Tag: Startups

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Biohacking Medical

Day 1890 and It Bears Repeating Or Does It?

I can’t say I have fully recovered from pushing myself to my operational limits to do work (which looks a lot like socializing in my line of work) while still recovering from an infection after dental work.

It’s always recovering from an infection these days. I’ve been on some kind of antibiotic or anti-fungal every day since October.

2025 for me was getting an infection and then recovering from an infection on repeat. Ever since I decided to swap my biological injection 15 months ago from Coesyntx to Bimzelx and I think I’ve hit my limit.

It’s just too damn depressing that it’s a constant threat that I’ll have either a soft tissue infection or an abscess or a swollen gland that turns into a staphylococcus colony.

It’s as if I’ve got no skin biome left which is almost certainly true. I think I’d rather have CRP and sed rates and risk other infections than be rotating antibiotic varietals like some kind of junky afraid to develop a dependency.

Except instead of pain pills or lady downers it’s amoxicillin versus doxycycline versus Cipro with the occasional dalliance with a macrolide. I’ve also come to appreciate the benefits of Fluconzole. It’s not great. If you want a quick AI generated overview scan along

  • Beta-lactams: This broad group includes penicillins (e.g., amoxicillin), cephalosporins (e.g., cephalexin), and carbapenems (e.g., meropenem). They work by inhibiting cell wall synthesis.
  • Macrolides: (e.g., azithromycin, erythromycin) These inhibit protein synthesis and are often used for respiratory infections.
  • Tetracyclines: (e.g., doxycycline) Used for a wide range of infections, they inhibit protein synthesis.
  • Fluoroquinolones: (e.g., ciprofloxacin, levofloxacin) Broad-spectrum antibiotics that inhibit DNA synthesis.

My problem is that going back to my old biologic will take three to four months to full dose and it’s not a risk free process. And my full biometric panel is better on Bimzelx so is it really so bad that my resting heart rate is in the upper nineties every other week?

I think it may be time for me to make a pilgrims to the remaining clinics and pretend that I have any remaining institutional trust. Maybe I can vibe code something usual along the way.

I intend to support others on this journey as I’ve been chronically this journey a long time and the times are changing as we bring more artificial intelligence to the inference issues around our biometrics.

Categories
Chronic Disease Startups

Day 1889 and Recovering from Normalcy

I had such a lovely day touching grass (and sand) yesterday. I slowly worked through a 36-48 hours of of talking, walking, strategizing and occasionally reapplying sunscreen (I still got burned a little on my shoulders) with a friend who is preparing for big life and company changes.

These are the activities of normal life that I cherish, but my body seems hardly able to manage the strain this week. Now perhaps these activities are stressful on the mind and soul, but should they really be so physiologically taxing for me?

My Whoop is showing high strain

Now yes I am recovering from some dental work and on antibiotics but shouldn’t I be able to have a calm day that most would consider restorative? The serene peace of sitting on sandy shores should surely outweigh any areas from consequential questions of power, compute, realism and human purpose right?

I have barely been able to get out of bed today and the ten minutes of squats and planks I did to test my capacity spiked my heart rate into the stratosphere.

Which is odd as I woke up with my RHR in the 60s which is much better than usual. I only get into the 60s or 70s consistently when I am on heavy antibiotics.

The two weeks I was on Cipro recovering from surgery this summer my RHR was in the mid sixties so clearly I’ve got something going on with low grade infections.

I struggled mightily to organize my thoughts enough to write even this post. I feel I might even have it in me to go for a walk. Which is encouraging as I missed the sunset. The sunsets are obviously an event when you have a beach or far off horizon to enjoy with then.

Categories
Aesthetics Community Internet Culture

Day 1888 and Touch Sand

As the “monitoring of the situation” reached whole new levels, I took some time to touch grass today. I don’t think I opened more phone more than a dozen times before writing tonight.

So many mutuals are teaching themselves automation skills by building situation monitoring boards that maybe the Department of War doesn’t need Claude. It was charmingly easy to keep up. Which is a very distorted and dystopian way of living out the hard realism of kinetic power in real time.

If America is backstopping Loyld’s of London shipping insurance, then to repeat a Keanu Reeves meme style. Yeah I’m thinking that America is back. But I’m getting to old for this shit. It’s all TV tropes now as we unmoor in the propaganda. Which is run by an honest to goodness critical theorist who trained with Jurgen Habermas.

