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Community Internet Culture Medical

Day 1440 and The Pain We Won’t Name

Americans are in pain. Literally and emotionally. How that happened isn’t my focus. We are in the middle of a national conversation about the failures of institutional medicine and its relationship to our government. We are treading in deep water and it’s best not to get swept away.

There are many communities that have emerged on Twitter, Reddit, YouTube, GoodReads and elsewhere dedicated to the many paths available to go about fixing the problems in your life. There millions of strong communities of interests, hobbies, courses, and network knowledge that can enable you.

One of those communities is called TPOT. What is TPOT, who is in TPOT, what are its values and what does it believe are all involved and sometimes contentious questions. Being illegible is a big thing.

We mostly agree it stands for “this particular corner of Twitter” which is a loose network of nodes of people interested in applying knowledge they learn across our networked multimedia to their real life.

The experimental “you can just do things” attitude is a big tent. You see DIY projects, tutorials, reading lists, artificial intelligence and coding discussions, fitness and biohacking experiments, nutrition and cooking, meditation and nervous system research, pain management, psychology and emotional wellness and much more. You also see more far out woo woo topics like psychedelics, evolutionary psychology, and many flavors of rationalism and epistemology.

One of the most qualified voices to speak on TPOT might be Brook Bowman of Vibe Camp. In my understanding of her interpretation, TPOT is a memetic virus and once you touch it you are in the topology of TPOT for good.

tpot is this crazy memetic virus where the term itself means so little and is so contagious that you kind of become part of it just by hearing about it

Brooke

This is protective and makes it resilient. The network is bigger than any node and this is a good thing

So TPOT is best understood as a network composed of many interoperable nodes of interests and many layers of engagement. A memetic complex that you become part of on contact. If you read my blog it’s likely have many clear lines to TPOT.

If you like fitness, coding, rationalism, nutrition, or even home improvement well congratulations you are one or two nodes away from “just do things” as a life philosophy yourself and might be a member of TPOT yourself if you talk about it on Twitter.

And this is now some very dangerous semiotic territory as we cope with the gaping wound that is American health and murder. And I am concerned the narratives are going to be heavily fought over territory.

Because it’s easy to dislike a techbro right now. It’s pretty easy to dismiss the group. I can see it now. “Are your friends into this weird sounding acronym TPOT? Have you heard someone say “you can just do things?” If so you need to alert the authorities!”

Of course this sounds funny and histrionic. It’s totally normal to take responsibility for what you can in your life and try out ways of improving your life somewhat.

Everyone is dealing with pain (chronic or otherwise). Being an adult is a set of emotional challenges to manage and most of us do so by making the shocking decision to take action and do something. That doesn’t mean this world is is dangerous. It certainly doesn’t mean murder. It means doing something in your day life like lifting some weights, shipping some code, checking your biometric data, and trying to be a friend to lessen the pain most of us are in.

Categories
Internet Culture Startups

Day 1421 and Culture Clashes

I sit in between half a dozen different community nodes thanks to my interests in open source software, decentralization, crypto, and autonomous systems technology.

This set of interest covers a lot of ground from ecosystem level collaboration in financial organizations like DAOs and to player versus AI agents coordination to peripheral control of drones and machinery.

Many different demographics are attracted to these frontiers for different reasons. Hackers have a very different mentality than mercenary technologists looking for maximum margin.

Open source has traditionally struggled more from a lack of financialization than from an obsession with it. Which seems less true in the crypto era than in previous more academic and defense oriented eras.

There are classic open source business models and anyone with age and experience in startups has some opinions which I leave as an exercise to the reader. They occasionally fail and an open core loses more than they’d like to professional services. I am writing on WordPress.

One strange aspect of what drives these frontier spaces to interact is that depending on how much leverage you find in building a network you may have different incentives than other builders and users. Expanding out to scaled use may drive a lot more value than the resources required. How the surplus gets divided is always contentious.

For some, the most crucial cultural goals is expanding access to automation and ripping away as many of the services and middle men as is feasible.

Decentralized systems make it harder for middle men to maintain monopolies. Thats its own goal for true believers. For others the goal massive financialization that drives network connectivity is the benefit. Self interest driving common goals is perfectly acceptable.

