Tag: Stress

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Media Politics

Day 1472 and Odds and Ends

I have now done six days of hyperbaric chamber oxygen therapy (HBOT for short) in a row. I also did a vitamin IV with glutathione so my morning was well occupied with maximizing wellness.

Because I was inside a chamber and tied to a chair for a few hours I was able to enjoy my backlog of reading. If you enjoy essays and e-ink books I personally use a combination of Readwise Reader and Daylight.

News and Essays

Peter Thiel has an op-ed in the financial times about the American ancien regime and the chance for the Internet era to enable us to grabble with the trouble of our elites.

A fan of Leibniz? The New Yorker reviews two books on his life. The polymath wrote quite a bit which endears me to him but our real debt to him goes beyond calculus notation. George Boole’s logic is partially informed by Leibniz.

Leibniz loved the simplicity and the suggestiveness of binary: he titled a draft paper “Wonderful Origin of All Numbers from 1 and 0, Which Serves as a Beautiful Representation of the Mystery of Creation, since Everything Arises from God and Nothing Else.”

Jacobin asks where all the good American Marxist academic work might be given that we perceive universities as hotbeds of socialism. Spoiler alert it’s hard to find.

Is middle age sexy? I went to read the styles piece in the New York Times only to discover that one must be over 50 to count. This elder millennial keeps trying to claim the mantle of middle age but Gen X and Boomers refuse to age.

Tips and Tricks

It’s wise to have a medical plan when traveling. American medications may be unavailable or even banned (Japan does not permit Adderall in the country).

I travel with a box of about 30 core medications to cover everything from allergies to food poisoning to bacterial infections.

Interested in becoming a Normie Man? Go on Joe Rogan. Not notable enough for an appearance. Let me suggest the rousing version of Copland’s Fanfare for the Common Man.

Categories
Biohacking Chronic Disease Medical

Day 1470 and Disappointing Biomarkers

After my anaphylactic adventures over New Year’s, I decided it was time for a fresh round of bloodwork to see just how my inflammatory responses were doing.

I got them back and it shows exactly what you’d imagine from a patient with an active autoimmune condition. My sed rate, or erythrocyte sedimentation rate (ESR) made a significant jump from last measurement.

I’d been on the high end of normal for almost two years and this set returned with doubling of the previous number. This biomarker is used in conjunction with C-reactive protein (CRP) test to determine overall inflammatory responses. That test came back modestly elevated but not atrocious. I also have elevated IgA levels, also known hypergammaglobulimia so that’s a bummer.

It would seem that my relatively well controlled autoimmune disorders (psoriatic arthritis and ankylosis) are moving to an active phase.

Given my use of IL-17 inhibitor injections along with a pain management protocol, lifestyle and nutrition management and a focus on holistic interventions, these results are obviously quite disappointing to me.

It would seem 2024 was harder on me than I’d have preferred and 2025 will be a year of doubling down on holistic therapeutics. Red light, infrared sauna, cryotherapy, hyperbaric chambers oxygenation, and any other anti-inflammatory treatment I can throw at it. Not that I’m looking forward to trying get another round of elimination diets but needs must.

I’ve not changed my the cornerstone therapy secukinumab since the pandemic, so it may be time to see other options like Janus Kinase (JAK) Inhibitors.

I’ve tried Tumor Necrosis Factor (TNF) Inhibitors as well as methotrexate (otherwise known as chemotherapy) and none of those treatments (Humira, Embrel) helped much and dosing on and off of biological injections is a long process. It can take up to six months to see results and changing a treatment that has been working comes with significant risks.

I’m lucky that even with these biomarkers I am still functional. I am able to work semi-normal hours and am able to groom and exercise. I have no personal life to speak of nor do I have hobbies beyond my work (unless reading counts) so I’m lucky to love my family and work enough to have it provide enough meaning to keep going.

Much of my success in treating this chronic complex case has been made easier with the breakthroughs in artificial intelligence.

Even as my physicians have retired and my care team rotates, I am able to progress and learn more thanks to large language models and search tools like Perplexity. I’m confident I will find a way to get back to remission quickly with little disruption.

Nothing provides me as much motivation to work as disease. I see how I and other patients like me suffer and I double down.

The progress we’ve made on autoimmune conditions in the wake of Covid and the rapid progression of protein discoveries as more AI tooling comes online. A chaotic world with a chaotic body drives my investing. We can do better as I see so much progress.

Categories
Community Preparedness

Day 1469 and Prayers and Hope

My in-laws live on the west side of Los Angeles as well as one of my portfolio founders, significant extended family and many dear friends including one of my closest and best friends. I am afraid for all them as the fires in Pacific Palisades has rapidly spread.