So instead I stared out over the horizon as the wind gently brought fresh air in from across a wide open vista. I enjoyed my friend’s company as we talked about jhanna meditation and compute pricing. We saw a seal winning along the shoreline. I put on sunscreen twice as we stayed out in the sun.

How luxurious is it I had long leisurely in-person time with a friend. Not all of my business is with friends but I cherish the ones with whom I do.

We walked and talked and broke for lunch and discussed problems from the most abstract to the most precise. Having given the world so much access to all of human creation and taste, did the market provide an original version of the driftwood horse decoration or has there only ever been the mass market design? Neal Stephenson fans get it. Baudrillard too.

Fashion people and technology people worry about these questions of taste because they are questions of control and tooling. The source culture of engineering culture shared context. How abstract is too abstract? What is enough to enable the builder to use your tool?

It was good to be outside in the sun with someone and talk. That activity needs no shared context beyond humanity. We have missed it in the hubbub.

Isn’t it funny how just as the internet is losing its humans, the humans who met only thanks to the marvels of the network are finding new offline systems? The network can reprogram itself.

I have dear friends and successful investments that I have spent hardly a single moment commingled in time and place with. I imagine that age is either just beginning or just ending and I am not sure which. So today I was outside in the sun talking. I don’t know if we made any progress but maybe I’ll only know in the far future.

Categories
Politics Preparedness Startups

Day 1887 and Trust Me Bro

I don’t feel terrific so I’ll keep this as a ramble but with some links. I fear some sort of Rubicon has was crossed, which we will only recognize in hindsight, in the fight for property rights in America versus the tyranny of failing state capacity.

I am referring to the contract dispute between foundation model developer Anthropic and American Secretary of War Hegseth that boiled over on Friday night as some sort of Murderbot surveillance subplot parsed only by lawyers, policy wonks and anyone who remembers the patriotism of Chelsea Manning.

Right before America and Israel went all Epic Fury on Iran over the weekend, somehow it was felt a messy public fight between defense contractor and the civilian oversight of our military was ok? Good thing everyone is too distracted to care.

Funny how one can go from cheering on our military’s capacity for innovation one week and the next to be waving one’s arms screaming “no oh no no no” but that’s just politics as run by the instincts of reality television I suppose.

The best writing on this so far has been Dean Ball (who worked in this Trump administration on its AI position statement not so long ago) who feels that Hegseth took an approach on renegotiating a contract with a frontier AI model developer that has consequences.

Loosely and I am missing much Anthropic had its previous contract to parse classified documents in the Department of Defense (now the Department of War) negotiated by the prior administration. Some aspects of this contract wasn’t going to work for the Trump administration. Anthropic didn’t want to change it and Hegseth threatened to call Anthropic a supply chain risk unless it complied. They didn’t and Sam Altman signed a deal.

Wrapped up in this is that of course we all eventually comply with Leviathan who has the monopoly on violence. I don’t claim any expertise here but lots of people understand defense contractor law.

On its face Anthropic looks like the moral high ground and the position all capitalists and private property respected would prefer. However, it’s in Dean’s words, a bit weird for a company to tell the state that a private corporation has a say in policy as opposed to our democratic institutions.

Anthropic is essentially using the contractual vehicle to impose what feel less like technical constraints and more like policy constraints on the military

This is all complicated by the model developer having wishes for frontier AI development to be nationalized and for their work in particular to be safeguarded by a different political administration. It has become a right versus left thing as it was bound to do.

Now Anthropic gets to enjoy the full throated defense of its industry peers and even conservative policy makers like Dean, because our current state capacity is not what I’d call excellent when it comes to our civilian government capacity. Honestly our military still seems to be crushing it.

Secretary Hegseth looked a bit like he was over reaching in his command that he get his demands met. Americans are very touchy about surveillance of if’s citizens and much less touchy about autonomous weapons so it’s natural to be a bit suspicious if you are a millennial who remembers the Global War on Terror. If you are Zoomer who doesn’t know who Chelsea Manning is please go ask Claude.

However it’s not at all clear that Hegseth’s original negotiations were out of hand as of course it’s the state who decides legal use not the private company and we are meant to have laws, judicial process and all the rest. It’s just that we don’t. So what on earth do we do about it? Trust me bro is not a policy.

Categories
Aesthetics Travel

Day 1878 and Checking Into Hotel California

Yesterday I was on about the “ride share” and gig economy intermediaries, but today it’s the “home share” economy. The short term rental world of permanent vacation properties amid a housing crisis for the rest of us.

