Categories
Travel

Day 1715 and My No Good Horrible Very Bad Transit Day

As I often do on transcontinental travel days, I wrote my post for the day first thing in the morning. I wasn’t sure how the journey would go so I thought “let’s post this early” in case things get hairy. And boy did it.

I was leaving Europe just as Poland closed its airspace after a Russian drone attack. Tensions were already high as Israel had attacked Hamas inside Qatar’s capital of Doha. Greyzone war that blur attacks on national sovereignty through target or weapon choices make everyone twitchy.

It’s a weird thing to complain about air travel on 9/11, but I don’t think much of the security theater we’ve accepted over the years did much to keep my transit safe yesterday. Twenty four years later we go through the motions of keeping air travel safe from terror because what else are we going to do?

In fact, it didn’t seem as if security was particularly tight yesterday so much as particularly incompetent. It was chaotic confusion everywhere from passport checks to boarding flights.

I had a Frankfurt to Chicago polar day flight, along with a positioning flight on each side. I went through a lot of security screenings and passport checks yesterday and stood in more lines than I can count.

In Frankfurt the lines were so long that even with planned two hour airport transit time, I was among the last to board my flight.

The “special purposes” line I begged my way into as my inbound was delayed by fog was glacial in its pace. It seems the new transit grift is wheelchairs. So perfectly abled people are now pretending at disability to board early and use special security screening lines.

It left wishing I’d registered my real disability as I attempted to run the two miles of the international terminal with suitcase and backpack torquing my spine so I wouldn’t miss my flight to Chicago.

Deplaning at Chicago I couldn’t even count the full set of wheelchairs waiting.

Add in enormous confused families using the special purpose line, who spoke neither German nor English, with 3-4 bags a piece and every sort of banned item from pocket knives to 1.5l bottles of liquids and I am shocked anyone made it through security to their flights on time.

I watched a foursome of black Arabic speaking grandmothers in hijabs and wheelchairs shouting at German security guards and their extended families as I waited for my turn. Their fierce attitudes did not speed anything up that I could tell.

I saw them 9 hours later gathering somehow even more checked luggage upon arrival in O’Hare. I’m glad my Global Entry let me pass them by at passport control as I did not want to be behind them again.

Not that I got through Chicago’s security lines unscathed. The TSA pre-check lines were four times as long as the regular line. Figuring I was well packed I could handle the normal line. Naturally I got randomly selected and unpacked basically everything

As I stood in my socks waiting for the agents to stop gossiping and listen to the only working agent explain to them that “yes that the ice pack was for medications so they can move this along” I got an alert on my phone that the conservative political organizer Charlie Kirk had been shot.

I wandered in a daze to the United club where I was denied entry. This despite booking a business class ticket for the entire transit through their own hub via their Star Alliance partnership with Lufthansa, I couldn’t use the club as “the last leg of my flight didn’t qualify.”

I knew this was possible as this last leg issue happened to me on my last transit through O’Hare so I’d bought a day pass ahead of time. But they weren’t honoring those as it was too busy. I schlepped to another club in the terminal where they were still letting in day passes. There I listened to scared speculation from two blonde women about Mr Kirk’s status.

Another hour later I made my way onto my flight to Montana. I decided to just jump to the front of the line as I was in first with seat 2B. If everyone is ignoring lines then it was irrational to keep trying to politely queue.

As the plane boarded it was all talk of Mr Kirk. A news alert crossed my phone saying he had been killed.

A gentleman was playing a video of stitched together angles of footage on his phone with full audio on. You could hear the bullet hit again and again.

The cabin attendant told him to turn it off, saying sir please have some respect for the dead. A few hours later, still living, I made it home to Montana.

Categories
Aesthetics Politics

Day 1713 and Breaks and Ends

It’s hard not see every day as more of a beak with the past even as so much remains the same. No wonder the French have that handy slogan about “plus ça change” as systems remain even with violence. They really know how to balance being disgruntled with the past.

I was suggesting La Haine to someone earlier this week as the French movie that made an impression on Gen X and elder millennials who paid attention to Francophone culture. It’s hard not to think current problems are similar tensions recycled for a whole new era. Atmospheric, vulgar and dangerous are the keywords.