As I watch the current season of hyper self interested memecoin cryptomania engage with the academic utopian open source artificial intelligence community, I am reminded of so many of the classic issues we have in financing and sharing in the spoils of common infrastructure. Who benefits is a question we should all be asking more regularly

Categories
Media Reading

Day 1410 and Luxury Content

Institutional trust in the media has reached a new low point for Americans. The news exists in a strange place for many of us as we must stay informed but it is no longer has quite the same halo of necessity when it comes to life and culture beyond the headlines.

Many of us read significant amounts of “need to know” publications for our professional lives. I myself read Bloomberg, the Financial Times, and The Wall Street Journal every day along with more specialized media like Axios Pro-Rata and various venture and startup specific media.

Culture is different. Wanting to be in touch with the ideas that shape a nation is a luxury you don’t need to be wealthy to enjoy. To engage in ideas is to have the means to enjoy a life of the mind. You must choose to spend your precious time on it. Time is the only luxury which can’t be bought.

Media is changing as news and cultural content diverge. We used to be awash in a sea of periodicals. As a child I’d bike to the Boulder library and read it all. Thats how I became a fan of the Economist. I loved culture magazines just as much. Some still retain their pride of place through institutional nostalgia like Vanity Fair and Vogue. But can the New York Times hold a grasp on culture like it used to do?

As we face down an election with clear cultural and political bifurcations, what does it mean to be a consumer of not simply news but the culture of the moment?

Dirt editor Daisy Alioto bitingly called it luxury content and sent the LinkedIn striving aspirants scattering.

Someone told me they don’t always open Dirt because it’s not framed as “need to know.” Yeah, that’s why it’s luxury content, because you don’t NEED it. Take your ass back to Axios

To want a cultural publication like Dirt, and enjoy its view of the world, is to appreciate the premium we place on taste.

To be au courant means deciding where our time goes when it’s not an obligation. And I’m sorry to say to Condé Nast that their grip on culture looks more tenuous than ever.

Oliver Hsu tweeted this spread of new print periodicals dedicated to the culture of technology and economy.

Telescope, Arena, and Palladium are all pointing to new appetites. We want the luxury of futurism. To be caught only in the moment is to reveal a perhaps embarrassingly high time preference for algorithmically forced immediacy. “I want it now!”

Doom scrolling the news may be fun. Many billionaires spend time on Twitter because of its close proximity to sentiment. We all need to know the narratives catching attention.

But want do we want? Well who rather enjoy an essay from a writer who shows you the culture beyond your feed? Giving your attention to those who respect it will always be a luxury.

Categories
Internet Culture Media Politics

Day 1402 and Scape Squirrel Iconoclasts

I am a bit tired today. I’ve had a busy month of travel and the last week was particularly intense.

I have been in bed most of the day and the immobility coming with this day of fatigue has allowed me to thoroughly participate in a number of extremely online activities.

A squirrel named Peanut was euthanized

If you’ve not been following along the TLDR is that a squirrel named Peanut living in an animal sanctuary run by New Yorkers Mark and Daniela Longo was seized by the Department of Environmental Conservation and subsequently euthanized.

A raccoon was also taken and killed but Peanut was an Internet celebrity and we live in an age of viral contagion and within a few hours all Twitter could talk about was Peanut.

Why does this matter? Well, giant bureaucracies killing pets has an uncomfortable history in America. If you want to dig on the lesser known lore check out gun subreddits for ATF dog killer memes.

So potent is this history it has emerged as the ideal 11th hour election meme for the restless population that is uncomfortable about the power of the federal government.

I’ll quote my friend Anton’s tweet from a thread I’d recommend on Christian semiotics and Peanut.

actually you know what? the squirrel is an anti-christ. we are in the midst of a huge mimetic crisis and rather than scapegoating the squirrel to eliminate the conflict and avert violence, we instead elevate the squirrel’s death to heighten the conflict even further – @atroyn

Different political alignments experience the fear of governmental overreach, and in particular its monopoly on violence, in different ways. We occasionally make martyrs of those who experience that this violence to understand its horrors.