Having had a streak of bad luck at hotels in California I am back to my old faithful of Airbnb. Except I seem to have accidentally checked myself into Hotel California. It’s such a lovely place.

But everyone else here is a Boomer but me. I’ve not seen any children or grandchildren. Everyone is over sixty. It’s a heaven ban paradise for those who can afford to live a permanent coastal lifestyle. And for those of us who can rent it for a few days on business.

The Airbnb is in a large complex that is above a stretch of beach one can hike down to for walks. Nearby amenities are yuppie in nature with bistros, coffee shops and Pilates studies. While it is easy driving to its most proximate big city, it doesn’t feel like anyone is going to an office in this suburb.

The Airbnb is run by a management company seemingly owned by an enterprising woman who got prime real estate when rates were lower. I deduced this by scraping all her listings and when they first went online.

I doubt she is interested in letting her investment properties take any damage as no one under 25 is allowed to book and she explicitly states that “it is not child proofed” so you are liable for any issues. Which would explain the demographics.

This is a place for adults, and more specifically adults who have the freedom to work where and when they like.

Or perhaps more accurately are not obliged to work any longer. What a seductive life to live. No wonder there are so many slim, fit, smiling Patagonia swaddled mature people.

“Hotel California” is, according to the Eagles’ Don Henley, a metaphorical song about the dark side of the American dream, particularly the excess and decadence of 1970s Los Angeles. Via Wikipedia

It’s definitely not a Margaritaville sort of place. With koi ponds and soft beiges and tasteful landscaping, it’s too costal grandmother in its aesthetics. But it is certainly decadent. Maybe the American dream of thirty year retirement is the decadence they warned us about in Hotel California. It’s not that they can’t check out. It’s that they won’t.

If you walk among the promenade that overlooks the ocean, you will notice many of the townhomes have signs in their windows advertising their management company. It is all second homes and beach cottages and handled by professionals.

If it weren’t a gate community with guards and a lot of security cameras I’d honestly be terrified to advertise that folks might not be home. But then again, what is anyone going to steal that these denizens can’t easily replace?

They sold out the future already. The thieves are inside the complex. It’s the rest of us looking in who should wonder why it is that no one can check out. It’s just such a lovely place.

Categories
Internet Culture Preparedness

Day 1868 and Educating An An Entire Species or Start With Your Family

A viral essay was posted a few days ago by a Matt Schumer meant to help introduce the current state of artificial intelligence tools to people who do not work in technology.

It’s a very compelling piece of writing (or maybe it’s just reading), which I believe is well received by normal people especially older family members or technical skeptics. They are often the hardest to reach because of age and experience gaps and a smooth essay goes down well.

The author is the founder of HyperWrite. His company offers a suite of AI writing and research tools. So yes, his excellent writing and wide reach (over 40 million views so far) were achieved thanks his fluent use of AI for both writing and promotion.

The end result of using tools is an excellent essay distributed far and wide. Or if you prefer, the end product was a tool shaped object which gave people a sense of understanding. That’s valuable.

Don’t let his usage of AI in producing this writing and publishing stop you from taking his points seriously. In fact, it should encourage you to read it and consider if you want to share it.

You too will soon be competing in a world where regular people like Matt are capable of super human feats. Perhaps you’d like the same leverage for yourself and your family.

All of us can learn to work with the amplifying effects of networks and artificial intelligence algorithms with practice and usage. Allowing us global reach and potentially maximizing the potential of our insights and points of view. That should make us feel better about where we are headed and not worse.

I feel it is useful to share the essay with your skeptical family and friends who are either scared, confused, angry or indifferent about the rapid changes because it is the current reality we all live in.

I know it’s hard as a middle aged professional to learn new tricks. I’m in the middle of it too. But we have to educate all of us and it’s going to take some time. I’d rather we get started on it. And on that note my lunch break from Montana’s digital innovation committee is only an hour so I’ll get back to it.

Categories
Aesthetics Travel

Day 1864 and Retail Therapy in Fashion Exile Land

Maybe it’s because it’s been such a wild week in the financial markets, but I’ve been thinking back to one of my moves to San Francisco just before the Great Recession. It’s a story about buying clothing but I’ll get to that.

I had just come off the high of being the first publisher to break (by live streaming and photography) a new fashion designer who would become one of the biggest names of his generation.

The low hit me as I realized I was unable to afford any of the pieces in his collection. And nor was I able to buy them anyway as the whole collection sold out instantly in New York City. I look back on being backstage at his first (and subsequent) shows with much fondness. Once he threw a full on carnival in a parking lot! Imagine models tossing their size 9.5 Manolo’s on concrete to hop into a bouncy castle.