The Hate or La Haine by Matthieu Kassovitz

The addiction economy repackaged the same old things that kept our attention economy running. And they will keep running it till it is so refined and so well packaged you won’t even remember that Starship Troopers was meant as a satire of fascism.

We repeat so much. The Churn as the Expanse called it.

Amos: This boss I used to work for in Baltimore, he called it the Churn. When the rules of the game change.
Kenzo: What game?
Amos: The only game. Survival. When the jungle tears itself down and builds itself into something new. The Expanse

Survival breaks out into the only game all the time and we are always running a Red Queens race. So try not to get too distracted. Ween yourself off of anything that you’ve not got any reason to hold dear. Change to meet what you can so long as you can still see yourself.

Categories
Medical

Day 1697 and Gut Brain Axis Misery Meets Peptide Season

It would seem I found an antibiotic that disagrees with me. As the tail end of my soft tissue recovery from my abscess surgery and deep tissue infection appears in sight I had a setback with an additional antibiotic.

Cephalexin was one of the top choices on the pathology report from the hospital and recommended as a first line treatment by the surgeon, several artificial intelligence differential diagnostic secondary checks and my primary care doctor.

They did not prescribe it first and I found out why yesterday when I felt as if I’d hurt a shoulder ligament doing, of all things, tai chi. I was despondent over it (ironically another side effect). The gut-brain axis gets weird when you kill off bad microflora.

So yeah not the antibiotic for me. As it turns out we recently learned it’s associated with tendon rupture. Not quite as bad as the other more infamous Cipro. Which ironically I was on with no issues. But Cephalexin has got some risks to tendons and ligaments too.

Being on an immune suppressant (an IL-17 called Bimzelx) for ankylosing spondylitis and psoriatic arthritis has improved a number of biomarkers but also made me susceptible to skin infections. Like the kind that require slicing. Not fun.

Now in the wake of the deep tissue infection, we had a systemic MSSA problem. It was entirely rational to nuke that thing from orbit. Any resurgence needs maximum force to prevent chances for regrowth. You simply have to to be very watchful for side effects in all things now.

I feel like I’m in some awful healthcare version of pimp my ride. Pimp my diagnosis?

So I heard you had side effects so I gave you a side effect for that side effect.“

And so I’ve been sent down the peptide rabbit hole to see if that might help with tissue healing. My shoulder is probably fine as I stopped quite quickly but a reminder that I need to be watchful of what I’m taking and experiment carefully.

Naturally I’m already considering my risk profile carefully but as it’s peptide season in Silicon Valley (who isn’t on at least a micro dose of a next generation GLP-1 agonist or some new fangled GIP.

Why not add some more to the mix? Strong tissues and lean mass being protective against many a problem. Behold a little Grok breakdown of what I was recommended.

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds to copper ions, forming a complex that plays a role in tissue repair and regeneration. Its mechanism in tendon healing involves several key processes:

  • Collagen and Extracellular Matrix Synthesis: GHK-Cu directly acts on fibroblasts (cells responsible for producing connective tissue) by increasing the production of mRNA and proteins for collagen (types I and III), elastin, proteoglycans, glycosaminoglycans, and decorin. This enhances the structural integrity of tendons during repair. Sources Sources
  • Angiogenesis and Nerve Outgrowth: It stimulates the growth of blood vessels (angiogenesis) and nerves, improving nutrient delivery and innervation to the healing site, which accelerates wound contraction and tissue remodeling. Sources
  • Anti-Inflammatory and Antioxidant Effects: GHK-Cu blocks the release of tissue-damaging free iron from ferritin channels, reducing oxidative stress and lipid peroxidation after injury. It also modulates inflammation to create a favorable environment for healing. Sources Sources
  • Systemic Effects: When administered, it can enhance healing systemically, even if injected away from the injury site, by regulating copper-dependent enzymes involved in cell growth and repair.

Research, primarily from animal models and in vitro studies, suggests these actions lead to faster tendon recovery, but human clinical trials are limited, and it’s not FDA-approved for therapeutic use.

