I love Carl Sagan’s Contact. I first read the book in my middle school years and was allowed to watch the movie starring Jodie Foster despite having a very limited “screen time” diet.
As I got older I was allowed to watch edifying science fiction and book adaption only if I had read the source material. Contact passed both tests
It’s a beautiful story of faith and science about on a radio astronomer who finds a signal from alien intelligence which kicks off a planet wide space race to make contact.
There is a scene in the film where our protagonist Dr Arroway is set to launch a machine which we humans do not fully understand but is presumed to be some sort of transportation device.
Just as the countdown nears zero, she loses contact with the ground team. Roaring machinery and turbulence drowns her voice as she repeats over and over “I am OK to go” until a blind colleague finally picks her voice out of the static. The capsule is let go. I won’t spoiler it.
I’m OK To Go
I had a little moment of being out of contact myself today. I am now the proud owner of a hyperbaric chamber but still getting used to the machine. Alex, watching me as I adjusted, communicated with me through the glass with gestures.
Hyperbaric chamber oxygen therapy has roots in diving as managing pressure changes is an important aspect of safety for underwater and high altitude work.
When diving you don’t give a thumbs up to show you are alright. Thumbs up actually means ascend. You give the OK sign to communicate that you are doing fine.
The “OK” hand signal in diving is formed by touching the tip of the thumb and index finger together to make a circle, with the other three fingers extended upward.
Even as I was a little dizzy and struggling to acclimate I was ultimately “ok to go.”
An auspicious pair of numbers for today’s date and I started something new which has been in the works since January began today. Our long awaited hyperbaric chamber has arrived and been fully set up in our yellow barn.
A lazy boy lounger and oxygen under two atmospheres of pressure.
It feels good to begin a positive focused wellness activity after what was otherwise a chaotic week of travel, geopolitics and violence.
As expected, it is not fun living through my own investment thesis. So you better believe I test my theories on myself. I want to survive the Jackpot.
Before Trump’s inauguration, we decided to purchase a hyperbaric chamber after one of our mutuals told us about his HBOT trial at a conference in the fall. It went very well for him and the research is promising for inflammatory conditions.
Over the winter break I happened to be in a city where I could test HBOT cheaply and was very impressed with the results in only ten sessions during a flare in my autoimmune condition. Crimping from Bryan Johnson
Hyperbaric Oxygen Therapy (HBOT) involves breathing pure or nearly pure oxygen (95-100%) in a pressurized chamber at anything above atmospheric pressure (2 ATA is equivalent to being 33 feet under seawater).
The increased pressure enhances the lungs’ ability to absorb oxygen, boosting oxygen levels throughout the body. The therapy aims to promote rejuvenation by increasing oxygen concentration in tissues, supporting healing, cellular repair, and vascularization.
This sent me down a rabbit hole as I did a bunch of deep dives, got some text books and came to a simple conclusion after a lot of medical papers that it’s pretty simple.
It’s almost philosophically the way of life in the mountain west. Oxygen and pressure work on the biomechanics of a functional body. Alas getting my basic market model to Montana ended up being a cluster fork of issues. We placed the order in January.
For months we waited for what we’d been told would be a 6-8 week process. Alas all hell broke loose. We had tariffs uncertainty with the importer and the OEM.
I have now, in September, after a long journey but a simple set up process, begun my first intensive protocol for autoimmune diseases on our own hyperbaric chamber.
Love your body enough to put it under pressure and take a deep breath.
I will complete a minimum of 40 sessions (5 sessions weekly) at 2 atmospheric pressures, in a hard chamber from OxyRevo with each session 90 minutes while breathing 100% oxygen for 20 minutes separated by a 5 minute break.
If you are interested and see strip mall options note that these are not consumer grade machines. The protocol requires a hard chamber to achieve that pressures. It’s quite a bit higher than soft chambers on the market.
There are risks associated with HBOT from correct pressurization issues to impacts like tinnitus. The more prepared you are to adapt to changing pressure with breathing techniques and equalization (looking to divers for these protocols) the happier your central nervous system will be.
As I often do on transcontinental travel days, I wrote my post for the day first thing in the morning. I wasn’t sure how the journey would go so I thought “let’s post this early” in case things get hairy. And boy did it.
It’s a weird thing to complain about air travel on 9/11, but I don’t think much of the security theater we’ve accepted over the years did much to keep my transit safe yesterday. Twenty four years later we go through the motions of keeping air travel safe from terror because what else are we going to do?