Those models were his muses and he was known for an off-duty model look. I am about a foot too short, 20-30lbs too fat, and three cup sizes too large to be mistaken for a model so not an ideal customer.

Normally one could politely ask for samples or gifting if one helped break a collection, but this was not a sample collection that would have fit me. I’m a size 7 shoe and those boobs do me no favors for hanger sizes.

Still I wanted one item badly. Even if I couldn’t afford it and I couldn’t find it in stores, I kept an eye out everywhere for it.

The coveted item was a pair of high waisted pleated black wool trousers (lined with an ample cuff) that was the wearable merchandising anchor to a collection that was otherwise a bit tricky for mere mortals to wear.

For the men (and some women) who haven’t given thought to runway models, the metrics are specific. You need to be over 5’ 10”, never over 115lbs and have an A cup to fit a designer runway model call sheet.

These aren’t aesthetic preferences, just that models are a glorified hanger and not a person for purposes of ease of fitting. Yes it’s a bit degrading.

And so I resigned myself to never getting those pants and having only the glory of discovery and first to market coverage. Though the proof on that may be debated.

But then a small miracle happened. As I was relocating to San Francisco (by the buyer of my first startup) I began to get invited to events and parties.

A brand new Barney’s opened up off Union Square in San Francisco. An old girlfriend who had just married and moved to San Francisco told me “you will love the shopping out here as the good stuff never sells out!”

Mind you the collection had sold out in other fashion capitals. I had called around. I asked all the major stockists. It just wasn’t to be had anywhere.

But the new Barney’s was very late in opening and had stock from the previous season saved. I missed the opening party but thought maybe I’ll see something from the newer collection and I’ll splurge.

Well I got even luckier than I imagined. The pants were not only at the new Barney’s but on the sale rack. No one in the market had even liked them.

The salesgirl said weren’t moving as they were too formal and too trend forward for the town. They were having trouble moving most of the pieces from the designer in fact.

There were multiple pairs of the pants in size 38. That is a size 6 in American sizing which is almost always the first to sell out. I purchased it without even thinking. They were 40% off.

I still wear them to this day. And anytime I visit a bigger city or capital with a retailer of high end fashion, or designer goods, I’ll go looking. Sometimes in the strangest places you will find the exact item you wanted marked off in the middle of February.

Categories
Aesthetics Travel

Day 1861 and Mispricing The Market

I’m sure most of the world will be fixated on various financial corrections in global markets but I spent a chunk of my day dealing with currency changes (that will be 7% of your withdrawal thank you) that reflect nonsense from monetary arbitrages, regulatory graft and foreign exchange transactions so I’m in absolutely no mood.

Then I went to what counts as the diplomat and foreign money mall and got Pizza Hut, frozen yogurt and Korean skincare. I don’t even like Pizza Hut but I was so sick of managing dislocations and figured I’d rather send it back to America. My patriotic consumption for the day.

I don’t know if it’s an urban legend that our military can deploy food franchises in twenty four hours in a conflict zone but we sure seem to figured out emerging markets.

It’s a shame we won’t let some markets emerge and be shaped by pressures. The vape kiosk was doing a brisk business and I was frustrated to see the owner of the favored electric vape was based in Shenzen. What an opportunity lost for American brands.

I’d say half the parking lot was Mercedes and the other half was BYD if that counts for anything. I haven’t seen an abundance of American cars and I think we all know why.

But then my savior was found in a brightly colored kiosk with no customers at all. A swath of Korean skincare brands that proved to be authentic. Blessedly many global K beauty brands have adopted QR codes to manage the misuse.

I am adapt at spotting packaging dupes and frauds thanks to the de minimus years importers of fakes flooded Amazon, eBay and other retailers with third party resellers.

Everything was half off as at their full retail price they were still not moving. I scooped up $30 bucks of masks from brands like Mishha and Some By Mi. My skin was fully irritated by smog, stress, and wider disappointment. The globalization era is in full swing in plenty of markets but everyone gets their cut. If a brand doesn’t command a local market then an enterprising consumer can enjoy a temporary mispricing. Sometimes this mispricing last for far too long.

Incumbents have strange advantages they are loathe to give up. I came out angrier at banks than usual, as angry at central banks as ever, and very pleased that the local consumer base wasn’t yet wise to the benefits of a product that commands a premium elsewhere. I might go get more.