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is a synthetic peptide derived from thymosin beta-4, a protein involved in actin regulation. It primarily aids tendon healing by promoting cellular mobility and regeneration:

  • Actin Upregulation and Cell Migration: TB-500 binds to actin, a key protein in cell structure, enhancing cell migration (chemotaxis) and proliferation. This allows fibroblasts and other repair cells to quickly move to the injury site, accelerating tissue repair. Sources
  • Angiogenesis: It stimulates the formation of new blood vessels, improving blood flow and oxygen delivery to damaged tendons, which supports faster healing.
  • Anti-Inflammatory and Antifibrotic Properties: TB-500 modulates inflammation by reducing pro-inflammatory cytokines and preventing excessive fibrosis (scar tissue formation), creating a balanced healing environment.
  • Tissue Regeneration: In animal studies, it promotes overall wound healing and tissue regeneration, though evidence for tendon-specific effects in humans is anecdotal and lacks robust clinical data.

TB-500’s effects are mostly observed in preclinical research, with potential for muscle, tendon, and ligament repair, but it’s not approved for human use and carries risks.

BPC-157 (Body Protective Compound-157)

BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, known for its protective and regenerative effects on various tissues, including tendons:

  • Fibroblast Activation and Migration: It promotes the outgrowth, survival, and migration of tendon fibroblasts under stress, enhancing cell proliferation and tendon explant growth in vitro.
  • Growth Hormone Receptor Upregulation: BPC-157 dose-dependently increases the expression of growth hormone receptors in tendon fibroblasts at both mRNA and protein levels, facilitating anabolic processes for tissue repair. 19 14
  • Angiogenesis via VEGFR2 Pathway: It activates vascular endothelial growth factor receptor 2 (VEGFR2), leading to the VEGFR2-Akt-eNOS signaling pathway, which promotes new blood vessel formation and improves nutrient supply to healing tendons. 22
  • FAK-Paxillin Pathway and Anti-Inflammatory Effects: BPC-157 activates focal adhesion kinase (FAK) and paxillin, proteins that regulate cell adhesion and motility, while also exerting protective effects against inflammation and organ damage. 24 25 20
  • Overall Tissue Protection: It accelerates post-injury healing in muscles, tendons, and ligaments, restoring function similar to uninjured tissue in animal models. 27 26

Extensive animal studies support BPC-157’s role in tendon and ligament recovery, but human evidence is limited to anecdotal reports, and it’s not FDA-approved, with potential unknown side effects.

Categories
Internet Culture

Day 1691 and Don’t Let History Be Written By Cthulhu Hentai Watchers

I sometimes think my best work is as a reply guy on Twitter. If the future of the Internet is to be made entirely of bots, I shall mourn the creative glory we will all lose.

We will all be missing out on the bizarrely specific interplay between post and reply guy. The signal, node, and repeater that is the feed where humans can still bounce off intuition and humor. They know the algorithm merely as the setting for their gamble.

I’ve been doing what is probably a terribly ineffectual public education campaign on artificial intelligence and its role in improving problems in the here and now.

But I am often cheeky about the ideological disagreements the more practical minded builders have with a pretty standard issue Bay Area sex cult. Having been raised adjacent to a lot of hippies, cultists, religious fundamentalists and any variety of new age woo woo Art Bell types I’m actually generally quite tolerant of our weirdos.

Of course this is a challenge as we build out the most important informational and systemic organizational technology of our species. Math has taken humans pretty far.

And mathematicians are quite often mad so I don’t see how it should be such a worry. Still I myself don’t want to be stuck inside an information hazard where I am tortured for eternity either. And therein lies the tweet

Look I’m just saying it’s my personal opinion, but I think it’s bad that the future of our knowledge graph is being made by those who get off on Lovecraft but like that’s just honestly mostly a personal human alignment thing because I don’t wanna be tentacle tortured in @RokoMijic basilisk

If you are familiar with the odd pockets of specialties you probably know that say furries are particularly good at network security and that transwomen are well represented in artificial intelligence.

Unfortunately other groups represented across the space including hardware, software and the philosophy of the space can be somewhat less wholesome than a fursona or a cute catboy.

The Rationalists have some members with odd extracurriculars in their science fiction. I’ve read some good stuff in the genre. Maybe this interest in fiction is probably how they imagine such horrific futures for us in artificial intelligence. Very improbable ones even.

