Tag: Wellness

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Biohacking Medical

Day 1915 and Physiological Stressers

Last October I did an experiment to balance out my core hormones by inserting pellets of testosterone and estradiol into my left buttcheck.

We’re started me with 10mg of estradiol (range 6-25mg with 8-10mg being most common), and 75mg of testosterone (range 50-150mg with the most common being 75-100mg. Day 1748

If you are interested in learning why women are optimizing their hormones, Cate Hall wrote an amazing piece on how it affected her life. A week or two after I did my own experiment the New York Times did a long lifestyle piece on the treatment’s growing popularity.

I had been working to raise my testosterone level to a baseline minimum with diet and supplements like DHEA with mixed success which is how we ended up trialing this new pellet method. And it worked very well very fast you can see from several rounds of bloodwork.

We did not do the full 75mg but landed around 62mg in the pellet which raised my testosterone right off the bat. It then quickly dropped off from very high to comfortably high. This go around we will do a lower testosterone dose to start and a lower estradiol one as well and test within the month to see if we can moderate them better over time.

Alas I did have some complications on my first attempt as my insertion sight got infected rather badly and took over a month to resolve.

If thr last fifteen months on my immunotherapy Bimzelx has had a theme it would be soft tissue infections. I am however as far out from a shot as I can be and am planning to stop it entirely as a girl can’t spend her whole life on antibiotics.

Though I am on quite a dose at the moment as we won’t make the same mistake twice. We stitched me up and prophylactically began a dose of a very intense antibiotic with the hope that I won’t lose a whole month of the four that these pellets dissolve through fighting cellulitis.

My goal is a balanced blend of estradiol, testosterone and progesterone so I have energy and focus and maybe fewer migraines during my luteal phase. You may wonder why I share all of this personal information and I wonder why more women don’t share it. We are in a brave new world of challenges in our healthcare and environment and the more we can share with each other the better our chances at finding solutions for all of us.

Categories
Biohacking Chronic Disease

Day 1914 and Restoration Hardware

Montana spring doesn’t come at the Equinox but today we had both sun and warm temperatures. I am grateful for the weather as I needed a day of restoration as I felt quite rundown from my sprint through Washington D.C last week.

After a morning walk to take in the sunlight, I went through my collection of “restoration hardware” in an effort to build my resilience. I am restarting another round of hyperbaric chamber oxygen therapy as it has been four months since my original 40 session course.

I ran my infrared mask not only on my face but my neck, scalp and another personal area “down under” as a have been struggling with soft tissue infections with my autoimmune therapy Bimzelx.

I have decided to stop the Bimzelx entirely and see where my bloodwork goes as my inflammation biometrics look good and it’s been a source of so much trouble. I gave it an 18 month run and while the results have been positive in my bloodwork the cure may be worse than the disease.

Now I’m laying on my heater PEMF mat from Higher Dose as the red light of the bedroom lulls my circadian rhythm down into the evening hours. I have no idea if it does much but the heat is soothing.

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Biohacking

Day 1912 and Informing Ourselves

Some 20 years ago, before I knew I’d have medical troubles of any length, my college job was working for a medical ethicist who was a physician with a grant to study informed consent.

Now, years later, as I have worked my way through institutional resistance to how I may come to be disabled and generally dismissed as a patient, I come to find that much of the skepticism my mother had as a crunchy hippie is now functionally being proved a quarter century on. These uncomfortable trends drives skepticism in even the most informed minds. And most patients can only ever be expert on their symptoms.

This comes at the end of a crisis of communication about the value of public health and personal responsibility in a community. Many people did not feel that they were given adequate consent and no longer trust anything said by doctors. Would most medical professionals agree they had informed consent? I think most argue they were. I agree.

Now of course we’re all desperately trying to prevent harms here and patients more than ever feel that, as they don’t trust what’s coming to them because we’ve not effectively decoupled population-level information from the individual human behind a given case. Is that informed consent? Yeah as best we can do it.

Now how does research play into all this? I also happen to have the misfortune of having working on the early years of on one of the worst medical misinformation spreaders in all of healthcare. I say this lovingly: it is Gwyneth Paltrow.