Please pray for the city of Los Angeles and her people as these fires rage. A dry year with little rain and unpredictable Santa Ana winds have led to a precarious situation.

Officials warned of devastating losses as the main blaze raced through the affluent Pacific Palisades neighborhood. The fast-moving fire spread across nearly 3,000 acres and was still 0% contained early Wednesday, according to the Los Angeles Fire Department –WSJ

A professional colleague known well to the venture community Mark Suster is quoted in this WSJ piece as he and his family were evacuated. I fear many more may be in his position. I pray their homes are not lost.

I have an especially strong emotional reaction to these types of rapid urban firestorms after living through Boulder’s Marshall Fire two years ago. Over three thousand homes were lost. It was devastating to my hometown and it is still rebuilding three years later.

I advocate for preparedness as both an individual and a community. I have lots of posts and media on the top if you are interested. When these tragedies strike, show up for your neighbors and your family by preparing so that when the worst happens you can be at your best for people.

Categories
Chronic Disease Medical

Day 1468 and Going HBOT

I was extremely frustrated with an autoimmune reaction that got out of hand over New Year’s. I don’t care for taking corticosteroids as their side effects are quite severe even if they can be the only option when an immune response refuses to calm down.

To repair the damage, I went to a holistic clinic that offers a range of services like infrared saunas, IV therapies, cryotherapy and hyperbaric chambers.

I’d heard good things about using HBOT therapy for autoimmune responses, particularly ones that are rheumatoid in nature. I’ve done two sessions so far and I have seen a remarkably swift improvement in inflammation and pain.

I’ve got 8 more ahead of me along with some glutathione and vitamin IV drips so I’m hoping to be ship shape soon.

News and Sundries

The Chinese venture ecosystem has funds engaging in some suboptimal behaviors. They are clawing back personal assets, banning them from services and putting founders on no fly lists. Which is needless to say not the best way to encourage innovation.

Mark Zuckerberg is taking a new tack with speech at Meta. The company employing content moderators for what is true is out and enabling Twitter style community notes are in.

Many moons ago Antonio Garcia Martinez warned that Facebook shouldn’t be involved in policing and censoring speech as it would lead down a dark path.

Much To Consider

Is most memetic self help that propagates well online now predatory in nature? A tweet thread to consider for those looking to have emotions or control them.

Categories
Chronic Disease

Day 1466 and Bubbles

I feel as if I have bubbles in my joints. They move and grow and every change hurts so badly I can’t stop myself from crying.

I’ve put out a request for biohacking help as it doesn’t seem like my current routines (which have been stable enough for normal work) are doing the trick any longer.

It’s hard sometimes to tell the difference between pain itself and the fear of the pain not relenting when the pain becomes acute. I get scared that the ever increasing pain won’t be controllable.

I’ll riffle through NSAIDs, Tramadol, and the dreaded stronger options as I do box breathing and voo-hum breathes. I’m practiced at throwing my attention away from the pain but the physiological impact is the same even if my mind can distance itself.

Before I was first diagnosed with ankylosing spondylitis and psoriatic arthritis, I had doctors try to convince me it was all in my head. “Take an Ativan!” I’ve never quite lost the fear that I won’t be taken seriously as pain management is such a clusterfork in America.

Addicts abound and doctors are often skeptical and malicious. It can feel as if those of us with chronic pain from illness will never be able to get enough distance between our genuine needs and the “drug seeking” junkies in crisis on our streets. We get treated like criminals with suspicion while zombies on the streets find other ways.

I’ve never known the supposed euphoria of an opioid like OxyContin as for me the rare occasion where I take on feels more like a brief respite from horror. There is no joy or ebullience. Only a mind of normality of function and clarity of mind which I imagine normal life is like for most people.

Categories
Medical

Day 1465 and Biohacking Help Request

I’m having a bit of trouble with an autoimmune flare so I’ll keep the narrative but short.

Essays

Everything is About Sex. Femininity is About Power

Shopping

I am going to take a course with a Twitter mutual on building an AI life coach for myself. It’s an exercise in accountability for my playtime & learning.

Considering buying this Hooli vagus nerve stimulator.

Tweets

Geeks, Mops and Sociopaths in the Memetic Of Woke

Medical

I’m looking for my next step in my medical care. If you’ve been watching the blog over the last few years you’ve seen my struggles with chronic health issues and the work I do to be well enough to pursue my work.

But I’m at an impasse and I know we must have more solutions than what I’ve got. Looking for a doctor or research group that may have protocols or care capacity for the autoimmune buffet of nonsense that plagues so many. I have ankylosis & psoriatic arthritis, joint pain & anaphylactic allergy issues along with migraines.