Categories
Finance Startups

Day 1858 and Parked Outside the Flow

The crazier the informational world gets, the more inclined I am to tune it all out. The flows of information are fun sure but it’s only useful to financiers, degenerates and the global management class. I really only rate into very bottom of one. No, not the degenerate class.

As 2026 has become the year of repositioning for “whatever is coming,” I am unsure of much I wish to return from the hinterlands into the flow. Being inside the flow looks enticing but it’s Thor the only way to do business.

The thing is that I began my own career by participating (in a small way) in what Will Manidis calls The Flow. Being inside has its perks and I saw a lot which enabled me to make some very good investments.

What is the flow? It’s a metaphor for a 24/7 club of information, a formal and informal circuit of social and business obligations, and series of social & professional inputs that sometimes generate spectacular output.

It’s no wonder people think investing looks like gambling when you put it that way. It takes a lot of shrewd social manners and access to resources to be inside the flow and those are distinct barriers for anyone outside the global ten percent.

So where to go if you are an American? Well, stay put somewhere you can be stable and secure. Sure the middle powers will tell you that they can save the liberal order but in reality it’s all state capitalism by strong man and technocrats. And I’m not either and I’d wager most truly new things that will matter won’t be easily secured by old mechanism of power.

What Manidis rightly points out in his Flow essay, is that you can build businesses and make good money for investors and limited partners outside of the flow. You can focus on your unique insights and build something great.

I hope I offer some proof of that myself. I flash the codes for my odd little node and traffic occasionally routes through me. I found crypto winners and the future of atomics outside the flow. And I think I’d rather like to spend my Sundays seeing what’s happening outside the nightclub of financial flows.

If you want to be outside you can be. I just might be already. You can find me in the proverbial parking lot of the Flow (the open internet) yapping, chilling, lighting and fighting with the cool kids. You will always know where to find me. I’ll be one DM away.

Categories
Culture Travel

Day 1835 and Sweater Shaving As My Travel Yak Shaving

If you are an engineer you may have heard someone irritated with a project that has drifted out of scope because unforeseen new problems are blocking completion as “yak shaving”

In software and engineering, people use “yak shaving” to describe being forced into a long dependency chain: updating a tool, which requires upgrading a library, which requires fixing build scripts, before touching the actual feature or bug. Perplexity Synopsis via TechTarget

If you find yourself obsessing over small problems that are absolutely “core dependencies” and getting lost in all the problems that must be done before you can do the actual thing you might be Yak Shaving.

Somehow this is related to a Yen and Stimpy episode about a fake holiday. Coined by what I assume is a Gen X coder (who else watches MYV cartoons) named Carlin Vieri in the 1990s at the MIT AI Lab.

Sometimes a seemingly useless task (reading a manual or fixing a subroutine) does actually do need doing in order to progress on the wider task. But you have to be wary that you aren’t simply procrastinating on supposedly crucial preparations for the actual task.

Well I am packing myself up for week long trip, and while I know basically what needs to be packed and how I’d like it organized, I have not put anything in my bags yet. Want to guess why?

A piling cashmere turtleneck with a cheap sweater shaver filled with fuzzy bits of wool

I am yak shaving by shaving my wool sweaters. It’s now midwinter and my favorite pieces have little bits of pilling in areas that rub or have had more friction. Longer fibers pill less but all wool fibers including cashmere eventually pill a little bit.

We are in an age of down market cashmere thanks to the proliferation of the contemporary price point (lets say under $150) cashmere sweater thanks to the success of Uniqlo, Nadaam, Quincy and Italic.

My older sweaters from past well managed contemporary brands like Ann Taylor are in excellent shape as are my higher end pieces from APC and it’s ilk.

But more disposable 3-4 year basics I wear down? Well sweater care is a constant issue, especially the texture of a pilling fuzzy sweater bothers you. And it somewhat bothers me.

Cashmere are isn’t too hard. You can brush them gently and hand comb the pilling out. You hand wash, lay flat and fold your sweaters. You can use a sweater stone to gently brush them out. And that’s worth it for something that lasts. But the Italic sweater above gets a shave.

You can see from the picture I’ve got a lot of fuzzy bits inside the cheap shaver I bought off an Amazon seller years ago. It has lasted longer than some of my sweaters.Alas if I don’t want to look sloppy then shave I must.

If you want elegant functional code even in your basic systems well sometimes you must yak shave. If you want an elegant functional wardrobe sometimes you must sweater shave.