Now if you root around Twitter, you will find commentary about how the supplements hawked on Goop and the supplements hawked on various right-wing sites are functionally identical. But she got a lot right because she is a rich well connected white woman with money. So again who is informed and to what degree?

Unfortunately some of the things that are sold as treatments or supplements they sell are real and have proven out. We’re working our way through the science on our gut biome, infection and its links to preventable autoimmune diseases, and any number of other previously heretical paths.

But we’ve really not transformed the way we process our information on what we know and what is actually considered best practices. The gap is very wide. Like a chasm. I am way outside the norms because I fucked myself up believing I wouldn’t be a statistic as it mostly worked for most women.

So I live with issues. But do I think that people have a right to experiment with what we think might be snake oil? Absolutely. Everyone calculates their own risk. Heck Sarno is just one giant placebo doctor on letting go.

We know that some of the avenues of exploration will prove to be placebo effect if they work. And we still somewhat trust things that are actually going to cause harm aren’t really making it into the popular press and mass consumption unless there’s some evidence. I sort of believe that to be true.

More people should feel that they have the right, if they have informed themselves over a period of time as patients, to work around the system if they make no progress despite best efforts and years of work.

There’s just a lot to balance on being informed about your conditions and your capacity to manage your own health that is up to you. I think that generally speaking the paternalistic attitude has not produced superior outcomes.

And the quality of care I get as someone who can pay for health care anywhere in the world, it is galling to me that the gap between what we know and how far we can go in practice is so wide.

So let the guy advertise the doggy cancer vaccine because at least it’s teaching people that we have solutions to more than they know. They can judge risk reward and be a little bit strange. Humans are humans.

You get to decide it based on your own understanding of your own life and you get what you get. I was disabled by my own misjudgment of informed consent on treatments recommended by a COO of a major company who paid to have as a perk to her workforce. Egg freezing was an approved elective procedure that everyone was on board with ten years ago.

I was informed. I consented. I got it wrong. Now let me see if I can fix it in my own manner of choosing. And I won’t trust mere authority next time. Neither celebrity nor pharmaceutical company is to be trusted.

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Biohacking Chronic Disease

Day 1899 and Off To Sleep

I regret to say that after yesterday’s various excitements through my continued ill health; did not leave me with anything for today.

I crawled out of bed for a coffee far too late. Was greeted by marginally better biometrics such I think my Whoop took pity on me by giving me a green.

The trouble with context and personalization? It was only barely better than the reds of the worst that continued into a week of yellows where my resting heart rate and heart rate variability went in the wrong direction.

I largely spent today sleeping because I could t get enough last night. I hope you don’t mind if I go back to my nap as waking up was a challenge.

Categories
Aesthetics Travel

Day 1893 and Gusty Groaning Roaring Winds

Yesterday I went from the bright blustery Pacific surf beaches of San Diego to the fault block ridges of the Bridger Range in Montana’s Rocky Mountains. Going from one climate to another in the span of a few hours remains a wonder for me.

While I enjoyed the nervous system soothing peace that comes with watching the waves, I did feel a sense of relief coming over the snow capped peaks into the Gallatin Valley.

It’s been a dry winter with very little snow pack, ans the accumulation is much needed. It’s odd for Montana to have had so little snow this winter. I missed much of it but in truth I’ve seen more real winter in the mountains of Sarajevo and Greece than Montana.

I’ve been at sea level for long enough that I am nervous about my adjustment to altitude. After unpacking and restocking groceries, I went for a mile and a half loop that is my usual leg stretching route.

My V02 max remained identical to the scoring from the day before at sea level. My other biometrics are in a difficult place with my resting heart rate high and my heart volatility quite low

Twenty mile an hour gusts wiped across the valley which encouraged me to move a little faster than usual and breath deeply when I could. It was a stark contrast from the slow ambling cross sandy beaches that made up my recent exercise. The stress of altitude isn’t just the oxygen and exposure to the sun but the generally more challenging conditions.

While the mountains have enjoyed some fresh snow, the valley is brown and dry. It’s bizarrely warm at 58 degrees as we spring forward. The record high for March 8th is 62 in 2004 but we are meant to see an inch of snow and a drop back into the lower 30s.

