It has not been an easy year for me or my family. The struggle to find a path to a sustainable place of health feels harder than ever.
I am living in some type of thermodynamic hell. Everything I try comes with equally forceful reactions and I wish I could say more of them were positive.
Even when results look positive they have high costs that make me reconsider if I should have done it at all. Switching my immune suppression drug put my inflammatory markers in the best place we’ve seen them in years.
Alas it is so effective that I’ve had four major skin infections in 2025 of which four required going under the knife. And the fourth was caused by a small incision that was considered so safe and routine we almost didn’t consider antibiotics at all.
I just so badly want something to work in a way that doesn’t come with staggeringly high costs. Normally I’d link around to all the relevant posts but I just need a break so I’ll leave it as an exercise.
But can you imagine anything more depressing than having an infection on your ass? I sure can’t. I am stuck trying to keep pressure off of it while working on all the various projects of life and I am a slow healer.
I don’t even get to see if the HBOT is doing anything for my main concerns, as if it is we are only going to see it when I clear this crazy infection.
I suppose the good news is that one of the best treatments for high risk wound care is actually hyperbaric oxygen therapy so the positive and the negative are at least balanced.
My inner child finds the idea asking if “you want to see something gross” to be funny. Of course, I want to see.
Gore and violence don’t get this reaction from me. I dislike it in movies and in the real world. But to see gross and the weird in the real world. I get it. Maybe lots of humans thinks seeing gross things are cool.
I think it is a bit sweet. It is as a very human reaction go “ewww cool” when faced with non lethal wounds. Maybe it’s truer with boys than girls, but if a kid said “do you want to see something gross?!” in Colorado when I was a tween the answer was a rousing yaah! Gross things are cool.
Maybe it’s a type of survival mechanisms where if we can learn more about what is lethal, and lethal injuries look like, it then improves our Darwinian fitness. We judge risk more accurately.
Flesh wounds need proper care and do turn out absolutely fine. And boy have we improved on the science of wound care since I was a kid. We have evolved past the bandaid.
But even in a hard situation like a fire burn or the dermis getting sliced open, I still had a bit of that bravery of a little girl. That is cool! The bravado of a human who believes we can fix it
If you enjoy a story of plucky Rocky Mountain woman learning to do emergency care for herself and her community I’m glad we shared this time together.
Hopefully you never need these emergency skills. We take learn the risks and practice for them so we may never experience them.
So if you don’t feel this way, I’m giving you your ticket out of here. Stop reading now. But if you want to see something gross stay on.
This is my wound on Wednesday morning after I had the procedure. It’s much bigger a slice than I’d expected but first time practitioners (I asked for the experiment) and while the treatment is safe across most vectors, I was a nervous immune compromised patient who prepared for the worse.
So this a real 10/10 “let’s see how it goes from here” experiment especially if the returns it delivers are real. I hope for the energy, pain tolerance and healing benefits the average patient sees
So I am using a 90 minute full 2 atmosphere protocol already as I go went this treatment. I had also begun testing the GLOW stack from a peptide spot where I trust the owner. I’m helping him test. And this is the recommended stack for recovery.
.01 of the GLOW stack which is a regenerative peptide therapy with three peptides—BPC‑157, TB‑500, and GHK‑Cu—it was made to promote healing, tissue regeneration, and collagen production,
So I am absolutely throwing the gold care package at this. I am taking collagen and biotin, we’ve got the local food and the lack of seed oils, we’ve got the best current standard for peptides on injury and surgical recovery.
And somehow I am still scared. I never heal well or easily. I bruise easily and badly. I was so slow this summer to heal from an abscess surgery. I took a risk and I worried.
But I woke up this morning and my open wound has closed and the bruising has retreated in just five days to this. I’ll be in the scar mitigation territory in no time, and soon it won’t even be visible to the naked eye.
Day 5 of recovery from testosterone pellets
Progressively, the wound has moved from acute bruising and erythema toward decreased inflammation and resorption of bruising, with steady wound closure. Monitoring should continue, but the pattern suggests healthy tissue repair
So I hope you enjoyed seeing something gross. As it is keeping less and less gross by the minute.
Many moons ago, when I was first attempting to get a diagnosis for why I was always in pain and exhausted, I got a battery of allergy tests. I did the “gold standard of allergy testing” called patch testing which is a form of pin prick testing designed to pick up responses that may be delayed.
It was an awful experience. I barely made it through the 5 day trial between the 100 allergen pin pricks and final measurements.
I remember begging the doctor for a way to measure early. I asked if I could take some Benadryl to take the edge off. Alas the only way it would be accurate and covered by my insurance is if I gutted it out.
You are not allowed to shower, sweat, be exposed to UV rays (no going outside) or take immune suppressants that might subdue your body’s response.