I’ve worked with woo, lifestyle and nutrition changes, supplements, osteopathy, injections and IVs, longevity science & expensive biologics to pursue the functionality I have now to work. But I long to work the hours of my youth and I don’t believe science has progressed so little that arthritis and migraines should be so painful and exhausting. So please feel free to DM on Twitter with recommendations for clinics and physicians.

Categories
Emotional Work Internet Culture

Day 1460 and Review Process

I began my review of my “round up” for the year post today. I was going post by post dredging memories and taking notes by hand. I’m embarrassed to say it took me almost 7 weeks of post scrolling to realize I was going through 2023 and not 2024.

Now you might argue that I’m tired as it’s been a long year, but just how crazy do things got to be when time is so punctuated with “happenings” that it’s genuinely hard to remember even the most shocking of events?

How is it that wars, elections, and major technological breakthroughs are just the daily happenings? Can it be that this much travel is required to do business? How long have we been living through this acceleration in politics and technology?

I want the narrative through lines of life to be more comprehensible. It is however clear that we are in a roiling period of chaos and even as I may remain ahead of some aspects I’ll always experience a trend multiple times.

Things that were huge this year were trends last year and were mere subcultures the year before that. Such is how information propagates in a networked world. I’m not even fully saturated on my own thesis.

Categories
Chronic Disease Medical

Day 1456 and Altered Window of Immunity

You ever push yourself so hard (physically, emotionally, mentally) that you crash afterwards? This is a common human experience. It’s called an altered window of immunity. Over exert yourself and you get sick.

I’ve come to understand the Christmas Break period as my yearly window of altered immunity. One reason I like to fast during the Holy Nights is to bring down my own physical and emotional reactivity.

When basic functions feel stressful and even small involuntary processes like digestion feel inflammatory then the work of living feels toxic. At that point one hopes rest is enough to get it out of your system.

The human tendency to ignore small problems until they become big problems is surely part of a wider cycle of disease. We wait to rest and repair till it’s too late and find ourselves crashing. For everyone bobbing along on the waves of life be sure to take a deep breath before plunging back under. It just might save your life.

Categories
Aesthetics Culture

Day 1453 and Shopping Malls at Christmas

I partook in the time honored tradition of going to a mall before Christmas. My family was inconsistent in its treatment of the holiday when I was growing up and consumerism was not a value we celebrated.

And yet now I think it’s a wonder America has exported the triumph of the American consumer at its most intense and made Christmas shopping a mentality globally. Consumer debt is a marvelous when it’s priced in American dollars.

Our holidays are now times for displaying status and taste in so much of the world. I think it’s reasonable to say we’ve been post scarcity since the mass commercial fertilizer and it’s all been status signaling since then. We all live materially better lives. Arguments for the impoverishment of our souls are still quite valid.

Yet here I am buying stuff before Christmas. Nothing makes me feel more like a piece of the capital markets like buying consumer electronics at Christmas.

The prices are better only because we’ve been trained into a consistent purchasing pattern. We can predict consumer sentiment and meet those demands partially as a function of training the consumer when to shop. The propaganda of the markets.

So I get to enjoy the overstimulating existential horror that is the wall of televisions ready to be Christmas gifts. The high fidelity color and intense noise is an assault on the senses. No wonder reality is a disappointment. I’ve never seen so crisp a picture. It’s all just a bit too much.

Categories
Biohacking Chronic Disease

1452 and Bone Deep Weather

When the weather begins a shift to wet, cold or otherwise stormy, I feel it like some poor grandmother in a folktale.

My joints begin to ache, I feel swelling across my fascia and my ankylosis pain intensifies. Why do joints hurt when a storm system moves in? We’ve got a couple plausible explanations for all too common phenomena.

Barometric Pressure Changes: Before a rainstorm, barometric pressure (the weight of the air) typically drops. This decrease in external pressure can allow tissues surrounding the joints to expand.

Humidity and Inflammation: Rainy weather often brings high humidity, which may worsen inflammation in joints, particularly for those with conditions like arthritis.

Thanks to Perplexity the bone deep discomfort of a storm front becomes much easier to understand.

Cold conditions can stiffen joints by thickening the synovial fluid that lubricates them. Reduced blood circulation may also contribute. Changes in weather can make nerves more sensitive which amplifying pain signals.

The remedies for these changes are pretty basic. Stay warm, get your blood flowing with some light exercise, stay hydrated, stretch and take anti-inflammatory medications like NSAIDs to mitigate discomfort.

I asked Grok to draw me as a cyborg granny out in front of a storm

Prompted Grok to draw me as an arthritic cyborg granny in a rocking chair waiting and watching as a storm comes in.