So it’s on me to joke and show you where the weird can be and remind you not to take this too seriously as the experiment contains all of human knowledge. How we prioritize what is another matter. You might call that alignment.

I’m sure we are all wondering which AI safety researchers want to have sex with the many tentacled Lovecraftian old gods. The number of AI researchers with Cthulhu hentai is non-zero.

So the sake of our right to decentralized compute, and indeed our right to do math and compute, we need as many types people as possible engaging with models as possible.

Find ways to learn this new way of thinking and engaging with information and searching for information with a billion parameters at play. Some corners of the most doom and gloom road have some uncomfortable fixations. And artificial intelligence needs all of us.

Categories
Politics

Day 1689 and Drumhead or Not Rushing To Judge What We Don’t Know

I wonder how much of the moral education of Americans comes thanks to Gene Roddenberry. Star Trek is a very American show. It was pitched to Desilu Studios (owned by Desi Arnaz and Lucille Ball of I Love Lucy fame) as a space western.

The cowboy frontier spirit of Captain Kirk has an honor code based on the worthiness of exploration. When the millenials got a reboot in the Next Generation, Captain Picard added the gravitas of excellence through the pursuit of the truth.

It’s hard to think of a show that embraces an anglosphere manifest destiny with more vigor and it is grounded in the enlightenment values of science and moral philosophy. It’s a very American show.

I was watching a fairly minor TNG episode while eating today The Drumhead. An ambassador starts a witch hunt insinuating treason. Apparent drumhead courts were a military summary judgement court.

A legal drama ensues where Picard quotes the ambassador’s father famous words about the dangers of denying basic rights to even one man in the name of protection of society makes us all less free.

Feeling rather on the nose for the moment right? Picard reminds Worf as it wraps up the witch hunt being proven a lie, that those who cloak their misdeeds with the pretense of serving a greater good are often the most difficult. Spreading fear and mistrust in the name of righteousness must be guarded against.

“Vigilance, Mr. Worf. That is the price we have to continually pay.”

We have a chance at preserving and expanding the enlightenment values that brought our species to this moment, an American moment, by enabling more of us. We can educate ourselves and access the world and the many virtues to which humanity has aspired to by working hard to master them ourselves. This is the empowerment of compute.

We have tools available to us to be vigilant in what is the great good of civilization we wish to protect in an open, decentralized and networked internet.

That we can at scale train a new inference search capacity for the sum of our knowledge and reality is a utopian reality even Gene Roddenberry didn’t dream we’d have.

Don’t rush to summary judgement in fear over the future we can build with protocols and networks that can be encrypted and decentralized. That we can model them with artificial intelligence, and by asking questions well, get back information, code and even machine and biological diagnostics is a huge achievement for our species.

To push the fear of the greater good over its consequence can go from legitimate concerns to a drumhead summary judgement quickly. Risking the freedom to use something that is both just emerging and even in that infancy so promising. That it is helpful in the now seems to showcase both western traditions and enlightenment values.

It’s an American ideal that we must all be free to think and speak the truth, search for the truth and can calculate and provide a mathematical proof of truth that needs no trust because it can be know. We have a right to compute.

Artificial intelligence solves problems now. It’s better than humans now at many types of tasks even as it still a new tool and unrefined and even brittle in its capacities still. It’s took only as good as its craftsman’s understanding of it and we are still learning how to build it.

Artificial intelligence can give us the internet we deserve. I support the right to repair movement because I believe we should know and seek the freedom to own things we have purchased and modify them.

Right now AI helps humans can solve immediate problems from tractor repair to wound care. Maybe machines get better as we get better at using them because we do it with them. We figure things out by building.

Don’t let your worldview be constrained. You can know the freedom of living in a society that values your rights. And the right to compute weaves together many of your most sacred rights. And if we infringe on it for some of us it infringes us on us.

Categories
Biohacking Chronic Disease Medical

Day 1688 and Deciding What To Outsource to Artificial Intelligence for Health and Wellness

One of my Twitter mutuals recently published an artificial intelligence prompt for making an adaptive fitness coach which works inside any of the major large models.

Having recently been saved from going septic and a gnarly deep tissue infection thanks to clever diagnostics from the commercial chatbots I am considering what else they might be able to help me along with in my day to day.