In fact, it didn’t seem as if security was particularly tight yesterday so much as particularly incompetent. It was chaotic confusion everywhere from passport checks to boarding flights.
I had a Frankfurt to Chicago polar day flight, along with a positioning flight on each side. I went through a lot of security screenings and passport checks yesterday and stood in more lines than I can count.
In Frankfurt the lines were so long that even with planned two hour airport transit time, I was among the last to board my flight.
The “special purposes” line I begged my way into as my inbound was delayed by fog was glacial in its pace. It seems the new transit grift is wheelchairs. So perfectly abled people are now pretending at disability to board early and use special security screening lines.
It left wishing I’d registered my real disability as I attempted to run the two miles of the international terminal with suitcase and backpack torquing my spine so I wouldn’t miss my flight to Chicago.
Deplaning at Chicago I couldn’t even count the full set of wheelchairs waiting.
Add in enormous confused families using the special purpose line, who spoke neither German nor English, with 3-4 bags a piece and every sort of banned item from pocket knives to 1.5l bottles of liquids and I am shocked anyone made it through security to their flights on time.
I watched a foursome of black Arabic speaking grandmothers in hijabs and wheelchairs shouting at German security guards and their extended families as I waited for my turn. Their fierce attitudes did not speed anything up that I could tell.
I saw them 9 hours later gathering somehow even more checked luggage upon arrival in O’Hare. I’m glad my Global Entry let me pass them by at passport control as I did not want to be behind them again.
Not that I got through Chicago’s security lines unscathed. The TSA pre-check lines were four times as long as the regular line. Figuring I was well packed I could handle the normal line. Naturally I got randomly selected and unpacked basically everything
As I stood in my socks waiting for the agents to stop gossiping and listen to the only working agent explain to them that “yes that the ice pack was for medications so they can move this along” I got an alert on my phone that the conservative political organizer Charlie Kirk had been shot.
I wandered in a daze to the United club where I was denied entry. This despite booking a business class ticket for the entire transit through their own hub via their Star Alliance partnership with Lufthansa, I couldn’t use the club as “the last leg of my flight didn’t qualify.”
I knew this was possible as this last leg issue happened to me on my last transit through O’Hare so I’d bought a day pass ahead of time. But they weren’t honoring those as it was too busy. I schlepped to another club in the terminal where they were still letting in day passes. There I listened to scared speculation from two blonde women about Mr Kirk’s status.
Another hour later I made my way onto my flight to Montana. I decided to just jump to the front of the line as I was in first with seat 2B. If everyone is ignoring lines then it was irrational to keep trying to politely queue.
As the plane boarded it was all talk of Mr Kirk. A news alert crossed my phone saying he had been killed.
A gentleman was playing a video of stitched together angles of footage on his phone with full audio on. You could hear the bullet hit again and again.
The cabin attendant told him to turn it off, saying sir please have some respect for the dead. A few hours later, still living, I made it home to Montana.
It’s hard not see every day as more of a beak with the past even as so much remains the same. No wonder the French have that handy slogan about “plus ça change” as systems remain even with violence. They really know how to balance being disgruntled with the past.
I was suggesting La Haine to someone earlier this week as the French movie that made an impression on Gen X and elder millennials who paid attention to Francophone culture. It’s hard not to think current problems are similar tensions recycled for a whole new era. Atmospheric, vulgar and dangerous are the keywords.
The addiction economy repackaged the same old things that kept our attention economy running. And they will keep running it till it is so refined and so well packaged you won’t even remember that Starship Troopers was meant as a satire of fascism.
We repeat so much. The Churn as the Expanse called it.
Amos: This boss I used to work for in Baltimore, he called it the Churn. When the rules of the game change. Kenzo: What game? Amos: The only game. Survival. When the jungle tears itself down and builds itself into something new. The Expanse
Survival breaks out into the only game all the time and we are always running a Red Queens race. So try not to get too distracted. Ween yourself off of anything that you’ve not got any reason to hold dear. Change to meet what you can so long as you can still see yourself.
Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.
They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.
So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.
Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.
Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.
I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?
“So I heard you had side effects so I gave you a side effect for that side effect.“
And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.
Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.
Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.
GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:
Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. SourcesSources
Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. SourcesSources
Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.
Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.
TB-500 (Thymosin Beta-4 Fragment)
TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:
Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.
TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.
BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:
Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26
Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.
I sometimes think my best work is as a reply guy on Twitter. If the future of the Internet is to be made entirely of bots, I shall mourn the creative glory we will all lose.