Squirrel martyrdom invokes an entirely BLM than the BLM who arose after the death of George Floyd. I say let us consider them both iconoclasts (in the religious sense) of the same fear of death through state means. They are symbols of idolatry who become sanctified.

Floyd’s death touched on frustration over systemic racism in the judicial system, Peanut’s death touches on frustration over government overreach – John Ennis

Leviathan wakes and we tremble.

Categories
Culture Travel

Day 1392 and Miami

I’ve been so completely engrossed in the Infinite Backrooms and Truth Terminal saga that I have not posted about my upcoming travel to Miami next week.

I am just enjoying our first frost here in Montana and yet I’ll be pulled down too soon from our wonderful fall. All to enjoy hot takes and hot climates. I don’t like hot climates so I guess I’m going for the takes. Founders and LPs (and those with opinions on LPs) are priorities.

If you will be in Miami attending the conference I am hinting at please do look me up. The weirder the better. I’ll also be accompanied by my better half Alex Miller. Come for the tractor discussions and stay for the semiotics discourse.

Apparently there will be a costume party but one can simply choose black tie. One thing I like about it Miami is how it celebrates dressing up. I can wear a billowing pink gown or a dolman sleeve full length velet fishtailed dress and not be out of place. It’s just very tropical.

I think I’ll enjoy packing simply because it’s nice to have an excuse to wear white sneakers and floral robes. I can even get excited by doing some fun makeup. You have to live joyfully when the theme is the apocalypse.

Categories
Culture Internet Culture

1348 and Boy Who Cried Racism

I was blessedly off the internet for a portion of last week so I didn’t experience the controversy first hand but racist engagement bait has officially become a growth strategy in startup-land.

A anonymous Twitter shit poaster handle Vittorio (who was an affiliate for a payments company called Warp) decided to post white supremacist content to his main account.

He has since deleted his account but not without some of the most heinous bigotry I’ve seen being put on display across Twitter. Be warned the follow screenshot below is offensive and upsetting.

Not so long ago being called a racist was a serious accusation which stained one’s entire life both personally and professionally.

It seems as if sometime between the Great Awokening and our Current Moment the once potent charge of racism has lost some its meaning. As identity politics and critical theory became mainstream more and more people, movements, industries and actions were labeled as “racist” in turn diminishing the potency of the term.

It’s the parable of the boy who cried wolf writ large across the very discriminatory Internet. We are experiencing the aftermath of years of “The Boy Who Cried Racism” and predictable it’s quite ugly.

The term has lost its power and actual racists are no longer afraid of the big bad wolf or anyone warning of its approach.

As being called a racist became a commonplace “insult” across social media more people decided maybe it wasn’t so bad to be labeled as one. Being called racist now even has shock value that can be leveraged.

It’s happened to other terms like sexist, homophobic, and fascist. We no longer fear the terms, like we no longer fear warnings of the wolf. But racists are dangerous. So are fascists and sexists.

Created using DALL-E-3 with prompt “make me an imagine of a boy based on the parable “the boy who cried wolf” but he is crying “racism”

I believe we now have so much blatant racism on social timelines as we’ve decided to label everything racist.

Perhaps it’s time to make it rude to label everything racist so we can once again heed the warnings when real racism rears its ugly head.

Categories
Aesthetics Internet Culture Politics

Day 1328 and Weebs as New Social Elites

Yesterday, Occulus and Anduril co-founder Palmer Luckey, posted a picture of him doing Nyan Neko Sugar Girl cosplay to his Twitter account. It’s a Fanime from 2010.

DragonCon enjoyers

On the heels of a sympathetic long form essay in Tablet Magazine that went viral, Palmer posting friendly cat girl jokes on main was clarion call to the one demographic that really matters in America right now. Nerds are the entry into the elite class.

Every flavor of nerd is flexing their might. Autistic weebs are claiming their power in the American elite class. And our politicians ans generals should be thrilled. It’s not not a moment too soon to put the engineers in on the great game

Showing off your niche knowledge is a favored elite game. Millenials & Zoomers understand their reality is being built upon arcane information and have gone for the deep cuts to keep up.