We shall see how I adapt but I need some rest as the rate of change for everything is as jarring as waking up on the beach and falling asleep up in the mountains in the space of one day.

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Aesthetics Travel

Day 1892 and California Soul

As you may have guessed I wasn’t in Montana the last few weeks. I was in San Diego for a short stint. Some might call it working remotely. I’d also say I was testing a few health theories which remain inconclusive.

It’s always hard to determine health experiment when a random bit of personal maintenance details like needing dental work messes your data up. Biohacking works best in routine and I only keep them up seasonally.

I did get to spend quiet time on bluffs and beaches with my thoughts and a few friends. I’ve been listening to cocktail lounge classics intermixed with California Soul. Do you know the way to San Jose?

Connie Francis knows the way to San Jose

Going to California in the winter and it not being San Francisco is a bit of a new thing even though my husband went to college at UCSD. Any hints of early results in biotechnology used to come through their labs. And even some of their neurologists contributed important math to gradient descent

It’s a shame to have lost so much of the frontier to the petty encroachment of fiefdoms and institutional capture. California has a lovely soul. And imagining my parents finding a cheap way into housing in San Jose seems almost comical but maybe you could put $100 down and get a car. But now the place with a lot of space to get some peace of mind is the rocky mountainside. Maybe one day they will fix prop 13.

Coastal grandmother

Categories
Chronic Disease Startups

Day 1889 and Recovering from Normalcy

I had such a lovely day touching grass (and sand) yesterday. I slowly worked through a 36-48 hours of of talking, walking, strategizing and occasionally reapplying sunscreen (I still got burned a little on my shoulders) with a friend who is preparing for big life and company changes.

These are the activities of normal life that I cherish, but my body seems hardly able to manage the strain this week. Now perhaps these activities are stressful on the mind and soul, but should they really be so physiologically taxing for me?

My Whoop is showing high strain

Now yes I am recovering from some dental work and on antibiotics but shouldn’t I be able to have a calm day that most would consider restorative? The serene peace of sitting on sandy shores should surely outweigh any areas from consequential questions of power, compute, realism and human purpose right?

I have barely been able to get out of bed today and the ten minutes of squats and planks I did to test my capacity spiked my heart rate into the stratosphere.

Which is odd as I woke up with my RHR in the 60s which is much better than usual. I only get into the 60s or 70s consistently when I am on heavy antibiotics.

The two weeks I was on Cipro recovering from surgery this summer my RHR was in the mid sixties so clearly I’ve got something going on with low grade infections.

I struggled mightily to organize my thoughts enough to write even this post. I feel I might even have it in me to go for a walk. Which is encouraging as I missed the sunset. The sunsets are obviously an event when you have a beach or far off horizon to enjoy with then.

Categories
Biohacking Internet Culture Politics

Day 1886 and Whoop There It Is

Quite a weekend for Americans and the wider Persian Gulf. Let us hope it is resolved swiftly and with the least loss of life possible.

It happened quickly. On Friday night policy types were arguing about artificial intelligence with our department of war about use cases and contacts. And then on Saturday we bombed Iran and they bombed pretty much every neighbor they have. No wonder they had a midnight deadline eh?

I’ll stick to human interest here but Chief of Staff Susie Wiles appeared to be wearing a Whoop tracker in a secure room which was confirmed by the company’s CEO by tweet.

The original concern being that some fitness trackers break NSA protocols as they have audio recording and other data recording which wouldn’t be appropriate in a dark room type the situation room.

Interestingly Whoop is approved by the NSA for use in these situations. Per the CEO the Whoop does not include a microphone, GPS, or cellular capability of any kind and has long been on the NSA approved PED list.

I myself wear both an Apple Watch and a Whoop everywhere but I rarely need to be out of the prying ears of recoding devices but it’s good to know.

Whoop’s CEO joked that given the success of the mission Susie Wiles must have had a green recovery score (quality sleep, low resting heart rate and high HRV) though I imagine she must be feeling the stress now that it’s over.

I wonder if her score worse than mine. I needed steroids and antibiotics to manage the flare post dental work and my body is under more strain than you’d imagine.