Being failed rather regularly by doctors over a decade of chronic illnesses has made me skeptical of the institutions in American medicine. But having one doctor (a dermatologist) miss a glaringly obvious differential really shook me.

Her dismissal of the details and particulars wasn’t malice, but a function of the systemic inability to put enough attention on the details of the person in front of her. Attention really was all she needed ironically.

I’m sure she didn’t set out to be that kind of doctor, I’d bet she hates that it’s all 90 second visits and Medicare coding and making money for the private equity group who owns the clinic. I feel for her. She surely wants to get back to doctoring.

No one can spot every detail and retain the complexities of every case. Especially one like mine. But a computer has a much better shot at mimicking Dr House than I do at finding a Dr House for myself. And it certainly has a better chance than someone who let the system dominate them into breezing over the details.

So I am using my mutual’s prompt to see if I can outsource a very slow and adaptive return to fitness after my month off from exercise to recover from surgery. I like what I’m seeing from all models that I’ve tried it on but I imagine I’ll have all the same “me” problems with overdoing it and pushing too hard. But who knows, maybe this aspect of wellness is better handled by machine than by me.

Categories
Internet Culture Reading

Day 1676 and Having Public Fun in the Artificial Intelligence Era

It’s August and vacation season is in full swing. It seems as if all of Europe is off for the month. For the Americans who work around the school year, it’s their time for a week off as well.

We rarely vacation for an extended period and when we do it’s not generally during high season. Off season is where it’s at in my mind. But sometimes you need some fun when it’s been a hard time.

I’m struggling with how much I put online about my comings and goings and when I do it. Being careful used to mean not letting thieves know if you weren’t home but now the world is a mix of digital and physical security layered over artificial intelligence tools that can pinpoint you easily.

Opsec isn’t a thing elder millennials considered too carefully with digital identities in the early years of the internet but everything is changing. Dead internet theory may become true as the internet of bots begin.

I don’t intend to cede the digital commons though. I want my written voice to be integrated into the vast data troves that shift the records and is woven into the understanding of artificial intelligence and machine learning models.

The more these modalities of information storage and retrieval impact our human minds, the more necessary it is write oneself into “the Akashic records” that form our digitalization of information. Humans used to read and write machines but now machines and their media are just as likely to read and write our minds

So what are we to do about living in public? Humans are mortal but records of our world have a shot at reaching the future and shaping understanding.

Blogging has ended up being one of the best mediums for being scraped, organized and cited well by current artificial intelligence.

Open graph protocols, structured metadata structure, canonical URLS, tagging and linking, and authorial data and publication time are all part of a digital commons that have a distinct advantage over other closed garden content repositories for artificial intelligence. Being legible to the machines is now as important than being legible to each other.

So having your fun in public and making it accessible just might be one of the most important things you can do to be a part of the record of our world. It’s just a terrifying prospect to be so easily seen.

Categories
Travel

Day 1675 and Running to Stand Still

The accelerationist types must be feeling smug as the disorientation caused by so much of the world speeding up is a persistent feature of life now.

I’m trying to organize a fairly elaborate vacation that I should have nailed down the details on at least a month ago. I am alas doing it what is functionally last minute and I’m panting at the effort of coordinating preferences, availability, timing and the thousand other logistical details.

We have a range of preferences to accommodate and it’s driving me a little bit nuts and I have no one but myself to blame. I cant manage more than three hours in a sitting position in a car or airplane without hurting. Standing helps but it’s really laying down and relaxing my spine that helps.

The other preferences are more of the one person likes fine dining and Michelin caliber restaurants and another likes delivery and Netflix.

We have to balance intensive activities in hot weather like hiking and sightseeing against the desire to lay out in the sun near a body of water. Really all the classics of different strokes for different folks.

I don’t want to be too ambitious about any of this as I am really just barely out of the woods from July. And I’m being vague about when and where, as I’ll like pretend like we have some amount of operational security. Writing is all about the specific but the best I can do is say it will involve driving and water.