I was struggling to breathe, my entire body itched and ached, and I had a migraine so bad I couldn’t see for the stars & dizziness. It’s possible I wasn’t stable enough to have adequately consented to the test but I did get my final results.
Out of 100 common allergens tested it was confirmed I was extremely allergic to 10 of them with another moderate sensitivity set of twenty or so that I should merely try to avoid as opposed to my firm “no go” list.
The dermatologist gave me a sheet with 75 different chemical names and formats that I might encounter in the wild from these core allergens:
I instructed to search ingredient lists for these names any time I purchased a household product, personal care item, cosmetic or other item which might include these ingredients which ranged from nail care to vaccines.
It was honestly quite overwhelming. And some of the above ingredients are in basically everything. I dare you to avoid Limonene for a month.
So my husband and one of our best friends did what any practical minded engineer would do and they made me simple Google sheet where all 75 varietals could be checked if I plugged in the ingredients from any item.
I used it for years. I’d plug in the INCI from every brand I encountered into the sheet no matter what. I gave away a lot of products to friends.
Today it occurred to Alex that we should probably vibe code the thing into a proper web application using Replit so other people could check ingredient lists for their own allergies.
You can set your own allergens or click a few buttons for common allergens and “clean ingredient standards” and run a check for an all clear.
It isn’t super fancy but it doesn’t need to be. It just needed to keep your data safe, be easy to log into so you can securely check and access your personal list and generally functional enough to change and set allergens. We’ve put it on our own little domain just to see how much this will cost to run (and we’ve set up alerts so it doesn’t go bonkers) but we figured this should be accessible and simple.
And while there are other options on the market, most are bloated, overly paranoid and designed for scaring California moms rather than quickly helping people with clear preferences for avoidance and actual tested allergies. So hopefully our pain can help you breathe easier.
Some options for chemicals and irritants you can select on our app. My own settings of allergies and sensitivities
She had had teeny tiny testosterone pellets placed into her subcutaneous fat and had remarkable results in terms of energy and focus. This and that happened, and the summer was a mess, but today was the day I finally followed in her footsteps.
Vials of compounded testosterone
We’re started me with 10mg of estradiol (range 6-25mg with 8-10mg being most common), and 75mg of testosterone (range 50-150mg with the most common being 75-100).
We’ll aim for labs at 4-6 weeks after insertion which would represent peak levels. We will repeat dosing at 3-6 month intervals. We will check levels at 4 months or so, or earlier if I feel the effects waning.
Do be warned that within a paragraph or so, there will be images of needles, scalpels, and some blood. So feel free to not scroll down further.
Part of the difficulty with dosing this stuff is that the pellet doses are wonky and frequently out of stock – estradiol comes in 6mg and 10mg increments so 8mg is impossible.
Naturally, we’ve made surprisingly little progress when it comes to women’s health, particularly as it relates to hormones.
Prepared and ready to go
But as I am happy to be a guinea pig and my luteal phase is a mess of migraines and misery I figured I had little to lose and much to gain. I was the first patient my doctor has done the procedure on so if anyone in Bozeman is interested, you can confidently give it a go with him as I’ve survived it.
These cool tubes don’t actually go inside too far but sort of shoot the pellet into the incisions
I was given a local numbing agent with epinephrine. I needed a surprising amount of it but I was a bit nervous. Once I was just able to feel pressure and no pain it was time to make a small incision with a scalpel and in popped the tiny bit of hormone on the left butt cheek.
No big deal at all.
But if you don’t want to see it going in don’t scroll.
Just giving you space to turn back.
A tiny incision in my goose bumped bum with the little pellets easily tucked in
I am all bandaged up and still riding the cortisone of it all but I feel alright. I’ll be adding in progesterone orally to temper the estrogen as that’s another matter. I’m excited to report back on it as if I have even a fraction of Cate’s experience with it I’ll be quite happy. Also it’s about $70 a month so not cheap but not at all expensive for something that could potentially mitigate some long term issues I’ve struggled with for years.
Being a victim in your own life is a choice. We get dealt a hand of cards and we have a say in how we play it even if it’s a crappy hand. The odds being what they are you probably got dealt some bad cards.
I’ve learned the most about empathy from the men in my life. It’s not always true for women but being raised to accommodate is part of being the weaker sex. One need not always accommodate in life though. Sometimes their problems just not about you at all. And that is ultimately alright. Everyone hurts including you.
Of course it’s unwise to reinforce a victim mindset in people, but sometimes people actually just have been victimized, sometimes repeatedly and brutally, and lasering in on their small slice of responsibility just reinforces their pervasive sense of being totally alone. At some point you hope they look at their patterns and see if change is possible. But if they’re going to get there, it’s going to be because someone was kind enough to sit with them, believe them and hold space for them until they were ready. VividVoid
Letting someone see you in the way that they need to see you has its purpose. It’s a beautiful thing to sit quietly and let someone really blame you. Be disliked. Letting someone who has genuinely got shit going on just be furious at you is a form of empathy. Be their villain.