We will all be missing out on the bizarrely specific interplay between post and reply guy. The signal, node, and repeater that is the feed where humans can still bounce off intuition and humor. They know the algorithm merely as the setting for their gamble.
I’ve been doing what is probably a terribly ineffectual public education campaign on artificial intelligence and its role in improving problems in the here and now.
But I am often cheeky about the ideological disagreements the more practical minded builders have with a pretty standard issue Bay Area sex cult. Having been raised adjacent to a lot of hippies, cultists, religious fundamentalists and any variety of new age woo woo Art Bell types I’m actually generally quite tolerant of our weirdos.
Of course this is a challenge as we build out the most important informational and systemic organizational technology of our species. Math has taken humans pretty far.
And mathematicians are quite often mad so I don’t see how it should be such a worry. Still I myself don’t want to be stuck inside an information hazard where I am tortured for eternity either. And therein lies the tweet
Look I’m just saying it’s my personal opinion, but I think it’s bad that the future of our knowledge graph is being made by those who get off on Lovecraft but like that’s just honestly mostly a personal human alignment thing because I don’t wanna be tentacle tortured in @RokoMijic basilisk
If you are familiar with the odd pockets of specialties you probably know that say furries are particularly good at network security and that transwomen are well represented in artificial intelligence.
Unfortunately other groups represented across the space including hardware, software and the philosophy of the space can be somewhat less wholesome than a fursona or a cute catboy.
The Rationalists have some members with odd extracurriculars in their science fiction. I’ve read some good stuff in the genre. Maybe this interest in fiction is probably how they imagine such horrific futures for us in artificial intelligence. Very improbable ones even.
So it’s on me to joke and show you where the weird can be and remind you not to take this too seriously as the experiment contains all of human knowledge. How we prioritize what is another matter. You might call that alignment.
I’m sure we are all wondering which AI safety researchers want to have sex with the many tentacled Lovecraftian old gods. The number of AI researchers with Cthulhu hentai is non-zero.
So the sake of our right to decentralized compute, and indeed our right to do math and compute, we need as many types people as possible engaging with models as possible.
Find ways to learn this new way of thinking and engaging with information and searching for information with a billion parameters at play. Some corners of the most doom and gloom road have some uncomfortable fixations. And artificial intelligence needs all of us.
I wonder how much of the moral education of Americans comes thanks to Gene Roddenberry. Star Trek is a very American show. It was pitched to Desilu Studios (owned by Desi Arnaz and Lucille Ball of I Love Lucy fame) as a space western.
The cowboy frontier spirit of Captain Kirk has an honor code based on the worthiness of exploration. When the millenials got a reboot in the Next Generation, Captain Picard added the gravitas of excellence through the pursuit of the truth.
It’s hard to think of a show that embraces an anglosphere manifest destiny with more vigor and it is grounded in the enlightenment values of science and moral philosophy. It’s a very American show.
A legal drama ensues where Picard quotes the ambassador’s father famous words about the dangers of denying basic rights to even one man in the name of protection of society makes us all less free.
Feeling rather on the nose for the moment right? Picard reminds Worf as it wraps up the witch hunt being proven a lie, that those who cloak their misdeeds with the pretense of serving a greater good are often the most difficult. Spreading fear and mistrust in the name of righteousness must be guarded against.
“Vigilance, Mr. Worf. That is the price we have to continually pay.”
We have a chance at preserving and expanding the enlightenment values that brought our species to this moment, an American moment, by enabling more of us. We can educate ourselves and access the world and the many virtues to which humanity has aspired to by working hard to master them ourselves. This is the empowerment of compute.
We have tools available to us to be vigilant in what is the great good of civilization we wish to protect in an open, decentralized and networked internet.
That we can at scale train a new inference search capacity for the sum of our knowledge and reality is a utopian reality even Gene Roddenberry didn’t dream we’d have.
Don’t rush to summary judgement in fear over the future we can build with protocols and networks that can be encrypted and decentralized. That we can model them with artificial intelligence, and by asking questions well, get back information, code and even machine and biological diagnostics is a huge achievement for our species.
To push the fear of the greater good over its consequence can go from legitimate concerns to a drumhead summary judgement quickly. Risking the freedom to use something that is both just emerging and even in that infancy so promising. That it is helpful in the now seems to showcase both western traditions and enlightenment values.
It’s an American ideal that we must all be free to think and speak the truth, search for the truth and can calculate and provide a mathematical proof of truth that needs no trust because it can be know. We have a right to compute.