Categories
Community Politics

Day 1669 and Seeing Without A State

We are entering an era where technology is liable to be the scapegoat for a number of problems that are all too human. Seeing state failures and institutional failures and deciding to blame something new rather than human nature is very much human nature

We are looking for someone or something to blame for human nature and the thing that makes the current world different from the hazy memories of childhood are an easy place to start.

The rate of change fights with the basic realities of being evolved apes. And the social dynamics of our ancestors are pretty gnarly so I don’t blame religion for wanting to obfuscate the evidence of our base nature. We have to believe we can be better.

The trade offs involved in providing communal protection has meant submissions to various forms of power and hierarchy and yet we still have social scandals over genes, jeans, semiotics and the perversion of our biology. It’s not a day to discus sex and advertising online.

I look at this chronology of my life and have pride in its daily discipline even as I know being myself online is a risk. I see day 1669 and want to make a nice joke. I believe in the commons and my freedoms within it.

It’s just getting more dangerous to be online. I am considering how I bring myself to a world where I’ve always be extremely present online under my own identity. I want to train the intelligences we develop on top of our digital commons and feel the pull of that responsibility.

Then I see another grid failure. I see a plane crash. We have terrifying realizations that we can’t rely on the systems of the past for where our future is headed.

We have European software developers now noticing what Balaji was pilloried for pointing out. The nation state and the network state are coexisting already as anarcho-tyranny increases.

In American and Western Europe we are already seeing daily examples of anarcho-tyranny. The state can hurt you but not help you. Communal needs we once enabled the state to run and provide can’t be counted on in water, energy, and infrastructure. You have to build systems for yourself where and when you can while you still can.

Categories
Chronic Disease Medical

Day 1664 and Pathology Report

Well, we finally got the culture and pathology reports back from the hospital in Istanbul. For those not following along I had an almost emergency surgery of an abscess that got infected.

And it’s kind of a good news, bad news situation. I dislike the useless preventive care dermatologist who dismissed me even more now.

The good news is that nothing malignant or cancerous is going on. The bad news is that the abscess was a gnarly mix of acute and chronic inflammatory issues that turned from a basic case of folliculitis (albeit 3cm deep so required slicing) to a nasty MSSA case that is resistant to the doxycycline typically prescribed. Yay.

Didn’t know hairs could grow sideways and frack your tissues till they produce a juicy abscess.

A little synopsis of the reports thanks to our favorite LLM Perplexity analyzing the reports with the additional context of my health history, recently bloodwork and current medical regimen.

  1. Pathology Report Review
    Gross Description
    • Multiple grey-white tissue fragments, largest 0.6×0.3×0.3cm.
    • Specimens from the excised lesion.
    Microscopy
    • Neutrophilic (PMN) inflammatory exudate on surface, consistent with acute infection.
    • Proliferative vascular stroma, frequent erythrocytes, and mixed chronic inflammatory infiltrate (suggesting ongoing/recurrent inflammation).
    • Fibrinous exudate, abscess cavity, active chronic inflammation, granulation tissue: typical of a maturing or organizing abscess.
    • Panniculitis: inflammation extending into subcutaneous fat.
    No evidence of malignancy was found.
    Interpretation: This confirms an abscess with active, mixed (acute-on-chronic) inflammation and granulation, but no neoplastic (cancerous) changes.
  2. Microbiology Report Review
    Culture
    • Growth: Staphylococcus aureus (methicillin-sensitive; MSSA)
    • Sensitive: Erythromycin, fusidic acid, linezolid, teicoplanin, tigecycline, trimethoprim-sulfamethoxazole.
    • Moderate: Levofloxacin.
    • Resistant: Tetracycline.
    Gram Stain
    • Numerous leukocytes and Gram-positive cocci in clusters, confirmatory of acute bacterial infection and consistent with S. aureus.

So the doxycline and indeed any of the basic tetracycline types I’ve been taking are useless. The extra five days of Augmentin were all for naught after I finished the Cipro. Thank goodness for topical antibiotic I am using is fusidic acid.

I’ll be moving to erythromycin orally and hoping for the best as once I finished the Cipro I started Augmentin which seems to have been functionally useless as a holding pattern antibiotic based on this report.

I’ve had a systemic staph infection before and it’s no fun. I’ve done IV antibiotics and I don’t know if I’d like a repeat. It’s my hope that Erythromycin does the job from here.