While on Tablet I came across their coverage of the Democratic National Convention where bizarre communist fervor from identities as inscrutable as Zoomer Hoxhaists are on display. Enver Hoxha being the infamous (and possibly crazy) communist dictator of Albania and not a good guy. But clearly some idiotic online intellectual has to treat history as if it were finding a cool band.

So if you subscribe to hidden knowledge as social capital then it’s time to read up on Gaetano Mosca and the Italian school of elitism. For discourse watchers, they were notable anti-fascist thinkers.

If you made it through the marathon Joe Rogan episode interviewing Peter Thiel you might have caught the memes about Chimp Empire. Well turns out that’s topical and an approachable angle.

every society could be split between two social classes: the one who rules and the one which is ruled

The current elite class of interests has looked beyond our military industrial complex to to Silicon Valley. They have known for sometime if you want to beat the communists (or the fascists or the oligarchy) then partnering with the new nerd elite is now your move.

Don’t worry Douglas MacArthur was a red blooded American military man and a weeb. Autists long a good track record in defense innovation.

If you want an eye to the future then learn the ways of the weeb. Drone warfare and embodied habits? Take it a step further WinterMute. Your transgendered simulated intelligence running that drone was trained on green text and it’s time you learn to speak like a native of the hive mind.

Rise up cat girls! Now is the hour of the weeb. Do it for America. Do it for capitalism. Do it so we get some sick Mecha suits from Uncle Sam.

Categories
Emotional Work Politics

Day 1315 and Ratfucking Season

I’ve been engaging in more of American political discourse online as we head into the main campaign season. That’s probably a mistake.

American is no country for old libertarians. Or in my case middle aged small “l” libertarians who aren’t keen on more government involvement in anything. Cyperpunk is became daily life and the crypto-libertarian instincts some of us were raised into make us distrust this particular flavor.

But I’m in a pretty decent mood all things considered. Perhaps the typical depressive lassitude of the sunny season is being mitigated by the climate controlled extremely online nature of the networked era. Madness without breaking a sweat.

My people are not much for sunnier climes and our popular culture representations have more than a touch of summer madness. Better to keep us indoors when the mercury climbs.

And yet the madness seeps in to the virtual worlds of media. August is full of ugly surprises.Which brings me to the rat fucking.

As I said, I’m watching American politics. It’s definitely Knives Out season and as my friend Jon Stokes points out the semiotics are ugly. Now that we have the Vice Presidency match up set as Ohio Senator JD Vance versus Minnesota Governor Tim Walz we can run cultural scripts. It’s already ugly, sexualized and bullying.

meme warfare b/c it codes Vance as the self-loathing, repressed kinkster who hasn’t yet come out to a loving ally dad who’ll embrace him & pass the torch to him

This is ratfucking season and the Democrats are on top of their game. Politico has a short history of ratfucking which anyone interested in political campaigns would do well to read.

Roger Stone has been with us doing dirty tricks for so long sometimes we forget that both sides are up to it and have been since before Nixon.

Like my goodness how things don’t repeat but rhyme in twisted new ways. We’ve got a Kennedy with a car crash crash and carcasses in the news.

It’s wild that the same people are still around and involved and somehow not dead. You shouldn’t get to do the “Summer of 68” twice in my opinion. And absolutely nobody wants a repeat of the 70s. Can you imagine cultural stagflation? Actually maybe I can

Maybe we are doing reinforcement learning in a simulation of some sort and we actually are in a gradient descent of madness being smeared across an event horizon of frenzied power dreams of an artificial American swampland simulation that ran too long. It’s all awfully crisp.

Categories
Aesthetics Politics

Day 1303 and Toaster F*ckers

If you are someone with a gentle constitution who finds vulgar language or discussions of sexual appetites upsetting, this post won’t be for you.

I doubt I have readers like this as one of my most viral pieces was titled “dickriding” but just in case you’ve been warned. I’ll be discussing the toaster fucking problem today.

I’m not a big consumer of pornography nor do I enjoy most fetishes but I generally share the attitude that you shouldn’t yuck someone else’s yum. Millennials are a tolerant sort. Yet I wonder if it’s time for us to revisit philosopher Karl Popper’s Paradox of Tolerance theory.