I’m learning to sit comfortably while being someone’s villain. If that’s what they need in their hardest hour I can be that. It’s not something you should give too freely but this is where boundaries are a blessing.
I’ve seen more men than women be capable of handling this kind of rejection. The empathy of not engaging. Let them be hurt. You can suck if they need it. I believe it’s a strength to cultivate comfort being the bad guy
Every parent learns to do it, anyone with responsibility for making a goal or a bottom line or a budget work knows that sometimes you just have to be the bad guy to make it work.
The parameters of all of that is hard and we are reworking our way through helping people overcome their hurt. We’ve let cultural expectations dictate so much.
Everyone is fighting their own hardest battle and if you let them be mad at you and don’t take it personally you just might help.
I love Carl Sagan’s Contact. I first read the book in my middle school years and was allowed to watch the movie starring Jodie Foster despite having a very limited “screen time” diet.
As I got older I was allowed to watch edifying science fiction and book adaption only if I had read the source material. Contact passed both tests
It’s a beautiful story of faith and science about on a radio astronomer who finds a signal from alien intelligence which kicks off a planet wide space race to make contact.
There is a scene in the film where our protagonist Dr Arroway is set to launch a machine which we humans do not fully understand but is presumed to be some sort of transportation device.
Just as the countdown nears zero, she loses contact with the ground team. Roaring machinery and turbulence drowns her voice as she repeats over and over “I am OK to go” until a blind colleague finally picks her voice out of the static. The capsule is let go. I won’t spoiler it.
I’m OK To Go
I had a little moment of being out of contact myself today. I am now the proud owner of a hyperbaric chamber but still getting used to the machine. Alex, watching me as I adjusted, communicated with me through the glass with gestures.
Hyperbaric chamber oxygen therapy has roots in diving as managing pressure changes is an important aspect of safety for underwater and high altitude work.
When diving you don’t give a thumbs up to show you are alright. Thumbs up actually means ascend. You give the OK sign to communicate that you are doing fine.
The “OK” hand signal in diving is formed by touching the tip of the thumb and index finger together to make a circle, with the other three fingers extended upward.
Even as I was a little dizzy and struggling to acclimate I was ultimately “ok to go.”
An auspicious pair of numbers for today’s date and I started something new which has been in the works since January began today. Our long awaited hyperbaric chamber has arrived and been fully set up in our yellow barn.
A lazy boy lounger and oxygen under two atmospheres of pressure.
It feels good to begin a positive focused wellness activity after what was otherwise a chaotic week of travel, geopolitics and violence.
As expected, it is not fun living through my own investment thesis. So you better believe I test my theories on myself. I want to survive the Jackpot.
Before Trump’s inauguration, we decided to purchase a hyperbaric chamber after one of our mutuals told us about his HBOT trial at a conference in the fall. It went very well for him and the research is promising for inflammatory conditions.
Over the winter break I happened to be in a city where I could test HBOT cheaply and was very impressed with the results in only ten sessions during a flare in my autoimmune condition. Crimping from Bryan Johnson
Hyperbaric Oxygen Therapy (HBOT) involves breathing pure or nearly pure oxygen (95-100%) in a pressurized chamber at anything above atmospheric pressure (2 ATA is equivalent to being 33 feet under seawater).
The increased pressure enhances the lungs’ ability to absorb oxygen, boosting oxygen levels throughout the body. The therapy aims to promote rejuvenation by increasing oxygen concentration in tissues, supporting healing, cellular repair, and vascularization.
This sent me down a rabbit hole as I did a bunch of deep dives, got some text books and came to a simple conclusion after a lot of medical papers that it’s pretty simple.
It’s almost philosophically the way of life in the mountain west. Oxygen and pressure work on the biomechanics of a functional body. Alas getting my basic market model to Montana ended up being a cluster fork of issues. We placed the order in January.
For months we waited for what we’d been told would be a 6-8 week process. Alas all hell broke loose. We had tariffs uncertainty with the importer and the OEM.
I have now, in September, after a long journey but a simple set up process, begun my first intensive protocol for autoimmune diseases on our own hyperbaric chamber.
Love your body enough to put it under pressure and take a deep breath.
I will complete a minimum of 40 sessions (5 sessions weekly) at 2 atmospheric pressures, in a hard chamber from OxyRevo with each session 90 minutes while breathing 100% oxygen for 20 minutes separated by a 5 minute break.
If you are interested and see strip mall options note that these are not consumer grade machines. The protocol requires a hard chamber to achieve that pressures. It’s quite a bit higher than soft chambers on the market.
There are risks associated with HBOT from correct pressurization issues to impacts like tinnitus. The more prepared you are to adapt to changing pressure with breathing techniques and equalization (looking to divers for these protocols) the happier your central nervous system will be.