It’s somehow nice to know that the most powerful people on the planet use the same tools as I do to track their biometrics. From billionaire founders like Bryan Johnson to the Chief of Staff of the President to little old me. We all wear the same track. If you want a referral code here you go.

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Biohacking Medical Travel

Day 1856 and Always Something So Always Trying Something

The world is a topsy turvy place and I am doing my best to meet it head on. Physically I’ve managed a surprisingly steady period from December through January, even though I spent a decent portion of that on the road.

I credit this mostly to using antibiotic and anti-fungal regimens prophylactically. The biologic immune suppressant I currently take for my ankylosing spondylitis is quite frankly too good at its job. And I’ve tried quite a few.

That means I am locked in a battle of constant vigilance in order to keep my inflammation numbers down while also not becoming a host to bacterial, fungal or other infections. It’s a balance that is anything but delicate.

In 2025 I had been unable to fight off skin, soft tissue and mucosal infections seemingly at all. Even with extensive protocols for decolonization (intranasal mupirocin, chlorhexidine washes, environmental decontamination) I had four major infections.

Of those infections, three required surgery and the fourth was the result of a very minor incision to insert testosterone and estradiol pellets. Those surgical interventions proved very trying and also very expensive.

The last one (testosterone) helped quite a bit with energy but being energetic doesn’t matter much if you can’t fight off infections.

So while I know there is an individual and social long‑term systemic risk in using antibiotic prophylaxis, I will say it does seem to be helpful in mediating say outbursts of allergens flaring into soft tissue infections from skin breakage or having exposure to molds and fungal growths that fester in old damp buildings and water systems creep their way into any opening available.

Since it is always something, I figure I need to always be trying something. Frankly I am over the push and pull of managing medical care in America. It’s a mess and mostly designed at risk mitigation for the health systems.

I have found going abroad to be much more useful and cost effective in many cases. I may even find that it would be useful to document the experience in a format beyond a blog as I doubt I’m the only person manage complex chronic disease.

Categories
Travel

Day 1847 and Cardio versus Packing versus Ski Bunnies

I’ll be on the road for a portion of tomorrow. Other members of my traveling party have already pulled ahead to parts unknown, as shifting obligations and vehicle needs turned schedules this way and that. Nomads as we adapt to a new world.

Europe is in a tense state and the weather hasn’t helped much. As I’m writing, Davos is awaiting Trump speech in the Swiss mountain town.

I finished a workout in the hotel gym but my room wasn’t quite ready for me, so I went down to the lounge to take in the BBC having had my fill of Bloomberg commentary while in the gym.

Management must keep up with their bosses

You can probably spot the hotel brand and imagine easily my experience intaking the World Economic Forum by proxy as I attempt to manage my life and health in the unspooling of the order of things.

I packed up a slightly unusual range of things for my transit tomorrow, as I had been going by car but will hop a low cost carrier to recenter. Somehow this has my large luggage separated from me. I’m carrying a very fine leather duffle I recently acquired as a gift for my husband.

Will this work for my carry on and personal item?

I have gone from doing a bit of cardio bunny as I work to improve my V02 max to a pack rabbit, as I moved around this and that to be sure my cascade of items and medications were within reach and packed appropriately. And would make weight but I’ll get to it.

I’ll not end my travels as a snow bunny in Davos though I have seen rather a lot of snow in Southern Europe as far south as Greece.

Why are bunnies on my mind? Well I have to keep in mind some odd weights for the low cost carrier I’ll be using for a short hop. Just look at this guide to baggage.

3kg is a silly amount of weight for a bag. That’s the weight of a house pet like a bunmy

3kg (3 kilograms) is equivalent to approximately 6.6 pounds. While this weight is roughly the size of a medium-to-large house rabbit rather than a “small” one, it is a common weight for many everyday household items like a large bag of flour or three liters of milk. Via Perplexity and Weight of Stuff

For whatever odd reason, the carrier listed your personal item or under seat bag as needing to weigh 3kg. This is about the weight of a house rabbit.

Which is honestly not a lot. I doubt any purse I’ve ever carried is under 3kg when you account for laptop, shoes, cosmetics, wallet and other sundries. But we shall see if my backpack can do it. Nothing but pajamas and medications ought to keep it light.