Karl Popper’s Paradox of Tolerance, introduced in his 1945 work The Open Society and Its Enemies, posits that unlimited tolerance can lead to the demise of tolerance itself. Popper argues that if a society tolerates intolerant ideologies without limits, those ideologies will eventually dominate and suppress tolerance. Therefore, to preserve a tolerant society, it must be intolerant of intolerance.

via PerplexityAI

I’ve have a lot of skepticism about how one executes on being intolerant of intolerance. It’s often illustrated with Nazis. Now there are many ideologies I find intolerable but as an American who believes in free speech I will fight for the right to be intolerant. As long as you aren’t trying to mess with my inviolable rights go ahead with your weird shit sexually, politically or otherwise.

Naturally this has yielded some people who go a lot further than you’d like. There is a Hacker News post that has come to be known as the “toaster fucker problem.” I’ll post it in whole so you can get the flavor of just how far people will go for their weird niche obsessions.

I blame the internet. Back in the days before it, we had to learn to live with those around us, now you can just go out and find someone as equally stupid as yourself.

I call it the toaster fucker problem. Man wakes up in 1980, tells his friends “I want to fuck a toaster” Friends quite rightly berate and laugh at him, guy deals with it, maybe gets some therapy and goes on a bit better adjusted.

Guy in 2021 tells his friends that he wants to fuck a toaster, gets laughed at, immediately jumps on facebook and finds “Toaster Fucker Support group” where he reads that he’s actually oppressed and he needs to cut out everyone around him and should only listen to his fellow toaster fuckers.

Apply this analogy to literally any insular bubble, it applies as equally to /r/thedonald as it does to the emaciated Che Guevara larpers that cry thinking about ringing their favourite pizza place.

Now you think surely internet fetishism has nothing useful to teach me. Surely this sort of thing wouldn’t bleed into serious spaces like politics or economics but after 2016 all bets are clearly off as to the seriousness of our political discourse.

Everyone is fully free to go to the absolute lunatic fringes of every issue because no matter how wild your beliefs you can find someone else online who shares it.

If you want to fuck a toaster not only will you find fellow fetishists but Rule 34 suggests there is probably pornography of it. Who could have guessed the consequences of 1987’s cartoon The Brave Little Toaster right?

Because totally regular people are no longer shamed for being into weird shit you can, and do, see totally regular people discussing weird shit.

It’s often hard to judges what real and what’s fake. A Twitter shit poaster went viral for suggesting that Vice Presidential candidate J.D. Vance fucked a couch. The memes are amazing.

It was was fact checked as false by the AP and other news organizations. The comedians will never let it go as hey these days who knows if the guy is a couch fucker. A popular Netflix cartoon called Bigmouth made horny tweens fucking a cushion a plot arc so maybe the millennial senator from Ohio might be too.

Now as much as I’m all for presenting all sides of an issue it’s very possible that we can take people at their words. We don’t need to ramp everything up to toaster fucking. It’s perfectly fine to discuss things on the merits without going to the edge of the metaphorical map of social propriety. So I guess I’ll be looking for a copy of Popper on the book shelf this weekend.

Categories
Biohacking Chronic Disease

Day 1283 and nAChRs

Never one to take things laying down, I started a crazy “n of 1” experiment today. My family doctor prioritizes keeping up on literature. We’d chat about anti-inflammatory research in reputable journals.

But I am on week seven of Covid symptoms simply not clearing. I’ve been coughing when under stress or exertion, my seasonal allergies exacerbated the issue, my reconditioning of my cardiovascular system wasn’t going great and I was exhausted.

At a visit with my osteopath who helps with my chronic autoimmune issues in my spine (I’ve been diagnosed with ankylosing spondylitis) I mentioned my ribs felt tender and constricted from Covid coughing.

She asked me if I was familiar with the research coming out about Nicotinic acetylcholine receptors and Covid-19 treatments. She’s casual like that.

Now I am a child of the internet so I’m passingly familiar with Gwen’s work documenting scientific literature on nicotine but I had not ever thought I’d try it myself.

In a joking “don’t try this at home” way my osteopath said she’d seen folks use nicotine patches for a week to shorten their Covid symptoms to some success.

Now for some caveats. In any type of crazy self treatment it’s important to consider your risks and consult a professional. Don’t do anything without your doctor’s input. Every medicinal treatment has risk and side effects.