As I often do on transcontinental travel days, I wrote my post for the day first thing in the morning. I wasn’t sure how the journey would go so I thought “let’s post this early” in case things get hairy. And boy did it.
It’s a weird thing to complain about air travel on 9/11, but I don’t think much of the security theater we’ve accepted over the years did much to keep my transit safe yesterday. Twenty four years later we go through the motions of keeping air travel safe from terror because what else are we going to do?
In fact, it didn’t seem as if security was particularly tight yesterday so much as particularly incompetent. It was chaotic confusion everywhere from passport checks to boarding flights.
I had a Frankfurt to Chicago polar day flight, along with a positioning flight on each side. I went through a lot of security screenings and passport checks yesterday and stood in more lines than I can count.
In Frankfurt the lines were so long that even with planned two hour airport transit time, I was among the last to board my flight.
The “special purposes” line I begged my way into as my inbound was delayed by fog was glacial in its pace. It seems the new transit grift is wheelchairs. So perfectly abled people are now pretending at disability to board early and use special security screening lines.
It left wishing I’d registered my real disability as I attempted to run the two miles of the international terminal with suitcase and backpack torquing my spine so I wouldn’t miss my flight to Chicago.
Deplaning at Chicago I couldn’t even count the full set of wheelchairs waiting.
Add in enormous confused families using the special purpose line, who spoke neither German nor English, with 3-4 bags a piece and every sort of banned item from pocket knives to 1.5l bottles of liquids and I am shocked anyone made it through security to their flights on time.
I watched a foursome of black Arabic speaking grandmothers in hijabs and wheelchairs shouting at German security guards and their extended families as I waited for my turn. Their fierce attitudes did not speed anything up that I could tell.
I saw them 9 hours later gathering somehow even more checked luggage upon arrival in O’Hare. I’m glad my Global Entry let me pass them by at passport control as I did not want to be behind them again.
Not that I got through Chicago’s security lines unscathed. The TSA pre-check lines were four times as long as the regular line. Figuring I was well packed I could handle the normal line. Naturally I got randomly selected and unpacked basically everything
As I stood in my socks waiting for the agents to stop gossiping and listen to the only working agent explain to them that “yes that the ice pack was for medications so they can move this along” I got an alert on my phone that the conservative political organizer Charlie Kirk had been shot.
I wandered in a daze to the United club where I was denied entry. This despite booking a business class ticket for the entire transit through their own hub via their Star Alliance partnership with Lufthansa, I couldn’t use the club as “the last leg of my flight didn’t qualify.”
I knew this was possible as this last leg issue happened to me on my last transit through O’Hare so I’d bought a day pass ahead of time. But they weren’t honoring those as it was too busy. I schlepped to another club in the terminal where they were still letting in day passes. There I listened to scared speculation from two blonde women about Mr Kirk’s status.
Another hour later I made my way onto my flight to Montana. I decided to just jump to the front of the line as I was in first with seat 2B. If everyone is ignoring lines then it was irrational to keep trying to politely queue.
As the plane boarded it was all talk of Mr Kirk. A news alert crossed my phone saying he had been killed.
A gentleman was playing a video of stitched together angles of footage on his phone with full audio on. You could hear the bullet hit again and again.
The cabin attendant told him to turn it off, saying sir please have some respect for the dead. A few hours later, still living, I made it home to Montana.
It’s hard not see every day as more of a beak with the past even as so much remains the same. No wonder the French have that handy slogan about “plus ça change” as systems remain even with violence. They really know how to balance being disgruntled with the past.
I was suggesting La Haine to someone earlier this week as the French movie that made an impression on Gen X and elder millennials who paid attention to Francophone culture. It’s hard not to think current problems are similar tensions recycled for a whole new era. Atmospheric, vulgar and dangerous are the keywords.
The addiction economy repackaged the same old things that kept our attention economy running. And they will keep running it till it is so refined and so well packaged you won’t even remember that Starship Troopers was meant as a satire of fascism.
We repeat so much. The Churn as the Expanse called it.
Amos: This boss I used to work for in Baltimore, he called it the Churn. When the rules of the game change. Kenzo: What game? Amos: The only game. Survival. When the jungle tears itself down and builds itself into something new. The Expanse
Survival breaks out into the only game all the time and we are always running a Red Queens race. So try not to get too distracted. Ween yourself off of anything that you’ve not got any reason to hold dear. Change to meet what you can so long as you can still see yourself.
Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.
They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.
So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.
Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.
Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.
I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?
“So I heard you had side effects so I gave you a side effect for that side effect.“
And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.
Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.
Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.
GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:
Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. SourcesSources
Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. SourcesSources
Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.
Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.
TB-500 (Thymosin Beta-4 Fragment)
TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:
Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.
TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.
BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:
Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26
Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.