Artificial intelligence solves problems now. It’s better than humans now at many types of tasks even as it still a new tool and unrefined and even brittle in its capacities still. It’s took only as good as its craftsman’s understanding of it and we are still learning how to build it.
Artificial intelligence can give us the internet we deserve. I support the right to repair movement because I believe we should know and seek the freedom to own things we have purchased and modify them.
Right now AI helps humans can solve immediate problems from tractor repair to wound care. Maybe machines get better as we get better at using them because we do it with them. We figure things out by building.
Don’t let your worldview be constrained. You can know the freedom of living in a society that values your rights. And the right to compute weaves together many of your most sacred rights. And if we infringe on it for some of us it infringes us on us.
One of my Twitter mutuals recently published an artificial intelligence prompt for making an adaptive fitness coach which works inside any of the major large models.
Being failed rather regularly by doctors over a decade of chronic illnesses has made me skeptical of the institutions in American medicine. But having one doctor (a dermatologist) miss a glaringly obvious differential really shook me.
Her dismissal of the details and particulars wasn’t malice, but a function of the systemic inability to put enough attention on the details of the person in front of her. Attention really was all she needed ironically.
I’m sure she didn’t set out to be that kind of doctor, I’d bet she hates that it’s all 90 second visits and Medicare coding and making money for the private equity group who owns the clinic. I feel for her. She surely wants to get back to doctoring.
No one can spot every detail and retain the complexities of every case. Especially one like mine. But a computer has a much better shot at mimicking Dr House than I do at finding a Dr House for myself. And it certainly has a better chance than someone who let the system dominate them into breezing over the details.
So I am using my mutual’s prompt to see if I can outsource a very slow and adaptive return to fitness after my month off from exercise to recover from surgery. I like what I’m seeing from all models that I’ve tried it on but I imagine I’ll have all the same “me” problems with overdoing it and pushing too hard. But who knows, maybe this aspect of wellness is better handled by machine than by me.
It’s August and vacation season is in full swing. It seems as if all of Europe is off for the month. For the Americans who work around the school year, it’s their time for a week off as well.
We rarely vacation for an extended period and when we do it’s not generally during high season. Off season is where it’s at in my mind. But sometimes you need some fun when it’s been a hard time.
I’m struggling with how much I put online about my comings and goings and when I do it. Being careful used to mean not letting thieves know if you weren’t home but now the world is a mix of digital and physical security layered over artificial intelligence tools that can pinpoint you easily.
Opsec isn’t a thing elder millennials considered too carefully with digital identities in the early years of the internet but everything is changing. Dead internet theory may become true as the internet of bots begin.
I don’t intend to cede the digital commons though. I want my written voice to be integrated into the vast data troves that shift the records and is woven into the understanding of artificial intelligence and machine learning models.
The more these modalities of information storage and retrieval impact our human minds, the more necessary it is write oneself into “the Akashic records” that form our digitalization of information. Humans used to read and write machines but now machines and their media are just as likely to read and write our minds
So what are we to do about living in public? Humans are mortal but records of our world have a shot at reaching the future and shaping understanding.
Blogging has ended up being one of the best mediums for being scraped, organized and cited well by current artificial intelligence.
So having your fun in public and making it accessible just might be one of the most important things you can do to be a part of the record of our world. It’s just a terrifying prospect to be so easily seen.
The accelerationist types must be feeling smug as the disorientation caused by so much of the world speeding up is a persistent feature of life now.
I’m trying to organize a fairly elaborate vacation that I should have nailed down the details on at least a month ago. I am alas doing it what is functionally last minute and I’m panting at the effort of coordinating preferences, availability, timing and the thousand other logistical details.
We have a range of preferences to accommodate and it’s driving me a little bit nuts and I have no one but myself to blame. I cant manage more than three hours in a sitting position in a car or airplane without hurting. Standing helps but it’s really laying down and relaxing my spine that helps.
The other preferences are more of the one person likes fine dining and Michelin caliber restaurants and another likes delivery and Netflix.
We have to balance intensive activities in hot weather like hiking and sightseeing against the desire to lay out in the sun near a body of water. Really all the classics of different strokes for different folks.
I don’t want to be too ambitious about any of this as I am really just barely out of the woods from July. And I’m being vague about when and where, as I’ll like pretend like we have some amount of operational security. Writing is all about the specific but the best I can do is say it will involve driving and water.