I am using going to use a 7mg slow release nicotine patch (of the type made for smoking cessation) for the next 3-5 days to see if it impacts my over-stayed their welcome Covid symptoms. I started my experiment at 9am Saturday July 6th.

I am treating this as a “kitchen table” science experiment in which I am clearly an N of 1 from which you can only take anecdotal evidence. But maybe one data point becomes many and with the network effects of social media maybe we push forward other experiments.

Here is what I know so far thanks to searches from perplexity AI but I encountered some of the papers through mutuals on Twitter, some on forums, others I’d discussed with physicians, some were just raw dogging Google Scholar.

The AI synopsis I’m sharing isn’t meant to be conclusive just to give interested parties a starting place to see why I believe this is an experiment I’m comfortable running on myself.

Nicotinic acetylcholine receptors (nAChRs) have been proposed as potential therapeutic targets for COVID-19. Research suggests that the SARS-CoV-2 spike protein may interact with nAChRs, potentially influencing the disease’s pathophysiology[1].

Nicotine and other nAChR agonists could modulate inflammation and the immune response, offering therapeutic benefits[2][3].

Sources
[1] Simulations support the interaction of the SARS-CoV-2 spike protein
[2] Disorders of the Cholinergic System in COVID-19 Era—A Review of
[3] SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine

Given that I’m working with inflammation as my primary issue which is not modulated even without Covid, I was obviously quite curious to learn about this cholinergic system and potential for up regulation. I’d seen discussions as early as 2020 about the curious fact that smokers had experienced some protection from Covid infections.

This all clicked in my head as being testable on my own without significant risk. Gwern had significantly reduced my concern about nicotine usage where previously as a child of the drug wars I’d put smoking nicotine in basically the same category of dangers as injecting heroin. It is not.

It seems it is possible we’ve got an explanation for why smokers didn’t catch covid at the rates you’d expect and they did better with the infections. We may even have things to learn from it to improve treatments.

Nicotine agonists could potentially be used to prevent inflammation in COVID-19 patients by modulating the immune response. Nicotine, a cholinergic agonist, has been shown to inhibit the release of pro-inflammatory cytokines, which could help mitigate the cytokine storm associated with severe COVID-19[1][2][3].

The cholinergic anti-inflammatory pathway, activated by nicotine, suppresses maladaptive inflammatory responses, suggesting that nicotine or similar agonists might offer therapeutic benefits in managing COVID-19-induced inflammation[3][4][5].

Sources via PerplexityAI.
[1] Nicotine and Covid
[2] Can nicotine alleviate the dysregulated inflammation in COVID-19? L
[3] Medicinal nicotine in COVID-19 acute respiratory distress syndrome
[4] Nicotine and the nicotinic cholinergic system in COVID‐19 – PMC
[5] Cytokine Release Syndrome (CRS) and Nicotine in COVID-19

Stopping a maladaptive inflammatory response is one of my top goals. If I can test it out with a cheap over the counter substance well I’m interested.

Andre Watson the CEO of Ligandal (not an investor just a fan) an AI discovery platform for precision targeting of therapies suggested a method of action for nicotine’s effect.

Nicotine and quercetin were some of the earliest predicted compounds to reduce the binding affinity of the spike protein to ACE2 — which in turn, we described the MOA of here: biorxiv.org/
TL;DR is that reducing the affinity may increase neutralizing immune response.

I do want to reinforce that I am aware nicotine is addictive. I’ve had to take drugs that form chemical dependencies in the past. I’ve used Prednisone in the less controlled phases of my spinal condition and tittering off that steroid is a nightmare. But it can be done. It is doable with a plan, careful monitoring, and supervision.

All evidence suggests this experiment isn’t long enough for me to develop a dependency let alone an addiction. I am thankfully free from any genetic predisposition to addiction in my family.

I plan to do a B3 Niacin flush at the end which is meant to help tittering. I will also be monitoring my heart rate as Nicotine has a tendency to raise your BPM so if I don’t like what I see I’ll lower dosage or stop usage.

With all that said, let’s see if it helps me out. I’ll post because it is in my nature.