I still find that an a funny notion.

That said, it did take the full two hours to get into the giant event hall which made all the rush and planning a laugh. More people left the line and went back to work than stayed at 10am but everyone determined to participate seemed to make the best of it.

I asked if this was normal for a DC event and no one seemed to be from DC. So I didn’t get any good answers. This was an unexpected wrinkle that the venue was full was full up as an enormous crowd circled the block twice.

Since we remainders had decided to make the best of it we got to know each rather. Every man was quite a gentleman as we chatted oblivious to status till we were let in and others let us all know the pecking order. One of the young men I spent my wait, who is I learned later was literally the heir to one of the most important fortunes on the planet. Another was launching containerized autonomous weapons.

But that time of work and waiting was rather like being on an elevator stuck together, we might as well get to know each other. We are all equal before a tough door.

Thankfully we did get into the room before Jamie Dimon spoke. And he was the big boss of the handsome executive crowd.

I titled this “all the twinks standing in line for the bathroom” as yes a lot of handsome queer men were in attendance. But twink is an all purpose gender fluid aesthetic and not reflective of anyone’s sexual preferences.

And the line for the men’s y was a lot longer than the women’s. Ten to one ratios make me think this would be quite the dating scene for the ambitious woman.

But yes there are a lot of very well groomed young men in Washington D.C and everyone wants to build solutions for America. And being beautiful doesn’t hurt. To my single lady have you consider meeting a man in DC? Good odds and I doubt even a fraction of the twinks are gay.

Categories
Community Internet Culture Politics

Day 1903 and Ranting About Bentham

The tyranny of small differences can be the most vicious. I love vendettas in fashion and venture as they are connoisseurs of grievance.

Small communities with insular structures simmer embittered for years. You always know where someone, who is otherwise quite close to you, has committed a venal sin which cannot be forgiven.

But many times these small differences are actually the stuff of the breach. Once crossed you can never return. The opening cannot be closed without a great sacrifice. And these sacrifices are your character.

I am as well versed in the ridiculous schisms of my own affinity groups. As libertarians I’ll go on about the Cato libertarians, I’ll support my an-caps but I I’ll blood feud with the rest.

I feel this way about rationalists and the way they have introduced utilitarianism to Silicon Valley. And I want to be sympathetic here because there are aspects of effective altruism that are perfectly reasonable at first. I like prudent spending and reducing suffering with effective allocation.

But utilitarianism, taken to its end, has issues that anyone who has read Jeremy Bentham has to grapple with. The means do not justify the ends. We are all struggling with the horrors of the problems this creates in a modern society.

I saw the value of the manufactured meme campaign of effective acceleration as it oddly ended up dragging us to the middle. That was the intention and it achieved it. One can have many disagreements in the details.

However I do not think that political actors as far apart as Steve Bannon and MIRI agree on anything philosophically except “we want control over artificial intelligence so the people who are lesser than me can have no say.”

I cannot see how opposing forms of populist control can travel together without fear for character.

Everyone tries to be agreeable right up until coercive violence from Leviathan is required. And I guess some of you don’t think too hard about hard power huh?

I happen to find the request to have so much control over your fellow Americans to be an offensive view.

You think so little of the citizens of your own country when our core constitutional values require us to have so much more responsibility for ourselves?

I do think it is actually a moderate viewpoint that I believe in all of us. I believe in Americans no matter how stupid we can be. Remember that whole being a libertarian thing. I think personal responsibility requires more and Americans have delivered more despite our many failures.

I recognize that my personal stance here is not the final stance, especially as something of an outlier but because we have checks and balances, I know my involved citizenship demands that I declare where I stand.

Which is why the right to compute law that Montana adopted was a largely uncontroversial and popular when it was a bill. Before politics got involved, regular citizens, who were not whipped into a froth or frenzy, could understand that participating in the digital economy is crucial to living in the modern world.

It impacts our first, second, and fourth amendment rights directly because it demands we answer questions about property.

The wider existential issues on artificial intelligence do not get to be more important than our existing jurisprudence nor the opinions of our citizens.

The way we legislate and the value of our system of government, both state and federal, have a part to play. It’s funny the libertarian is making this argument I know, but it is a good revealed values exercise. Don’t get trapped by charlatans who have already declared that the ends justify the means. We both know they don’t.